JP2011516480A - 栄養補助食品および関連する方法 - Google Patents
栄養補助食品および関連する方法 Download PDFInfo
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Abstract
Description
I.総論
一般的に、本発明は、果実、野菜、及びハーブを含む組成物に関する。一つの実施形態において、当該組成物は、果実成分、野菜成分、及びハーブ成分を含み得、ここで前記果実成分は、シトラス・バイオフラボノイド及びザクロの少なくとも一つであり;前記野菜成分は、アスパラガス、ルテイン、リコピン、及び、クレソンの少なくとも一つであり、そして前記ハーブ成分は、バジル、オレガノ、及びローズマリーの少なくとも一つである。当該組成物はまた、クロマチンの安定性に影響を与える既知の治療法と組み合され得、それにより、かかる治療法の有害な効果を限定する。
当該組成物は、著しい健康上の利益を提供する、果実、野菜、ハーブ及び他の成分の組み合わせを含み得る。以下の表は、組成物中に含まれ得る、代表的な一日量の好適な果実、野菜、ハーブ、ビタミン及びミネラルを示す。投与量及び方法は、所望の適用ごとに変化し得る。例えば用量Aは、本発明の目的のために好適である、各々の成分の用量の範囲を示す。用量Bは、特定の実施形態の用量を示す。表1〜5における単位「mg」は、記載された量が、例えば「JU」と記載されていない限り、一日用量あたり2錠で提供される、例えばミリグラムの数で与えられる。したがって、単一の錠剤あたりの特定成分の量を決定するために、各々の表に記載された量が半分にされなければならない。
a)果実、野菜、及びハーブ成分、b)ビタミン、並びにc)ミネラルを提供するために、3つの錠剤が調製され得る。第一の錠剤は、表1〜3の果実、野菜、及びハーブ成分を含む。第一の錠剤中の各々の成分の量は、表で列挙された量が2つのかかる錠剤中に存在する量であるため、表の用量Bに列挙された量の半分である。第一の錠剤はまた、担体、及び他の錠剤化補助剤(tableting aid)、例えば二酸化ケイ素、酸化マグネシウム、炭酸カルシウム、クロスカルメロースナトリウム、微結晶セルロース、及びステアリン酸マグネシウムを、当業者に周知の目的のために変化され得る量で含み得る。
以下の例は、上記3つの錠剤を製造する方法に関する。当該成分は、上の表1〜5に記載されたものと同一である。しかし、以下の実施例の目的のために、表1〜3からの果実、野菜及びハーブ成分を含む錠剤は、「錠剤1」と呼び;表4からのビタミン成分を含む錠剤は「錠剤2」と呼び;表5からのミネラル成分を含む錠剤は「錠剤3」と呼ぶ。当該錠剤及び他の好適な送達ビヒクルを製造するための他の方法が、所望であれば使用され得ることが強調される。
混合トコフェロール、D−アルファ−トコフェロール(サクシネート)、及び二酸化ケイ素(NF微粉末)を、20メッシュスクリーンを備えたSWECOセパレーターを通じて、100立方フィートのPKブレンダーへと入れた。当該成分を10分間混合した。酸化マグネシウム(D.C.ヘビー)、アセロラ濃縮物、シトラス・バイオフラボノイド複合体、プラム濃縮物、リンゴ抽出物、ローズマリー抽出物、バジル抽出物、ブドウの皮抽出物、クランベリー抽出物、ケール粉末、アスパラガス抽出物、ブルーベリー抽出物、パセリ乾燥体、オレガノ抽出物、セージ抽出物、ザクロ抽出物、及びイノシトールを、20メッシュスクリーンを備えたSWECOセパレーターを通じて、100立方フィートのPKブレンダーへと入れた。当該成分を10分間混合した。
アセロラ濃縮物、微結晶セルロース(シリカ状)、及びアルファリポ酸を、20メッシュスクリーンを備えたSWECOセパレーターを通じて、直接的に100立方フィートのPKブレンダーへと入れた。当該成分を10分間混合した。次に、以下の成分を、20メッシュスクリーンを備えたSWECOセパレーターを通じて、直接的に100立方フィートのPKブレンダーへと入れた:チアミン・モノニトレート(97%)、リボフラビン、ナイアシンアミド、ビオチン粉砕物(1%)、ビタミンB12(1.1%)、パントテン酸カルシウム粒状物、葉酸、ピリドキシン塩酸塩(95%)、及びコリン酒石酸水素塩。当該成分を10分間混合した。次に以下の品目を、20メッシュスクリーンを備えたSWECOセパレーターを通じて、直接的に100立方フィートのPKブレンダーへと入れた:ベータカロテン(ビードレット)、ビタミンD3(ビードレット)、酵母(標準化された)、及びビタミンA(酢酸塩)。当該混合物をさらに10分間混合した。
