JP2011516610A - C型肝炎ウイルス複製の新規な阻害剤 - Google Patents

C型肝炎ウイルス複製の新規な阻害剤 Download PDF

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JP2011516610A
JP2011516610A JP2011505149A JP2011505149A JP2011516610A JP 2011516610 A JP2011516610 A JP 2011516610A JP 2011505149 A JP2011505149 A JP 2011505149A JP 2011505149 A JP2011505149 A JP 2011505149A JP 2011516610 A JP2011516610 A JP 2011516610A
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JP2011516610A5 (OSRAM
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レオニード・ビーゲルマン
グアンギ・ワン
ブラッド・オー・バックマン
アンティッサ・ディミトロヴァ・ストイチェヴァ
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インターミューン・インコーポレーテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15Six-membered rings
    • C07D285/16Thiadiazines; Hydrogenated thiadiazines
    • C07D285/181,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/201,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/221,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/241,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • C07D285/261,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
    • C07D285/301,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with hydrocarbon radicals, substituted by hetero atoms, attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
JP2011505149A 2008-04-15 2009-04-14 C型肝炎ウイルス複製の新規な阻害剤 Pending JP2011516610A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US4521408P 2008-04-15 2008-04-15
US4521908P 2008-04-15 2008-04-15
US61/045,214 2008-04-15
US61/045,219 2008-04-15
US10985608P 2008-10-30 2008-10-30
US61/109,856 2008-10-30
US11791608P 2008-11-25 2008-11-25
US61/117,916 2008-11-25
US14833709P 2009-01-29 2009-01-29
US61/148,337 2009-01-29
PCT/US2009/040567 WO2009134616A2 (en) 2008-04-15 2009-04-14 Novel inhibitors of hepatitis c virus replication

Publications (2)

Publication Number Publication Date
JP2011516610A true JP2011516610A (ja) 2011-05-26
JP2011516610A5 JP2011516610A5 (OSRAM) 2012-06-07

Family

ID=41078055

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JP2011505149A Pending JP2011516610A (ja) 2008-04-15 2009-04-14 C型肝炎ウイルス複製の新規な阻害剤

Country Status (10)

Country Link
US (1) US20090257979A1 (OSRAM)
EP (1) EP2283002A2 (OSRAM)
JP (1) JP2011516610A (OSRAM)
KR (1) KR20110004439A (OSRAM)
CN (1) CN102026990A (OSRAM)
AU (1) AU2009241514A1 (OSRAM)
BR (1) BRPI0911259A2 (OSRAM)
CA (1) CA2720846A1 (OSRAM)
MX (1) MX2010011307A (OSRAM)
WO (1) WO2009134616A2 (OSRAM)

Cited By (5)

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JP2014526562A (ja) * 2011-09-26 2014-10-06 ガレラ・セラピューティクス・リミテッド・ライアビリティ・カンパニー 疾患の治療方法
US10597415B2 (en) 2015-08-11 2020-03-24 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
US10610533B2 (en) 2006-10-12 2020-04-07 Galera Labs, Llc Methods of treating oral mucositis
US11246950B2 (en) 2017-04-13 2022-02-15 Galera Labs, Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex
US12156863B2 (en) 2016-09-01 2024-12-03 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound

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WO2011049988A2 (en) * 2009-10-20 2011-04-28 Eiger Biopharmaceuticals, Inc. Indazoles to treat flaviviridae virus infection
TW201121968A (en) * 2009-11-09 2011-07-01 Intermune Inc Novel inhibitors of hepatitis C virus replication
AU2013201406B2 (en) 2011-10-21 2014-10-02 Abbvie Ireland Unlimited Company Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
EP2583680A3 (en) 2011-10-21 2013-06-12 Abbvie Inc. Mono (PSI-7977) or combination treatment of DAAs for use in treating HCV
WO2015018797A2 (en) * 2013-08-05 2015-02-12 Haplogen Gmbh Antiviral compounds
US10237458B2 (en) * 2015-03-16 2019-03-19 Micro Actuator Co., Ltd. Filter switching device used for camera module and mobile device including camera module
WO2017189978A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
WO2017192740A2 (en) 2016-05-03 2017-11-09 Galera Labs, Llc Combination therapy for cancer treatment

