JP2011513483A5 - - Google Patents

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Publication number
JP2011513483A5
JP2011513483A5 JP2010550685A JP2010550685A JP2011513483A5 JP 2011513483 A5 JP2011513483 A5 JP 2011513483A5 JP 2010550685 A JP2010550685 A JP 2010550685A JP 2010550685 A JP2010550685 A JP 2010550685A JP 2011513483 A5 JP2011513483 A5 JP 2011513483A5
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JP
Japan
Prior art keywords
pharmaceutical composition
composition according
gsk
disease
formula
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JP2010550685A
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English (en)
Japanese (ja)
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JP2011513483A (ja
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Priority claimed from PCT/US2009/001534 external-priority patent/WO2009145814A2/en
Publication of JP2011513483A publication Critical patent/JP2011513483A/ja
Publication of JP2011513483A5 publication Critical patent/JP2011513483A5/ja
Pending legal-status Critical Current

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JP2010550685A 2008-03-10 2009-03-10 タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン Pending JP2011513483A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3529008P 2008-03-10 2008-03-10
PCT/US2009/001534 WO2009145814A2 (en) 2008-03-10 2009-03-10 Pyrimidines and pyridines useful as inhibitors of protein kinases

Publications (2)

Publication Number Publication Date
JP2011513483A JP2011513483A (ja) 2011-04-28
JP2011513483A5 true JP2011513483A5 (https=) 2012-09-06

Family

ID=41268452

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010550685A Pending JP2011513483A (ja) 2008-03-10 2009-03-10 タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン

Country Status (4)

Country Link
US (1) US20110224197A1 (https=)
EP (1) EP2262498A2 (https=)
JP (1) JP2011513483A (https=)
WO (1) WO2009145814A2 (https=)

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AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
CN104039784B (zh) 2011-09-02 2017-08-22 拜耳知识产权有限责任公司 取代的增环嘧啶及其用途
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
PE20142359A1 (es) 2011-11-25 2015-01-09 Bayer Pharma AG Procedimiento de preparacion de 5-fluoro-1h-pirazolopiridinas sustituidas
DE102012200360A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte Triazine und ihre Verwendung
DE102012200352A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung
DE102012200349A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung
ES2644781T3 (es) 2012-03-06 2017-11-30 Bayer Intellectual Property Gmbh Azabiciclos sustituidos y su uso
CN106279202A (zh) * 2012-05-03 2017-01-04 霍夫曼-拉罗奇有限公司 作为lrrk2调节剂用于治疗帕金森病的吡唑氨基嘧啶衍生物
RU2637947C2 (ru) * 2012-05-03 2017-12-08 Дженентек, Инк. Производные пиразоламинопиримидина в качестве модуляторов обогащенной лейциновыми повторами киназы 2
CN103896856B (zh) * 2012-12-25 2016-06-08 叶龙 一种多取代单环嘧啶类jnk激酶抑制剂及其制备方法和用途
CN105102457A (zh) 2013-02-21 2015-11-25 阿德弗里奥药品有限责任公司 {4,6-二氨基-2-[1-(2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-基]嘧啶-5-基}甲基氨基甲酸甲酯的形式
AU2014289312A1 (en) 2013-07-10 2016-02-11 Bayer Pharma Aktiengesellschaft Benzyl-1H-pyrazolo(3,4-b)pyridines and use thereof
HRP20181272T1 (hr) 2013-11-13 2018-10-05 Vertex Pharmaceuticals Incorporated Postupci priprave inhibitora replikacije virusa influence
RS59144B1 (sr) 2013-11-13 2019-09-30 Vertex Pharma Inhibitori replikacije virusa influence
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
AU2016270373A1 (en) 2015-06-05 2018-01-04 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
JP2018525345A (ja) 2015-07-01 2018-09-06 ノースウェスタン ユニバーシティ 置換キナゾリン化合物及びグルコセレブロシダーゼ活性の調節のためのその使用
CN108003092B (zh) * 2017-12-21 2021-04-02 重庆中邦科技有限公司 一种2,3-二氯吡啶的合成方法

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AU2007338754A1 (en) * 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
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CA2695753A1 (en) * 2007-08-15 2009-02-19 Vertex Pharmaceuticals Incorporated Compounds useful as protein kinases inhibitors
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