JP2008546374A5

JP2008546374A5 -

Download PDF

Info

Publication number: JP2008546374A5
Authority: JP; Japan
Prior art keywords: mcp; antibody; human; cells; binding
Prior art date: 2006-05-19
Legal status : Granted

Application number

JP2008512576A

Other languages

English (en)

Japanese (ja)

Other versions

JP4975020B2 (ja

JP2008546374A (ja

Filing date

2006-05-19

Publication date

2012-04-05

2006-05-19 Application filed filed Critical

2006-05-19 Priority claimed from PCT/US2006/019627 external-priority patent/WO2006125202A2/en

2008-12-25 Publication of JP2008546374A publication Critical patent/JP2008546374A/ja

2012-04-05 Publication of JP2008546374A5 publication Critical patent/JP2008546374A5/ja

2012-07-11 Application granted granted Critical

2012-07-11 Publication of JP4975020B2 publication Critical patent/JP4975020B2/ja

2026-05-19 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

230000027455 binding Effects 0.000 claims description 122
108010047041 Complementarity Determining Regions Proteins 0.000 claims description 46
150000001413 amino acids Chemical class 0.000 claims description 38
125000003275 alpha amino acid group Chemical group 0.000 claims description 30
238000004519 manufacturing process Methods 0.000 claims description 21
239000003085 diluting agent Substances 0.000 claims description 16
239000008194 pharmaceutical composition Substances 0.000 claims description 10
102000014962 Monocyte Chemoattractant Proteins Human genes 0.000 claims description 8
108010064136 Monocyte Chemoattractant Proteins Proteins 0.000 claims description 8
239000005022 packaging material Substances 0.000 claims description 8
239000003937 drug carrier Substances 0.000 claims description 3
210000004027 cell Anatomy 0.000 description 239
102100021943 C-C motif chemokine 2 Human genes 0.000 description 177
101710155857 C-C motif chemokine 2 Proteins 0.000 description 170
241000282414 Homo sapiens Species 0.000 description 142
238000000034 method Methods 0.000 description 129
108090000623 proteins and genes Proteins 0.000 description 110
239000000203 mixture Substances 0.000 description 83
239000000427 antigen Substances 0.000 description 65
239000012634 fragment Substances 0.000 description 64
101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 description 62
238000003556 assay Methods 0.000 description 62
108091007433 antigens Proteins 0.000 description 61
102000036639 antigens Human genes 0.000 description 61
150000007523 nucleic acids Chemical class 0.000 description 61
102000046768 human CCL2 Human genes 0.000 description 58
239000013598 vector Substances 0.000 description 57
102000039446 nucleic acids Human genes 0.000 description 55
108020004707 nucleic acids Proteins 0.000 description 55
239000003814 drug Substances 0.000 description 54
230000000694 effects Effects 0.000 description 53
229940079593 drug Drugs 0.000 description 50
230000014509 gene expression Effects 0.000 description 50
235000001014 amino acid Nutrition 0.000 description 42
102000004169 proteins and genes Human genes 0.000 description 42
235000018102 proteins Nutrition 0.000 description 41
238000004091 panning Methods 0.000 description 39
239000000243 solution Substances 0.000 description 38
229940024606 amino acid Drugs 0.000 description 37
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 35
-1 rDNA Proteins 0.000 description 35
206010028980 Neoplasm Diseases 0.000 description 34
108090000765 processed proteins & peptides Proteins 0.000 description 34
210000001519 tissue Anatomy 0.000 description 34
241001465754 Metazoa Species 0.000 description 33
230000005764 inhibitory process Effects 0.000 description 32
238000010367 cloning Methods 0.000 description 31
239000013604 expression vector Substances 0.000 description 30
201000010099 disease Diseases 0.000 description 29
238000009472 formulation Methods 0.000 description 29
108060003951 Immunoglobulin Proteins 0.000 description 28
239000011230 binding agent Substances 0.000 description 28
102000018358 immunoglobulin Human genes 0.000 description 28
235000014113 dietary fatty acids Nutrition 0.000 description 27
229930195729 fatty acid Natural products 0.000 description 27
239000000194 fatty acid Substances 0.000 description 27
102100023688 Eotaxin Human genes 0.000 description 26
241000699666 Mus <mouse, genus> Species 0.000 description 26
108020004414 DNA Proteins 0.000 description 25
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 24
210000000056 organ Anatomy 0.000 description 24
102100034871 C-C motif chemokine 8 Human genes 0.000 description 23
239000000872 buffer Substances 0.000 description 23
239000002953 phosphate buffered saline Substances 0.000 description 23
239000013612 plasmid Substances 0.000 description 23
101710155833 C-C motif chemokine 8 Proteins 0.000 description 22
AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 description 22
238000011282 treatment Methods 0.000 description 22
208000027418 Wounds and injury Diseases 0.000 description 21
239000000047 product Substances 0.000 description 21
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 20
206010052428 Wound Diseases 0.000 description 20
230000004071 biological effect Effects 0.000 description 20
238000005516 engineering process Methods 0.000 description 20
230000035800 maturation Effects 0.000 description 20
102000019034 Chemokines Human genes 0.000 description 19
108010012236 Chemokines Proteins 0.000 description 19
230000009824 affinity maturation Effects 0.000 description 19
230000008569 process Effects 0.000 description 19
102000005962 receptors Human genes 0.000 description 19
108020003175 receptors Proteins 0.000 description 19
238000012216 screening Methods 0.000 description 19
102100032366 C-C motif chemokine 7 Human genes 0.000 description 18
230000001976 improved effect Effects 0.000 description 18
102000040430 polynucleotide Human genes 0.000 description 18
108091033319 polynucleotide Proteins 0.000 description 18
239000002157 polynucleotide Substances 0.000 description 18
101710155834 C-C motif chemokine 7 Proteins 0.000 description 17
230000009260 cross reactivity Effects 0.000 description 17
229920001223 polyethylene glycol Polymers 0.000 description 17
101710139422 Eotaxin Proteins 0.000 description 16
102220548557 Macrophage-capping protein_V41I_mutation Human genes 0.000 description 16
230000035605 chemotaxis Effects 0.000 description 16
241000588724 Escherichia coli Species 0.000 description 15
150000004665 fatty acids Chemical class 0.000 description 15
230000003472 neutralizing effect Effects 0.000 description 15
238000005457 optimization Methods 0.000 description 15
102000004196 processed proteins & peptides Human genes 0.000 description 15
241000699670 Mus sp. Species 0.000 description 14
239000003795 chemical substances by application Substances 0.000 description 14
230000027425 release of sequestered calcium ion into cytosol Effects 0.000 description 14
101100112922 Candida albicans CDR3 gene Proteins 0.000 description 13
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 13
238000012512 characterization method Methods 0.000 description 13
210000004962 mammalian cell Anatomy 0.000 description 13
229960000485 methotrexate Drugs 0.000 description 13
238000003199 nucleic acid amplification method Methods 0.000 description 13
239000000546 pharmaceutical excipient Substances 0.000 description 13
230000001105 regulatory effect Effects 0.000 description 13
239000002904 solvent Substances 0.000 description 13
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
102000004497 CCR2 Receptors Human genes 0.000 description 12
108010017312 CCR2 Receptors Proteins 0.000 description 12
102100040247 Tumor necrosis factor Human genes 0.000 description 12
230000003321 amplification Effects 0.000 description 12
239000002299 complementary DNA Substances 0.000 description 12
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 12
229910052737 gold Inorganic materials 0.000 description 12
239000010931 gold Substances 0.000 description 12
210000001616 monocyte Anatomy 0.000 description 12
229920000642 polymer Polymers 0.000 description 12
238000003653 radioligand binding assay Methods 0.000 description 12
238000012360 testing method Methods 0.000 description 12
230000009261 transgenic effect Effects 0.000 description 12
102100031151 C-C chemokine receptor type 2 Human genes 0.000 description 11
101710149815 C-C chemokine receptor type 2 Proteins 0.000 description 11
102100023702 C-C motif chemokine 13 Human genes 0.000 description 11
102000004127 Cytokines Human genes 0.000 description 11
108090000695 Cytokines Proteins 0.000 description 11
241000196324 Embryophyta Species 0.000 description 11
229960002685 biotin Drugs 0.000 description 11
239000011616 biotin Substances 0.000 description 11
238000001943 fluorescence-activated cell sorting Methods 0.000 description 11
238000009396 hybridization Methods 0.000 description 11
239000012212 insulator Substances 0.000 description 11
238000005259 measurement Methods 0.000 description 11
239000002609 medium Substances 0.000 description 11
239000000843 powder Substances 0.000 description 11
239000003755 preservative agent Substances 0.000 description 11
101710112613 C-C motif chemokine 13 Proteins 0.000 description 10
108010082548 Chemokine CCL11 Proteins 0.000 description 10
206010035226 Plasma cell myeloma Diseases 0.000 description 10
239000002202 Polyethylene glycol Substances 0.000 description 10
229920001213 Polysorbate 20 Polymers 0.000 description 10
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
238000004458 analytical method Methods 0.000 description 10
230000003302 anti-idiotype Effects 0.000 description 10
235000020958 biotin Nutrition 0.000 description 10
108020001096 dihydrofolate reductase Proteins 0.000 description 10
238000004090 dissolution Methods 0.000 description 10
239000003623 enhancer Substances 0.000 description 10
229940088597 hormone Drugs 0.000 description 10
230000001965 increasing effect Effects 0.000 description 10
108010087904 neutravidin Proteins 0.000 description 10
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 10
238000002360 preparation method Methods 0.000 description 10
230000000717 retained effect Effects 0.000 description 10
238000006467 substitution reaction Methods 0.000 description 10
208000011580 syndromic disease Diseases 0.000 description 10
239000003053 toxin Substances 0.000 description 10
231100000765 toxin Toxicity 0.000 description 10
108700012359 toxins Proteins 0.000 description 10
238000013518 transcription Methods 0.000 description 10
230000035897 transcription Effects 0.000 description 10
230000004614 tumor growth Effects 0.000 description 10
102100024746 Dihydrofolate reductase Human genes 0.000 description 9
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 9
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 9
241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 9
241000700159 Rattus Species 0.000 description 9
239000005557 antagonist Substances 0.000 description 9
239000003242 anti bacterial agent Substances 0.000 description 9
210000003719 b-lymphocyte Anatomy 0.000 description 9
230000000295 complement effect Effects 0.000 description 9
230000006870 function Effects 0.000 description 9
239000003446 ligand Substances 0.000 description 9
239000003550 marker Substances 0.000 description 9
201000000050 myeloid neoplasm Diseases 0.000 description 9
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 9
230000033300 receptor internalization Effects 0.000 description 9
238000011160 research Methods 0.000 description 9
239000000126 substance Substances 0.000 description 9
238000002560 therapeutic procedure Methods 0.000 description 9
238000004448 titration Methods 0.000 description 9
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
241000894006 Bacteria Species 0.000 description 8
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 8
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 8
108010076504 Protein Sorting Signals Proteins 0.000 description 8
239000011575 calcium Substances 0.000 description 8
229910052791 calcium Inorganic materials 0.000 description 8
230000000875 corresponding effect Effects 0.000 description 8
238000001514 detection method Methods 0.000 description 8
206010012601 diabetes mellitus Diseases 0.000 description 8
238000010494 dissociation reaction Methods 0.000 description 8
230000005593 dissociations Effects 0.000 description 8
239000005556 hormone Substances 0.000 description 8
210000004408 hybridoma Anatomy 0.000 description 8
230000000670 limiting effect Effects 0.000 description 8
150000003839 salts Chemical class 0.000 description 8
239000007790 solid phase Substances 0.000 description 8
239000000725 suspension Substances 0.000 description 8
230000001225 therapeutic effect Effects 0.000 description 8
108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
241000283707 Capra Species 0.000 description 7
229920002307 Dextran Polymers 0.000 description 7
241000282412 Homo Species 0.000 description 7
101000946794 Homo sapiens C-C motif chemokine 8 Proteins 0.000 description 7
108010021625 Immunoglobulin Fragments Proteins 0.000 description 7
102000008394 Immunoglobulin Fragments Human genes 0.000 description 7
108091028043 Nucleic acid sequence Proteins 0.000 description 7
102220492441 Selenoprotein V_F43Y_mutation Human genes 0.000 description 7
206010052779 Transplant rejections Diseases 0.000 description 7
241000700605 Viruses Species 0.000 description 7
238000007792 addition Methods 0.000 description 7
239000000556 agonist Substances 0.000 description 7
239000006285 cell suspension Substances 0.000 description 7
238000006243 chemical reaction Methods 0.000 description 7
230000001684 chronic effect Effects 0.000 description 7
230000004927 fusion Effects 0.000 description 7
210000004602 germ cell Anatomy 0.000 description 7
108010082117 matrigel Proteins 0.000 description 7
230000001404 mediated effect Effects 0.000 description 7
239000002245 particle Substances 0.000 description 7
239000012071 phase Substances 0.000 description 7
230000008488 polyadenylation Effects 0.000 description 7
229920001184 polypeptide Polymers 0.000 description 7
230000002335 preservative effect Effects 0.000 description 7
230000002829 reductive effect Effects 0.000 description 7
210000003491 skin Anatomy 0.000 description 7
238000003786 synthesis reaction Methods 0.000 description 7
241000701022 Cytomegalovirus Species 0.000 description 6
