JP2011517548A - 抗mcp−1抗体、組成物、方法及び使用 - Google Patents

抗mcp−1抗体、組成物、方法及び使用 Download PDF

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Publication number
JP2011517548A
JP2011517548A JP2010515209A JP2010515209A JP2011517548A JP 2011517548 A JP2011517548 A JP 2011517548A JP 2010515209 A JP2010515209 A JP 2010515209A JP 2010515209 A JP2010515209 A JP 2010515209A JP 2011517548 A JP2011517548 A JP 2011517548A
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Prior art keywords
mcp
antibody
human
cells
binding
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JP2010515209A
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English (en)
Japanese (ja)
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JP2011517548A5 (enExample
Inventor
ダス,アヌク
スイート,レイモンド
ツイ,ピング
ベセア,デイドラ
ウー,シエング−ジウン
カング,ジエイムズ
ベイカー,アンドリー
Original Assignee
セントコア・オーソ・バイオテツク・インコーポレーテツド
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Publication of JP2011517548A publication Critical patent/JP2011517548A/ja
Publication of JP2011517548A5 publication Critical patent/JP2011517548A5/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
JP2010515209A 2007-06-29 2008-06-30 抗mcp−1抗体、組成物、方法及び使用 Pending JP2011517548A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94698807P 2007-06-29 2007-06-29
US60/946,988 2007-06-29
PCT/US2008/068696 WO2009006359A2 (en) 2007-06-29 2008-06-30 Anti- mcp-1 antibodies, compositions, methods and uses

Publications (2)

Publication Number Publication Date
JP2011517548A true JP2011517548A (ja) 2011-06-16
JP2011517548A5 JP2011517548A5 (enExample) 2011-08-04

Family

ID=40158715

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010515209A Pending JP2011517548A (ja) 2007-06-29 2008-06-30 抗mcp−1抗体、組成物、方法及び使用

Country Status (8)

Country Link
US (1) US20100254992A1 (enExample)
EP (1) EP2170387A4 (enExample)
JP (1) JP2011517548A (enExample)
CN (1) CN101827610A (enExample)
AU (1) AU2008269954A1 (enExample)
CA (1) CA2692392A1 (enExample)
IL (1) IL202996A0 (enExample)
WO (1) WO2009006359A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023506811A (ja) * 2019-12-18 2023-02-20 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 二重特異性抗ccl2抗体

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2686008A1 (en) * 2011-03-15 2014-01-22 INSERM - Institut National de la Santé et de la Recherche Médicale Compositions and methods for inhibiting tumor development caused by chemotherapy induced senescence
CN110072883A (zh) 2016-09-28 2019-07-30 科巴公司 治疗性mots-c相关的肽
EP3773627A1 (en) 2018-03-27 2021-02-17 Cohbar Inc. Peptide-containing formulations
CN112358547A (zh) * 2020-09-30 2021-02-12 浙江大学 抗人cxcl-2单克隆抗体3-d3及其编码基因和应用
AU2022295067A1 (en) * 2021-06-18 2023-12-21 F. Hoffmann-La Roche Ag Bispecific anti-ccl2 antibodies
CN118620076B (zh) * 2024-07-03 2024-12-17 武汉爱博泰克生物科技有限公司 用于检测鼠单核细胞趋化蛋白1的抗体和抗体对及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006125202A2 (en) * 2005-05-19 2006-11-23 Centocor, Inc. Anti- mcp-1 antibodies, compositions, methods and uses

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510264A (en) * 1993-09-28 1996-04-23 Insight Biotech Inc. Antibodies which bind meningitis related homologous antigenic sequences
US6696248B1 (en) * 1995-08-18 2004-02-24 Morphosys Ag Protein/(poly)peptide libraries
JPH0967399A (ja) * 1995-08-30 1997-03-11 Mitsui Toatsu Chem Inc 抗mcp−1ヒトモノクローナル抗体
PL209786B1 (pl) * 1999-01-15 2011-10-31 Genentech Inc Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna
GB0016138D0 (en) * 2000-06-30 2000-08-23 Novartis Ag Organic compounds
RU2339647C2 (ru) * 2002-08-19 2008-11-27 Астразенека Аб Антитела против моноцитарного хемоаттрактантного белка-1 (мср-1) и их применение
CA2507080C (en) * 2002-11-27 2015-01-06 Biogen Idec Ma Inc. Humanized antibodies against monocyte chemotactic proteins
WO2006125201A2 (en) * 2005-05-19 2006-11-23 Centocor, Inc. Anti-biotin-pegylated-mcp-1 mutein antibodies, compositions, methods and uses
US8114964B2 (en) * 2005-05-19 2012-02-14 Centocor, Inc. Anti-MCP-1 antibodies, compositions, methods and uses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006125202A2 (en) * 2005-05-19 2006-11-23 Centocor, Inc. Anti- mcp-1 antibodies, compositions, methods and uses

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023506811A (ja) * 2019-12-18 2023-02-20 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 二重特異性抗ccl2抗体
JP7415005B2 (ja) 2019-12-18 2024-01-16 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 二重特異性抗ccl2抗体
JP2024050565A (ja) * 2019-12-18 2024-04-10 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 二重特異性抗ccl2抗体

Also Published As

Publication number Publication date
CA2692392A1 (en) 2009-01-08
EP2170387A2 (en) 2010-04-07
WO2009006359A2 (en) 2009-01-08
WO2009006359A8 (en) 2009-12-30
EP2170387A4 (en) 2011-01-19
CN101827610A (zh) 2010-09-08
US20100254992A1 (en) 2010-10-07
IL202996A0 (en) 2011-08-01
AU2008269954A1 (en) 2009-01-08

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