亜鉛・アミノ酸キレート、混合トコフェロール、及び二酸化ケイ素(NF微粉末)を、20メッシュスクリーンを備えたSWECOセパレーターを通じて、100立方フィートのPKブレンダーへと入れた。当該成分を10分間混合した。共に処理されたアルファルファ濃縮物/微結晶セルロース/炭酸カルシウム、セレン酵母、微結晶セルロース、銅・アミノ酸キレート、マンガン・アミノ酸キレート、ヨウ化カリウム粉砕物、クロム・アミノ酸キレート、モリブデン・アミノ酸キレート、アブラナ属乾燥体、クレソン乾燥体、及びクロスカルメロースナトリウムを、20メッシュスクリーンを備えたSWECOセパレーターを通じて、100立方フィートのPKブレンダーへと入れた。当該成分を10分間混合した。
臨床試験は、治験審査委員会が承認した二重盲プラセボ対照並行群試験であった。
対象は、カリフォルニア及びハワイにおける120人の健常な成人日系アメリカ人であった。対象は、民族的には日本人であり(両親及び4人の祖父母の両方が民族的に日本人)、そして主に日本食を食した。
対象は、指示通りに(一日あたり12錠)組成物又はプラセボのいずれかを8週間服用した。当該組成物は、Alticorから、トリプルX(TripleX)(商標)の名前で日本において現在市販されているものと同じものである。全ての製造物はコーティングされ、そして二重盲を保持するために、コードの付されたホイルの箱中で提供された。
結果測定の、4つの主な分類が存在した:(1)各々の水溶性抗酸化性栄養分[ビタミンc]、及び各々の脂溶性抗酸化性栄養分[ベータカロテン]の血漿濃度、(2)「抗ホモシステインの三種類」である、ビタミンB6、ビタミン12、及び葉酸の、並びにホモシステインの血漿濃度、(3)遺伝的安定性のニュートリゲノミクス的機構、並びに(4)血漿代謝特性の変化。
血漿栄養分及びホモシステインの変化のスコア結果を、群間比較のための独立群t検定で評価した。0.5よりも小さいAP値が有意であると考えられた。
臨床試験を行い、本発明の組成物の有効性を確認した。当該組成物の消費は特に:植物化学物質の食事性欠乏症を改善し;身体内における抗酸化物質量を改善し;フリーラジカル損傷を減少させ;血漿のビタミン、ミネラル、及び植物化学物質濃度を増加させ;そして血漿中及び全身的な抗酸化物質の能力を改善することが期待された。
Claims (16)
- 果実成分、野菜成分、及びハーブ成分を含む組成物の有効量を投与することによって、クロマチンの安定性に関連する遺伝子の発現を調節するための方法であって、前記果実成分がザクロ及びシトラス・バイオフラボノイドの少なくとも一つであり、前記野菜成分がアスパラガス、ルテイン、リコピン、及びクレソンの少なくとも一つであり、そして前記ハーブ成分がバジル、オレガノ、及びローズマリーの少なくとも一つであり、前記組成物がクロマチンの安定性に関連する遺伝子の発現を調節する、前記方法。
- 前記投与のステップが、各々一日に2回投与される、3つの錠剤の形態で前記組成物を対象へ投与することを含む、請求項1に記載の方法。
- 前記投与のステップが、クロマチン安定性関連遺伝子の発現を上方制御する組成物を投与することを含む、請求項1に記載の方法。
- 果実成分、野菜成分、及びハーブ成分を含む組成物の有効量を投与することによって、DNA修復関連遺伝子の発現を調節するための方法であって、前記果実成分がザクロ及びシトラス・バイオフラボノイドの少なくとも一つであり、前記野菜成分がアスパラガス、ルテイン、リコピン、及びクレソンの少なくとも一つであり、そして前記ハーブ成分がバジル、オレガノ、及びローズマリーの少なくとも一つであり、前記組成物がDNA修復に関連する遺伝子の発現を調節する、前記方法。
- 前記投与のステップが、各々一日に2回投与される、3つの錠剤の形態で前記組成物を対象へ投与することを含む、請求項4に記載の方法。
