CA2718713A1

CA2718713A1 - Therapeutic compounds

Therapeutic compounds Download PDF

Info

Publication number: CA2718713A1
Authority: CA; Canada
Prior art keywords: compound; pharmaceutically acceptable; formula; disease; acceptable salt
Prior art date: 2008-03-18
Legal status : Abandoned

Application number

CA2718713A

Other languages

English (en)

French (fr)

Inventor

Mark Holoboski

Robert M. Burk

Mari F. Posner

Current Assignee

Allergan Inc

Original Assignee

Allergan Inc

Priority date

2008-03-18

Filing date

2009-03-18

Publication date

2009-09-24

2009-03-18 Application filed by Allergan Inc filed Critical Allergan Inc

2009-09-24 Publication of CA2718713A1 publication Critical patent/CA2718713A1/en

Status Abandoned legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 164
230000001225 therapeutic effect Effects 0.000 title description 6
150000003839 salts Chemical class 0.000 claims abstract description 45
238000000034 method Methods 0.000 claims abstract description 37
230000003779 hair growth Effects 0.000 claims abstract description 14
206010030043 Ocular hypertension Diseases 0.000 claims abstract description 9
230000000638 stimulation Effects 0.000 claims abstract description 9
238000011282 treatment Methods 0.000 claims description 28
208000010412 Glaucoma Diseases 0.000 claims description 26
241000124008 Mammalia Species 0.000 claims description 20
229910052717 sulfur Inorganic materials 0.000 claims description 16
201000004384 Alopecia Diseases 0.000 claims description 13
125000004432 carbon atom Chemical group C* 0.000 claims description 13
230000003676 hair loss Effects 0.000 claims description 11
229910052760 oxygen Inorganic materials 0.000 claims description 10
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
229910052801 chlorine Inorganic materials 0.000 claims description 6
229910052731 fluorine Inorganic materials 0.000 claims description 6
229910052794 bromium Inorganic materials 0.000 claims description 5
229910052739 hydrogen Inorganic materials 0.000 claims description 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 2
239000000203 mixture Substances 0.000 abstract description 38
239000003814 drug Substances 0.000 abstract description 28
208000022559 Inflammatory bowel disease Diseases 0.000 abstract description 6
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 54
235000002639 sodium chloride Nutrition 0.000 description 36
230000004410 intraocular pressure Effects 0.000 description 34
230000007423 decrease Effects 0.000 description 32
239000000651 prodrug Substances 0.000 description 26
229940002612 prodrug Drugs 0.000 description 26
206010020772 Hypertension Diseases 0.000 description 24
210000004209 hair Anatomy 0.000 description 24
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 22
239000000243 solution Substances 0.000 description 20
229940079593 drug Drugs 0.000 description 19
241000282472 Canis lupus familiaris Species 0.000 description 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 18
230000001631 hypertensive effect Effects 0.000 description 18
241000282693 Cercopithecidae Species 0.000 description 16
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
238000003818 flash chromatography Methods 0.000 description 15
-1 and the like Chemical class 0.000 description 14
201000010099 disease Diseases 0.000 description 14
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 14
125000001424 substituent group Chemical group 0.000 description 14
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 12
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
150000002148 esters Chemical class 0.000 description 12
150000003180 prostaglandins Chemical class 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
206010061218 Inflammation Diseases 0.000 description 11
235000019439 ethyl acetate Nutrition 0.000 description 11
230000004054 inflammatory process Effects 0.000 description 11
WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 10
238000006243 chemical reaction Methods 0.000 description 10
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
238000009472 formulation Methods 0.000 description 9
229920000642 polymer Polymers 0.000 description 9
239000003755 preservative agent Substances 0.000 description 9
230000000699 topical effect Effects 0.000 description 9
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
239000007788 liquid Substances 0.000 description 8
208000002780 macular degeneration Diseases 0.000 description 8
206010028980 Neoplasm Diseases 0.000 description 7
208000017442 Retinal disease Diseases 0.000 description 7
239000002253 acid Substances 0.000 description 7
230000001154 acute effect Effects 0.000 description 7
239000000556 agonist Substances 0.000 description 7
125000000217 alkyl group Chemical group 0.000 description 7
125000004429 atom Chemical group 0.000 description 7
210000001072 colon Anatomy 0.000 description 7
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 7
210000000744 eyelid Anatomy 0.000 description 7
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 7
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 7
230000002207 retinal effect Effects 0.000 description 7
238000003756 stirring Methods 0.000 description 7
239000003981 vehicle Substances 0.000 description 7
208000011231 Crohn disease Diseases 0.000 description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
206010046851 Uveitis Diseases 0.000 description 6
206010064930 age-related macular degeneration Diseases 0.000 description 6
239000008346 aqueous phase Substances 0.000 description 6
229960002470 bimatoprost Drugs 0.000 description 6
AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 description 6
229910052799 carbon Inorganic materials 0.000 description 6
RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 6
229910052943 magnesium sulfate Inorganic materials 0.000 description 6
235000019341 magnesium sulphate Nutrition 0.000 description 6
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 6
239000002674 ointment Substances 0.000 description 6
239000012074 organic phase Substances 0.000 description 6
239000008194 pharmaceutical composition Substances 0.000 description 6
239000012071 phase Substances 0.000 description 6
238000000746 purification Methods 0.000 description 6
239000011541 reaction mixture Substances 0.000 description 6
239000000741 silica gel Substances 0.000 description 6
229910002027 silica gel Inorganic materials 0.000 description 6
206010012689 Diabetic retinopathy Diseases 0.000 description 5
208000002367 Retinal Perforations Diseases 0.000 description 5
208000029977 White Dot Syndromes Diseases 0.000 description 5
239000000872 buffer Substances 0.000 description 5
239000006071 cream Substances 0.000 description 5
206010012601 diabetes mellitus Diseases 0.000 description 5
230000002757 inflammatory effect Effects 0.000 description 5
238000002360 preparation method Methods 0.000 description 5
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
210000004761 scalp Anatomy 0.000 description 5
239000007787 solid Substances 0.000 description 5
239000000725 suspension Substances 0.000 description 5
208000011580 syndromic disease Diseases 0.000 description 5
206010007027 Calculus urinary Diseases 0.000 description 4
206010009900 Colitis ulcerative Diseases 0.000 description 4
201000004624 Dermatitis Diseases 0.000 description 4
