MX2010011307A

MX2010011307A - Nuevos inhibidores de la replicacion del virus de hepatitis c.

Nuevos inhibidores de la replicacion del virus de hepatitis c.

Info

Publication number: MX2010011307A
Authority: MX; Mexico
Prior art keywords: optionally substituted; compound; ifn; substituted alkyl; group
Prior art date: 2008-04-15

Application number

MX2010011307A

Other languages

English (en)

Spanish (es)

Inventor

Leonid Beigelman

Guangyi Wang

Brad O Buckman

Antitsa Dimitrova Stoycheva

Original Assignee

Intermune Inc

Priority date

2008-04-15

Filing date

2009-04-14

Publication date

2010-11-09

2009-04-14 Application filed by Intermune Inc filed Critical Intermune Inc

2010-11-09 Publication of MX2010011307A publication Critical patent/MX2010011307A/es

Links

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230000029812 viral genome replication Effects 0.000 title description 6
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238000000034 method Methods 0.000 claims abstract description 300
239000000203 mixture Substances 0.000 claims abstract description 113
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
208000010710 hepatitis C virus infection Diseases 0.000 claims abstract description 7
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239000003814 drug Substances 0.000 claims description 222
125000000547 substituted alkyl group Chemical group 0.000 claims description 218
239000001257 hydrogen Substances 0.000 claims description 112
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208000015181 infectious disease Diseases 0.000 claims description 105
125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 100
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 86
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 86
229910052736 halogen Inorganic materials 0.000 claims description 80
150000002367 halogens Chemical group 0.000 claims description 80
125000005415 substituted alkoxy group Chemical group 0.000 claims description 78
108010047761 Interferon-alpha Proteins 0.000 claims description 74
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238000002360 preparation method Methods 0.000 claims description 73
125000001072 heteroaryl group Chemical group 0.000 claims description 72
125000000623 heterocyclic group Chemical group 0.000 claims description 69
108010010648 interferon alfacon-1 Proteins 0.000 claims description 69
-1 alkyl-CO- Chemical group 0.000 claims description 63
125000004093 cyano group Chemical group *C#N 0.000 claims description 63
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125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 61
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OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims description 57
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HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims description 53
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