JP2011511793A - 口内乾燥の処置のための組成物および方法 - Google Patents
口内乾燥の処置のための組成物および方法 Download PDFInfo
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- JP2011511793A JP2011511793A JP2010546016A JP2010546016A JP2011511793A JP 2011511793 A JP2011511793 A JP 2011511793A JP 2010546016 A JP2010546016 A JP 2010546016A JP 2010546016 A JP2010546016 A JP 2010546016A JP 2011511793 A JP2011511793 A JP 2011511793A
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- Prior art keywords
- basic amino
- dry mouth
- amino acid
- arginine
- ion source
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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Abstract
【選択図】なし
Description
i.カルシウムおよび/またはホスフェートイオン源、たとえば炭酸カルシウムおよび/または可溶性カルシウム塩、たとえば塩化カルシウム、乳酸カルシウム;
ii.可溶性ホスフェート塩、たとえば一塩基性リン酸カリウムまたは二塩基性リン酸カリウム;および/または
iii.リン酸カルシウム、たとえば第二リン酸カルシウム;カリウムイオン源、たとえば塩化カリウム、一塩基性リン酸カリウムまたは二塩基性リン酸カリウム、および/または硝酸カリウム;
iv.フッ化物源、たとえば可溶性フッ化物塩、たとえばフッ化ナトリウムまたはモノフルオロリン酸ナトリウム;
v.マグネシウム源、たとえば塩化マグネシウム;唾液の流出を誘発する着香剤、たとえばカプサシエン(capsacien);ならびに/あるいは
vi.ポリオール系湿潤剤、たとえばグリセロール、糖アルコール(たとえばソルビトール、キシリトール)から選択されるもの;
ならびにその組合わせ;
たとえば下記のいずれかの組成物:
1.0.1.塩基性アミノ酸がアルギニン、リジン、シトルリン、オルニチン、クレアチン、ヒスチジン、ジアミノブタン酸、ジアミノプロピオン酸(diaminoproprionic acid)、その塩類、および/またはその組合わせである、組成物1.0;
1.0.2.塩基性アミノ酸がL−立体配置をもつ、組成物1.0または1.0.1;
1.0.3.塩基性アミノ酸を含むジ−またはトリ−ペプチドの塩の形で供給される、前記のいずれかの組成物;
1.0.4.塩基性アミノ酸がアルギニンである、前記のいずれかの組成物;
1.0.5.塩基性アミノ酸がL−アルギニンである、前記のいずれかの組成物;
1.0.6.塩基性アミノ酸が部分的または完全に塩の型である、前記のいずれかの組成物;
1.0.7.塩基性アミノ酸がリン酸アルギニンである、組成物1.0.6;
1.0.8.塩基性アミノ酸が塩酸アルギニンの形である、組成物1.0.6;
1.0.9.塩基性アミノ酸が硫酸アルギニンである、組成物1.0.6;
1.0.10.塩基性アミノ酸が重炭酸アルギニンである、組成物1.0.6;
1.0.11.塩基性アミノ酸の塩が配合物中においてその場で、酸または酸の塩類による塩基性アミノ酸の中和により形成される、前記のいずれかの組成物;
1.0.12.フッ化物塩と組み合わせる前に、塩基性アミノ酸の中和により塩基性アミノ酸の塩を形成してプレミックスを調製する、前記のいずれかの組成物;
1.0.13.塩基性アミノ酸の重量を遊離塩基形として計算して、塩基性アミノ酸が全組成物重量の約0.1〜20%、たとえば約1重量%〜約10重量%に相当する量で存在する、前記のいずれかの組成物;
1.0.14.塩基性アミノ酸が全組成物重量の約7.5重量%の量で存在する、組成物1.0.11;
1.0.15.塩基性アミノ酸が全組成物重量の約5重量%の量で存在する、組成物1.0.11;
1.0.16.塩基性アミノ酸が全組成物重量の約3.75重量%の量で存在する、組成物1.0.11;