238000002965 ELISA Methods 0.000 description 6
108010029961 Filgrastim Proteins 0.000 description 6
102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 6
102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 6
101000978392 Homo sapiens Eotaxin Proteins 0.000 description 6
108091006905 Human Serum Albumin Proteins 0.000 description 6
102000008100 Human Serum Albumin Human genes 0.000 description 6
108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 6
102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 6
108010090804 Streptavidin Proteins 0.000 description 6
108700019146 Transgenes Proteins 0.000 description 6
239000002253 acid Substances 0.000 description 6
230000000692 anti-sense effect Effects 0.000 description 6
238000004166 bioassay Methods 0.000 description 6
230000001275 ca(2+)-mobilization Effects 0.000 description 6
201000011510 cancer Diseases 0.000 description 6
150000001720 carbohydrates Chemical class 0.000 description 6
235000014633 carbohydrates Nutrition 0.000 description 6
210000004978 chinese hamster ovary cell Anatomy 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 description 6
231100000655 enterotoxin Toxicity 0.000 description 6
102000043805 human CCL8 Human genes 0.000 description 6
230000000147 hypnotic effect Effects 0.000 description 6
238000000338 in vitro Methods 0.000 description 6
238000001727 in vivo Methods 0.000 description 6
238000011534 incubation Methods 0.000 description 6
208000014674 injury Diseases 0.000 description 6
125000005647 linker group Chemical group 0.000 description 6
230000003211 malignant effect Effects 0.000 description 6
239000000463 material Substances 0.000 description 6
108020004999 messenger RNA Proteins 0.000 description 6
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 6
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 6
230000002685 pulmonary effect Effects 0.000 description 6
239000011780 sodium chloride Substances 0.000 description 6
230000003612 virological effect Effects 0.000 description 6
238000005406 washing Methods 0.000 description 6
LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 5
241000251468 Actinopterygii Species 0.000 description 5
102000001902 CC Chemokines Human genes 0.000 description 5
108010040471 CC Chemokines Proteins 0.000 description 5
208000024172 Cardiovascular disease Diseases 0.000 description 5
108091026890 Coding region Proteins 0.000 description 5
102000053602 DNA Human genes 0.000 description 5
101710146739 Enterotoxin Proteins 0.000 description 5
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 5
206010020751 Hypersensitivity Diseases 0.000 description 5
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 5
206010025323 Lymphomas Diseases 0.000 description 5
101100495072 Macaca fascicularis CCL2 gene Proteins 0.000 description 5
241000124008 Mammalia Species 0.000 description 5
208000012902 Nervous system disease Diseases 0.000 description 5
206010035664 Pneumonia Diseases 0.000 description 5
239000004793 Polystyrene Substances 0.000 description 5
239000007983 Tris buffer Substances 0.000 description 5
230000003213 activating effect Effects 0.000 description 5
239000013543 active substance Substances 0.000 description 5
239000000654 additive Substances 0.000 description 5
239000000443 aerosol Substances 0.000 description 5
125000000539 amino acid group Chemical group 0.000 description 5
239000002246 antineoplastic agent Substances 0.000 description 5
208000006673 asthma Diseases 0.000 description 5
230000000903 blocking effect Effects 0.000 description 5
210000003169 central nervous system Anatomy 0.000 description 5
230000001419 dependent effect Effects 0.000 description 5
208000035475 disorder Diseases 0.000 description 5
239000000147 enterotoxin Substances 0.000 description 5
210000003527 eukaryotic cell Anatomy 0.000 description 5
239000000284 extract Substances 0.000 description 5
108010074605 gamma-Globulins Proteins 0.000 description 5
239000007789 gas Substances 0.000 description 5
229920001477 hydrophilic polymer Polymers 0.000 description 5
230000003053 immunization Effects 0.000 description 5
230000004048 modification Effects 0.000 description 5
238000012986 modification Methods 0.000 description 5
239000003607 modifier Substances 0.000 description 5
210000000440 neutrophil Anatomy 0.000 description 5
235000016709 nutrition Nutrition 0.000 description 5
229920002223 polystyrene Polymers 0.000 description 5
238000000746 purification Methods 0.000 description 5
239000002287 radioligand Substances 0.000 description 5
210000002966 serum Anatomy 0.000 description 5
235000000346 sugar Nutrition 0.000 description 5
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 5
239000003981 vehicle Substances 0.000 description 5
LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 4
108091003079 Bovine Serum Albumin Proteins 0.000 description 4
102100031172 C-C chemokine receptor type 1 Human genes 0.000 description 4
101710149814 C-C chemokine receptor type 1 Proteins 0.000 description 4
102100036849 C-C motif chemokine 24 Human genes 0.000 description 4
102100021935 C-C motif chemokine 26 Human genes 0.000 description 4
102100032367 C-C motif chemokine 5 Human genes 0.000 description 4
108010083647 Chemokine CCL24 Proteins 0.000 description 4
108010083698 Chemokine CCL26 Proteins 0.000 description 4
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 4
108091035707 Consensus sequence Proteins 0.000 description 4
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
206010016654 Fibrosis Diseases 0.000 description 4
239000004471 Glycine Substances 0.000 description 4
101000978379 Homo sapiens C-C motif chemokine 13 Proteins 0.000 description 4
101000797758 Homo sapiens C-C motif chemokine 7 Proteins 0.000 description 4
201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 description 4
208000029523 Interstitial Lung disease Diseases 0.000 description 4
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 4
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 4
241000282567 Macaca fascicularis Species 0.000 description 4
241001529936 Murinae Species 0.000 description 4
101000978374 Mus musculus C-C motif chemokine 12 Proteins 0.000 description 4
230000004988 N-glycosylation Effects 0.000 description 4
206010061902 Pancreatic neoplasm Diseases 0.000 description 4
241001494479 Pecora Species 0.000 description 4
241000288906 Primates Species 0.000 description 4
201000004681 Psoriasis Diseases 0.000 description 4
241000283984 Rodentia Species 0.000 description 4
240000004808 Saccharomyces cerevisiae Species 0.000 description 4
206010039710 Scleroderma Diseases 0.000 description 4
241000607768 Shigella Species 0.000 description 4
210000001744 T-lymphocyte Anatomy 0.000 description 4
239000004098 Tetracycline Substances 0.000 description 4
239000004480 active ingredient Substances 0.000 description 4
235000004279 alanine Nutrition 0.000 description 4
229940100198 alkylating agent Drugs 0.000 description 4
239000002168 alkylating agent Substances 0.000 description 4
208000026935 allergic disease Diseases 0.000 description 4
150000001412 amines Chemical class 0.000 description 4
230000000340 anti-metabolite Effects 0.000 description 4
210000000628 antibody-producing cell Anatomy 0.000 description 4
239000003146 anticoagulant agent Substances 0.000 description 4
239000000935 antidepressant agent Substances 0.000 description 4
229940100197 antimetabolite Drugs 0.000 description 4
239000002256 antimetabolite Substances 0.000 description 4
238000013459 approach Methods 0.000 description 4
239000008346 aqueous phase Substances 0.000 description 4
210000003403 autonomic nervous system Anatomy 0.000 description 4
230000001580 bacterial effect Effects 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
230000037396 body weight Effects 0.000 description 4
238000004113 cell culture Methods 0.000 description 4
210000000349 chromosome Anatomy 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
238000012217 deletion Methods 0.000 description 4
230000037430 deletion Effects 0.000 description 4
230000002526 effect on cardiovascular system Effects 0.000 description 4
238000011156 evaluation Methods 0.000 description 4
230000003176 fibrotic effect Effects 0.000 description 4
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 4
230000036039 immunity Effects 0.000 description 4
230000005847 immunogenicity Effects 0.000 description 4
230000016784 immunoglobulin production Effects 0.000 description 4
230000006872 improvement Effects 0.000 description 4
208000015181 infectious disease Diseases 0.000 description 4
238000003780 insertion Methods 0.000 description 4
230000037431 insertion Effects 0.000 description 4
230000003993 interaction Effects 0.000 description 4
208000036971 interstitial lung disease 2 Diseases 0.000 description 4
238000007912 intraperitoneal administration Methods 0.000 description 4
238000002955 isolation Methods 0.000 description 4
210000002540 macrophage Anatomy 0.000 description 4
229910052757 nitrogen Inorganic materials 0.000 description 4
230000009871 nonspecific binding Effects 0.000 description 4
201000002528 pancreatic cancer Diseases 0.000 description 4
230000036961 partial effect Effects 0.000 description 4
230000007170 pathology Effects 0.000 description 4
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
229920001451 polypropylene glycol Polymers 0.000 description 4
229920001282 polysaccharide Polymers 0.000 description 4
229920000053 polysorbate 80 Polymers 0.000 description 4
238000000159 protein binding assay Methods 0.000 description 4
238000010188 recombinant method Methods 0.000 description 4
230000009467 reduction Effects 0.000 description 4
230000010076 replication Effects 0.000 description 4
239000000523 sample Substances 0.000 description 4
108010038379 sargramostim Proteins 0.000 description 4
238000001542 size-exclusion chromatography Methods 0.000 description 4
230000009870 specific binding Effects 0.000 description 4
150000003431 steroids Chemical class 0.000 description 4
238000007920 subcutaneous administration Methods 0.000 description 4
239000006228 supernatant Substances 0.000 description 4
238000001356 surgical procedure Methods 0.000 description 4
235000019364 tetracycline Nutrition 0.000 description 4
150000003522 tetracyclines Chemical class 0.000 description 4
238000011830 transgenic mouse model Methods 0.000 description 4
230000014616 translation Effects 0.000 description 4
230000008733 trauma Effects 0.000 description 4
241001515965 unidentified phage Species 0.000 description 4
UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 3
229930182837 (R)-adrenaline Natural products 0.000 description 3
HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 description 3
ZAVJTSLIGAGALR-UHFFFAOYSA-N 2-(2,2,2-trifluoroacetyl)cyclooctan-1-one Chemical compound FC(F)(F)C(=O)C1CCCCCCC1=O ZAVJTSLIGAGALR-UHFFFAOYSA-N 0.000 description 3
PFWLFWPASULGAN-UHFFFAOYSA-N 7-methylxanthine Chemical compound N1C(=O)NC(=O)C2=C1N=CN2C PFWLFWPASULGAN-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
206010001052 Acute respiratory distress syndrome Diseases 0.000 description 3
208000035143 Bacterial infection Diseases 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
108050006947 CXC Chemokine Proteins 0.000 description 3
102000019388 CXC chemokine Human genes 0.000 description 3
229930186147 Cephalosporin Natural products 0.000 description 3
108010055166 Chemokine CCL5 Proteins 0.000 description 3
101100007328 Cocos nucifera COS-1 gene Proteins 0.000 description 3
108010035532 Collagen Proteins 0.000 description 3
102000008186 Collagen Human genes 0.000 description 3
208000035473 Communicable disease Diseases 0.000 description 3
206010010774 Constipation Diseases 0.000 description 3
241000699802 Cricetulus griseus Species 0.000 description 3
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 3
108010036949 Cyclosporine Proteins 0.000 description 3
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
101150074155 DHFR gene Proteins 0.000 description 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
102000004190 Enzymes Human genes 0.000 description 3
108090000790 Enzymes Proteins 0.000 description 3
108010074604 Epoetin Alfa Proteins 0.000 description 3
102000003951 Erythropoietin Human genes 0.000 description 3
108090000394 Erythropoietin Proteins 0.000 description 3
108010008165 Etanercept Proteins 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 3
108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 3
241000238631 Hexapoda Species 0.000 description 3
101000713078 Homo sapiens C-C motif chemokine 24 Proteins 0.000 description 3
101000897493 Homo sapiens C-C motif chemokine 26 Proteins 0.000 description 3
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 3
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 3
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
239000004472 Lysine Substances 0.000 description 3
229930195725 Mannitol Natural products 0.000 description 3
206010027480 Metastatic malignant melanoma Diseases 0.000 description 3
241000283973 Oryctolagus cuniculus Species 0.000 description 3
229930182555 Penicillin Natural products 0.000 description 3
239000004698 Polyethylene Substances 0.000 description 3
108010039918 Polylysine Proteins 0.000 description 3
208000012322 Raynaud phenomenon Diseases 0.000 description 3
108020004511 Recombinant DNA Proteins 0.000 description 3
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 3
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 3
208000013616 Respiratory Distress Syndrome Diseases 0.000 description 3
239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 3
238000011579 SCID mouse model Methods 0.000 description 3
239000000150 Sympathomimetic Substances 0.000 description 3
108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 3
241000607598 Vibrio Species 0.000 description 3
208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 3
201000000028 adult respiratory distress syndrome Diseases 0.000 description 3
125000000217 alkyl group Chemical group 0.000 description 3
229940126575 aminoglycoside Drugs 0.000 description 3
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 3
229960000723 ampicillin Drugs 0.000 description 3
239000003263 anabolic agent Substances 0.000 description 3
230000003444 anaesthetic effect Effects 0.000 description 3
230000000202 analgesic effect Effects 0.000 description 3
230000000507 anthelmentic effect Effects 0.000 description 3
