JP2011515491A - Ｎ−［［４−フルオロ−２−（５−メチル−１Ｈ−１，２，４−トリアゾール−１−イル）フェニル］メチル］−４，６，７，９−テトラヒドロ−３−ヒドロキシ−９，９−ジメチル−４−オキソ−ピリミド［２，１−ｃ］［１，４］オキサジン−２−カルボキシアミド，ナトリウム塩一水和物の結晶形 - Google Patents

Ｎ−［［４−フルオロ−２−（５−メチル−１Ｈ−１，２，４−トリアゾール−１−イル）フェニル］メチル］−４，６，７，９−テトラヒドロ−３−ヒドロキシ−９，９−ジメチル−４−オキソ−ピリミド［２，１−ｃ］［１，４］オキサジン−２−カルボキシアミド，ナトリウム塩一水和物の結晶形 Download PDF

Info

Publication number
JP2011515491A
JP2011515491A JP2011502043A JP2011502043A JP2011515491A JP 2011515491 A JP2011515491 A JP 2011515491A JP 2011502043 A JP2011502043 A JP 2011502043A JP 2011502043 A JP2011502043 A JP 2011502043A JP 2011515491 A JP2011515491 A JP 2011515491A
Authority
JP
Japan
Prior art keywords
hiv
inhibitors
compound
crystalline form
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011502043A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011515491A5 (enExample
Inventor
キャンディス・ワイ・チョイ
アリシア・ティー・フアイ・ヌグ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2011515491A publication Critical patent/JP2011515491A/ja
Publication of JP2011515491A5 publication Critical patent/JP2011515491A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011502043A 2008-03-27 2009-03-26 Ｎ−［［４−フルオロ−２−（５−メチル−１Ｈ−１，２，４−トリアゾール−１−イル）フェニル］メチル］−４，６，７，９−テトラヒドロ−３−ヒドロキシ−９，９−ジメチル−４−オキソ−ピリミド［２，１−ｃ］［１，４］オキサジン−２−カルボキシアミド，ナトリウム塩一水和物の結晶形 Pending JP2011515491A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3998908P 2008-03-27 2008-03-27
US61/039,989 2008-03-27
PCT/US2009/038362 WO2009120841A1 (en) 2008-03-27 2009-03-26 Crystalline form of n-[[4-fluoro-2-(5-methyl-1h-1,2,4-triazol-1-yl)phenyl]methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide, sodium salt monohydrate

Publications (2)

Publication Number Publication Date
JP2011515491A true JP2011515491A (ja) 2011-05-19
JP2011515491A5 JP2011515491A5 (enExample) 2012-03-01

Family

ID=41008867

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011502043A Pending JP2011515491A (ja) 2008-03-27 2009-03-26 Ｎ−［［４−フルオロ−２−（５−メチル−１Ｈ−１，２，４−トリアゾール−１−イル）フェニル］メチル］−４，６，７，９−テトラヒドロ−３−ヒドロキシ−９，９−ジメチル−４−オキソ−ピリミド［２，１−ｃ］［１，４］オキサジン−２−カルボキシアミド，ナトリウム塩一水和物の結晶形

Country Status (8)

Country Link
US (1) US7968541B2 (enExample)
EP (1) EP2280980B1 (enExample)
JP (1) JP2011515491A (enExample)
KR (1) KR20100138959A (enExample)
CN (1) CN102046637B (enExample)
AU (1) AU2009228254A1 (enExample)
MX (1) MX2010010244A (enExample)
WO (1) WO2009120841A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106478661A (zh) * 2015-08-25 2017-03-08 华北制药集团新药研究开发有限责任公司 苯并恶唑并恶嗪酮类化合物wa1-089的晶型e及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003519698A (ja) * 2000-01-07 2003-06-24 トランスフォーム ファーマスーティカルズ，インコーポレイテッド 多様な固体形態のハイスループットでの形成、同定および分析
JP2008501018A (ja) * 2004-05-28 2008-01-17 ブリストル−マイヤーズ　スクイブ　カンパニー Ｈｉｖインテグラーゼインヒビターとしての二環式ヘテロ環

