JP2011516613A - 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物 - Google Patents

好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物 Download PDF

Info

Publication number
JP2011516613A
JP2011516613A JP2011505164A JP2011505164A JP2011516613A JP 2011516613 A JP2011516613 A JP 2011516613A JP 2011505164 A JP2011505164 A JP 2011505164A JP 2011505164 A JP2011505164 A JP 2011505164A JP 2011516613 A JP2011516613 A JP 2011516613A
Authority
JP
Japan
Prior art keywords
posaconazole
hpmcas
composition
pharmaceutical composition
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011505164A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011516613A5 (enExample
Inventor
ラリー ユン ファン，
デイビッド ハリス，
チャンシェン ワン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2011516613A publication Critical patent/JP2011516613A/ja
Publication of JP2011516613A5 publication Critical patent/JP2011516613A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2011505164A 2008-04-15 2009-04-15 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物 Withdrawn JP2011516613A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4517708P 2008-04-15 2008-04-15
US61/045,177 2008-04-15
PCT/US2009/040653 WO2009129301A2 (en) 2008-04-15 2009-04-15 Oral pharmaceutical compositions in a molecular solid dispersion

Publications (2)

Publication Number Publication Date
JP2011516613A true JP2011516613A (ja) 2011-05-26
JP2011516613A5 JP2011516613A5 (enExample) 2013-03-21

Family

ID=41165581

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011505164A Withdrawn JP2011516613A (ja) 2008-04-15 2009-04-15 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物

Country Status (6)

Country Link
US (1) US20110034478A1 (enExample)
EP (1) EP2278957A2 (enExample)
JP (1) JP2011516613A (enExample)
AU (1) AU2009236290A1 (enExample)
CA (1) CA2720851A1 (enExample)
WO (1) WO2009129301A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522816A (ja) * 2011-06-22 2014-09-08 ビョーメ バイオサイエンシズ ピーブイティー．リミテッド コンジュゲートベースの抗真菌性および抗菌性プロドラッグ
EP3023110A1 (en) 2014-11-18 2016-05-25 Shin-Etsu Chemical Co., Ltd. Solution for spray drying comprising hypromellose acetate succinate and method for producing solid dispersion

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104983701A (zh) * 2008-04-15 2015-10-21 默沙东公司 优选含有泊沙康唑和hpmcas的固体分散体形式的口服药物组合物
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
TW201010708A (en) * 2008-06-02 2010-03-16 Intervet Int Bv Composition comprising an antibiotic and a corticosteroid
WO2013123254A1 (en) 2012-02-15 2013-08-22 Cydex Pharmaceuticals, Inc. Manufacturing process for cyclodextrin derivatives
US9493582B2 (en) 2012-02-28 2016-11-15 Cydex Pharmaceuticals, Inc. Alkylated cyclodextrin compositions and processes for preparing and using the same
HK1213585A1 (zh) 2012-10-22 2016-07-08 Cydex Pharmaceuticals, Inc. 烷基化环糊精组合物及其制备和使用方法
WO2014196519A1 (ja) 2013-06-03 2014-12-11 信越化学工業株式会社 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法
EP2837391B1 (en) 2013-08-12 2017-05-10 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate for use as hot-melt extrusion carrier, hot-melt extrusion composition, and method for producing hot-melt extrudate
EP3183295B1 (en) 2014-08-22 2023-08-02 CyDex Pharmaceuticals, Inc. Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same
AU2015348043B2 (en) 2014-11-21 2019-08-22 F2G Limited Antifungal agents
US11058682B2 (en) * 2015-08-08 2021-07-13 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Gastro-resistant formulation containing posaconazole
EP3925601B1 (en) 2016-02-26 2024-07-17 Alfred E. Tiefenbacher (GmbH & Co. KG) Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor
WO2017032908A1 (en) * 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
CN106265526A (zh) * 2016-09-22 2017-01-04 山东大学 一种抗真菌药物泊沙康唑的固体分散体及制备方法与应用
WO2020159562A1 (en) 2019-01-29 2020-08-06 Slayback Pharma Llc Pharmaceutical compositions of posaconazole
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
WO2022034232A1 (en) 2020-08-13 2022-02-17 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Gastro-resistant high-strength formulation containing posaconazole
EP4119128A1 (en) * 2021-07-13 2023-01-18 Dr. Falk Pharma Gmbh Pharmaceutical composition for the oral administration of poorly soluble drugs comprising an amorphous solid dispersion
AU2022324717A1 (en) 2021-11-25 2024-06-13 Alfred E. Tiefenbacher (Gmbh Und Co. Kg) Granules containing posaconazole
EP4091604B1 (en) 2021-11-25 2024-04-03 Alfred E. Tiefenbacher (GmbH & Co. KG) Granules containing posaconazole
CN117545470A (zh) * 2023-09-18 2024-02-09 北京德立福瑞医药科技有限公司 泊沙康唑固体分散体及其制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4916134A (en) * 1987-03-25 1990-04-10 Janssen Pharmacuetica N.V. 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones
US5278175A (en) * 1990-02-02 1994-01-11 Pfizer Inc. Triazole antifungal agents
US5661151A (en) * 1993-12-21 1997-08-26 Schering Corporation Tetrahydrofuran antifungals
US5703079A (en) * 1993-12-21 1997-12-30 Schering Corporation Tetrahydrofuran antifungals
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
US5790957A (en) * 1995-09-12 1998-08-04 Nokia Mobile Phones Ltd. Speech recall in cellular telephone
US5834472A (en) * 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
US5972381A (en) * 1996-06-28 1999-10-26 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
US6713481B1 (en) * 1997-10-17 2004-03-30 David R. Andrews Crystalline antifungal polymorph
TR200003598T2 (tr) * 1998-03-26 2001-06-21 Japan Tobacco Inc. Amid türevleri ve nosiseptin antagonistleri
EP2415462A1 (en) * 1999-12-23 2012-02-08 Mayne Pharma International Pty Ltd. Improved pharmaceutical compositions for poorly soluble drugs
AR028253A1 (es) * 2000-03-16 2003-04-30 Pfizer Prod Inc Inhibidores de la glucogeno fosforilasa
GB0104752D0 (en) * 2001-02-27 2001-04-18 Astrazeneca Ab Pharmaceutical compositions
BR0208626A (pt) * 2001-04-03 2004-03-09 Schering Corp Composição antifúngica com biodisponibilidade intensificada
US20060160823A1 (en) * 2004-05-28 2006-07-20 Leonore Witchey-Lakshmanan Particulate-stabilized injectable pharmaceutical compositions of Posaconazole
WO2006034080A2 (en) * 2004-09-17 2006-03-30 Nektar Therapeutics Formulation comprising itraconazole
US20060275230A1 (en) * 2004-12-10 2006-12-07 Frank Kochinke Compositions and methods for treating conditions of the nail unit
JP2009514884A (ja) * 2005-11-04 2009-04-09 イーストマン ケミカル カンパニー 難溶性医薬活性剤の投与のためのカルボキシアルキルセルロースエステル
CN104983701A (zh) * 2008-04-15 2015-10-21 默沙东公司 优选含有泊沙康唑和hpmcas的固体分散体形式的口服药物组合物