208000015924 Lithiasis Diseases 0.000 description 4
241001465754 Metazoa Species 0.000 description 4
239000007832 Na2SO4 Substances 0.000 description 4
208000001132 Osteoporosis Diseases 0.000 description 4
208000002193 Pain Diseases 0.000 description 4
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
201000006704 Ulcerative Colitis Diseases 0.000 description 4
239000003963 antioxidant agent Substances 0.000 description 4
229960000686 benzalkonium chloride Drugs 0.000 description 4
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 4
239000012267 brine Substances 0.000 description 4
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 4
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 4
150000002009 diols Chemical class 0.000 description 4
208000035475 disorder Diseases 0.000 description 4
210000004709 eyebrow Anatomy 0.000 description 4
MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 4
238000001727 in vivo Methods 0.000 description 4
208000014674 injury Diseases 0.000 description 4
201000008482 osteoarthritis Diseases 0.000 description 4
229940094443 oxytocics prostaglandins Drugs 0.000 description 4
230000036407 pain Effects 0.000 description 4
208000004644 retinal vein occlusion Diseases 0.000 description 4
206010039073 rheumatoid arthritis Diseases 0.000 description 4
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
229910052938 sodium sulfate Inorganic materials 0.000 description 4
235000011152 sodium sulphate Nutrition 0.000 description 4
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000004094 surface-active agent Substances 0.000 description 4
230000009885 systemic effect Effects 0.000 description 4
125000004973 1-butenyl group Chemical group C(=CCC)* 0.000 description 3
201000002862 Angle-Closure Glaucoma Diseases 0.000 description 3
208000009137 Behcet syndrome Diseases 0.000 description 3
229920002307 Dextran Polymers 0.000 description 3
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
208000031886 HIV Infections Diseases 0.000 description 3
208000037357 HIV infectious disease Diseases 0.000 description 3
IOOXLMIGPXXEHO-SOEQMCAUSA-N O[C@H]([C@@H]1OC2(CCO)C(O)C=C3)C=C[C@H]4[C@]5([H])N(C)CC[C@@]41C2=C3C5 Chemical compound O[C@H]([C@@H]1OC2(CCO)C(O)C=C3)C=C[C@H]4[C@]5([H])N(C)CC[C@@]41C2=C3C5 IOOXLMIGPXXEHO-SOEQMCAUSA-N 0.000 description 3
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 3
239000004372 Polyvinyl alcohol Substances 0.000 description 3
206010038848 Retinal detachment Diseases 0.000 description 3
206010038923 Retinopathy Diseases 0.000 description 3
230000002159 abnormal effect Effects 0.000 description 3
239000000048 adrenergic agonist Substances 0.000 description 3
150000001412 amines Chemical class 0.000 description 3
210000002159 anterior chamber Anatomy 0.000 description 3
210000001742 aqueous humor Anatomy 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
208000006673 asthma Diseases 0.000 description 3
239000012298 atmosphere Substances 0.000 description 3
125000000751 azo group Chemical group [*]N=N[*] 0.000 description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
150000001720 carbohydrates Chemical class 0.000 description 3
235000014633 carbohydrates Nutrition 0.000 description 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
150000001732 carboxylic acid derivatives Chemical class 0.000 description 3
150000001768 cations Chemical class 0.000 description 3
239000002738 chelating agent Substances 0.000 description 3
230000001684 chronic effect Effects 0.000 description 3
239000002537 cosmetic Substances 0.000 description 3
239000002552 dosage form Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000003995 emulsifying agent Substances 0.000 description 3
210000000981 epithelium Anatomy 0.000 description 3
210000001035 gastrointestinal tract Anatomy 0.000 description 3
239000000499 gel Substances 0.000 description 3
235000011187 glycerol Nutrition 0.000 description 3
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
231100000252 nontoxic Toxicity 0.000 description 3
230000003000 nontoxic effect Effects 0.000 description 3
238000007911 parenteral administration Methods 0.000 description 3
RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 3
239000000546 pharmaceutical excipient Substances 0.000 description 3
229920002451 polyvinyl alcohol Polymers 0.000 description 3
235000019422 polyvinyl alcohol Nutrition 0.000 description 3
230000002335 preservative effect Effects 0.000 description 3
230000002062 proliferating effect Effects 0.000 description 3
230000004264 retinal detachment Effects 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
239000011995 wilkinson's catalyst Substances 0.000 description 3
UTODFRQBVUVYOB-UHFFFAOYSA-P wilkinson's catalyst Chemical compound [Cl-].C1=CC=CC=C1P(C=1C=CC=CC=1)(C=1C=CC=CC=1)[Rh+](P(C=1C=CC=CC=1)(C=1C=CC=CC=1)C=1C=CC=CC=1)P(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 UTODFRQBVUVYOB-UHFFFAOYSA-P 0.000 description 3
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 description 2
GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 description 2
PXGPLTODNUVGFL-BRIYLRKRSA-N (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid Chemical compound CCCCC[C@H](O)C=C[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=CCCCC(O)=O PXGPLTODNUVGFL-BRIYLRKRSA-N 0.000 description 2
GQWXBYJSOKINKZ-MATCXZOGSA-N (z)-7-[(1s,2r,3r,5r)-5-cyano-2-[(e)-4-(1-ethylcyclobutyl)-4-hydroxybut-1-enyl]-3-hydroxycyclopentyl]hept-5-enoic acid Chemical compound C(\[C@@H]1[C@H]([C@H](C#N)C[C@H]1O)C\C=C/CCCC(O)=O)=C/CC(O)C1(CC)CCC1 GQWXBYJSOKINKZ-MATCXZOGSA-N 0.000 description 2
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 2
IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 2
GVQSVHPVLOKUOS-PLVPTFOKSA-N 5-[3-[(1s,2r,3r,5r)-5-cyano-2-[(e)-4-(1-ethylcyclobutyl)-4-hydroxybut-1-enyl]-3-hydroxycyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound C(\[C@@H]1[C@H]([C@H](C#N)C[C@H]1O)CCCC=1SC(=CC=1)C(O)=O)=C/CC(O)C1(CC)CCC1 GVQSVHPVLOKUOS-PLVPTFOKSA-N 0.000 description 2
VDLVHBBVQXXADH-PPSGHYAZSA-N 7-[(1s,2r,3r,5r)-5-cyano-2-[4-(1-ethylcyclobutyl)-4-hydroxybutyl]-3-hydroxycyclopentyl]heptanoic acid Chemical compound C([C@@H]1[C@H]([C@H](C#N)C[C@H]1O)CCCCCCC(O)=O)CCC(O)C1(CC)CCC1 VDLVHBBVQXXADH-PPSGHYAZSA-N 0.000 description 2
208000035939 Alveolitis allergic Diseases 0.000 description 2
208000024827 Alzheimer disease Diseases 0.000 description 2
206010002383 Angina Pectoris Diseases 0.000 description 2
206010002556 Ankylosing Spondylitis Diseases 0.000 description 2
208000032467 Aplastic anaemia Diseases 0.000 description 2
208000006820 Arthralgia Diseases 0.000 description 2
208000004300 Atrophic Gastritis Diseases 0.000 description 2
208000027496 Behcet disease Diseases 0.000 description 2
208000020084 Bone disease Diseases 0.000 description 2
206010006002 Bone pain Diseases 0.000 description 2
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 2
206010048962 Brain oedema Diseases 0.000 description 2
206010006811 Bursitis Diseases 0.000 description 2
206010006895 Cachexia Diseases 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
201000009030 Carcinoma Diseases 0.000 description 2
208000009447 Cardiac Edema Diseases 0.000 description 2
206010007559 Cardiac failure congestive Diseases 0.000 description 2
208000014882 Carotid artery disease Diseases 0.000 description 2
208000002177 Cataract Diseases 0.000 description 2
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