229940124339 anthelmintic agent Drugs 0.000 description 3
239000000921 anthelmintic agent Substances 0.000 description 3
230000009830 antibody antigen interaction Effects 0.000 description 3
229940127219 anticoagulant drug Drugs 0.000 description 3
229940005513 antidepressants Drugs 0.000 description 3
239000003793 antidiarrheal agent Substances 0.000 description 3
229940121375 antifungal agent Drugs 0.000 description 3
239000003435 antirheumatic agent Substances 0.000 description 3
239000003434 antitussive agent Substances 0.000 description 3
229940124584 antitussives Drugs 0.000 description 3
239000003699 antiulcer agent Substances 0.000 description 3
239000003443 antiviral agent Substances 0.000 description 3
229940121357 antivirals Drugs 0.000 description 3
239000002249 anxiolytic agent Substances 0.000 description 3
206010003119 arrhythmia Diseases 0.000 description 3
AUJRCFUBUPVWSZ-XTZHGVARSA-M auranofin Chemical compound CCP(CC)(CC)=[Au]S[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O AUJRCFUBUPVWSZ-XTZHGVARSA-M 0.000 description 3
229960005207 auranofin Drugs 0.000 description 3
229960002170 azathioprine Drugs 0.000 description 3
LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 3
208000022362 bacterial infectious disease Diseases 0.000 description 3
229960004669 basiliximab Drugs 0.000 description 3
229940125388 beta agonist Drugs 0.000 description 3
229940041011 carbapenems Drugs 0.000 description 3
125000004432 carbon atom Chemical group C* 0.000 description 3
230000001413 cellular effect Effects 0.000 description 3
229940124587 cephalosporin Drugs 0.000 description 3
150000001780 cephalosporins Chemical class 0.000 description 3
239000005482 chemotactic factor Substances 0.000 description 3
229960001265 ciclosporin Drugs 0.000 description 3
230000001886 ciliary effect Effects 0.000 description 3
208000019425 cirrhosis of liver Diseases 0.000 description 3
229920001436 collagen Polymers 0.000 description 3
238000010276 construction Methods 0.000 description 3
239000003246 corticosteroid Substances 0.000 description 3
229960000265 cromoglicic acid Drugs 0.000 description 3
IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 3
229930182912 cyclosporin Natural products 0.000 description 3
235000018417 cysteine Nutrition 0.000 description 3
229960002806 daclizumab Drugs 0.000 description 3
230000007850 degeneration Effects 0.000 description 3
238000011161 development Methods 0.000 description 3
230000018109 developmental process Effects 0.000 description 3
238000010790 dilution Methods 0.000 description 3
239000012895 dilution Substances 0.000 description 3
239000006185 dispersion Substances 0.000 description 3
229960003530 donepezil Drugs 0.000 description 3
108010067396 dornase alfa Proteins 0.000 description 3
230000009977 dual effect Effects 0.000 description 3
229940088598 enzyme Drugs 0.000 description 3
229960005139 epinephrine Drugs 0.000 description 3
229960003388 epoetin alfa Drugs 0.000 description 3
229940105423 erythropoietin Drugs 0.000 description 3
150000002148 esters Chemical class 0.000 description 3
239000002834 estrogen receptor modulator Substances 0.000 description 3
229960000403 etanercept Drugs 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
239000012091 fetal bovine serum Substances 0.000 description 3
229960004177 filgrastim Drugs 0.000 description 3
229940124307 fluoroquinolone Drugs 0.000 description 3
108020001507 fusion proteins Proteins 0.000 description 3
102000037865 fusion proteins Human genes 0.000 description 3
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 3
150000004676 glycans Chemical class 0.000 description 3
230000013595 glycosylation Effects 0.000 description 3
238000006206 glycosylation reaction Methods 0.000 description 3
230000012010 growth Effects 0.000 description 3
239000000122 growth hormone Substances 0.000 description 3
230000035876 healing Effects 0.000 description 3
230000036541 health Effects 0.000 description 3
102000043798 human CCL11 Human genes 0.000 description 3
102000043801 human CCL24 Human genes 0.000 description 3
102000051934 human CCL26 Human genes 0.000 description 3
229960002927 hydroxychloroquine sulfate Drugs 0.000 description 3
230000009610 hypersensitivity Effects 0.000 description 3
229960003444 immunosuppressant agent Drugs 0.000 description 3
239000003018 immunosuppressive agent Substances 0.000 description 3
230000008676 import Effects 0.000 description 3
230000001939 inductive effect Effects 0.000 description 3
230000002757 inflammatory effect Effects 0.000 description 3
238000001802 infusion Methods 0.000 description 3
238000007918 intramuscular administration Methods 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 description 3
229960000681 leflunomide Drugs 0.000 description 3
239000003589 local anesthetic agent Substances 0.000 description 3
210000004072 lung Anatomy 0.000 description 3
210000004698 lymphocyte Anatomy 0.000 description 3
239000008176 lyophilized powder Substances 0.000 description 3
239000003120 macrolide antibiotic agent Substances 0.000 description 3
229940041033 macrolides Drugs 0.000 description 3
239000000594 mannitol Substances 0.000 description 3
235000010355 mannitol Nutrition 0.000 description 3
238000001819 mass spectrum Methods 0.000 description 3
208000021039 metastatic melanoma Diseases 0.000 description 3
HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 3
239000011859 microparticle Substances 0.000 description 3
201000006417 multiple sclerosis Diseases 0.000 description 3
210000003205 muscle Anatomy 0.000 description 3
229960000951 mycophenolic acid Drugs 0.000 description 3
HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 3
230000002911 mydriatic effect Effects 0.000 description 3
208000010125 myocardial infarction Diseases 0.000 description 3
239000003158 myorelaxant agent Substances 0.000 description 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
239000006199 nebulizer Substances 0.000 description 3
230000001613 neoplastic effect Effects 0.000 description 3
229940029345 neupogen Drugs 0.000 description 3
239000000842 neuromuscular blocking agent Substances 0.000 description 3
238000006386 neutralization reaction Methods 0.000 description 3
239000000346 nonvolatile oil Substances 0.000 description 3
230000000414 obstructive effect Effects 0.000 description 3
210000001672 ovary Anatomy 0.000 description 3
238000007911 parenteral administration Methods 0.000 description 3
230000001575 pathological effect Effects 0.000 description 3
150000002960 penicillins Chemical class 0.000 description 3
230000002093 peripheral effect Effects 0.000 description 3
238000001050 pharmacotherapy Methods 0.000 description 3
229960005190 phenylalanine Drugs 0.000 description 3
239000008363 phosphate buffer Substances 0.000 description 3
229920003023 plastic Polymers 0.000 description 3
239000004033 plastic Substances 0.000 description 3
229920000656 polylysine Polymers 0.000 description 3
238000003752 polymerase chain reaction Methods 0.000 description 3
239000005017 polysaccharide Substances 0.000 description 3
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 3
210000001236 prokaryotic cell Anatomy 0.000 description 3
239000012217 radiopharmaceutical Substances 0.000 description 3
229940121896 radiopharmaceutical Drugs 0.000 description 3
230000002799 radiopharmaceutical effect Effects 0.000 description 3
230000008707 rearrangement Effects 0.000 description 3
238000003259 recombinant expression Methods 0.000 description 3
230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 3
210000002345 respiratory system Anatomy 0.000 description 3
230000004044 response Effects 0.000 description 3
208000037803 restenosis Diseases 0.000 description 3
206010039073 rheumatoid arthritis Diseases 0.000 description 3
229960002530 sargramostim Drugs 0.000 description 3
239000000932 sedative agent Substances 0.000 description 3
230000035945 sensitivity Effects 0.000 description 3
AGHLUVOCTHWMJV-UHFFFAOYSA-J sodium;gold(3+);2-sulfanylbutanedioate Chemical compound [Na+].[Au+3].[O-]C(=O)CC(S)C([O-])=O.[O-]C(=O)CC(S)C([O-])=O AGHLUVOCTHWMJV-UHFFFAOYSA-J 0.000 description 3
125000006850 spacer group Chemical group 0.000 description 3
241000894007 species Species 0.000 description 3
238000001694 spray drying Methods 0.000 description 3
150000005846 sugar alcohols Chemical class 0.000 description 3
150000008163 sugars Chemical class 0.000 description 3
229940124530 sulfonamide Drugs 0.000 description 3
150000003456 sulfonamides Chemical class 0.000 description 3
230000001975 sympathomimetic effect Effects 0.000 description 3
208000024891 symptom Diseases 0.000 description 3
YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 description 3
229960001685 tacrine Drugs 0.000 description 3
229940040944 tetracyclines Drugs 0.000 description 3
229940124597 therapeutic agent Drugs 0.000 description 3
210000001685 thyroid gland Anatomy 0.000 description 3
238000013519 translation Methods 0.000 description 3
210000004881 tumor cell Anatomy 0.000 description 3
102000003298 tumor necrosis factor receptor Human genes 0.000 description 3
241000701447 unidentified baculovirus Species 0.000 description 3
238000002255 vaccination Methods 0.000 description 3
229940088594 vitamin Drugs 0.000 description 3
229930003231 vitamin Natural products 0.000 description 3
235000013343 vitamin Nutrition 0.000 description 3
239000011782 vitamin Substances 0.000 description 3
230000003442 weekly effect Effects 0.000 description 3
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 2
WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 description 2
CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 2
208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 2
208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
102000009027 Albumins Human genes 0.000 description 2
108010088751 Albumins Proteins 0.000 description 2
102000002260 Alkaline Phosphatase Human genes 0.000 description 2
108020004774 Alkaline Phosphatase Proteins 0.000 description 2
208000024827 Alzheimer disease Diseases 0.000 description 2
208000003343 Antiphospholipid Syndrome Diseases 0.000 description 2
108020005544 Antisense RNA Proteins 0.000 description 2
YZXBAPSDXZZRGB-DOFZRALJSA-M Arachidonate Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC([O-])=O YZXBAPSDXZZRGB-DOFZRALJSA-M 0.000 description 2
239000004475 Arginine Substances 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
206010003591 Ataxia Diseases 0.000 description 2
201000001320 Atherosclerosis Diseases 0.000 description 2
208000012657 Atopic disease Diseases 0.000 description 2
102100022718 Atypical chemokine receptor 2 Human genes 0.000 description 2
XHVAWZZCDCWGBK-WYRLRVFGSA-M Aurothioglucose Chemical compound OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O XHVAWZZCDCWGBK-WYRLRVFGSA-M 0.000 description 2
208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 2
208000033222 Biliary cirrhosis primary Diseases 0.000 description 2
208000006386 Bone Resorption Diseases 0.000 description 2
108700013048 CCL2 Proteins 0.000 description 2
102000004499 CCR3 Receptors Human genes 0.000 description 2
108010017316 CCR3 Receptors Proteins 0.000 description 2
206010006895 Cachexia Diseases 0.000 description 2
101710132601 Capsid protein Proteins 0.000 description 2
201000009030 Carcinoma Diseases 0.000 description 2
208000031229 Cardiomyopathies Diseases 0.000 description 2
DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 2
102000014914 Carrier Proteins Human genes 0.000 description 2
208000015879 Cerebellar disease Diseases 0.000 description 2
102000009410 Chemokine receptor Human genes 0.000 description 2
108050000299 Chemokine receptor Proteins 0.000 description 2
241001559589 Cullen Species 0.000 description 2
201000003883 Cystic fibrosis Diseases 0.000 description 2
RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
102000004163 DNA-directed RNA polymerases Human genes 0.000 description 2
201000004624 Dermatitis Diseases 0.000 description 2
206010012442 Dermatitis contact Diseases 0.000 description 2
206010012689 Diabetic retinopathy Diseases 0.000 description 2
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
241001269524 Dura Species 0.000 description 2
102100027285 Fanconi anemia group B protein Human genes 0.000 description 2
108010087819 Fc receptors Proteins 0.000 description 2
102000009109 Fc receptors Human genes 0.000 description 2
102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 2
108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
108700028146 Genetic Enhancer Elements Proteins 0.000 description 2
108700007698 Genetic Terminator Regions Proteins 0.000 description 2
206010018364 Glomerulonephritis Diseases 0.000 description 2
INGJLBQKTRJLFO-UKJIMTQDSA-N Glu-Ile-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CCC(O)=O INGJLBQKTRJLFO-UKJIMTQDSA-N 0.000 description 2
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
108010051696 Growth Hormone Proteins 0.000 description 2
102000018997 Growth Hormone Human genes 0.000 description 2
206010019280 Heart failures Diseases 0.000 description 2
208000032843 Hemorrhage Diseases 0.000 description 2
101000678892 Homo sapiens Atypical chemokine receptor 2 Proteins 0.000 description 2
101000777558 Homo sapiens C-C chemokine receptor type 10 Proteins 0.000 description 2
101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 description 2
101000914679 Homo sapiens Fanconi anemia group B protein Proteins 0.000 description 2
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 2
108700005091 Immunoglobulin Genes Proteins 0.000 description 2
102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 2
108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 2
206010061218 Inflammation Diseases 0.000 description 2
108010002350 Interleukin-2 Proteins 0.000 description 2
102000000588 Interleukin-2 Human genes 0.000 description 2
108091092195 Intron Proteins 0.000 description 2
206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 2
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
208000019693 Lung disease Diseases 0.000 description 2
101710091439 Major capsid protein 1 Proteins 0.000 description 2
206010060880 Monoclonal gammopathy Diseases 0.000 description 2
241000699660 Mus musculus Species 0.000 description 2
201000003793 Myelodysplastic syndrome Diseases 0.000 description 2
208000033776 Myeloid Acute Leukemia Diseases 0.000 description 2
229930193140 Neomycin Natural products 0.000 description 2