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JPS6025984A (ja) * 1983-07-22 1985-02-08 Tokyo Inst Of Technol ベンゾチアジアジン誘導体の製造方法
JPH0216448A (ja) * 1988-07-04 1990-01-19 Fuji Photo Film Co Ltd 化学物質の分配係数の推算処理方法
JP2006509042A (ja) * 2002-11-01 2006-03-16 アボット・ラボラトリーズ 抗感染薬
WO2006093801A1 (en) * 2005-02-25 2006-09-08 Abbott Laboratories Thiadiazine derivatives useful as anti-infective agents

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US6242443B1 (en) * 1996-06-21 2001-06-05 Novo Nordisk Ais 1,2,4-benzothiadiazine derivatives, their preparation and use
US6156700A (en) * 1997-09-17 2000-12-05 American Cyanmid Company 3-(1,2-Benzisothiazol- and isoxazol-5-yl)-2,4(1H,3H)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3H)-pyrimidinone or thione herbicidal agents
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KR20050122220A (ko) * 2003-03-25 2005-12-28 다케다 샌디에고, 인코포레이티드 디펩티딜 펩티다제 억제제
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JPS6025984A (ja) * 1983-07-22 1985-02-08 Tokyo Inst Of Technol ベンゾチアジアジン誘導体の製造方法
JPH0216448A (ja) * 1988-07-04 1990-01-19 Fuji Photo Film Co Ltd 化学物質の分配係数の推算処理方法
JP2006509042A (ja) * 2002-11-01 2006-03-16 アボット・ラボラトリーズ 抗感染薬
WO2006093801A1 (en) * 2005-02-25 2006-09-08 Abbott Laboratories Thiadiazine derivatives useful as anti-infective agents

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10610533B2 (en) 2006-10-12 2020-04-07 Galera Labs, Llc Methods of treating oral mucositis
US11612608B2 (en) 2006-10-12 2023-03-28 Galera Labs, Llc Methods of treating oral mucositis
US11826373B2 (en) 2011-09-26 2023-11-28 Galera Labs, Llc Methods for treatment of diseases
US10137133B2 (en) 2011-09-26 2018-11-27 Galera Labs, Llc Methods for treatment of diseases
US10493081B2 (en) 2011-09-26 2019-12-03 Galera Labs, Llc Methods for treatment of diseases
JP2014526562A (ja) * 2011-09-26 2014-10-06 ガレラ・セラピューティクス・リミテッド・ライアビリティ・カンパニー 疾患の治療方法
JP2020183416A (ja) * 2011-09-26 2020-11-12 ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーGalera Labs, Llc 疾患の治療方法
JP7697688B2 (ja) 2011-09-26 2025-06-24 ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー 疾患の治療方法
JP7562125B2 (ja) 2011-09-26 2024-10-07 ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー 疾患の治療方法
JP2023027289A (ja) * 2011-09-26 2023-03-01 ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー 疾患の治療方法
US10597415B2 (en) 2015-08-11 2020-03-24 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
US12077549B2 (en) 2015-08-11 2024-09-03 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
US11066433B2 (en) 2015-08-11 2021-07-20 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
US12156863B2 (en) 2016-09-01 2024-12-03 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound
US11246950B2 (en) 2017-04-13 2022-02-15 Galera Labs, Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex

Also Published As

Publication number Publication date
KR20110004439A (ko) 2011-01-13
BRPI0911259A2 (pt) 2015-10-06
MX2010011307A (es) 2010-11-09
WO2009134616A3 (en) 2010-03-18
CN102026990A (zh) 2011-04-20
WO2009134616A8 (en) 2010-05-14
AU2009241514A1 (en) 2009-11-05
US20090257979A1 (en) 2009-10-15
CA2720846A1 (en) 2009-11-05
WO2009134616A2 (en) 2009-11-05
EP2283002A2 (en) 2011-02-16

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