208000015943 Coeliac disease Diseases 0.000 description 2
241000272201 Columbiformes Species 0.000 description 2
206010010741 Conjunctivitis Diseases 0.000 description 2
206010010774 Constipation Diseases 0.000 description 2
229920000858 Cyclodextrin Polymers 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
206010012442 Dermatitis contact Diseases 0.000 description 2
208000002249 Diabetes Complications Diseases 0.000 description 2
206010012655 Diabetic complications Diseases 0.000 description 2
206010012688 Diabetic retinal oedema Diseases 0.000 description 2
206010012735 Diarrhoea Diseases 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
229920003134 Eudragit® polymer Polymers 0.000 description 2
208000000381 Familial Hypophosphatemia Diseases 0.000 description 2
208000027445 Farmer Lung Diseases 0.000 description 2
206010016654 Fibrosis Diseases 0.000 description 2
208000007882 Gastritis Diseases 0.000 description 2
208000036495 Gastritis atrophic Diseases 0.000 description 2
201000005569 Gout Diseases 0.000 description 2
206010018634 Gouty Arthritis Diseases 0.000 description 2
206010019280 Heart failures Diseases 0.000 description 2
208000017604 Hodgkin disease Diseases 0.000 description 2
208000010747 Hodgkins lymphoma Diseases 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
208000037147 Hypercalcaemia Diseases 0.000 description 2
206010020584 Hypercalcaemia of malignancy Diseases 0.000 description 2
201000002980 Hyperparathyroidism Diseases 0.000 description 2
206010051232 Hyperphosphaturia Diseases 0.000 description 2
208000003456 Juvenile Arthritis Diseases 0.000 description 2
206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 2
208000011200 Kawasaki disease Diseases 0.000 description 2
208000019693 Lung disease Diseases 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
208000029725 Metabolic bone disease Diseases 0.000 description 2
206010027452 Metastases to bone Diseases 0.000 description 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
208000000112 Myalgia Diseases 0.000 description 2
229910002651 NO3 Inorganic materials 0.000 description 2
206010065673 Nephritic syndrome Diseases 0.000 description 2
206010029164 Nephrotic syndrome Diseases 0.000 description 2
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
206010030113 Oedema Diseases 0.000 description 2
206010030302 Oliguria Diseases 0.000 description 2
208000003076 Osteolysis Diseases 0.000 description 2
206010049088 Osteopenia Diseases 0.000 description 2
208000027067 Paget disease of bone Diseases 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
206010036618 Premenstrual syndrome Diseases 0.000 description 2
206010063664 Presumed ocular histoplasmosis syndrome Diseases 0.000 description 2
201000004681 Psoriasis Diseases 0.000 description 2
206010037660 Pyrexia Diseases 0.000 description 2
206010062237 Renal impairment Diseases 0.000 description 2
201000007527 Retinal artery occlusion Diseases 0.000 description 2
201000007737 Retinal degeneration Diseases 0.000 description 2
206010038897 Retinal tear Diseases 0.000 description 2
206010038910 Retinitis Diseases 0.000 description 2
208000007014 Retinitis pigmentosa Diseases 0.000 description 2
201000001880 Sexual dysfunction Diseases 0.000 description 2
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
208000027073 Stargardt disease Diseases 0.000 description 2
206010042496 Sunburn Diseases 0.000 description 2
208000000491 Tendinopathy Diseases 0.000 description 2
206010043255 Tendonitis Diseases 0.000 description 2
208000007536 Thrombosis Diseases 0.000 description 2
201000005485 Toxoplasmosis Diseases 0.000 description 2
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
208000009911 Urinary Calculi Diseases 0.000 description 2
208000027418 Wounds and injury Diseases 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
201000001326 acute closed-angle glaucoma Diseases 0.000 description 2
206010000891 acute myocardial infarction Diseases 0.000 description 2
239000000654 additive Substances 0.000 description 2
239000000443 aerosol Substances 0.000 description 2
125000002723 alicyclic group Chemical group 0.000 description 2
125000005907 alkyl ester group Chemical group 0.000 description 2
208000026935 allergic disease Diseases 0.000 description 2
231100000360 alopecia Toxicity 0.000 description 2
229960000711 alprostadil Drugs 0.000 description 2
229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 description 2
230000003078 antioxidant effect Effects 0.000 description 2
208000002399 aphthous stomatitis Diseases 0.000 description 2
125000003118 aryl group Chemical group 0.000 description 2
208000010668 atopic eczema Diseases 0.000 description 2
239000000227 bioadhesive Substances 0.000 description 2
208000016738 bone Paget disease Diseases 0.000 description 2
230000004097 bone metabolism Effects 0.000 description 2
208000006752 brain edema Diseases 0.000 description 2
206010006451 bronchitis Diseases 0.000 description 2
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
201000011510 cancer Diseases 0.000 description 2
208000020670 canker sore Diseases 0.000 description 2
201000005667 central retinal vein occlusion Diseases 0.000 description 2
229960003260 chlorhexidine Drugs 0.000 description 2
229960004926 chlorobutanol Drugs 0.000 description 2
208000016644 chronic atrophic gastritis Diseases 0.000 description 2
230000007882 cirrhosis Effects 0.000 description 2
208000019425 cirrhosis of liver Diseases 0.000 description 2
208000010247 contact dermatitis Diseases 0.000 description 2
125000004122 cyclic group Chemical group 0.000 description 2
230000006378 damage Effects 0.000 description 2
230000007812 deficiency Effects 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
239000008121 dextrose Substances 0.000 description 2
201000011190 diabetic macular edema Diseases 0.000 description 2
239000003937 drug carrier Substances 0.000 description 2
150000002066 eicosanoids Chemical class 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
208000022195 farmer lung disease Diseases 0.000 description 2
230000027950 fever generation Effects 0.000 description 2
230000007160 gastrointestinal dysfunction Effects 0.000 description 2
208000007565 gingivitis Diseases 0.000 description 2
229930182470 glycoside Natural products 0.000 description 2
150000002338 glycosides Chemical class 0.000 description 2
208000006454 hepatitis Diseases 0.000 description 2
231100000283 hepatitis Toxicity 0.000 description 2
125000001072 heteroaryl group Chemical group 0.000 description 2
208000008750 humoral hypercalcemia of malignancy Diseases 0.000 description 2
229920002674 hyaluronan Polymers 0.000 description 2
229960003160 hyaluronic acid Drugs 0.000 description 2
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
230000000148 hypercalcaemia Effects 0.000 description 2
208000030915 hypercalcemia disease Diseases 0.000 description 2
230000003832 immune regulation Effects 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
208000002551 irritable bowel syndrome Diseases 0.000 description 2
208000017169 kidney disease Diseases 0.000 description 2
230000005977 kidney dysfunction Effects 0.000 description 2
239000000865 liniment Substances 0.000 description 2
208000019423 liver disease Diseases 0.000 description 2
230000005976 liver dysfunction Effects 0.000 description 2