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522816A (ja) * 2011-06-22 2014-09-08 ビョーメ バイオサイエンシズ ピーブイティー．リミテッド コンジュゲートベースの抗真菌性および抗菌性プロドラッグ
JP2018100285A (ja) * 2011-06-22 2018-06-28 ビョーメ バイオサイエンシズ ピーブイティー．リミテッド コンジュゲートベースの抗真菌性および抗菌性プロドラッグ
EP3023110A1 (en) 2014-11-18 2016-05-25 Shin-Etsu Chemical Co., Ltd. Solution for spray drying comprising hypromellose acetate succinate and method for producing solid dispersion
KR20160059427A (ko) 2014-11-18 2016-05-26 신에쓰 가가꾸 고교 가부시끼가이샤 히프로멜로오스 아세트산에스테르 숙신산에스테르를 사용한 스프레이 드라이용 용액 및 고체 분산체의 제조 방법
US10493161B2 (en) 2014-11-18 2019-12-03 Shin-Etsu Chemical Co., Ltd. Solution for spray drying comprising hypromellose acetate succinate and method for producing solid dispersion
KR20210002091A (ko) 2014-11-18 2021-01-06 신에쓰 가가꾸 고교 가부시끼가이샤 히프로멜로오스 아세트산에스테르 숙신산에스테르를 사용한 스프레이 드라이용 용액 및 고체 분산체의 제조 방법

Also Published As

Publication number Publication date
EP2278957A2 (en) 2011-02-02
WO2009129301A3 (en) 2009-12-23
CA2720851A1 (en) 2009-10-22
WO2009129301A2 (en) 2009-10-22
US20110034478A1 (en) 2011-02-10
AU2009236290A1 (en) 2009-10-22

Similar Documents

Publication Publication Date Title
JP2011516613A (ja) 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物
JP7627302B2 (ja) パルボシクリブの固形剤形
US20250144112A1 (en) Suspension for oral administration comprising amorphous tolvaptan
HK1248547A1 (zh) 包含替诺福韦和恩曲他滨的药物制剂
JP2025134801A (ja) オラパリブの溶解度及び生体利用効率が改善された組成物
EP4037659B1 (en) Pharmaceutical composition comprising enzalutamide
EP2280711A1 (en) Methods, dosage forms, and kits for administering ziprasidone without food
US10888519B2 (en) Immediate release pharmaceutical composition of iron chelating agents
CN104884050A (zh) 用于治疗hiv感染的药物组合物
US20120141586A1 (en) Thrombin receptor antagonist and clopidogrel fixed dose tablet
WO2010111264A2 (en) Rasagiline formulations
JP5635491B2 (ja) 固形医薬組成物
JP2010536798A (ja) 難溶性薬物の生体利用率を制御するための方法及び組成物
US9968607B2 (en) Pharmaceutical compositions of raltegravir, methods of preparation and methods of use therof
WO2023168295A1 (en) Therapeutic compounds, formulations, and use thereof
US11260055B2 (en) Oral pharmaceutical composition of lurasidone and preparation thereof
US12465565B2 (en) Pharmaceutical compositions of raltegravir
WO2026019402A1 (en) A pharmaceutical composition comprising nanosuspension of canagliflozin
WO2026019401A1 (en) A nanosuspension composition comprising canagliflozin
CN116437902A (zh) 包含美洛昔康的医药组成物
HK1198466B (en) Prasugrel-containing immediate release stable oral pharmaceutical compositions
HK1198466A1 (en) Prasugrel-containing immediate release stable oral pharmaceutical compositions

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120221

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120221

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130124

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20130812