1.0.17.塩基性アミノ酸が全組成物重量の約1.5重量%の量で存在する、組成物1.0.11;
1.0.18.フッ化物塩が、フッ化スズ(II)、フッ化ナトリウム、フッ化カリウム、モノフルオロリン酸ナトリウム、フルオロケイ酸ナトリウム、フルオロケイ酸アンモニウム、フッ化アミン(たとえばN’−オクタデシルトリメチレンジアミン−N,N,N’−トリス(2−エタノール)−ジヒドロフルオリド)、フッ化アンモニウム、フッ化チタン、ヘキサフルオロ硫酸塩、およびその組合わせから選択される、前記のいずれかの組成物;
1.0.19.フッ化物塩がフルオロリン酸塩である、前記のいずれかの組成物;
1.0.20.フッ化物塩がモノフルオロリン酸ナトリウムである、前記のいずれかの組成物;
1.0.21.フッ化物塩がフッ化ナトリウムである、前記のいずれかの組成物;
1.0.22.フッ化物塩が全組成物重量の約0.01重量%〜約2重量%の量で存在する、前記のいずれかの組成物;
1.0.23.フッ化物塩が全組成物重量の約0.1〜約0.2重量%の量のフッ化物イオンを供給する、前記のいずれかの組成物;
1.0.24.可溶性フッ化物塩が約50〜10,000ppmの量のフッ化物イオンを供給する、前記のいずれかの組成物;
1.0.25.100〜約250ppmの有効フッ化物イオンを含むマウスウォッシュ(mouthwash)である、前記のいずれかの組成物;
1.0.26.約750〜2000ppmの有効フッ化物イオンを含む歯磨剤である、前記のいずれかの組成物;
1.0.27.組成物が、750〜2000ppmのフッ化物イオンを含む、前記のいずれかの組成物;
1.0.28.組成物が、1000〜1500ppmのフッ化物イオンを含む、前記のいずれかの組成物;
1.0.29.組成物が、約1450ppmのフッ化物イオンを含む、前記のいずれかの組成物;
1.0.30.pHが約6〜約9、たとえば6.5〜7.4、または7.5〜9である、前記のいずれかの組成物;
1.0.31.pHが約6.5〜約7.4である、前記のいずれかの組成物;
1.0.32.pHが約6.8〜約7.2である、前記のいずれかの組成物;
1.0.33.pHがほぼ中性である、前記のいずれかの組成物;
1.0.34.さらに研磨剤または粒状物質を含む、前記のいずれかの組成物;
1.0.35.接着剤または粒状物質が、炭酸水素ナトリウム、リン酸カルシウム(たとえば第二リン酸カルシウム・2水和物)、硫酸カルシウム、沈降炭酸カルシウム、シリカ(たとえば水和シリカ)、酸化鉄、酸化アルミニウム、パーライト、プラスチック粒子、たとえばポリエチレン、およびその組合わせから選択される、上記の組成物;
1.0.36.研磨剤または粒状物質が、リン酸カルシウム(たとえば第二リン酸カルシウム・2水和物)、硫酸カルシウム、沈降炭酸カルシウム、シリカ(たとえば水和シリカ)、およびその組合わせから選択される、上記の組成物;
1.0.37.全組成物重量の約15重量%〜約70重量%の量の研磨剤を含む、前記のいずれかの組成物;
1.0.38.約5マイクロメートル未満のd50を有する少なくとも約5%の小粒子研磨剤画分を含む、前記のいずれかの組成物;
1.0.39.150未満、たとえば約40〜140のRDAを有する、前記のいずれかの組成物;
1.0.40.陰イオン界面活性剤が下記のものから選択される、前記のいずれかの組成物:
a.高級脂肪酸モノグリセリドモノスルフェートの水溶性塩(たとえば、水素化ヤシ(椰子)油脂肪酸のモノスルフェート化モノグリセリドのナトリウム塩、たとえばナトリウムN−メチル N−ココイルタウレート、ナトリウムココモ−グリセリドスルフェート)、
b.高級アルキルスルフェート、たとえばラウリル硫酸ナトリウム、
c.高級アルキル−エーテルスルフェート、たとえば次式のもの:
CH3(CH2)mCH2(OCH2CH2)nOSO3X、ここでmは6〜16、たとえば10であり、nは1〜6、たとえば2、3または4であり、XはNaまたはKである(たとえばナトリウムラウレス−2スルフェート(CH3(CH2)10CH2(OCH2CH2)2OSO3Na))、
d.高級アルキルアリールスルホネート(たとえばドデシルベンゼンスルホン酸ナトリウム(ラウリルベンゼンスルホン酸ナトリウム))、
e.高級アルキルスルホアセテート(たとえばナトリウムラウリルスルホアセテート(ドデシルナトリウムスルホアセテート)、1,2 ジヒドロキシプロパンスルホネートの高級脂肪酸エステル、スルホコラウレート(N−2−エチルラウレートカリウムスルホアセトアミド)およびラウリルサルコシン酸ナトリウム)、