206010025135 lupus erythematosus Diseases 0.000 description 2
239000002932 luster Substances 0.000 description 2
208000029791 lytic metastatic bone lesion Diseases 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
201000005857 malignant hypertension Diseases 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
201000008265 mesangial proliferative glomerulonephritis Diseases 0.000 description 2
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
208000001725 mucocutaneous lymph node syndrome Diseases 0.000 description 2
210000003205 muscle Anatomy 0.000 description 2
206010028417 myasthenia gravis Diseases 0.000 description 2
208000031225 myocardial ischemia Diseases 0.000 description 2
201000008383 nephritis Diseases 0.000 description 2
150000002825 nitriles Chemical class 0.000 description 2
239000003921 oil Substances 0.000 description 2
239000006179 pH buffering agent Substances 0.000 description 2
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
230000001991 pathophysiological effect Effects 0.000 description 2
229910052698 phosphorus Inorganic materials 0.000 description 2
208000005987 polymyositis Diseases 0.000 description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
229920001282 polysaccharide Polymers 0.000 description 2
229920000053 polysorbate 80 Polymers 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
208000001685 postmenopausal osteoporosis Diseases 0.000 description 2
201000000484 premenstrual tension Diseases 0.000 description 2
230000002265 prevention Effects 0.000 description 2
GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 description 2
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 2
WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 description 2
208000002815 pulmonary hypertension Diseases 0.000 description 2
239000008213 purified water Substances 0.000 description 2
201000003068 rheumatic fever Diseases 0.000 description 2
229960004889 salicylic acid Drugs 0.000 description 2
201000000306 sarcoidosis Diseases 0.000 description 2
231100000872 sexual dysfunction Toxicity 0.000 description 2
230000035939 shock Effects 0.000 description 2
239000001632 sodium acetate Substances 0.000 description 2
235000017281 sodium acetate Nutrition 0.000 description 2
229960004249 sodium acetate Drugs 0.000 description 2
235000017557 sodium bicarbonate Nutrition 0.000 description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
239000007909 solid dosage form Substances 0.000 description 2
150000003431 steroids Chemical class 0.000 description 2
238000001356 surgical procedure Methods 0.000 description 2
230000002459 sustained effect Effects 0.000 description 2
208000006379 syphilis Diseases 0.000 description 2
239000003826 tablet Substances 0.000 description 2
201000004415 tendinitis Diseases 0.000 description 2
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
QERYCTSHXKAMIS-UHFFFAOYSA-M thiophene-2-carboxylate Chemical compound [O-]C(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-M 0.000 description 2
206010043778 thyroiditis Diseases 0.000 description 2
230000008733 trauma Effects 0.000 description 2
210000002438 upper gastrointestinal tract Anatomy 0.000 description 2
208000008281 urolithiasis Diseases 0.000 description 2
230000001982 uveitic effect Effects 0.000 description 2
230000002792 vascular Effects 0.000 description 2
229960001722 verapamil Drugs 0.000 description 2
238000009736 wetting Methods 0.000 description 2
239000000080 wetting agent Substances 0.000 description 2
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 1
ZNMXKJDERFMXNF-ZETCQYMHSA-N (1r)-1-(2-hydroxy-1,3,2-benzodioxaborol-5-yl)-2-(methylamino)ethanol Chemical compound CNC[C@H](O)C1=CC=C2OB(O)OC2=C1 ZNMXKJDERFMXNF-ZETCQYMHSA-N 0.000 description 1
FJLRGFADCXTJNV-CAWMZFRYSA-N (1s)-1-(2,3-dihydro-1-benzothiophen-5-yl)-2-(4-phenylbutylamino)propan-1-ol Chemical compound CC([C@@H](O)C=1C=C2CCSC2=CC=1)NCCCCC1=CC=CC=C1 FJLRGFADCXTJNV-CAWMZFRYSA-N 0.000 description 1
HQTMLRUQTHILKM-CHKASDEDSA-N (2r)-4-methyl-2-propan-2-yl-2-[2-[4-[4-[2-(3,4,5-trimethoxyphenyl)ethyl]piperazin-1-yl]butoxy]phenyl]-1,4-benzothiazin-3-one;dihydrochloride Chemical compound Cl.Cl.COC1=C(OC)C(OC)=CC(CCN2CCN(CCCCOC=3C(=CC=CC=3)[C@@]3(C(N(C)C4=CC=CC=C4S3)=O)C(C)C)CC2)=C1 HQTMLRUQTHILKM-CHKASDEDSA-N 0.000 description 1
FMCAFXHLMUOIGG-JTJHWIPRSA-N (2s)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-formamido-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxy-2,5-dimethylphenyl)propanoyl]amino]-4-methylsulfanylbutanoic acid Chemical compound O=CN[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(=O)N[C@@H](CCSC)C(O)=O)CC1=CC(C)=C(O)C=C1C FMCAFXHLMUOIGG-JTJHWIPRSA-N 0.000 description 1
FMCAFXHLMUOIGG-IWFBPKFRSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-formamido-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxy-2,5-dimethylphenyl)propanoyl]amino]-4-methylsulfanylbutanoic acid Chemical compound O=CN[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(O)=O)CC1=CC(C)=C(O)C=C1C FMCAFXHLMUOIGG-IWFBPKFRSA-N 0.000 description 1
UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 description 1
WLRMANUAADYWEA-NWASOUNVSA-N (S)-timolol maleate Chemical compound OC(=O)\C=C/C(O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 WLRMANUAADYWEA-NWASOUNVSA-N 0.000 description 1
ICLYJLBTOGPLMC-KVVVOXFISA-N (z)-octadec-9-enoate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCC\C=C/CCCCCCCC(O)=O ICLYJLBTOGPLMC-KVVVOXFISA-N 0.000 description 1
JCIIKRHCWVHVFF-UHFFFAOYSA-N 1,2,4-thiadiazol-5-amine;hydrochloride Chemical compound Cl.NC1=NC=NS1 JCIIKRHCWVHVFF-UHFFFAOYSA-N 0.000 description 1
LLZRSOPHIGKISM-UHFFFAOYSA-N 1,4-diphenylpiperazine Chemical class C1CN(C=2C=CC=CC=2)CCN1C1=CC=CC=C1 LLZRSOPHIGKISM-UHFFFAOYSA-N 0.000 description 1
UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 description 1
AUEKAKHRRYWONI-UHFFFAOYSA-N 1-(4,4-diphenylbutyl)piperidine Chemical class C1CCCCN1CCCC(C=1C=CC=CC=1)C1=CC=CC=C1 AUEKAKHRRYWONI-UHFFFAOYSA-N 0.000 description 1
GGUSQTSTQSHJAH-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(4-fluorobenzyl)piperidin-1-yl]ethanol Chemical compound C=1C=C(Cl)C=CC=1C(O)CN(CC1)CCC1CC1=CC=C(F)C=C1 GGUSQTSTQSHJAH-UHFFFAOYSA-N 0.000 description 1
QEMSVZNTSXPFJA-HNAYVOBHSA-N 1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol Chemical compound C1([C@H](O)[C@H](C)N2CCC(O)(CC2)C=2C=CC=CC=2)=CC=C(O)C=C1 QEMSVZNTSXPFJA-HNAYVOBHSA-N 0.000 description 1
FSGCSTPOPBJYSX-VEIFNGETSA-N 131543-23-2 Chemical compound CS(O)(=O)=O.C([C@@H]1COC=2C=CC=C3C(C(=O)C=4C5=CC=CC=C5C=CC=4)=C(N1C3=2)C)N1CCOCC1 FSGCSTPOPBJYSX-VEIFNGETSA-N 0.000 description 1
ZBIAKUMOEKILTF-UHFFFAOYSA-N 2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide Chemical compound CC1=CC=CC(C)=C1NC(=O)CN1CCN(CCCC(C=2C=CC(F)=CC=2)C=2C=CC(F)=CC=2)CC1 ZBIAKUMOEKILTF-UHFFFAOYSA-N 0.000 description 1
LCQXXVFFJHBYME-UHFFFAOYSA-N 2-butyl-4-hydroxybenzoic acid Chemical compound CCCCC1=CC(O)=CC=C1C(O)=O LCQXXVFFJHBYME-UHFFFAOYSA-N 0.000 description 1
QPOFIDVRLWJICD-UHFFFAOYSA-N 3,3-diphenyl-n-(1-phenylpropan-2-yl)propan-1-amine;2-hydroxypropanoic acid Chemical compound CC(O)C(O)=O.C=1C=CC=CC=1C(C=1C=CC=CC=1)CCNC(C)CC1=CC=CC=C1 QPOFIDVRLWJICD-UHFFFAOYSA-N 0.000 description 1
UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 description 1
UYNVMODNBIQBMV-UHFFFAOYSA-N 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol Chemical compound C1CC(CC=2C=CC=CC=2)CCN1C(C)C(O)C1=CC=C(O)C=C1 UYNVMODNBIQBMV-UHFFFAOYSA-N 0.000 description 1
SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 description 1
125000005274 4-hydroxybenzoic acid group Chemical group 0.000 description 1
KUZSBKJSGSKPJH-VXGBXAGGSA-N 5-[(9R)-6-[(3R)-3-methylmorpholin-4-yl]-11-oxa-1,3,5-triazatricyclo[7.4.0.02,7]trideca-2,4,6-trien-4-yl]pyrazin-2-amine Chemical compound C[C@@H]1COCCN1c1nc(nc2N3CCOC[C@H]3Cc12)-c1cnc(N)cn1 KUZSBKJSGSKPJH-VXGBXAGGSA-N 0.000 description 1
NSVUMEUJZLBGGM-YCUJNSNJSA-N 5-[3-[(1s,2r,3r,5r)-5-cyano-2-[4-(1-ethylcyclobutyl)-4-hydroxybutyl]-3-hydroxycyclopentyl]propyl]thiophene-2-carboxylic acid Chemical compound C([C@@H]1[C@H]([C@H](C#N)C[C@H]1O)CCCC=1SC(=CC=1)C(O)=O)CCC(O)C1(CC)CCC1 NSVUMEUJZLBGGM-YCUJNSNJSA-N 0.000 description 1
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
XFIBGLJECINIMP-ZEMVHIBLSA-N 7-[(1s,2r,3r,5r)-5-cyano-3-hydroxy-2-[4-hydroxy-4-(1-thiophen-2-ylcyclobutyl)butyl]cyclopentyl]heptanoic acid Chemical compound C1CCC1(C=1SC=CC=1)C(O)CCC[C@H]1[C@H](O)C[C@@H](C#N)[C@@H]1CCCCCCC(O)=O XFIBGLJECINIMP-ZEMVHIBLSA-N 0.000 description 1
PZASAAIJIFDWSB-CKPDSHCKSA-N 8-[(1S)-1-[8-(trifluoromethyl)-7-[4-(trifluoromethyl)cyclohexyl]oxynaphthalen-2-yl]ethyl]-8-azabicyclo[3.2.1]octane-3-carboxylic acid Chemical compound FC(F)(F)C=1C2=CC([C@@H](N3C4CCC3CC(C4)C(O)=O)C)=CC=C2C=CC=1OC1CCC(C(F)(F)F)CC1 PZASAAIJIFDWSB-CKPDSHCKSA-N 0.000 description 1
QOYHHIBFXOOADH-UHFFFAOYSA-N 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 QOYHHIBFXOOADH-UHFFFAOYSA-N 0.000 description 1
MITGKKFYIJJQGL-UHFFFAOYSA-N 9-(4-chlorobenzoyl)-6-methylsulfonyl-2,3-dihydro-1H-carbazol-4-one Chemical compound ClC1=CC=C(C(=O)N2C3=CC=C(C=C3C=3C(CCCC2=3)=O)S(=O)(=O)C)C=C1 MITGKKFYIJJQGL-UHFFFAOYSA-N 0.000 description 1
102100028187 ATP-binding cassette sub-family C member 6 Human genes 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 1
208000004142 Acute Retinal Necrosis Syndrome Diseases 0.000 description 1
229940082496 Adrenoreceptor antagonist Drugs 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 description 1
239000004382 Amylase Substances 0.000 description 1
102000013142 Amylases Human genes 0.000 description 1
108010065511 Amylases Proteins 0.000 description 1
206010002329 Aneurysm Diseases 0.000 description 1
208000005598 Angioid Streaks Diseases 0.000 description 1
239000001904 Arabinogalactan Substances 0.000 description 1
229920000189 Arabinogalactan Polymers 0.000 description 1
208000031104 Arterial Occlusive disease Diseases 0.000 description 1
206010003571 Astrocytoma Diseases 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
201000007795 Bietti crystalline corneoretinal dystrophy Diseases 0.000 description 1
201000004569 Blindness Diseases 0.000 description 1
239000004255 Butylated hydroxyanisole Substances 0.000 description 1
239000004322 Butylated hydroxytoluene Substances 0.000 description 1
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
241000700198 Cavia Species 0.000 description 1
208000003569 Central serous chorioretinopathy Diseases 0.000 description 1
229920001661 Chitosan Polymers 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
229920001287 Chondroitin sulfate Polymers 0.000 description 1
208000033825 Chorioretinal atrophy Diseases 0.000 description 1
208000005590 Choroidal Neovascularization Diseases 0.000 description 1
206010070957 Choroidal haemangioma Diseases 0.000 description 1
206010060823 Choroidal neovascularisation Diseases 0.000 description 1
208000002691 Choroiditis Diseases 0.000 description 1
206010053567 Coagulopathies Diseases 0.000 description 1
FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 description 1
206010010356 Congenital anomaly Diseases 0.000 description 1
206010018325 Congenital glaucomas Diseases 0.000 description 1
206010058202 Cystoid macular oedema Diseases 0.000 description 1
206010048843 Cytomegalovirus chorioretinitis Diseases 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
206010012565 Developmental glaucoma Diseases 0.000 description 1
206010054044 Diabetic microangiopathy Diseases 0.000 description 1
208000019878 Eales disease Diseases 0.000 description 1
DWAWDSVKAUWFHC-UHFFFAOYSA-N Emopamil Chemical compound C=1C=CC=CC=1C(C(C)C)(C#N)CCCN(C)CCC1=CC=CC=C1 DWAWDSVKAUWFHC-UHFFFAOYSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
208000001351 Epiretinal Membrane Diseases 0.000 description 1
241001125671 Eretmochelys imbricata Species 0.000 description 1
208000031969 Eye Hemorrhage Diseases 0.000 description 1
208000028506 Familial Exudative Vitreoretinopathies Diseases 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
229940122459 Glutamate antagonist Drugs 0.000 description 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
229920002683 Glycosaminoglycan Polymers 0.000 description 1
229920002907 Guar gum Polymers 0.000 description 1
208000002927 Hamartoma Diseases 0.000 description 1
201000002563 Histoplasmosis Diseases 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
206010020880 Hypertrophy Diseases 0.000 description 1
206010058558 Hypoperfusion Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
208000026350 Inborn Genetic disease Diseases 0.000 description 1
206010022557 Intermediate uveitis Diseases 0.000 description 1
206010067684 Iris bombe Diseases 0.000 description 1
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
239000004166 Lanolin Substances 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
208000001344 Macular Edema Diseases 0.000 description 1
206010025412 Macular dystrophy congenital Diseases 0.000 description 1
208000035719 Maculopathy Diseases 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
206010027476 Metastases Diseases 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
208000009857 Microaneurysm Diseases 0.000 description 1
208000010164 Multifocal Choroiditis Diseases 0.000 description 1
208000006123 Myiasis Diseases 0.000 description 1
HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
FIWILGQIZHDAQG-UHFFFAOYSA-N NC1=C(C(=O)NCC2=CC=C(C=C2)OCC(F)(F)F)C=C(C(=N1)N)N1N=C(N=C1)C1(CC1)C(F)(F)F Chemical compound NC1=C(C(=O)NCC2=CC=C(C=C2)OCC(F)(F)F)C=C(C(=N1)N)N1N=C(N=C1)C1(CC1)C(F)(F)F FIWILGQIZHDAQG-UHFFFAOYSA-N 0.000 description 1
206010068960 Narrow anterior chamber angle Diseases 0.000 description 1
ZNSPHKJFQDEABI-NZQKXSOJSA-N Nc1nc(O[C@H](c2ccc(Cl)cc2-c2ccccc2)C(F)(F)F)cc(n1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1 Chemical compound Nc1nc(O[C@H](c2ccc(Cl)cc2-c2ccccc2)C(F)(F)F)cc(n1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1 ZNSPHKJFQDEABI-NZQKXSOJSA-N 0.000 description 1
206010065119 Necrotising herpetic retinopathy Diseases 0.000 description 1
241000772415 Neovison vison Species 0.000 description 1
ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 description 1
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
239000000006 Nitroglycerin Substances 0.000 description 1
208000022873 Ocular disease Diseases 0.000 description 1
206010069385 Ocular ischaemic syndrome Diseases 0.000 description 1
206010065700 Ocular sarcoidosis Diseases 0.000 description 1
206010030348 Open-Angle Glaucoma Diseases 0.000 description 1
208000003435 Optic Neuritis Diseases 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
206010065373 Papillophlebitis Diseases 0.000 description 1
208000004788 Pars Planitis Diseases 0.000 description 1
208000034247 Pattern dystrophy Diseases 0.000 description 1