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7157447B2 (en) * 2004-05-28 2007-01-02 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
WO2007064316A1 (en) * 2005-11-30 2007-06-07 Bristol-Myers Squibb Company Bicyclic heterocycles as hiv integrase inhibitors
WO2007064502A1 (en) * 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Forms of n-[(4-fluorophenyl)methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide
US7897593B2 (en) * 2006-05-30 2011-03-01 Bristol-Myers Squibb Company HIV integrase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003519698A (ja) * 2000-01-07 2003-06-24 トランスフォーム ファーマスーティカルズ，インコーポレイテッド 多様な固体形態のハイスループットでの形成、同定および分析
JP2008501018A (ja) * 2004-05-28 2008-01-17 ブリストル−マイヤーズ　スクイブ　カンパニー Ｈｉｖインテグラーゼインヒビターとしての二環式ヘテロ環

Also Published As

Publication number Publication date
WO2009120841A1 (en) 2009-10-01
EP2280980A1 (en) 2011-02-09
MX2010010244A (es) 2010-10-05
KR20100138959A (ko) 2010-12-31
AU2009228254A1 (en) 2009-10-01
US7968541B2 (en) 2011-06-28
US20090253692A1 (en) 2009-10-08
CN102046637B (zh) 2013-10-02
CN102046637A (zh) 2011-05-04
EP2280980B1 (en) 2016-03-23

Similar Documents

Publication Publication Date Title
JP7444957B2 (ja) ２－ヒドロキシ－６－（（２－（１－イソプロピル－１ｈ－ピラゾール－５－イル）ピリジン－３－イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形
US8541443B2 (en) Crystal of diamine derivative and method of producing same
JP2022536489A (ja) ６－（シクロプロパンカルボキサミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキサミドの結晶性塩形態
EP3808742A1 (en) Polymorph of selinexor
JP2025102940A (ja) マルチチロシンキナーゼ阻害剤の結晶形、調製方法およびその使用
EP1962600B1 (en) Metronidazole cocrystals
JP2025505655A (ja) １－（（ｓ）－４－（（ｒ）－７－（６－アミノ－４－メチル－３－（トリフルオロメチル）ピリジン－２－イル）－６－クロロ－８－フルオロ－２－（（（ｓ）－１－メチルピロリジン－２－イル）メトキシ）キナゾリン－４－イル）－３－メチルピペラジン－１－イル）プロパ－２－エン－１－オンの固体形態
JP2011515491A (ja) Ｎ−［［４−フルオロ−２−（５−メチル−１Ｈ−１，２，４−トリアゾール−１−イル）フェニル］メチル］−４，６，７，９−テトラヒドロ−３−ヒドロキシ−９，９−ジメチル−４−オキソ−ピリミド［２，１−ｃ］［１，４］オキサジン−２−カルボキシアミド，ナトリウム塩一水和物の結晶形
US9593116B2 (en) Crystalline forms of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide for the treatment of myeloproliferative disorders
US9464086B2 (en) Crystalline forms of N,N-dicyclopropyl-4-(1,5-dimethyl-1 H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-D]pyrrolo[2,3-B]pyridine-7-carboxamide for the treatment of myeloproliferative disorders
US9598413B2 (en) Crystalline form of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-D]pyrrolo[2,3-B]pyridine-7-carboxamide for the treatment of myeloproliferative disorders
US8691981B2 (en) Crystalline forms of (S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide
US7723338B2 (en) Crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-yl]-1,2-dioxoethyl]-piperazine
WO2025137366A2 (en) Solid-state forms of stat3 inhibitors and methods of use thereof
WO2017032705A1 (en) Crystalline form of omarigliptin
WO2018115046A1 (en) Crystalline solid forms of tenofovir alafenamide
HK40064763A (en) Crystalline form of a multi-tyrosine kinase inhibitor, method of preparation, and use thereof
WO2007064502A1 (en) Forms of n-[(4-fluorophenyl)methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide
JP2009527491A (ja) （３Ｒ，４Ｒ）−４−アミノ−１−［［４−［（３−メトキシフェニル）アミノ］ピロロ［２，１−ｆ］［１，２，４］トリアジン−５−イル］メチル］ピペリジン−３−オールの結晶形
HK40024130A (en) Malate salt and crystal form thereof
HK1231054A (en) Malate salt of n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms therof
HK1231054A1 (en) Malate salt of n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms therof
HK1232859B (en) Crystalline form of tiotropium bromide with lactose
HK1232859A1 (en) Crystalline form of tiotropium bromide with lactose

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120116

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120116

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130813

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131112

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131119

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140128