206010029164 Nephrotic syndrome Diseases 0.000 description 2
244000061176 Nicotiana tabacum Species 0.000 description 2
235000002637 Nicotiana tabacum Nutrition 0.000 description 2
108091034117 Oligonucleotide Proteins 0.000 description 2
108700026244 Open Reading Frames Proteins 0.000 description 2
208000001132 Osteoporosis Diseases 0.000 description 2
208000012868 Overgrowth Diseases 0.000 description 2
229930012538 Paclitaxel Natural products 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
229920000954 Polyglycolide Polymers 0.000 description 2
208000012654 Primary biliary cholangitis Diseases 0.000 description 2
208000028017 Psychotic disease Diseases 0.000 description 2
MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 2
208000003782 Raynaud disease Diseases 0.000 description 2
206010063837 Reperfusion injury Diseases 0.000 description 2
206010039085 Rhinitis allergic Diseases 0.000 description 2
241000607142 Salmonella Species 0.000 description 2
206010040047 Sepsis Diseases 0.000 description 2
208000003954 Spinal Muscular Atrophies of Childhood Diseases 0.000 description 2
241000191967 Staphylococcus aureus Species 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
108010022394 Threonine synthase Proteins 0.000 description 2
101710101607 Toxic shock syndrome toxin-1 Proteins 0.000 description 2
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
206010047115 Vasculitis Diseases 0.000 description 2
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
238000009825 accumulation Methods 0.000 description 2
230000001154 acute effect Effects 0.000 description 2
208000018254 acute transverse myelitis Diseases 0.000 description 2
238000001042 affinity chromatography Methods 0.000 description 2
230000000172 allergic effect Effects 0.000 description 2
201000010105 allergic rhinitis Diseases 0.000 description 2
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
125000003277 amino group Chemical group 0.000 description 2
229940070021 anabolic steroids Drugs 0.000 description 2
238000000540 analysis of variance Methods 0.000 description 2
230000033115 angiogenesis Effects 0.000 description 2
239000002333 angiotensin II receptor antagonist Substances 0.000 description 2
229940125364 angiotensin receptor blocker Drugs 0.000 description 2
230000000954 anitussive effect Effects 0.000 description 2
230000001430 anti-depressive effect Effects 0.000 description 2
230000001142 anti-diarrhea Effects 0.000 description 2
230000002924 anti-infective effect Effects 0.000 description 2
230000003561 anti-manic effect Effects 0.000 description 2
229940088710 antibiotic agent Drugs 0.000 description 2
229940125714 antidiarrheal agent Drugs 0.000 description 2
239000002111 antiemetic agent Substances 0.000 description 2
229960005475 antiinfective agent Drugs 0.000 description 2
229940045719 antineoplastic alkylating agent nitrosoureas Drugs 0.000 description 2
229940041181 antineoplastic drug Drugs 0.000 description 2
239000003963 antioxidant agent Substances 0.000 description 2
235000006708 antioxidants Nutrition 0.000 description 2
230000000949 anxiolytic effect Effects 0.000 description 2
229940005530 anxiolytics Drugs 0.000 description 2
229940114078 arachidonate Drugs 0.000 description 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
230000006793 arrhythmia Effects 0.000 description 2
230000003143 atherosclerotic effect Effects 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
208000010668 atopic eczema Diseases 0.000 description 2
229960001799 aurothioglucose Drugs 0.000 description 2
201000005008 bacterial sepsis Diseases 0.000 description 2
239000012148 binding buffer Substances 0.000 description 2
108091008324 binding proteins Proteins 0.000 description 2
229960000074 biopharmaceutical Drugs 0.000 description 2
229920001400 block copolymer Polymers 0.000 description 2
210000000601 blood cell Anatomy 0.000 description 2
210000001124 body fluid Anatomy 0.000 description 2
239000010839 body fluid Substances 0.000 description 2
210000000988 bone and bone Anatomy 0.000 description 2
230000024279 bone resorption Effects 0.000 description 2
210000004899 c-terminal region Anatomy 0.000 description 2
229910002091 carbon monoxide Inorganic materials 0.000 description 2
229960005243 carmustine Drugs 0.000 description 2
239000000969 carrier Substances 0.000 description 2
239000005018 casein Substances 0.000 description 2
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
235000021240 caseins Nutrition 0.000 description 2
238000000423 cell based assay Methods 0.000 description 2
239000002738 chelating agent Substances 0.000 description 2
125000003636 chemical group Chemical group 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
239000002975 chemoattractant Substances 0.000 description 2
230000003399 chemotactic effect Effects 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
238000004587 chromatography analysis Methods 0.000 description 2
230000007882 cirrhosis Effects 0.000 description 2
238000011260 co-administration Methods 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
238000002648 combination therapy Methods 0.000 description 2
230000002860 competitive effect Effects 0.000 description 2
239000003184 complementary RNA Substances 0.000 description 2
210000002808 connective tissue Anatomy 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
229960001334 corticosteroids Drugs 0.000 description 2
230000008878 coupling Effects 0.000 description 2
238000010168 coupling process Methods 0.000 description 2
238000005859 coupling reaction Methods 0.000 description 2
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
239000000430 cytokine receptor antagonist Substances 0.000 description 2
230000006378 damage Effects 0.000 description 2
238000000586 desensitisation Methods 0.000 description 2
230000001079 digestive effect Effects 0.000 description 2
102000004419 dihydrofolate reductase Human genes 0.000 description 2
150000002016 disaccharides Chemical class 0.000 description 2
HOWGUJZVBDQJKV-UHFFFAOYSA-N docosane Chemical compound CCCCCCCCCCCCCCCCCCCCCC HOWGUJZVBDQJKV-UHFFFAOYSA-N 0.000 description 2
DGXRZJSPDXZJFG-UHFFFAOYSA-N docosanedioic acid Chemical compound OC(=O)CCCCCCCCCCCCCCCCCCCCC(O)=O DGXRZJSPDXZJFG-UHFFFAOYSA-N 0.000 description 2
230000007783 downstream signaling Effects 0.000 description 2
239000003792 electrolyte Substances 0.000 description 2
238000004520 electroporation Methods 0.000 description 2
238000010828 elution Methods 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
230000002124 endocrine Effects 0.000 description 2
239000002158 endotoxin Substances 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
239000013613 expression plasmid Substances 0.000 description 2
238000010265 fast atom bombardment Methods 0.000 description 2
125000005313 fatty acid group Chemical group 0.000 description 2
230000004761 fibrosis Effects 0.000 description 2
238000004108 freeze drying Methods 0.000 description 2
125000000524 functional group Chemical group 0.000 description 2
239000000499 gel Substances 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
239000008103 glucose Substances 0.000 description 2
235000013922 glutamic acid Nutrition 0.000 description 2
239000004220 glutamic acid Substances 0.000 description 2
102000035122 glycosylated proteins Human genes 0.000 description 2
108091005608 glycosylated proteins Proteins 0.000 description 2
229940093915 gynecological organic acid Drugs 0.000 description 2
125000001475 halogen functional group Chemical group 0.000 description 2
210000002216 heart Anatomy 0.000 description 2
208000006454 hepatitis Diseases 0.000 description 2
231100000283 hepatitis Toxicity 0.000 description 2
238000004128 high performance liquid chromatography Methods 0.000 description 2
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
230000013632 homeostatic process Effects 0.000 description 2
239000003667 hormone antagonist Substances 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
239000003326 hypnotic agent Substances 0.000 description 2
CBFCDTFDPHXCNY-UHFFFAOYSA-N icosane Chemical compound CCCCCCCCCCCCCCCCCCCC CBFCDTFDPHXCNY-UHFFFAOYSA-N 0.000 description 2
230000028993 immune response Effects 0.000 description 2
208000026278 immune system disease Diseases 0.000 description 2
238000002649 immunization Methods 0.000 description 2
229940072221 immunoglobulins Drugs 0.000 description 2
239000002955 immunomodulating agent Substances 0.000 description 2
229940121354 immunomodulator Drugs 0.000 description 2
230000001861 immunosuppressant effect Effects 0.000 description 2
238000011065 in-situ storage Methods 0.000 description 2
230000002458 infectious effect Effects 0.000 description 2
230000004054 inflammatory process Effects 0.000 description 2
239000003112 inhibitor Substances 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
230000010354 integration Effects 0.000 description 2
230000003834 intracellular effect Effects 0.000 description 2
238000007914 intraventricular administration Methods 0.000 description 2
229960000310 isoleucine Drugs 0.000 description 2
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 2
BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 2
201000002215 juvenile rheumatoid arthritis Diseases 0.000 description 2
210000003292 kidney cell Anatomy 0.000 description 2
239000004310 lactic acid Substances 0.000 description 2
230000003902 lesion Effects 0.000 description 2
210000000265 leukocyte Anatomy 0.000 description 2
239000003199 leukotriene receptor blocking agent Substances 0.000 description 2
150000002632 lipids Chemical class 0.000 description 2
239000002502 liposome Substances 0.000 description 2
229960005015 local anesthetics Drugs 0.000 description 2
RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 2
229940127554 medical product Drugs 0.000 description 2
201000001441 melanoma Diseases 0.000 description 2
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
229940071648 metered dose inhaler Drugs 0.000 description 2
229930182817 methionine Natural products 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
235000010755 mineral Nutrition 0.000 description 2
239000011707 mineral Substances 0.000 description 2
230000000394 mitotic effect Effects 0.000 description 2
238000002156 mixing Methods 0.000 description 2
238000010369 molecular cloning Methods 0.000 description 2
150000002772 monosaccharides Chemical class 0.000 description 2
238000002703 mutagenesis Methods 0.000 description 2
231100000350 mutagenesis Toxicity 0.000 description 2
230000035772 mutation Effects 0.000 description 2
239000002637 mydriatic agent Substances 0.000 description 2
239000013642 negative control Substances 0.000 description 2
229960004927 neomycin Drugs 0.000 description 2
201000008383 nephritis Diseases 0.000 description 2
201000001119 neuropathy Diseases 0.000 description 2
230000007823 neuropathy Effects 0.000 description 2
239000002773 nucleotide Substances 0.000 description 2
125000003729 nucleotide group Chemical group 0.000 description 2
230000000474 nursing effect Effects 0.000 description 2
QWVGKYWNOKOFNN-UHFFFAOYSA-N o-cresol Chemical compound CC1=CC=CC=C1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 2
BNJOQKFENDDGSC-UHFFFAOYSA-N octadecanedioic acid Chemical compound OC(=O)CCCCCCCCCCCCCCCCC(O)=O BNJOQKFENDDGSC-UHFFFAOYSA-N 0.000 description 2
TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 2
229920001542 oligosaccharide Polymers 0.000 description 2
150000002482 oligosaccharides Chemical class 0.000 description 2
201000005737 orchitis Diseases 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
235000005985 organic acids Nutrition 0.000 description 2
125000000962 organic group Chemical group 0.000 description 2
230000003204 osmotic effect Effects 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 2
238000004806 packaging method and process Methods 0.000 description 2
229960001592 paclitaxel Drugs 0.000 description 2
208000008443 pancreatic carcinoma Diseases 0.000 description 2
229940090048 pen injector Drugs 0.000 description 2
210000005259 peripheral blood Anatomy 0.000 description 2
239000011886 peripheral blood Substances 0.000 description 2
208000033808 peripheral neuropathy Diseases 0.000 description 2
238000002823 phage display Methods 0.000 description 2
229940124531 pharmaceutical excipient Drugs 0.000 description 2
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
239000013600 plasmid vector Substances 0.000 description 2
229920001983 poloxamer Polymers 0.000 description 2
229920000747 poly(lactic acid) Polymers 0.000 description 2
229920001610 polycaprolactone Polymers 0.000 description 2
239000004633 polyglycolic acid Substances 0.000 description 2
239000004626 polylactic acid Substances 0.000 description 2
238000006116 polymerization reaction Methods 0.000 description 2
229920000136 polysorbate Polymers 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
239000003380 propellant Substances 0.000 description 2
238000003908 quality control method Methods 0.000 description 2
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 2
238000001525 receptor binding assay Methods 0.000 description 2
230000006798 recombination Effects 0.000 description 2
238000005215 recombination Methods 0.000 description 2
201000000306 sarcoidosis Diseases 0.000 description 2
230000003248 secreting effect Effects 0.000 description 2
230000028327 secretion Effects 0.000 description 2
230000001624 sedative effect Effects 0.000 description 2
239000006152 selective media Substances 0.000 description 2
230000035939 shock Effects 0.000 description 2
150000003384 small molecules Chemical class 0.000 description 2
239000011734 sodium Substances 0.000 description 2
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
238000001179 sorption measurement Methods 0.000 description 2
238000001228 spectrum Methods 0.000 description 2
210000000952 spleen Anatomy 0.000 description 2
206010041823 squamous cell carcinoma Diseases 0.000 description 2
238000010561 standard procedure Methods 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
239000000021 stimulant Substances 0.000 description 2
TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical compound OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 description 2
239000000758 substrate Substances 0.000 description 2
229910052717 sulfur Inorganic materials 0.000 description 2
229940064707 sympathomimetics Drugs 0.000 description 2
238000010189 synthetic method Methods 0.000 description 2