208000018262 Peripheral vascular disease Diseases 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 description 1
208000003971 Posterior uveitis Diseases 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
201000004613 Pseudoxanthoma elasticum Diseases 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
206010064714 Radiation retinopathy Diseases 0.000 description 1
241000700159 Rattus Species 0.000 description 1
208000008709 Retinal Telangiectasis Diseases 0.000 description 1
201000001949 Retinal Vasculitis Diseases 0.000 description 1
208000032430 Retinal dystrophy Diseases 0.000 description 1
208000032398 Retinal pigment epitheliopathy Diseases 0.000 description 1
206010038915 Retinitis viral Diseases 0.000 description 1
201000000582 Retinoblastoma Diseases 0.000 description 1
206010038935 Retinopathy sickle cell Diseases 0.000 description 1
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 description 1
229910006069 SO3H Inorganic materials 0.000 description 1
206010039705 Scleritis Diseases 0.000 description 1
206010039710 Scleroderma Diseases 0.000 description 1
LPMRCCNDNGONCD-RITPCOANSA-N Selfotel Chemical compound OC(=O)[C@@H]1C[C@H](CP(O)(O)=O)CCN1 LPMRCCNDNGONCD-RITPCOANSA-N 0.000 description 1
208000014286 Serpiginous choroiditis Diseases 0.000 description 1
208000022758 Sorsby fundus dystrophy Diseases 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
208000036038 Subretinal fibrosis Diseases 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
206010042742 Sympathetic ophthalmia Diseases 0.000 description 1
206010043189 Telangiectasia Diseases 0.000 description 1
206010044269 Toxocariasis Diseases 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
201000001408 X-linked juvenile retinoschisis 1 Diseases 0.000 description 1
208000017441 X-linked retinoschisis Diseases 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000008351 acetate buffer Substances 0.000 description 1
229960000571 acetazolamide Drugs 0.000 description 1
BZKPWHYZMXOIDC-UHFFFAOYSA-N acetazolamide Chemical compound CC(=O)NC1=NN=C(S(N)(=O)=O)S1 BZKPWHYZMXOIDC-UHFFFAOYSA-N 0.000 description 1
229960004308 acetylcysteine Drugs 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
208000023564 acute macular neuroretinopathy Diseases 0.000 description 1
208000019672 acute posterior multifocal placoid pigment epitheliopathy Diseases 0.000 description 1
239000000674 adrenergic antagonist Substances 0.000 description 1
125000003342 alkenyl group Chemical group 0.000 description 1
150000003973 alkyl amines Chemical group 0.000 description 1
125000000304 alkynyl group Chemical group 0.000 description 1
DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
229960003805 amantadine Drugs 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 description 1
229960002576 amiloride Drugs 0.000 description 1
239000003194 amino acid receptor blocking agent Substances 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
235000019418 amylase Nutrition 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 description 1
239000002220 antihypertensive agent Substances 0.000 description 1
229960002610 apraclonidine Drugs 0.000 description 1
IEJXVRYNEISIKR-UHFFFAOYSA-N apraclonidine Chemical compound ClC1=CC(N)=CC(Cl)=C1NC1=NCCN1 IEJXVRYNEISIKR-UHFFFAOYSA-N 0.000 description 1
235000019312 arabinogalactan Nutrition 0.000 description 1
150000007860 aryl ester derivatives Chemical class 0.000 description 1
239000012752 auxiliary agent Substances 0.000 description 1
VXMOONUMYLCFJD-DHLKQENFSA-N barnidipine Chemical compound C1([C@@H]2C(=C(C)NC(C)=C2C(=O)OC)C(=O)O[C@@H]2CN(CC=3C=CC=CC=3)CC2)=CC=CC([N+]([O-])=O)=C1 VXMOONUMYLCFJD-DHLKQENFSA-N 0.000 description 1
229960002992 barnidipine Drugs 0.000 description 1
150000007657 benzothiazepines Chemical class 0.000 description 1
UIEATEWHFDRYRU-UHFFFAOYSA-N bepridil Chemical compound C1CCCN1C(COCC(C)C)CN(C=1C=CC=CC=1)CC1=CC=CC=C1 UIEATEWHFDRYRU-UHFFFAOYSA-N 0.000 description 1
229960003665 bepridil Drugs 0.000 description 1
229960004324 betaxolol Drugs 0.000 description 1
CHDPSNLJFOQTRK-UHFFFAOYSA-N betaxolol hydrochloride Chemical compound [Cl-].C1=CC(OCC(O)C[NH2+]C(C)C)=CC=C1CCOCC1CC1 CHDPSNLJFOQTRK-UHFFFAOYSA-N 0.000 description 1
230000002146 bilateral effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
206010072959 birdshot chorioretinopathy Diseases 0.000 description 1
208000015294 blood coagulation disease Diseases 0.000 description 1
210000001185 bone marrow Anatomy 0.000 description 1
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
239000004327 boric acid Substances 0.000 description 1
201000005845 branch retinal artery occlusion Diseases 0.000 description 1
229960003679 brimonidine Drugs 0.000 description 1
229960000722 brinzolamide Drugs 0.000 description 1
HCRKCZRJWPKOAR-JTQLQIEISA-N brinzolamide Chemical compound CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 HCRKCZRJWPKOAR-JTQLQIEISA-N 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
229940043253 butylated hydroxyanisole Drugs 0.000 description 1
235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
229940095259 butylated hydroxytoluene Drugs 0.000 description 1
229960001948 caffeine Drugs 0.000 description 1
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229930003827 cannabinoid Natural products 0.000 description 1
239000003557 cannabinoid Substances 0.000 description 1
229940065144 cannabinoids Drugs 0.000 description 1
229960004484 carbachol Drugs 0.000 description 1
AIXAANGOTKPUOY-UHFFFAOYSA-N carbachol Chemical compound [Cl-].C[N+](C)(C)CCOC(N)=O AIXAANGOTKPUOY-UHFFFAOYSA-N 0.000 description 1
239000003489 carbonate dehydratase inhibitor Substances 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
150000007942 carboxylates Chemical group 0.000 description 1
229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
229960001222 carteolol Drugs 0.000 description 1
LWAFSWPYPHEXKX-UHFFFAOYSA-N carteolol Chemical compound N1C(=O)CCC2=C1C=CC=C2OCC(O)CNC(C)(C)C LWAFSWPYPHEXKX-UHFFFAOYSA-N 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
201000005849 central retinal artery occlusion Diseases 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000064 cholinergic agonist Substances 0.000 description 1
230000001713 cholinergic effect Effects 0.000 description 1
229940059329 chondroitin sulfate Drugs 0.000 description 1
208000027129 choroid disease Diseases 0.000 description 1
201000005682 chronic closed-angle glaucoma Diseases 0.000 description 1
239000007979 citrate buffer Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
238000011284 combination treatment Methods 0.000 description 1
229940125876 compound 15a Drugs 0.000 description 1
201000008615 cone dystrophy Diseases 0.000 description 1
208000006623 congenital stationary night blindness Diseases 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000011109 contamination Methods 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
239000006184 cosolvent Substances 0.000 description 1
229940097362 cyclodextrins Drugs 0.000 description 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
201000010206 cystoid macular edema Diseases 0.000 description 1
208000001763 cytomegalovirus retinitis Diseases 0.000 description 1
230000002939 deleterious effect Effects 0.000 description 1
RWZVPVOZTJJMNU-UHFFFAOYSA-N demarcarium Chemical compound C=1C=CC([N+](C)(C)C)=CC=1OC(=O)N(C)CCCCCCCCCCN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 RWZVPVOZTJJMNU-UHFFFAOYSA-N 0.000 description 1