- 前記投与のステップが、前記組成物を投与し、それによりDNA修復関連遺伝子の発現を上方制御することを含む、請求項4に記載の方法。
- 果実成分、野菜成分、及びハーブ成分を含む組成物の有効量を投与することによって、クロマチン損傷のリスクを減少させるための方法であって、前記果実成分がザクロ及びシトラス・バイオフラボノイドの少なくとも一つであり、前記野菜成分がアスパラガス、ルテイン、リコピン、及びクレソンの少なくとも一つであり、そして前記ハーブ成分がバジル、オレガノ、及びローズマリーの少なくとも一つであり、前記組成物が遺伝子の発現を調節し、それによりクロマチン損傷のリスクを減少させることを含む、前記方法。
- 前記投与のステップが、各々一日に2回投与される、3つの錠剤の形態で前記組成物を対象へ投与することを含む、請求項7に記載の方法。
- 前記投与のステップが、クロマチン安定性関連遺伝子の発現を上方制御する組成物を投与することを含む、請求項7に記載の方法。
- 果実成分、野菜成分、及びハーブ成分を含む組成物であって、前記果実成分がザクロ及びシトラス・バイオフラボノイドの少なくとも一つであり、前記野菜成分がアスパラガス、ルテイン、リコピン、及びクレソンの少なくとも一つであり、そして前記ハーブ成分がバジル、オレガノ、及びローズマリーの少なくとも一つであり、遺伝子の発現を調節し、それによりクロマチン損傷のリスクを減少させる、前記組成物の有効量;並びに、
クロマチンの安定性を変化させる、疾患を処置するための第二の組成物
を含む、併用療法。 - アルファルファ、アブラナ属、及びケールをさらに含む、請求項10に記載の併用療法。
- ビタミン及びミネラルをさらに含む、請求項10に記載の併用療法。
- 前記ビタミンが、ビタミンA、ビタミンC、ビタミンD、ビタミンE、ナイアシン、ビタミンB6、ビタミンB12、葉酸、ビオチン、及びパントテン酸から選択される、請求項12に記載の併用療法。
- 前記ミネラルが、カルシウム、マグネシウム、ヨウ素、カリウム、銅、亜鉛、リン、マンガン、クロム、セレン、及びモリブデンから選択される、請求項12に記載の併用療法。
- 前記シトラス・バイオフラボノイドが、濃縮形態で存在し、そしてナリンゲン(naringen)、ヘスペリジン、及びナリルチン(narirutin)を含む、請求項10に記載の併用療法。
- 前記果実成分、前記野菜成分、及び前記ハーブ成分が、3.5:1:1の比率で存在する、請求項10に記載の併用療法。
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US7939115B2 (en) | 2000-06-12 | 2011-05-10 | Access Business Group International Llc | Dietary supplement and related method |
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US9801814B2 (en) * | 2010-06-28 | 2017-10-31 | Nestec S.A. | Tube feed packages and methods for using same |
SI23754A (sl) * | 2010-08-31 | 2012-12-31 | Vitiva D.D. | Zaĺ äśita barve, barvanje ter antioskidativna in antimikrobioloĺ ka zaĺ äśita mesa in mesnih izdelkov |
US9289374B2 (en) | 2014-04-23 | 2016-03-22 | Lifevantage Corporation | Topical compositions and methods for reducing oxidative stress |
CN108025034B (zh) * | 2015-07-15 | 2022-09-30 | 新加坡科技研究局 | 乙型肝炎病毒复制的调控 |
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