JP2011515409A - 治療用化合物 - Google Patents

治療用化合物 Download PDF

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Publication number
JP2011515409A
JP2011515409A JP2011500916A JP2011500916A JP2011515409A JP 2011515409 A JP2011515409 A JP 2011515409A JP 2011500916 A JP2011500916 A JP 2011500916A JP 2011500916 A JP2011500916 A JP 2011500916A JP 2011515409 A JP2011515409 A JP 2011515409A
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JP
Japan
Prior art keywords
compound
pharmaceutically acceptable
disease
acceptable salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2011500916A
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English (en)
Japanese (ja)
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JP2011515409A5 (https=
Inventor
マーク ホロボスキー
ロバート エム バーク
マリ エフ ポスナー
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Allergan Inc
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Allergan Inc
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Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of JP2011515409A publication Critical patent/JP2011515409A/ja
Publication of JP2011515409A5 publication Critical patent/JP2011515409A5/ja
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2011500916A 2008-03-18 2009-03-18 治療用化合物 Ceased JP2011515409A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3762208P 2008-03-18 2008-03-18
US61/037,622 2008-03-18
US12/405,349 2009-03-17
US12/405,349 US7960378B2 (en) 2008-03-18 2009-03-17 Therapeutic compounds
PCT/US2009/037477 WO2009117467A2 (en) 2008-03-18 2009-03-18 Therapeutic compounds

Publications (2)

Publication Number Publication Date
JP2011515409A true JP2011515409A (ja) 2011-05-19
JP2011515409A5 JP2011515409A5 (https=) 2012-05-17

Family

ID=41089556

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011500916A Ceased JP2011515409A (ja) 2008-03-18 2009-03-18 治療用化合物

Country Status (7)

Country Link
US (1) US7960378B2 (https=)
EP (1) EP2279169A2 (https=)
JP (1) JP2011515409A (https=)
AU (1) AU2009225693B2 (https=)
BR (1) BRPI0909764A2 (https=)
CA (1) CA2718713A1 (https=)
WO (1) WO2009117467A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017509610A (ja) * 2014-02-20 2017-04-06 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ベータ−クロロシクロペンタンの親水性エステルプロドラッグの使用による角膜中心肥厚の減少

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2303836A1 (en) * 2008-05-09 2011-04-06 Allergan, Inc. Therapeutic cyclopentane derivatives
US8299068B2 (en) * 2010-01-29 2012-10-30 Allergan, Inc. Therapeutically active cyclopentanes
CN111018826B (zh) * 2019-12-25 2020-11-10 西华大学 2-氰基-5-氧代戊酸乙酯类化合物及其应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013A (en) * 1843-03-21 James stewabt
US7027A (en) * 1850-01-15 Circulak
WO1993014743A2 (en) * 1992-02-04 1993-08-05 Allergan, Inc. Polar c-1 esters of prostaglandins
JPH11193268A (ja) * 1997-02-04 1999-07-21 Ono Pharmaceut Co Ltd ω−シクロアルキル−プロスタグランジンＥ２誘導体
US6376533B1 (en) * 2000-10-20 2002-04-23 Allergan Sales, Inc. Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
JP2004529166A (ja) * 2001-05-08 2004-09-24 アラーガン、インコーポレイテッド 眼内圧降下剤としての３，７または３および７チアまたはオキサプロスタン酸誘導体
WO2008073752A2 (en) * 2006-12-11 2008-06-19 Allergan, Inc. Cyclobutyl derivatives for the treatment of glaucoma

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) * 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) * 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) * 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
GB8329559D0 (en) 1983-11-04 1983-12-07 Erba Farmitalia Furyl derivatives of 16-substituted prostaglandins preparations
US5476872A (en) * 1993-10-18 1995-12-19 Allergan, Inc. 1,11-diesters of prostaglandin-F2α having a polar ester group at C-1
NO317155B1 (no) * 1997-02-04 2004-08-30 Ono Pharmaceutical Co <omega>-cykloalkyl-prostagladin-E<N>2</N>-derivater
US6437146B1 (en) * 1998-09-25 2002-08-20 Fujisawa Pharmaceutical Co., Ltd. Oxazole compounds as prostaglandin e2 agonists or antagonists
NZ532519A (en) * 2001-11-05 2006-11-30 Allergan Inc Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
EP1812017A2 (en) * 2004-10-21 2007-08-01 Duke University Ophthamological drugs
WO2006096179A1 (en) 2005-03-07 2006-09-14 Carrier Corporation Compressor sound suppression
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
US7547727B2 (en) * 2006-05-22 2009-06-16 Allergan, Inc. Therapeutic cyclopentane derivatives
PL2084124T3 (pl) 2006-10-02 2014-08-29 Techfields Biochem Co Ltd Dodatnio naładowane rozpuszczalne w wodzie proleki prostaglandyn i związków pokrewnych o bardzo dużych szybkościach przenikania przez skórę

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013A (en) * 1843-03-21 James stewabt
US7027A (en) * 1850-01-15 Circulak
WO1993014743A2 (en) * 1992-02-04 1993-08-05 Allergan, Inc. Polar c-1 esters of prostaglandins
JPH11193268A (ja) * 1997-02-04 1999-07-21 Ono Pharmaceut Co Ltd ω−シクロアルキル−プロスタグランジンＥ２誘導体
US6376533B1 (en) * 2000-10-20 2002-04-23 Allergan Sales, Inc. Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
JP2004529166A (ja) * 2001-05-08 2004-09-24 アラーガン、インコーポレイテッド 眼内圧降下剤としての３，７または３および７チアまたはオキサプロスタン酸誘導体
WO2008073752A2 (en) * 2006-12-11 2008-06-19 Allergan, Inc. Cyclobutyl derivatives for the treatment of glaucoma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN5009020319; ＲＥＳＵＬ　Ｂ: 'Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ　Ｒｅｌａｔｉｏｎｓｈｉｐｓ　ｏｆ　Ｐｒｏｓｔａｇｌａｎｄｉｎ　Ａｎａｌｏｇｕｅｓ　ａｓ　Ｏｃｕｌａｒ　Ｈｙｐｏｔｅｎｓｉｖｅ　Ａｇｅｎｔｓ' ＣＵＲＲＥＮＴ　ＯＰＩＮＩＯＮ　ＩＮ　ＴＨＥＲＡＰＥＵＴＩＣ　ＰＡＴＥＮＴＳ Ｖ３　Ｎ６, 199306, Ｐ７８１-７９５ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017509610A (ja) * 2014-02-20 2017-04-06 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ ベータ−クロロシクロペンタンの親水性エステルプロドラッグの使用による角膜中心肥厚の減少

Also Published As

Publication number Publication date
US7960378B2 (en) 2011-06-14
BRPI0909764A2 (pt) 2015-10-06
CA2718713A1 (en) 2009-09-24
US20090239930A1 (en) 2009-09-24
EP2279169A2 (en) 2011-02-02
AU2009225693B2 (en) 2013-11-28
AU2009225693A1 (en) 2009-09-24
WO2009117467A3 (en) 2009-11-12
WO2009117467A2 (en) 2009-09-24

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