201000000596 systemic lupus erythematosus Diseases 0.000 description 2
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 2
HQHCYKULIHKCEB-UHFFFAOYSA-N tetradecanedioic acid Chemical compound OC(=O)CCCCCCCCCCCCC(O)=O HQHCYKULIHKCEB-UHFFFAOYSA-N 0.000 description 2
150000003573 thiols Chemical class 0.000 description 2
208000037816 tissue injury Diseases 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
230000010474 transient expression Effects 0.000 description 2
238000002054 transplantation Methods 0.000 description 2
208000009174 transverse myelitis Diseases 0.000 description 2
241001430294 unidentified retrovirus Species 0.000 description 2
239000004474 valine Substances 0.000 description 2
239000002023 wood Substances 0.000 description 2
230000029663 wound healing Effects 0.000 description 2
229940075420 xanthine Drugs 0.000 description 2
239000000811 xylitol Substances 0.000 description 2
235000010447 xylitol Nutrition 0.000 description 2
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
229960002675 xylitol Drugs 0.000 description 2
ABXYOVCSAGTJAC-JGWLITMVSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanethial Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=S ABXYOVCSAGTJAC-JGWLITMVSA-N 0.000 description 1
BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 description 1
VAIZVCMDJPBJCM-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-one;trihydrate Chemical compound O.O.O.FC(F)(F)C(=O)C(F)(F)F.FC(F)(F)C(=O)C(F)(F)F VAIZVCMDJPBJCM-UHFFFAOYSA-N 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
150000003923 2,5-pyrrolediones Chemical class 0.000 description 1
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
108050001326 26S Proteasome regulatory subunit 6A Proteins 0.000 description 1
102100029510 26S proteasome regulatory subunit 6A Human genes 0.000 description 1
108020005065 3' Flanking Region Proteins 0.000 description 1
SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 description 1
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
101710162847 8.6 kDa protein Proteins 0.000 description 1
208000030507 AIDS Diseases 0.000 description 1
102000007469 Actins Human genes 0.000 description 1
108010085238 Actins Proteins 0.000 description 1
208000009304 Acute Kidney Injury Diseases 0.000 description 1
206010000830 Acute leukaemia Diseases 0.000 description 1
208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
206010000871 Acute monocytic leukaemia Diseases 0.000 description 1
208000026872 Addison Disease Diseases 0.000 description 1
241000607534 Aeromonas Species 0.000 description 1
241000607516 Aeromonas caviae Species 0.000 description 1
108700018394 Aeromonas cytolytic enterotoxin Proteins 0.000 description 1
241000607528 Aeromonas hydrophila Species 0.000 description 1
241000607522 Aeromonas sobria Species 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
208000007848 Alcoholism Diseases 0.000 description 1
208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
201000004384 Alopecia Diseases 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
206010001881 Alveolar proteinosis Diseases 0.000 description 1
206010001889 Alveolitis Diseases 0.000 description 1
206010002198 Anaphylactic reaction Diseases 0.000 description 1
206010002383 Angina Pectoris Diseases 0.000 description 1
206010002388 Angina unstable Diseases 0.000 description 1
206010002556 Ankylosing Spondylitis Diseases 0.000 description 1
108090000669 Annexin A4 Proteins 0.000 description 1
102100034612 Annexin A4 Human genes 0.000 description 1
239000001904 Arabinogalactan Substances 0.000 description 1
229920000189 Arabinogalactan Polymers 0.000 description 1
200000000007 Arterial disease Diseases 0.000 description 1
206010003210 Arteriosclerosis Diseases 0.000 description 1
206010003226 Arteriovenous fistula Diseases 0.000 description 1
206010053555 Arthritis bacterial Diseases 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
108010011485 Aspartame Proteins 0.000 description 1
206010003497 Asphyxia Diseases 0.000 description 1
206010003598 Atelectasis Diseases 0.000 description 1
206010003658 Atrial Fibrillation Diseases 0.000 description 1
208000002102 Atrial Premature Complexes Diseases 0.000 description 1
206010003662 Atrial flutter Diseases 0.000 description 1
206010003671 Atrioventricular Block Diseases 0.000 description 1
206010003827 Autoimmune hepatitis Diseases 0.000 description 1
108090001008 Avidin Proteins 0.000 description 1
208000037157 Azotemia Diseases 0.000 description 1
208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
231100000699 Bacterial toxin Toxicity 0.000 description 1
KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
206010006002 Bone pain Diseases 0.000 description 1
206010006187 Breast cancer Diseases 0.000 description 1
208000026310 Breast neoplasm Diseases 0.000 description 1
206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 description 1
208000011691 Burkitt lymphomas Diseases 0.000 description 1
102100024167 C-C chemokine receptor type 3 Human genes 0.000 description 1
101710149862 C-C chemokine receptor type 3 Proteins 0.000 description 1
102000004500 CCR1 Receptors Human genes 0.000 description 1
108010017319 CCR1 Receptors Proteins 0.000 description 1
240000001432 Calendula officinalis Species 0.000 description 1
235000005881 Calendula officinalis Nutrition 0.000 description 1
101800000594 Capsid protein 1 Proteins 0.000 description 1
206010007559 Cardiac failure congestive Diseases 0.000 description 1
208000000135 Cardiovascular Syphilis Diseases 0.000 description 1
101150075117 Ccl12 gene Proteins 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
108020004998 Chloroplast DNA Proteins 0.000 description 1
108020005133 Chloroplast RNA Proteins 0.000 description 1
206010008631 Cholera Diseases 0.000 description 1
206010008748 Chorea Diseases 0.000 description 1
206010008909 Chronic Hepatitis Diseases 0.000 description 1
206010009208 Cirrhosis alcoholic Diseases 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
241000193163 Clostridioides difficile Species 0.000 description 1
241000193403 Clostridium Species 0.000 description 1
241000193155 Clostridium botulinum Species 0.000 description 1
241000193468 Clostridium perfringens Species 0.000 description 1
101710094648 Coat protein Proteins 0.000 description 1
108020004705 Codon Proteins 0.000 description 1
108700010070 Codon Usage Proteins 0.000 description 1
206010009944 Colon cancer Diseases 0.000 description 1
208000001333 Colorectal Neoplasms Diseases 0.000 description 1
108020004635 Complementary DNA Proteins 0.000 description 1
206010056370 Congestive cardiomyopathy Diseases 0.000 description 1
206010010741 Conjunctivitis Diseases 0.000 description 1
206010010744 Conjunctivitis allergic Diseases 0.000 description 1
208000034656 Contusions Diseases 0.000 description 1
241000557626 Corvus corax Species 0.000 description 1
208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
241000699800 Cricetinae Species 0.000 description 1
241000938605 Crocodylia Species 0.000 description 1
208000011231 Crohn disease Diseases 0.000 description 1
241000195493 Cryptophyta Species 0.000 description 1
229920001651 Cyanoacrylate Polymers 0.000 description 1
206010011703 Cyanosis Diseases 0.000 description 1
229920000858 Cyclodextrin Polymers 0.000 description 1
UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 1
GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
QWIZNVHXZXRPDR-UHFFFAOYSA-N D-melezitose Natural products O1C(CO)C(O)C(O)C(O)C1OC1C(O)C(CO)OC1(CO)OC1OC(CO)C(O)C(O)C1O QWIZNVHXZXRPDR-UHFFFAOYSA-N 0.000 description 1
230000007023 DNA restriction-modification system Effects 0.000 description 1
102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
206010012289 Dementia Diseases 0.000 description 1
206010067889 Dementia with Lewy bodies Diseases 0.000 description 1
208000016192 Demyelinating disease Diseases 0.000 description 1
206010012310 Dengue fever Diseases 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
208000007342 Diabetic Nephropathies Diseases 0.000 description 1
102000016607 Diphtheria Toxin Human genes 0.000 description 1
108010053187 Diphtheria Toxin Proteins 0.000 description 1
208000002251 Dissecting Aneurysm Diseases 0.000 description 1
102000015554 Dopamine receptor Human genes 0.000 description 1
108050004812 Dopamine receptor Proteins 0.000 description 1
201000010374 Down Syndrome Diseases 0.000 description 1
206010014612 Encephalitis viral Diseases 0.000 description 1
201000009273 Endometriosis Diseases 0.000 description 1
YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 1
241000283086 Equidae Species 0.000 description 1
241001646719 Escherichia coli O157:H7 Species 0.000 description 1
241000206602 Eukaryota Species 0.000 description 1
206010073306 Exposure to radiation Diseases 0.000 description 1
208000027776 Extrapyramidal disease Diseases 0.000 description 1
208000004248 Familial Primary Pulmonary Hypertension Diseases 0.000 description 1
208000002633 Febrile Neutropenia Diseases 0.000 description 1
229920001917 Ficoll Polymers 0.000 description 1
206010016717 Fistula Diseases 0.000 description 1
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
208000024412 Friedreich ataxia Diseases 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
206010017533 Fungal infection Diseases 0.000 description 1
206010058872 Fungal sepsis Diseases 0.000 description 1
108091006027 G proteins Proteins 0.000 description 1
101150074355 GS gene Proteins 0.000 description 1
102000030782 GTP binding Human genes 0.000 description 1
108091000058 GTP-Binding Proteins 0.000 description 1
201000000628 Gas Gangrene Diseases 0.000 description 1
208000032612 Glial tumor Diseases 0.000 description 1
206010018338 Glioma Diseases 0.000 description 1
ZFBBMCKQSNJZSN-AUTRQRHGSA-N Gln-Val-Gln Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O ZFBBMCKQSNJZSN-AUTRQRHGSA-N 0.000 description 1
102000006395 Globulins Human genes 0.000 description 1
108010044091 Globulins Proteins 0.000 description 1
102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
108010069236 Goserelin Proteins 0.000 description 1
BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 1
208000009329 Graft vs Host Disease Diseases 0.000 description 1
206010018691 Granuloma Diseases 0.000 description 1
206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
241000288105 Grus Species 0.000 description 1
239000007995 HEPES buffer Substances 0.000 description 1
208000031886 HIV Infections Diseases 0.000 description 1
208000037357 HIV infectious disease Diseases 0.000 description 1
208000031071 Hamman-Rich Syndrome Diseases 0.000 description 1
208000001204 Hashimoto Disease Diseases 0.000 description 1
208000030836 Hashimoto thyroiditis Diseases 0.000 description 1
206010019315 Heart transplant rejection Diseases 0.000 description 1
241000589989 Helicobacter Species 0.000 description 1
241000590002 Helicobacter pylori Species 0.000 description 1
208000018565 Hemochromatosis Diseases 0.000 description 1
208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 description 1
208000036066 Hemophagocytic Lymphohistiocytosis Diseases 0.000 description 1
206010019728 Hepatitis alcoholic Diseases 0.000 description 1
206010019755 Hepatitis chronic active Diseases 0.000 description 1
208000002972 Hepatolenticular Degeneration Diseases 0.000 description 1
208000002291 Histiocytic Sarcoma Diseases 0.000 description 1
208000032672 Histiocytosis haematophagic Diseases 0.000 description 1
208000017604 Hodgkin disease Diseases 0.000 description 1
208000010747 Hodgkins lymphoma Diseases 0.000 description 1
101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 description 1
101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 description 1
101100005713 Homo sapiens CD4 gene Proteins 0.000 description 1
101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 description 1
101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 description 1
101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 description 1
101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 description 1
101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 description 1
101001116548 Homo sapiens Protein CBFA2T1 Proteins 0.000 description 1
108010000521 Human Growth Hormone Proteins 0.000 description 1
102000002265 Human Growth Hormone Human genes 0.000 description 1
239000000854 Human Growth Hormone Substances 0.000 description 1
102000003839 Human Proteins Human genes 0.000 description 1
108090000144 Human Proteins Proteins 0.000 description 1
241000701109 Human adenovirus 2 Species 0.000 description 1
241000701024 Human betaherpesvirus 5 Species 0.000 description 1
241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
208000023105 Huntington disease Diseases 0.000 description 1
208000037147 Hypercalcaemia Diseases 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
206010020880 Hypertrophy Diseases 0.000 description 1
206010021143 Hypoxia Diseases 0.000 description 1
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
208000009995 Idiopathic pulmonary hemosiderosis Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
108700002232 Immediate-Early Genes Proteins 0.000 description 1
108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
102000013463 Immunoglobulin Light Chains Human genes 0.000 description 1
108010065825 Immunoglobulin Light Chains Proteins 0.000 description 1
102100022964 Immunoglobulin kappa variable 3-20 Human genes 0.000 description 1
208000004575 Infectious Arthritis Diseases 0.000 description 1
208000022559 Inflammatory bowel disease Diseases 0.000 description 1
206010022489 Insulin Resistance Diseases 0.000 description 1
108010078049 Interferon alpha-2 Proteins 0.000 description 1
102100039350 Interferon alpha-7 Human genes 0.000 description 1
108010047761 Interferon-alpha Proteins 0.000 description 1
102000006992 Interferon-alpha Human genes 0.000 description 1
108010002352 Interleukin-1 Proteins 0.000 description 1
206010072877 Intestinal fibrosis Diseases 0.000 description 1
206010022941 Iridocyclitis Diseases 0.000 description 1
208000032382 Ischaemic stroke Diseases 0.000 description 1
208000035901 Ischaemic ulcer Diseases 0.000 description 1
208000003456 Juvenile Arthritis Diseases 0.000 description 1
208000007766 Kaposi sarcoma Diseases 0.000 description 1
206010023330 Keloid scar Diseases 0.000 description 1
206010023439 Kidney transplant rejection Diseases 0.000 description 1
