JP2011516436A - 幹細胞又は骨髄細胞を用いる組織の再生のための方法及び組成物 - Google Patents
幹細胞又は骨髄細胞を用いる組織の再生のための方法及び組成物 Download PDFInfo
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| EP08006238.3 | 2008-03-31 | ||
| PCT/EP2009/002135 WO2009121503A2 (de) | 2008-03-31 | 2009-03-24 | Verfahren und zusammensetzung zur regeneration von gewebe mit hilfe von stamm- oder knochenmarkzellen |
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| JP2011516436A true JP2011516436A (ja) | 2011-05-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016529057A (ja) * | 2013-09-02 | 2016-09-23 | マフィン・インコーポレイテッドMuffin Incorporated | 細胞外マトリックス組織物質および骨原性タンパク質を含む生成物 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110280838A1 (en) * | 2007-12-27 | 2011-11-17 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells |
| WO2011153512A2 (en) * | 2010-06-03 | 2011-12-08 | Indiana University Research And Technology Corporation | Use of compounds with thrombopoietic activity to promote bone growth and healing |
| CN104524636B (zh) * | 2014-12-19 | 2017-06-16 | 中国人民解放军第四军医大学 | 通过定向诱导骨髓间充质干细胞获得组织工程软骨的方法 |
| RU2614665C1 (ru) * | 2015-12-18 | 2017-03-28 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Способ стимуляции репаративного ангиогенеза и регенерации соединительной ткани, при её повреждении, методом генной терапии с использованием видоспецифичных генов белковых факторов vegf и fgf2, в ветеринарии, и генетическая конструкция для реализации заявленного способа |
| CN106581772B (zh) * | 2016-12-02 | 2020-02-18 | 四川大学华西医院 | 携带G-CSF缓释系统的Fibrin-HA水凝胶及其制备方法和用途 |
| KR101772449B1 (ko) | 2016-12-27 | 2017-08-30 | 주식회사 하이센스바이오 | 신규한 펩타이드 |
| RU2687007C2 (ru) * | 2017-09-12 | 2019-05-06 | Общество с ограниченной ответственностью "Клеточные Системы" | Способ биотехнологического восстановления кожного покрова аллогенными стволовыми клетками человека |
| JP7110360B2 (ja) | 2017-10-09 | 2022-08-01 | テルモ ビーシーティー バイオテクノロジーズ,エルエルシー | 凍結乾燥方法 |
| KR101943978B1 (ko) | 2017-12-28 | 2019-01-30 | 주식회사 하이센스바이오 | 신규한 펩타이드 |
| RU2669726C1 (ru) * | 2018-01-10 | 2018-10-15 | Диана Малхазовна Обидняк | Способ повышения эффективности вспомогательных репродуктивных технологий у пациенток с повторными неэффективными попытками имплантации |
| CN113597532B (zh) | 2019-03-14 | 2023-02-17 | 泰尔茂比司特生物技术有限公司 | 冻干容器填充固定装置、系统及使用方法 |
| RU2747589C1 (ru) * | 2019-12-09 | 2021-05-11 | Руслан Яверович Атлуханов | Способ лечения повреждения мениска коленного сустава |
| CN116712597B (zh) * | 2023-06-12 | 2026-04-17 | 广州正源生物技术有限公司 | 一种复合生物敷料及其制备方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003523166A (ja) * | 1998-09-29 | 2003-08-05 | ガミダ セル リミテッド | 幹細胞および前駆細胞の増殖と分化を制御する方法 |
| JP2007517001A (ja) * | 2003-12-30 | 2007-06-28 | ビオネトス・ホールディング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 組織再生法 |
| JP2009538677A (ja) * | 2006-05-31 | 2009-11-12 | ビオリゲン・エス・アール・エル | 組織再生のためのバイオメンブレン |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE439849T1 (de) * | 1996-04-19 | 2009-09-15 | Osiris Therapeutics Inc | Die wiederherstellung und verstärkung von knochen mittels mesenchymalen stammzellen |
| AU2003253015A1 (en) * | 2002-06-20 | 2004-01-06 | Bionethos Holding Gmbh | Method and device for multiplying and differentiating cells in the presence of growth factors and of a biological matrix or of a supporting structure |
| US20040191215A1 (en) * | 2003-03-25 | 2004-09-30 | Michael Froix | Compositions for induction of a therapeutic response |
| DE102004004509B4 (de) * | 2004-01-23 | 2010-07-01 | Epoplus Gmbh Co.Kg | Einsatz von niedrig dosiertem Erythropoietin zur Stimulation endothelialer Vorläuferzellen sowie zur Organregeneration und Progressionsverlangsamung von Endorganschäden |
-
2009
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- 2009-03-24 EP EP09726923.7A patent/EP2273997B1/de active Active
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003523166A (ja) * | 1998-09-29 | 2003-08-05 | ガミダ セル リミテッド | 幹細胞および前駆細胞の増殖と分化を制御する方法 |
| JP2007517001A (ja) * | 2003-12-30 | 2007-06-28 | ビオネトス・ホールディング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 組織再生法 |
| JP2009538677A (ja) * | 2006-05-31 | 2009-11-12 | ビオリゲン・エス・アール・エル | 組織再生のためのバイオメンブレン |
Non-Patent Citations (1)
| Title |
|---|
| JPN6013042277; Mizuno H et al.: 'A novel approach to regenerating periodontal tissue by grafting autologous cultured periosteum.' Tissue Eng. Vol.12 No.5, 200605, pp.1227-1235 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016529057A (ja) * | 2013-09-02 | 2016-09-23 | マフィン・インコーポレイテッドMuffin Incorporated | 細胞外マトリックス組織物質および骨原性タンパク質を含む生成物 |
| JP2019122410A (ja) * | 2013-09-02 | 2019-07-25 | マフィン・インコーポレイテッドMuffin Incorporated | 細胞外マトリックス組織物質および骨原性タンパク質を含む生成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2273997B1 (de) | 2016-01-13 |
| RU2010142988A (ru) | 2012-05-10 |
| CA2719437A1 (en) | 2009-10-08 |
| EP2273997A2 (de) | 2011-01-19 |
| WO2009121503A3 (de) | 2009-11-26 |
| RU2491076C2 (ru) | 2013-08-27 |
| US20110020299A1 (en) | 2011-01-27 |
| WO2009121503A2 (de) | 2009-10-08 |
| AU2009231139A1 (en) | 2009-10-08 |
| CN101980714A (zh) | 2011-02-23 |
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