JP2011516610A - C型肝炎ウイルス複製の新規な阻害剤 - Google Patents

C型肝炎ウイルス複製の新規な阻害剤 Download PDF

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JP2011516610A
JP2011516610A JP2011505149A JP2011505149A JP2011516610A JP 2011516610 A JP2011516610 A JP 2011516610A JP 2011505149 A JP2011505149 A JP 2011505149A JP 2011505149 A JP2011505149 A JP 2011505149A JP 2011516610 A JP2011516610 A JP 2011516610A
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レオニード・ビーゲルマン
グアンギ・ワン
ブラッド・オー・バックマン
アンティッサ・ディミトロヴァ・ストイチェヴァ
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インターミューン・インコーポレーテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15Six-membered rings
    • C07D285/16Thiadiazines; Hydrogenated thiadiazines
    • C07D285/181,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/201,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/221,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/241,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • C07D285/261,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
    • C07D285/301,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with hydrocarbon radicals, substituted by hetero atoms, attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2011505149A 2008-04-15 2009-04-14 C型肝炎ウイルス複製の新規な阻害剤 Pending JP2011516610A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US4521908P 2008-04-15 2008-04-15
US4521408P 2008-04-15 2008-04-15
US61/045,219 2008-04-15
US61/045,214 2008-04-15
US10985608P 2008-10-30 2008-10-30
US61/109,856 2008-10-30
US11791608P 2008-11-25 2008-11-25
US61/117,916 2008-11-25
US14833709P 2009-01-29 2009-01-29
US61/148,337 2009-01-29
PCT/US2009/040567 WO2009134616A2 (en) 2008-04-15 2009-04-14 Novel inhibitors of hepatitis c virus replication

Publications (2)

Publication Number Publication Date
JP2011516610A true JP2011516610A (ja) 2011-05-26
JP2011516610A5 JP2011516610A5 (https=) 2012-06-07

Family

ID=41078055

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JP2011505149A Pending JP2011516610A (ja) 2008-04-15 2009-04-14 C型肝炎ウイルス複製の新規な阻害剤

Country Status (10)

Country Link
US (1) US20090257979A1 (https=)
EP (1) EP2283002A2 (https=)
JP (1) JP2011516610A (https=)
KR (1) KR20110004439A (https=)
CN (1) CN102026990A (https=)
AU (1) AU2009241514A1 (https=)
BR (1) BRPI0911259A2 (https=)
CA (1) CA2720846A1 (https=)
MX (1) MX2010011307A (https=)
WO (1) WO2009134616A2 (https=)

Cited By (5)

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JP2014526562A (ja) * 2011-09-26 2014-10-06 ガレラ・セラピューティクス・リミテッド・ライアビリティ・カンパニー 疾患の治療方法
US10597415B2 (en) 2015-08-11 2020-03-24 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
US10610533B2 (en) 2006-10-12 2020-04-07 Galera Labs, Llc Methods of treating oral mucositis
US11246950B2 (en) 2017-04-13 2022-02-15 Galera Labs, Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex
US12156863B2 (en) 2016-09-01 2024-12-03 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound

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CN102666537A (zh) * 2009-10-20 2012-09-12 艾格尔生物制药股份有限公司 治疗黄病毒科病毒感染的氮杂吲唑
TW201121968A (en) * 2009-11-09 2011-07-01 Intermune Inc Novel inhibitors of hepatitis C virus replication
DE202012012955U1 (de) 2011-10-21 2014-07-14 Abbvie Inc. Eine Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) für die Verwendung zur Behandlung von HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
EP2583677A3 (en) 2011-10-21 2013-07-03 Abbvie Inc. Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon.
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
WO2015018797A2 (en) * 2013-08-05 2015-02-12 Haplogen Gmbh Antiviral compounds
CN105991908B (zh) * 2015-03-16 2019-06-07 迈科威特株式会社 摄像机模块用滤光器转换装置及包含该模块的移动设备
EA201892448A1 (ru) 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения
KR20180132939A (ko) 2016-05-03 2018-12-12 갈레라 랩스, 엘엘씨 암 치료를 위한 조합 요법

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JPS6025984A (ja) * 1983-07-22 1985-02-08 Tokyo Inst Of Technol ベンゾチアジアジン誘導体の製造方法
JPH0216448A (ja) * 1988-07-04 1990-01-19 Fuji Photo Film Co Ltd 化学物質の分配係数の推算処理方法
JP2006509042A (ja) * 2002-11-01 2006-03-16 アボット・ラボラトリーズ 抗感染薬
WO2006093801A1 (en) * 2005-02-25 2006-09-08 Abbott Laboratories Thiadiazine derivatives useful as anti-infective agents

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JPS6025984A (ja) * 1983-07-22 1985-02-08 Tokyo Inst Of Technol ベンゾチアジアジン誘導体の製造方法
JPH0216448A (ja) * 1988-07-04 1990-01-19 Fuji Photo Film Co Ltd 化学物質の分配係数の推算処理方法
JP2006509042A (ja) * 2002-11-01 2006-03-16 アボット・ラボラトリーズ 抗感染薬
WO2006093801A1 (en) * 2005-02-25 2006-09-08 Abbott Laboratories Thiadiazine derivatives useful as anti-infective agents

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10610533B2 (en) 2006-10-12 2020-04-07 Galera Labs, Llc Methods of treating oral mucositis
US11612608B2 (en) 2006-10-12 2023-03-28 Galera Labs, Llc Methods of treating oral mucositis
JP2023027289A (ja) * 2011-09-26 2023-03-01 ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー 疾患の治療方法
JP7562125B2 (ja) 2011-09-26 2024-10-07 ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー 疾患の治療方法
US10493081B2 (en) 2011-09-26 2019-12-03 Galera Labs, Llc Methods for treatment of diseases
JP2020183416A (ja) * 2011-09-26 2020-11-12 ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーGalera Labs, Llc 疾患の治療方法
JP7697688B2 (ja) 2011-09-26 2025-06-24 ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー 疾患の治療方法
US11826373B2 (en) 2011-09-26 2023-11-28 Galera Labs, Llc Methods for treatment of diseases
JP2014526562A (ja) * 2011-09-26 2014-10-06 ガレラ・セラピューティクス・リミテッド・ライアビリティ・カンパニー 疾患の治療方法
US10137133B2 (en) 2011-09-26 2018-11-27 Galera Labs, Llc Methods for treatment of diseases
US12077549B2 (en) 2015-08-11 2024-09-03 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
US10597415B2 (en) 2015-08-11 2020-03-24 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
US11066433B2 (en) 2015-08-11 2021-07-20 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
US12156863B2 (en) 2016-09-01 2024-12-03 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound
US11246950B2 (en) 2017-04-13 2022-02-15 Galera Labs, Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex
US12551581B2 (en) 2017-04-13 2026-02-17 Galera Labs, Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex

Also Published As

Publication number Publication date
WO2009134616A3 (en) 2010-03-18
AU2009241514A1 (en) 2009-11-05
BRPI0911259A2 (pt) 2015-10-06
KR20110004439A (ko) 2011-01-13
CN102026990A (zh) 2011-04-20
MX2010011307A (es) 2010-11-09
EP2283002A2 (en) 2011-02-16
CA2720846A1 (en) 2009-11-05
WO2009134616A2 (en) 2009-11-05
US20090257979A1 (en) 2009-10-15
WO2009134616A8 (en) 2010-05-14

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