241000588748 Klebsiella Species 0.000 description 1
208000006264 Korsakoff syndrome Diseases 0.000 description 1
LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
229930182816 L-glutamine Natural products 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
101150027568 LC gene Proteins 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
201000005099 Langerhans cell histiocytosis Diseases 0.000 description 1
108090001090 Lectins Proteins 0.000 description 1
102000004856 Lectins Human genes 0.000 description 1
241000589248 Legionella Species 0.000 description 1
208000007764 Legionnaires' Disease Diseases 0.000 description 1
208000004554 Leishmaniasis Diseases 0.000 description 1
206010024229 Leprosy Diseases 0.000 description 1
108010000817 Leuprolide Proteins 0.000 description 1
208000009829 Lewy Body Disease Diseases 0.000 description 1
102000003960 Ligases Human genes 0.000 description 1
108090000364 Ligases Proteins 0.000 description 1
206010024558 Lip oedema Diseases 0.000 description 1
208000007021 Lipedema Diseases 0.000 description 1
206010024715 Liver transplant rejection Diseases 0.000 description 1
206010051604 Lung transplant rejection Diseases 0.000 description 1
208000005777 Lupus Nephritis Diseases 0.000 description 1
208000016604 Lyme disease Diseases 0.000 description 1
206010025282 Lymphoedema Diseases 0.000 description 1
101710125418 Major capsid protein Proteins 0.000 description 1
PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
239000005913 Maltodextrin Substances 0.000 description 1
229920002774 Maltodextrin Polymers 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
201000009906 Meningitis Diseases 0.000 description 1
206010027476 Metastases Diseases 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical group CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
208000019695 Migraine disease Diseases 0.000 description 1
241001385002 Minota Species 0.000 description 1
108020005196 Mitochondrial DNA Proteins 0.000 description 1
229940121849 Mitotic inhibitor Drugs 0.000 description 1
208000003250 Mixed connective tissue disease Diseases 0.000 description 1
208000035489 Monocytic Acute Leukemia Diseases 0.000 description 1
208000034578 Multiple myelomas Diseases 0.000 description 1
241000714177 Murine leukemia virus Species 0.000 description 1
101000897464 Mus musculus C-C motif chemokine 2 Proteins 0.000 description 1
101100382870 Mus musculus Ccl12 gene Proteins 0.000 description 1
101100495074 Mus musculus Ccl2 gene Proteins 0.000 description 1
101100278853 Mus musculus Dhfr gene Proteins 0.000 description 1
241000187479 Mycobacterium tuberculosis Species 0.000 description 1
241000204031 Mycoplasma Species 0.000 description 1
208000031888 Mycoses Diseases 0.000 description 1
201000002481 Myositis Diseases 0.000 description 1
KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
125000000729 N-terminal amino-acid group Chemical group 0.000 description 1
238000005481 NMR spectroscopy Methods 0.000 description 1
229920002274 Nalgene Polymers 0.000 description 1
208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 1
206010061306 Nasopharyngeal cancer Diseases 0.000 description 1
208000009905 Neurofibromatoses Diseases 0.000 description 1
102000008763 Neurofilament Proteins Human genes 0.000 description 1
108010088373 Neurofilament Proteins Proteins 0.000 description 1
101800000838 Neutrophil cationic peptide 1 Proteins 0.000 description 1
208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
101710141454 Nucleoprotein Proteins 0.000 description 1
108020005187 Oligonucleotide Probes Proteins 0.000 description 1
208000003435 Optic Neuritis Diseases 0.000 description 1
206010053869 POEMS syndrome Diseases 0.000 description 1
206010049169 Pancreas transplant rejection Diseases 0.000 description 1
206010033645 Pancreatitis Diseases 0.000 description 1
206010033647 Pancreatitis acute Diseases 0.000 description 1
208000002774 Paraproteinemias Diseases 0.000 description 1
108700020797 Parathyroid Hormone-Related Proteins 0.000 description 1
102000043299 Parathyroid hormone-related Human genes 0.000 description 1
208000018737 Parkinson disease Diseases 0.000 description 1
208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
241000721454 Pemphigus Species 0.000 description 1
108010067902 Peptide Library Proteins 0.000 description 1
208000025584 Pericardial disease Diseases 0.000 description 1
208000018262 Peripheral vascular disease Diseases 0.000 description 1
208000031845 Pernicious anaemia Diseases 0.000 description 1
206010057249 Phagocytosis Diseases 0.000 description 1
201000007100 Pharyngitis Diseases 0.000 description 1
102000011755 Phosphoglycerate Kinase Human genes 0.000 description 1
241000607000 Plesiomonas Species 0.000 description 1
208000005384 Pneumocystis Pneumonia Diseases 0.000 description 1
206010073755 Pneumocystis jirovecii pneumonia Diseases 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
206010036105 Polyneuropathy Diseases 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
229920001219 Polysorbate 40 Polymers 0.000 description 1
208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
101710083689 Probable capsid protein Proteins 0.000 description 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
208000032225 Proximal spinal muscular atrophy type 1 Diseases 0.000 description 1
208000033526 Proximal spinal muscular atrophy type 3 Diseases 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
201000001263 Psoriatic Arthritis Diseases 0.000 description 1
208000036824 Psoriatic arthropathy Diseases 0.000 description 1
208000007123 Pulmonary Atelectasis Diseases 0.000 description 1
206010064911 Pulmonary arterial hypertension Diseases 0.000 description 1
239000012979 RPMI medium Substances 0.000 description 1
239000012980 RPMI-1640 medium Substances 0.000 description 1
101100409194 Rattus norvegicus Ppargc1b gene Proteins 0.000 description 1
208000005587 Refsum Disease Diseases 0.000 description 1
208000006265 Renal cell carcinoma Diseases 0.000 description 1
208000033626 Renal failure acute Diseases 0.000 description 1
201000003099 Renovascular Hypertension Diseases 0.000 description 1
206010039094 Rhinitis perennial Diseases 0.000 description 1
108010039491 Ricin Proteins 0.000 description 1
241000714474 Rous sarcoma virus Species 0.000 description 1
241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 1
241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
206010039491 Sarcoma Diseases 0.000 description 1
206010039966 Senile dementia Diseases 0.000 description 1
206010040070 Septic Shock Diseases 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
206010062164 Seronegative arthritis Diseases 0.000 description 1
108010071390 Serum Albumin Proteins 0.000 description 1
102000007562 Serum Albumin Human genes 0.000 description 1
208000009714 Severe Dengue Diseases 0.000 description 1
108010079723 Shiga Toxin Proteins 0.000 description 1
206010050207 Skin fibrosis Diseases 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
244000061456 Solanum tuberosum Species 0.000 description 1
235000002595 Solanum tuberosum Nutrition 0.000 description 1
241000191940 Staphylococcus Species 0.000 description 1
208000007107 Stomach Ulcer Diseases 0.000 description 1
241000194017 Streptococcus Species 0.000 description 1
108010023197 Streptokinase Proteins 0.000 description 1
208000006011 Stroke Diseases 0.000 description 1
208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 1
206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
101001086866 Sus scrofa Pulmonary surfactant-associated protein B Proteins 0.000 description 1
206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 description 1
208000004732 Systemic Vasculitis Diseases 0.000 description 1
108091008874 T cell receptors Proteins 0.000 description 1
102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
208000001871 Tachycardia Diseases 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
206010043189 Telangiectasia Diseases 0.000 description 1
BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 description 1
101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 description 1
108091036066 Three prime untranslated region Proteins 0.000 description 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
239000004473 Threonine Substances 0.000 description 1
206010043561 Thrombocytopenic purpura Diseases 0.000 description 1
206010044248 Toxic shock syndrome Diseases 0.000 description 1
231100000650 Toxic shock syndrome Toxicity 0.000 description 1
206010070863 Toxicity to various agents Diseases 0.000 description 1
GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
206010053614 Type III immune complex mediated reaction Diseases 0.000 description 1
208000037386 Typhoid Diseases 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
208000007814 Unstable Angina Diseases 0.000 description 1
208000024780 Urticaria Diseases 0.000 description 1
206010046851 Uveitis Diseases 0.000 description 1
101150117115 V gene Proteins 0.000 description 1
206010046996 Varicose vein Diseases 0.000 description 1
206010047249 Venous thrombosis Diseases 0.000 description 1
241000607272 Vibrio parahaemolyticus Species 0.000 description 1
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
108020000999 Viral RNA Proteins 0.000 description 1
208000036142 Viral infection Diseases 0.000 description 1
206010047642 Vitiligo Diseases 0.000 description 1
201000008485 Wernicke-Korsakoff syndrome Diseases 0.000 description 1
239000005862 Whey Substances 0.000 description 1
102000007544 Whey Proteins Human genes 0.000 description 1
108010046377 Whey Proteins Proteins 0.000 description 1
208000018839 Wilson disease Diseases 0.000 description 1
241000607447 Yersinia enterocolitica Species 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
230000003187 abdominal effect Effects 0.000 description 1
208000004622 abetalipoproteinemia Diseases 0.000 description 1
238000002679 ablation Methods 0.000 description 1
239000008351 acetate buffer Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
YAJCHEVQCOHZDC-QMMNLEPNSA-N actrapid Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3N=CNC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@H](C)CC)[C@H](C)CC)[C@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C(N)=O)C1=CNC=N1 YAJCHEVQCOHZDC-QMMNLEPNSA-N 0.000 description 1
201000004073 acute interstitial pneumonia Diseases 0.000 description 1
201000011040 acute kidney failure Diseases 0.000 description 1
201000003229 acute pancreatitis Diseases 0.000 description 1
208000012998 acute renal failure Diseases 0.000 description 1
208000009956 adenocarcinoma Diseases 0.000 description 1
230000001464 adherent effect Effects 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
208000030597 adult Refsum disease Diseases 0.000 description 1
229960003227 afelimomab Drugs 0.000 description 1
238000001261 affinity purification Methods 0.000 description 1
239000008272 agar Substances 0.000 description 1
235000010419 agar Nutrition 0.000 description 1
238000005054 agglomeration Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 1
238000012867 alanine scanning Methods 0.000 description 1
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
208000002353 alcoholic hepatitis Diseases 0.000 description 1
208000010002 alcoholic liver cirrhosis Diseases 0.000 description 1
150000001299 aldehydes Chemical group 0.000 description 1
HAXFWIACAGNFHA-UHFFFAOYSA-N aldrithiol Chemical compound C=1C=CC=NC=1SSC1=CC=CC=N1 HAXFWIACAGNFHA-UHFFFAOYSA-N 0.000 description 1
SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 description 1
208000002205 allergic conjunctivitis Diseases 0.000 description 1
208000002029 allergic contact dermatitis Diseases 0.000 description 1
231100000360 alopecia Toxicity 0.000 description 1
208000006682 alpha 1-Antitrypsin Deficiency Diseases 0.000 description 1
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
102000013529 alpha-Fetoproteins Human genes 0.000 description 1
108010026331 alpha-Fetoproteins Proteins 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
238000012870 ammonium sulfate precipitation Methods 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
208000003455 anaphylaxis Diseases 0.000 description 1
208000007502 anemia Diseases 0.000 description 1
239000004037 angiogenesis inhibitor Substances 0.000 description 1
238000010171 animal model Methods 0.000 description 1
238000005571 anion exchange chromatography Methods 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
210000002226 anterior horn cell Anatomy 0.000 description 1
201000004612 anterior uveitis Diseases 0.000 description 1
230000000049 anti-anxiety effect Effects 0.000 description 1
230000001093 anti-cancer Effects 0.000 description 1
230000003474 anti-emetic effect Effects 0.000 description 1
230000003510 anti-fibrotic effect Effects 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
238000011091 antibody purification Methods 0.000 description 1
238000009175 antibody therapy Methods 0.000 description 1
230000009227 antibody-mediated cytotoxicity Effects 0.000 description 1
229940125683 antiemetic agent Drugs 0.000 description 1
229940030600 antihypertensive agent Drugs 0.000 description 1
239000002220 antihypertensive agent Substances 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
229940034982 antineoplastic agent Drugs 0.000 description 1
239000002216 antistatic agent Substances 0.000 description 1
210000000709 aorta Anatomy 0.000 description 1
210000000702 aorta abdominal Anatomy 0.000 description 1
208000007474 aortic aneurysm Diseases 0.000 description 1
206010002895 aortic dissection Diseases 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
235000019312 arabinogalactan Nutrition 0.000 description 1
230000005988 arterial dysfunction Effects 0.000 description 1
208000037849 arterial hypertension Diseases 0.000 description 1
208000011775 arteriosclerosis disease Diseases 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
239000000605 aspartame Substances 0.000 description 1
235000010357 aspartame Nutrition 0.000 description 1
229960003438 aspartame Drugs 0.000 description 1
229940009098 aspartate Drugs 0.000 description 1
235000003704 aspartic acid Nutrition 0.000 description 1
239000012131 assay buffer Substances 0.000 description 1
238000003149 assay kit Methods 0.000 description 1
206010003549 asthenia Diseases 0.000 description 1
229940127225 asthma medication Drugs 0.000 description 1
208000024998 atopic conjunctivitis Diseases 0.000 description 1