229960004656 demecarium Drugs 0.000 description 1
229960003957 dexamethasone Drugs 0.000 description 1
UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
201000009101 diabetic angiopathy Diseases 0.000 description 1
229960005081 diclofenamide Drugs 0.000 description 1
GJQPMPFPNINLKP-UHFFFAOYSA-N diclofenamide Chemical compound NS(=O)(=O)C1=CC(Cl)=C(Cl)C(S(N)(=O)=O)=C1 GJQPMPFPNINLKP-UHFFFAOYSA-N 0.000 description 1
125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 description 1
230000010339 dilation Effects 0.000 description 1
UBHZUDXTHNMNLD-UHFFFAOYSA-N dimethylsilane Chemical compound C[SiH2]C UBHZUDXTHNMNLD-UHFFFAOYSA-N 0.000 description 1
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
OCUJLLGVOUDECM-UHFFFAOYSA-N dipivefrin Chemical compound CNCC(O)C1=CC=C(OC(=O)C(C)(C)C)C(OC(=O)C(C)(C)C)=C1 OCUJLLGVOUDECM-UHFFFAOYSA-N 0.000 description 1
229960000966 dipivefrine Drugs 0.000 description 1
229960003933 dorzolamide Drugs 0.000 description 1
IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical compound CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 description 1
229960002017 echothiophate Drugs 0.000 description 1
BJOLKYGKSZKIGU-UHFFFAOYSA-N ecothiopate Chemical compound CCOP(=O)(OCC)SCC[N+](C)(C)C BJOLKYGKSZKIGU-UHFFFAOYSA-N 0.000 description 1
229940124274 edetate disodium Drugs 0.000 description 1
229950005455 eliprodil Drugs 0.000 description 1
239000003974 emollient agent Substances 0.000 description 1
229950009967 emopamil Drugs 0.000 description 1
206010014801 endophthalmitis Diseases 0.000 description 1
229960003072 epinephrine hydrochloride Drugs 0.000 description 1
125000004185 ester group Chemical group 0.000 description 1
NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
210000000416 exudates and transudate Anatomy 0.000 description 1
201000006902 exudative vitreoretinopathy Diseases 0.000 description 1
238000001914 filtration Methods 0.000 description 1
229960002011 fludrocortisone Drugs 0.000 description 1
AAXVEMMRQDVLJB-BULBTXNYSA-N fludrocortisone Chemical compound O=C1CC[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 AAXVEMMRQDVLJB-BULBTXNYSA-N 0.000 description 1
SMANXXCATUTDDT-QPJJXVBHSA-N flunarizine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 SMANXXCATUTDDT-QPJJXVBHSA-N 0.000 description 1
229960000326 flunarizine Drugs 0.000 description 1
WWSWYXNVCBLWNZ-QIZQQNKQSA-N fluprostenol Chemical compound C([C@H](O)\C=C\[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C\C=C/CCCC(O)=O)OC1=CC=CC(C(F)(F)F)=C1 WWSWYXNVCBLWNZ-QIZQQNKQSA-N 0.000 description 1
229950009951 fluprostenol Drugs 0.000 description 1
229960003532 fluspirilene Drugs 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
125000002541 furyl group Chemical group 0.000 description 1
208000016361 genetic disease Diseases 0.000 description 1
239000008103 glucose Substances 0.000 description 1
229930182480 glucuronide Natural products 0.000 description 1
150000008134 glucuronides Chemical class 0.000 description 1
235000013922 glutamic acid Nutrition 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
229940074045 glyceryl distearate Drugs 0.000 description 1
229940075507 glyceryl monostearate Drugs 0.000 description 1
229960003711 glyceryl trinitrate Drugs 0.000 description 1
KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
239000000665 guar gum Substances 0.000 description 1
235000010417 guar gum Nutrition 0.000 description 1
229960002154 guar gum Drugs 0.000 description 1
244000005709 gut microbiome Species 0.000 description 1
230000003648 hair appearance Effects 0.000 description 1
208000024963 hair loss Diseases 0.000 description 1
125000001475 halogen functional group Chemical group 0.000 description 1
210000003128 head Anatomy 0.000 description 1
208000034737 hemoglobinopathy Diseases 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000001183 hydrocarbyl group Chemical group 0.000 description 1
229960000890 hydrocortisone Drugs 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229960003998 ifenprodil Drugs 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
208000027866 inflammatory disease Diseases 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
150000007529 inorganic bases Chemical class 0.000 description 1
229910001410 inorganic ion Inorganic materials 0.000 description 1
238000007689 inspection Methods 0.000 description 1
GHXZPUGJZVBLGC-UHFFFAOYSA-N iodoethene Chemical compound IC=C GHXZPUGJZVBLGC-UHFFFAOYSA-N 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
XXUPXHKCPIKWLR-JHUOEJJVSA-N isopropyl unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OC(C)C XXUPXHKCPIKWLR-JHUOEJJVSA-N 0.000 description 1
235000015110 jellies Nutrition 0.000 description 1
239000008101 lactose Substances 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
229960001160 latanoprost Drugs 0.000 description 1
GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 description 1
229960000831 levobunolol Drugs 0.000 description 1
IXHBTMCLRNMKHZ-LBPRGKRZSA-N levobunolol Chemical compound O=C1CCCC2=C1C=CC=C2OC[C@@H](O)CNC(C)(C)C IXHBTMCLRNMKHZ-LBPRGKRZSA-N 0.000 description 1
229960001941 lidoflazine Drugs 0.000 description 1
210000000088 lip Anatomy 0.000 description 1
239000002502 liposome Substances 0.000 description 1
239000006193 liquid solution Substances 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
208000018769 loss of vision Diseases 0.000 description 1
231100000864 loss of vision Toxicity 0.000 description 1
239000006210 lotion Substances 0.000 description 1
210000003750 lower gastrointestinal tract Anatomy 0.000 description 1
208000019420 lymphoid neoplasm Diseases 0.000 description 1
208000029233 macular holes Diseases 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
238000007726 management method Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 description 1
229960004640 memantine Drugs 0.000 description 1
KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 1
229960004963 mesalazine Drugs 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
230000009401 metastasis Effects 0.000 description 1
229960004083 methazolamide Drugs 0.000 description 1
FLOSMHQXBMRNHR-DAXSKMNVSA-N methazolamide Chemical compound CC(=O)\N=C1/SC(S(N)(=O)=O)=NN1C FLOSMHQXBMRNHR-DAXSKMNVSA-N 0.000 description 1
AGJSNMGHAVDLRQ-HUUJSLGLSA-N methyl (2s)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-amino-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxy-2,3-dimethylphenyl)propanoyl]amino]-4-methylsulfanylbutanoate Chemical compound SC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(=O)N[C@@H](CCSC)C(=O)OC)CC1=CC=C(O)C(C)=C1C AGJSNMGHAVDLRQ-HUUJSLGLSA-N 0.000 description 1
AGJSNMGHAVDLRQ-IWFBPKFRSA-N methyl (2s)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-amino-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxy-2,3-dimethylphenyl)propanoyl]amino]-4-methylsulfanylbutanoate Chemical compound SC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)OC)CC1=CC=C(O)C(C)=C1C AGJSNMGHAVDLRQ-IWFBPKFRSA-N 0.000 description 1
LZMURISWYBPBND-UDGXSGNFSA-N methyl (z)-7-[(1s,2r,3r,5r)-3-[tert-butyl(dimethyl)silyl]oxy-2-[(e)-4-[tert-butyl(dimethyl)silyl]oxy-4-(1-ethylcyclobutyl)but-1-enyl]-5-cyanocyclopentyl]hept-5-enoate Chemical compound C(\[C@@H]1[C@H]([C@H](C#N)C[C@H]1O[Si](C)(C)C(C)(C)C)C\C=C/CCCC(=O)OC)=C/CC(O[Si](C)(C)C(C)(C)C)C1(CC)CCC1 LZMURISWYBPBND-UDGXSGNFSA-N 0.000 description 1