206010003668 atrial tachycardia Diseases 0.000 description 1
230000002238 attenuated effect Effects 0.000 description 1
239000012752 auxiliary agent Substances 0.000 description 1
VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 description 1
239000000688 bacterial toxin Substances 0.000 description 1
210000004227 basal ganglia Anatomy 0.000 description 1
208000018300 basal ganglia disease Diseases 0.000 description 1
210000003651 basophil Anatomy 0.000 description 1
239000011324 bead Substances 0.000 description 1
229940116224 behenate Drugs 0.000 description 1
UKMSUNONTOPOIO-UHFFFAOYSA-M behenate Chemical compound CCCCCCCCCCCCCCCCCCCCCC([O-])=O UKMSUNONTOPOIO-UHFFFAOYSA-M 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
229960000686 benzalkonium chloride Drugs 0.000 description 1
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
229960001950 benzethonium chloride Drugs 0.000 description 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
229960003237 betaine Drugs 0.000 description 1
230000000975 bioactive effect Effects 0.000 description 1
XFLVBMBRLSCJAI-ZKWXMUAHSA-N biotin amide Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)N)SC[C@@H]21 XFLVBMBRLSCJAI-ZKWXMUAHSA-N 0.000 description 1
XFLVBMBRLSCJAI-UHFFFAOYSA-N biotin amide Natural products N1C(=O)NC2C(CCCCC(=O)N)SCC21 XFLVBMBRLSCJAI-UHFFFAOYSA-N 0.000 description 1
238000007413 biotinylation Methods 0.000 description 1
230000006287 biotinylation Effects 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000010836 blood and blood product Substances 0.000 description 1
229940125691 blood product Drugs 0.000 description 1
210000001185 bone marrow Anatomy 0.000 description 1
108010006025 bovine growth hormone Proteins 0.000 description 1
229940098773 bovine serum albumin Drugs 0.000 description 1
201000009267 bronchiectasis Diseases 0.000 description 1
210000003123 bronchiole Anatomy 0.000 description 1
206010006451 bronchitis Diseases 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
210000004375 bundle of his Anatomy 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229960005069 calcium Drugs 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
238000004422 calculation algorithm Methods 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 1
229960004562 carboplatin Drugs 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
150000007942 carboxylates Chemical class 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
230000002612 cardiopulmonary effect Effects 0.000 description 1
210000000845 cartilage Anatomy 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
238000005277 cation exchange chromatography Methods 0.000 description 1
230000021164 cell adhesion Effects 0.000 description 1
238000013354 cell banking Methods 0.000 description 1
239000006143 cell culture medium Substances 0.000 description 1
230000003833 cell viability Effects 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
208000025434 cerebellar degeneration Diseases 0.000 description 1
210000001638 cerebellum Anatomy 0.000 description 1
230000002490 cerebral effect Effects 0.000 description 1
229960003115 certolizumab pegol Drugs 0.000 description 1
230000008859 change Effects 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
210000000038 chest Anatomy 0.000 description 1
229960002242 chlorocresol Drugs 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
208000019069 chronic childhood arthritis Diseases 0.000 description 1
208000025302 chronic primary adrenal insufficiency Diseases 0.000 description 1
229960004316 cisplatin Drugs 0.000 description 1
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
238000011259 co-electroporation Methods 0.000 description 1
238000012761 co-transfection Methods 0.000 description 1
238000011278 co-treatment Methods 0.000 description 1
238000004581 coalescence Methods 0.000 description 1
206010009887 colitis Diseases 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
230000000112 colonic effect Effects 0.000 description 1
201000010989 colorectal carcinoma Diseases 0.000 description 1
238000010961 commercial manufacture process Methods 0.000 description 1
238000004590 computer program Methods 0.000 description 1
201000000464 cone-rod dystrophy 2 Diseases 0.000 description 1
238000012790 confirmation Methods 0.000 description 1
230000001268 conjugating effect Effects 0.000 description 1
208000010247 contact dermatitis Diseases 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
230000009519 contusion Effects 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
208000029078 coronary artery disease Diseases 0.000 description 1
230000001054 cortical effect Effects 0.000 description 1
230000002594 corticospinal effect Effects 0.000 description 1
239000006071 cream Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
238000012258 culturing Methods 0.000 description 1
208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
150000001945 cysteines Chemical class 0.000 description 1
229960000684 cytarabine Drugs 0.000 description 1
239000000409 cytokine receptor agonist Substances 0.000 description 1
210000000805 cytoplasm Anatomy 0.000 description 1
230000001086 cytosolic effect Effects 0.000 description 1
231100000433 cytotoxic Toxicity 0.000 description 1
229940127089 cytotoxic agent Drugs 0.000 description 1
231100000599 cytotoxic agent Toxicity 0.000 description 1
230000001472 cytotoxic effect Effects 0.000 description 1
239000002619 cytotoxin Substances 0.000 description 1
230000034994 death Effects 0.000 description 1
230000002950 deficient Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
238000002716 delivery method Methods 0.000 description 1
208000017004 dementia pugilistica Diseases 0.000 description 1
230000003210 demyelinating effect Effects 0.000 description 1
201000002950 dengue hemorrhagic fever Diseases 0.000 description 1
238000000151 deposition Methods 0.000 description 1
239000003241 dermatological agent Substances 0.000 description 1
229940000033 dermatological agent Drugs 0.000 description 1
238000013461 design Methods 0.000 description 1
201000009803 desquamative interstitial pneumonia Diseases 0.000 description 1
229960003957 dexamethasone Drugs 0.000 description 1
UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
208000033679 diabetic kidney disease Diseases 0.000 description 1
150000001991 dicarboxylic acids Chemical class 0.000 description 1
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
OZRNSSUDZOLUSN-LBPRGKRZSA-N dihydrofolic acid Chemical compound N=1C=2C(=O)NC(N)=NC=2NCC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OZRNSSUDZOLUSN-LBPRGKRZSA-N 0.000 description 1
201000011304 dilated cardiomyopathy 1A Diseases 0.000 description 1
AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical compound CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
208000016097 disease of metabolism Diseases 0.000 description 1
238000009826 distribution Methods 0.000 description 1
239000003534 dna topoisomerase inhibitor Substances 0.000 description 1
SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical class CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
229960004679 doxorubicin Drugs 0.000 description 1
238000002651 drug therapy Methods 0.000 description 1
208000009985 drug-induced dyskinesia Diseases 0.000 description 1
229940112141 dry powder inhaler Drugs 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000000428 dust Substances 0.000 description 1
230000005684 electric field Effects 0.000 description 1
239000002895 emetic Substances 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
201000002491 encephalomyelitis Diseases 0.000 description 1
206010014665 endocarditis Diseases 0.000 description 1
210000003979 eosinophil Anatomy 0.000 description 1
201000010063 epididymitis Diseases 0.000 description 1
208000037828 epithelial carcinoma Diseases 0.000 description 1
201000011384 erythromelalgia Diseases 0.000 description 1
229960001842 estramustine Drugs 0.000 description 1
FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 description 1
HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 1
238000012869 ethanol precipitation Methods 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
229960005420 etoposide Drugs 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
230000005284 excitation Effects 0.000 description 1
208000021045 exocrine pancreatic carcinoma Diseases 0.000 description 1
239000002095 exotoxin Substances 0.000 description 1
231100000776 exotoxin Toxicity 0.000 description 1
238000000605 extraction Methods 0.000 description 1
201000001155 extrinsic allergic alveolitis Diseases 0.000 description 1
239000010685 fatty oil Substances 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
230000001605 fetal effect Effects 0.000 description 1
210000003754 fetus Anatomy 0.000 description 1
210000002950 fibroblast Anatomy 0.000 description 1
206010016629 fibroma Diseases 0.000 description 1
201000008825 fibrosarcoma of bone Diseases 0.000 description 1
239000010419 fine particle Substances 0.000 description 1
230000003890 fistula Effects 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
238000000684 flow cytometry Methods 0.000 description 1
229960002949 fluorouracil Drugs 0.000 description 1
229960002074 flutamide Drugs 0.000 description 1
MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 1
235000013305 food Nutrition 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
238000012395 formulation development Methods 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
230000037433 frameshift Effects 0.000 description 1
238000002825 functional assay Methods 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
201000005917 gastric ulcer Diseases 0.000 description 1
238000012637 gene transfection Methods 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
239000011521 glass Substances 0.000 description 1
108060003196 globin Proteins 0.000 description 1
239000000174 gluconic acid Substances 0.000 description 1
235000012208 gluconic acid Nutrition 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
150000002337 glycosamines Chemical group 0.000 description 1
229960002913 goserelin Drugs 0.000 description 1
208000024908 graft versus host disease Diseases 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
238000001631 haemodialysis Methods 0.000 description 1
201000009277 hairy cell leukemia Diseases 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
208000024348 heart neoplasm Diseases 0.000 description 1
208000018578 heart valve disease Diseases 0.000 description 1
229940037467 helicobacter pylori Drugs 0.000 description 1
201000011066 hemangioma Diseases 0.000 description 1
230000000322 hemodialysis Effects 0.000 description 1
230000002949 hemolytic effect Effects 0.000 description 1
208000014752 hemophagocytic syndrome Diseases 0.000 description 1
125000005842 heteroatom Chemical group 0.000 description 1
RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
102000054751 human RUNX1T1 Human genes 0.000 description 1
210000003917 human chromosome Anatomy 0.000 description 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
150000005828 hydrofluoroalkanes Chemical class 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
150000002433 hydrophilic molecules Chemical class 0.000 description 1
238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
238000012872 hydroxylapatite chromatography Methods 0.000 description 1
208000013403 hyperactivity Diseases 0.000 description 1
230000000148 hypercalcaemia Effects 0.000 description 1
208000030915 hypercalcemia disease Diseases 0.000 description 1
208000022098 hypersensitivity pneumonitis Diseases 0.000 description 1
230000001969 hypertrophic effect Effects 0.000 description 1
230000001146 hypoxic effect Effects 0.000 description 1
229960003685 imatinib mesylate Drugs 0.000 description 1
YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 description 1
210000002865 immune cell Anatomy 0.000 description 1
229940124622 immune-modulator drug Drugs 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
230000002584 immunomodulator Effects 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000002513 implantation Methods 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000000126 in silico method Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
208000000509 infertility Diseases 0.000 description 1
230000036512 infertility Effects 0.000 description 1
208000021267 infertility disease Diseases 0.000 description 1
230000028709 inflammatory response Effects 0.000 description 1
229960000598 infliximab Drugs 0.000 description 1
206010022000 influenza Diseases 0.000 description 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
229960000367 inositol Drugs 0.000 description 1
201000004332 intermediate coronary syndrome Diseases 0.000 description 1
229940036646 iodine-131-tositumomab Drugs 0.000 description 1
230000005865 ionizing radiation Effects 0.000 description 1
229960004768 irinotecan Drugs 0.000 description 1
UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
230000000302 ischemic effect Effects 0.000 description 1
239000007951 isotonicity adjuster Substances 0.000 description 1
238000005304 joining Methods 0.000 description 1
201000004815 juvenile spinal muscular atrophy Diseases 0.000 description 1
238000012004 kinetic exclusion assay Methods 0.000 description 1
238000002372 labelling Methods 0.000 description 1
239000000832 lactitol Substances 0.000 description 1
235000010448 lactitol Nutrition 0.000 description 1
VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
229960003451 lactitol Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
201000010901 lateral sclerosis Diseases 0.000 description 1
229940070765 laurate Drugs 0.000 description 1
239000002523 lectin Substances 0.000 description 1
208000032839 leukemia Diseases 0.000 description 1
229940087875 leukine Drugs 0.000 description 1
150000002617 leukotrienes Chemical class 0.000 description 1
GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 description 1
229960004338 leuprorelin Drugs 0.000 description 1
210000004558 lewy body Anatomy 0.000 description 1
108020001756 ligand binding domains Proteins 0.000 description 1
239000006193 liquid solution Substances 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000006210 lotion Substances 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
235000020121 low-fat milk Nutrition 0.000 description 1
201000003453 lung abscess Diseases 0.000 description 1
208000037841 lung tumor Diseases 0.000 description 1
210000002751 lymph Anatomy 0.000 description 1
210000001165 lymph node Anatomy 0.000 description 1
208000002502 lymphedema Diseases 0.000 description 1
208000005158 lymphoid interstitial pneumonia Diseases 0.000 description 1
239000006166 lysate Substances 0.000 description 1
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
208000002780 macular degeneration Diseases 0.000 description 1
239000006249 magnetic particle Substances 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
235000009973 maize Nutrition 0.000 description 1
201000004792 malaria Diseases 0.000 description 1
FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
230000036210 malignancy Effects 0.000 description 1
201000006812 malignant histiocytosis Diseases 0.000 description 1
208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
239000000845 maltitol Substances 0.000 description 1
235000010449 maltitol Nutrition 0.000 description 1
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
229940035436 maltitol Drugs 0.000 description 1
229940035034 maltodextrin Drugs 0.000 description 1
210000005075 mammary gland Anatomy 0.000 description 1
229960001855 mannitol Drugs 0.000 description 1
230000000873 masking effect Effects 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 1
229960004961 mechlorethamine Drugs 0.000 description 1
QWIZNVHXZXRPDR-WSCXOGSTSA-N melezitose Chemical compound O([C@@]1(O[C@@H]([C@H]([C@@H]1O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)CO)CO)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QWIZNVHXZXRPDR-WSCXOGSTSA-N 0.000 description 1
239000012528 membrane Substances 0.000 description 1
208000030159 metabolic disease Diseases 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
230000009401 metastasis Effects 0.000 description 1
206010061289 metastatic neoplasm Diseases 0.000 description 1
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
206010027599 migraine Diseases 0.000 description 1
OBBCSXFCDPPXOL-UHFFFAOYSA-N misonidazole Chemical compound COCC(O)CN1C=CN=C1[N+]([O-])=O OBBCSXFCDPPXOL-UHFFFAOYSA-N 0.000 description 1
229950010514 misonidazole Drugs 0.000 description 1
108091064355 mitochondrial RNA Proteins 0.000 description 1
230000002438 mitochondrial effect Effects 0.000 description 1
239000011812 mixed powder Substances 0.000 description 1
230000003020 moisturizing effect Effects 0.000 description 1
150000002763 monocarboxylic acids Chemical class 0.000 description 1
208000005264 motor neuron disease Diseases 0.000 description 1
208000017972 multifocal atrial tachycardia Diseases 0.000 description 1
206010028417 myasthenia gravis Diseases 0.000 description 1
206010028537 myelofibrosis Diseases 0.000 description 1
208000031225 myocardial ischemia Diseases 0.000 description 1
208000002089 myocardial stunning Diseases 0.000 description 1
229940105132 myristate Drugs 0.000 description 1
VAMFXQBUQXONLZ-UHFFFAOYSA-N n-alpha-eicosene Natural products CCCCCCCCCCCCCCCCCCC=C VAMFXQBUQXONLZ-UHFFFAOYSA-N 0.000 description 1
239000002105 nanoparticle Substances 0.000 description 1
239000002077 nanosphere Substances 0.000 description 1
150000002790 naphthalenes Chemical class 0.000 description 1
239000007923 nasal drop Substances 0.000 description 1
229940100662 nasal drops Drugs 0.000 description 1
201000011216 nasopharynx carcinoma Diseases 0.000 description 1
208000009928 nephrosis Diseases 0.000 description 1
231100001027 nephrosis Toxicity 0.000 description 1
230000004770 neurodegeneration Effects 0.000 description 1
208000015122 neurodegenerative disease Diseases 0.000 description 1
201000004931 neurofibromatosis Diseases 0.000 description 1
210000005044 neurofilament Anatomy 0.000 description 1
210000002569 neuron Anatomy 0.000 description 1
229960002653 nilutamide Drugs 0.000 description 1
XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 description 1
LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Substances [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 1
108091027963 non-coding RNA Proteins 0.000 description 1
102000042567 non-coding RNA Human genes 0.000 description 1
208000020942 non-infectious meningitis Diseases 0.000 description 1
239000002687 nonaqueous vehicle Substances 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
208000014055 occupational lung disease Diseases 0.000 description 1
RZJRJXONCZWCBN-UHFFFAOYSA-N octadecane Chemical class CCCCCCCCCCCCCCCCCC RZJRJXONCZWCBN-UHFFFAOYSA-N 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
239000002751 oligonucleotide probe Substances 0.000 description 1
238000011275 oncology therapy Methods 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
229920000620 organic polymer Polymers 0.000 description 1
201000008482 osteoarthritis Diseases 0.000 description 1
230000002018 overexpression Effects 0.000 description 1
238000012261 overproduction Methods 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
239000003002 pH adjusting agent Substances 0.000 description 1
210000002741 palatine tonsil Anatomy 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
208000012111 paraneoplastic syndrome Diseases 0.000 description 1
230000003071 parasitic effect Effects 0.000 description 1
230000000849 parathyroid Effects 0.000 description 1
230000001314 paroxysmal effect Effects 0.000 description 1
244000052769 pathogen Species 0.000 description 1
238000010647 peptide synthesis reaction Methods 0.000 description 1
206010034674 peritonitis Diseases 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
230000008782 phagocytosis Effects 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
239000008180 pharmaceutical surfactant Substances 0.000 description 1
230000003285 pharmacodynamic effect Effects 0.000 description 1
ORMNNUPLFAPCFD-DVLYDCSHSA-M phenethicillin potassium Chemical compound [K+].N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C([O-])=O)=O)C(=O)C(C)OC1=CC=CC=C1 ORMNNUPLFAPCFD-DVLYDCSHSA-M 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
229940080469 phosphocellulose Drugs 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 description 1
125000002743 phosphorus functional group Chemical group 0.000 description 1
238000005222 photoaffinity labeling Methods 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
208000024356 pleural disease Diseases 0.000 description 1
201000000317 pneumocystosis Diseases 0.000 description 1
229920001993 poloxamer 188 Polymers 0.000 description 1
229920000724 poly(L-arginine) polymer Polymers 0.000 description 1
229920001308 poly(aminoacid) Polymers 0.000 description 1
229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
229920001515 polyalkylene glycol Polymers 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
108010011110 polyarginine Proteins 0.000 description 1
108010064470 polyaspartate Proteins 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
239000004926 polymethyl methacrylate Substances 0.000 description 1
230000007824 polyneuropathy Effects 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229940068977 polysorbate 20 Drugs 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
201000011461 pre-eclampsia Diseases 0.000 description 1
230000002028 premature Effects 0.000 description 1
108010066381 preproinsulin Proteins 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
201000008312 primary pulmonary hypertension Diseases 0.000 description 1
238000012545 processing Methods 0.000 description 1
201000002212 progressive supranuclear palsy Diseases 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000006239 protecting group Chemical group 0.000 description 1
229940076372 protein antagonist Drugs 0.000 description 1
238000001742 protein purification Methods 0.000 description 1
230000017854 proteolysis Effects 0.000 description 1
238000001671 psychotherapy Methods 0.000 description 1
208000005069 pulmonary fibrosis Diseases 0.000 description 1
201000003456 pulmonary hemosiderosis Diseases 0.000 description 1
201000003651 pulmonary sarcoidosis Diseases 0.000 description 1
229940107568 pulmozyme Drugs 0.000 description 1
239000012264 purified product Substances 0.000 description 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
238000011002 quantification Methods 0.000 description 1
238000012207 quantitative assay Methods 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000008929 regeneration Effects 0.000 description 1
238000011069 regeneration method Methods 0.000 description 1
230000014493 regulation of gene expression Effects 0.000 description 1
229940116176 remicade Drugs 0.000 description 1
201000002793 renal fibrosis Diseases 0.000 description 1
230000001850 reproductive effect Effects 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
108091008146 restriction endonucleases Proteins 0.000 description 1
230000002207 retinal effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
210000003705 ribosome Anatomy 0.000 description 1
238000002702 ribosome display Methods 0.000 description 1
229960004641 rituximab Drugs 0.000 description 1
102220214819 rs754231971 Human genes 0.000 description 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
229940125723 sedative agent Drugs 0.000 description 1
201000001223 septic arthritis Diseases 0.000 description 1
238000012163 sequencing technique Methods 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
208000007056 sickle cell anemia Diseases 0.000 description 1
239000002356 single layer Substances 0.000 description 1
238000002741 site-directed mutagenesis Methods 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
239000002002 slurry Substances 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
210000000329 smooth muscle myocyte Anatomy 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229940083542 sodium Drugs 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
229940054269 sodium pyruvate Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
208000002320 spinal muscular atrophy Diseases 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
230000010473 stable expression Effects 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
229960005202 streptokinase Drugs 0.000 description 1
238000012916 structural analysis Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
VLYWMPOKSSWJAL-UHFFFAOYSA-N sulfamethoxypyridazine Chemical compound N1=NC(OC)=CC=C1NS(=O)(=O)C1=CC=C(N)C=C1 VLYWMPOKSSWJAL-UHFFFAOYSA-N 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
230000008093 supporting effect Effects 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
206010042772 syncope Diseases 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 1
239000003826 tablet Substances 0.000 description 1
230000006794 tachycardia Effects 0.000 description 1
229960001603 tamoxifen Drugs 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
208000009056 telangiectasis Diseases 0.000 description 1
229960004964 temozolomide Drugs 0.000 description 1
AOCSUUGBCMTKJH-UHFFFAOYSA-N tert-butyl n-(2-aminoethyl)carbamate Chemical compound CC(C)(C)OC(=O)NCCN AOCSUUGBCMTKJH-UHFFFAOYSA-N 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
BGHCVCJVXZWKCC-UHFFFAOYSA-N tetradecane Chemical class CCCCCCCCCCCCCC BGHCVCJVXZWKCC-UHFFFAOYSA-N 0.000 description 1
TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
150000004044 tetrasaccharides Chemical class 0.000 description 1
WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
210000000115 thoracic cavity Anatomy 0.000 description 1
206010043554 thrombocytopenia Diseases 0.000 description 1
230000002537 thrombolytic effect Effects 0.000 description 1
210000001541 thymus gland Anatomy 0.000 description 1
206010043778 thyroiditis Diseases 0.000 description 1
ORYDPOVDJJZGHQ-UHFFFAOYSA-N tirapazamine Chemical compound C1=CC=CC2=[N+]([O-])C(N)=N[N+]([O-])=C21 ORYDPOVDJJZGHQ-UHFFFAOYSA-N 0.000 description 1
229950002376 tirapazamine Drugs 0.000 description 1
230000009772 tissue formation Effects 0.000 description 1
230000017423 tissue regeneration Effects 0.000 description 1
230000007838 tissue remodeling Effects 0.000 description 1
229940044693 topoisomerase inhibitor Drugs 0.000 description 1
125000005490 tosylate group Chemical group 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000005026 transcription initiation Effects 0.000 description 1
230000002103 transcriptional effect Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000009466 transformation Effects 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
230000014621 translational initiation Effects 0.000 description 1
230000032258 transport Effects 0.000 description 1
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
229960001727 tretinoin Drugs 0.000 description 1
JXTPJDDICSTXJX-UHFFFAOYSA-N triacontane Chemical class CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
150000004043 trisaccharides Chemical class 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229940073585 tromethamine hydrochloride Drugs 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
201000008827 tuberculosis Diseases 0.000 description 1
208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
208000025883 type III hypersensitivity disease Diseases 0.000 description 1
230000005951 type IV hypersensitivity Effects 0.000 description 1
208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
201000008297 typhoid fever Diseases 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
208000009852 uremia Diseases 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
208000027185 varicose disease Diseases 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000002435 venom Substances 0.000 description 1
231100000611 venom Toxicity 0.000 description 1
210000001048 venom Anatomy 0.000 description 1
208000037997 venous disease Diseases 0.000 description 1
229940070384 ventolin Drugs 0.000 description 1
208000003663 ventricular fibrillation Diseases 0.000 description 1
230000035899 viability Effects 0.000 description 1
229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
229960004528 vincristine Drugs 0.000 description 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
201000002498 viral encephalitis Diseases 0.000 description 1
239000013603 viral vector Substances 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
239000011534 wash buffer Substances 0.000 description 1
238000004804 winding Methods 0.000 description 1
229940098232 yersinia enterocolitica Drugs 0.000 description 1

JP2008512576A 2005-05-19 2006-05-19 抗ｍｃｐ−１抗体、組成物、方法および使用 Expired - Fee Related JP4975020B2 (ja)