SRPNVXOAFZSLGJ-INVJFXHNSA-N methyl (z)-7-[(1s,2r,3r,5r)-5-cyano-2-[(e)-4-(1-ethylcyclobutyl)-4-hydroxybut-1-enyl]-3-hydroxycyclopentyl]hept-5-enoate Chemical compound C(\[C@@H]1[C@H]([C@H](C#N)C[C@H]1O)C\C=C/CCCC(=O)OC)=C/CC(O)C1(CC)CCC1 SRPNVXOAFZSLGJ-INVJFXHNSA-N 0.000 description 1
ASNLPXIJERRVQB-SLKSKBFMSA-N methyl 5-[3-[(1s,2r,3r,5r)-3-[tert-butyl(dimethyl)silyl]oxy-2-[(e)-4-[tert-butyl(dimethyl)silyl]oxy-4-(1-ethylcyclobutyl)but-1-enyl]-5-cyanocyclopentyl]propyl]thiophene-2-carboxylate Chemical compound C(\[C@@H]1[C@H]([C@H](C#N)C[C@H]1O[Si](C)(C)C(C)(C)C)CCCC=1SC(=CC=1)C(=O)OC)=C/CC(O[Si](C)(C)C(C)(C)C)C1(CC)CCC1 ASNLPXIJERRVQB-SLKSKBFMSA-N 0.000 description 1
ZOTPTJWAHGZUEK-JLVBGTNGSA-N methyl 5-[3-[(1s,2r,3r,5r)-5-cyano-2-[(e)-4-(1-ethylcyclobutyl)-4-hydroxybut-1-enyl]-3-hydroxycyclopentyl]propyl]thiophene-2-carboxylate Chemical compound C(\[C@@H]1[C@H]([C@H](C#N)C[C@H]1O)CCCC=1SC(=CC=1)C(=O)OC)=C/CC(O)C1(CC)CCC1 ZOTPTJWAHGZUEK-JLVBGTNGSA-N 0.000 description 1
RUBUMPWEASDFDO-HNNXBMFYSA-N methyl 5-[3-[(3r)-3-[tert-butyl(dimethyl)silyl]oxy-5-oxocyclopenten-1-yl]propyl]thiophene-2-carboxylate Chemical compound S1C(C(=O)OC)=CC=C1CCCC1=C[C@H](O[Si](C)(C)C(C)(C)C)CC1=O RUBUMPWEASDFDO-HNNXBMFYSA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
150000004702 methyl esters Chemical class 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
206010062198 microangiopathy Diseases 0.000 description 1
244000005706 microflora Species 0.000 description 1
201000002266 mite infestation Diseases 0.000 description 1
125000000896 monocarboxylic acid group Chemical group 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000004090 neuroprotective agent Substances 0.000 description 1
201000002165 neuroretinitis Diseases 0.000 description 1
229960001783 nicardipine Drugs 0.000 description 1
229960000715 nimodipine Drugs 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
208000008940 ocular tuberculosis Diseases 0.000 description 1
239000002997 ophthalmic solution Substances 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
208000008798 osteoma Diseases 0.000 description 1
239000006072 paste Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
239000003961 penetration enhancing agent Substances 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
230000003285 pharmacodynamic effect Effects 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
229940096826 phenylmercuric acetate Drugs 0.000 description 1
PDTFCHSETJBPTR-UHFFFAOYSA-N phenylmercuric nitrate Chemical compound [O-][N+](=O)O[Hg]C1=CC=CC=C1 PDTFCHSETJBPTR-UHFFFAOYSA-N 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 description 1
230000000649 photocoagulation Effects 0.000 description 1
238000002428 photodynamic therapy Methods 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
229960001697 physostigmine Drugs 0.000 description 1
PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 description 1
239000000049 pigment Substances 0.000 description 1
230000019612 pigmentation Effects 0.000 description 1
239000006187 pill Substances 0.000 description 1
229960001416 pilocarpine Drugs 0.000 description 1
229960002139 pilocarpine hydrochloride Drugs 0.000 description 1
RNAICSBVACLLGM-GNAZCLTHSA-N pilocarpine hydrochloride Chemical compound Cl.C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C RNAICSBVACLLGM-GNAZCLTHSA-N 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920001515 polyalkylene glycol Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229940068917 polyethylene glycols Drugs 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
201000004849 posterior scleritis Diseases 0.000 description 1
201000002267 posterior uveal melanoma Diseases 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
229940069328 povidone Drugs 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000002243 precursor Substances 0.000 description 1
229960005205 prednisolone Drugs 0.000 description 1
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
229940094472 prenylamine lactate Drugs 0.000 description 1
230000002250 progressing effect Effects 0.000 description 1
201000007914 proliferative diabetic retinopathy Diseases 0.000 description 1
208000023558 pseudoxanthoma elasticum (inherited or acquired) Diseases 0.000 description 1
208000034503 punctate inner choroidopathy Diseases 0.000 description 1
210000001747 pupil Anatomy 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
238000006894 reductive elimination reaction Methods 0.000 description 1
210000001525 retina Anatomy 0.000 description 1
230000004258 retinal degeneration Effects 0.000 description 1
201000007714 retinoschisis Diseases 0.000 description 1
238000012552 review Methods 0.000 description 1
229960000888 rimantadine Drugs 0.000 description 1
TZSZZENYCISATO-WIOPSUGQSA-N rodatristat Chemical compound CCOC(=O)[C@@H]1CC2(CN1)CCN(CC2)c1cc(O[C@H](c2ccc(Cl)cc2-c2ccccc2)C(F)(F)F)nc(N)n1 TZSZZENYCISATO-WIOPSUGQSA-N 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000002453 shampoo Substances 0.000 description 1
238000004088 simulation Methods 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
229940001584 sodium metabisulfite Drugs 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
229940001474 sodium thiosulfate Drugs 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
229940035044 sorbitan monolaurate Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000009897 systematic effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
208000009056 telangiectasis Diseases 0.000 description 1
VRNAKYCHGZYXOA-MDWZMJQESA-N tert-butyl-[(e)-1-(1-ethylcyclobutyl)-4-iodobut-3-enoxy]-dimethylsilane Chemical compound I/C=C/CC(O[Si](C)(C)C(C)(C)C)C1(CC)CCC1 VRNAKYCHGZYXOA-MDWZMJQESA-N 0.000 description 1
PODTWOILVUXXRL-AWNIVKPZSA-N tert-butyl-[(e)-1-[1-[(5-chlorothiophen-2-yl)methyl]cyclobutyl]-4-iodobut-3-enoxy]-dimethylsilane Chemical compound C=1C=C(Cl)SC=1CC1(C(C\C=C\I)O[Si](C)(C)C(C)(C)C)CCC1 PODTWOILVUXXRL-AWNIVKPZSA-N 0.000 description 1
TXIKWQLCERCUTQ-AWNIVKPZSA-N tert-butyl-[(e)-4-iodo-1-(1-thiophen-2-ylcyclobutyl)but-3-enoxy]-dimethylsilane Chemical compound C=1C=CSC=1C1(C(C\C=C\I)O[Si](C)(C)C(C)(C)C)CCC1 TXIKWQLCERCUTQ-AWNIVKPZSA-N 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
230000003813 thin hair Effects 0.000 description 1
QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 description 1
229960000454 timolol hemihydrate Drugs 0.000 description 1
229960005221 timolol maleate Drugs 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
210000001585 trabecular meshwork Anatomy 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
229960002368 travoprost Drugs 0.000 description 1
MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 description 1
125000005270 trialkylamine group Chemical group 0.000 description 1
229940117013 triethanolamine oleate Drugs 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
229960004418 trolamine Drugs 0.000 description 1
229960000281 trometamol Drugs 0.000 description 1
201000008827 tuberculosis Diseases 0.000 description 1
229950008081 unoprostone isopropyl Drugs 0.000 description 1
230000003074 vasoproliferative effect Effects 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
230000004393 visual impairment Effects 0.000 description 1
201000007790 vitelliform macular dystrophy Diseases 0.000 description 1