f.ならびにその混合物;
”高級アルキル”は、たとえばC6−30アルキルを意味する。具体的な態様において、陰イオン界面活性剤はラウリル硫酸ナトリウムおよびラウリルエーテル硫酸ナトリウムから選択される;
1.0.41.陰イオン界面活性剤が、ラウリル硫酸ナトリウム、ラウリルエーテル硫酸ナトリウム、およびその混合物から選択される、前記のいずれかの組成物;
1.0.42.陰イオン界面活性剤が、約0.3重量%から約4.5重量%までの量で存在する、前記のいずれかの組成物;
1.0.43.陽イオン、両性イオンおよび非イオン界面活性剤、ならびにその混合物から選択される界面活性剤をさらに含む、前記のいずれかの組成物;
1.0.44.少なくとも1種類の湿潤剤を含む、前記のいずれかの組成物;
1.0.45.グリセリン、ソルビトール、およびその組合わせから選択される少なくとも1種類の湿潤剤を含む、前記のいずれかの組成物;
1.0.46.キシリトールを含む、前記のいずれかの組成物;
1.0.47.少なくとも1種類のポリマーを含む、前記のいずれかの組成物;
1.0.48.ポリエチレングリコール、ポリビニルメチルエーテル−マレイン酸コポリマー、多糖類(たとえばセルロース誘導体、たとえばカルボキシメチルセルロース、または多糖ガム、たとえばキサンタンガムもしくはカラギーナンガム)、およびその組合わせから選択される少なくとも1種類のポリマーを含む、前記のいずれかの組成物;
1.0.49.ガムのストリップまたはフラグメントを含む、前記のいずれかの組成物;
1.0.50.着香剤、芳香剤および/または着色剤を含む、前記のいずれかの組成物;
1.0.51.水を含む、前記のいずれかの組成物;
1.0.52.下記のものから選択される抗細菌剤を含む、前記のいずれかの組成物:ハロゲン化ジフェニルエーテル(たとえばトリクロサン(triclosan))、草本エキスおよび精油(たとえばローズマリーエキス、茶エキス、モクレン(magnolia)エキス、チモール(thymol)、メントール、ユーカリプトール(eucalyptol)、ゲラニオール、カルバクロール(carvacrol)、シトラール(citral)、ヒノキトール(hinokitol)、カテコール、サリチル酸メチル、没食子酸エピガロカテキン(epigallocatechin gallate)、エピガロカテキン、没食子酸、ミスワク(ナチュラルブラシ)(miswak)エキス、シーバックソーン(sea−buckthorn)エキス)、ビスグアニド系防腐剤(たとえばクロルヘキシジン(chlorhexidine)、アレキシジン(alexidine)またはオクテニジン(octenidine))、第四級アンモニウム化合物(たとえばセチルピリジニウムクロリド(CPC)、塩化ベンザルコニウム、テトラデシルピリジニウムクロリド(TPC)、N−テトラデシル−4−エチルピリジニウムクロリド(TDEPC))、フェノール系防腐剤、ヘキセチジン(hexetidine)、オクテニジン、サンギナリン(sanguinarine)、ポビドンヨード(povidone iodine)、デルモピノール(delmopinol)、サリフルオル(salifluor)、金属イオン(たとえば亜鉛塩、たとえばクエン酸亜鉛、スズ(II)塩、銅塩、鉄塩)、サンギナリン、プロポリス(propolis)および酸素化剤(たとえば過酸化水素、緩衝化されたペルオキシホウ酸ナトリウムまたはペルオキシ炭酸ナトリウム)、フタル酸およびその塩、モノパーサル酸(monoperthalic acid)ならびにその塩およびエステル、ステアリン酸アスコルビル、オレオイルサルコシン(oleoyl sarcosine)、硫酸アルキル、スルホコハク酸ジオクチル、サリチルアニリド、臭化ドミフェン(domiphen bromide)、デルモピノール、オクタピノール(octapinol)および他のピペリジノ誘導体、ナイシン製剤、亜塩素酸塩、ならびに以上のいずれかの混合物;
1.0.53.抗炎症性化合物、たとえば下記のものを含む、前記のいずれかの組成物:マトリックスメタロプロテイナーゼ(MMP)、シクロオキシゲナーゼ(COX)、PGE2、インターロイキン1(IL−1)、IL−1β変換酵素(ICE)、トランスフォーミング成長因子β1(TGF−β1)、誘導性一酸化窒素シンターゼ(iNOS)、ヒアルロニダーゼ、カテプシン、核因子カッパB(NF−κB)、およびIL−1受容体関連キナーゼ(IRAK)から選択される宿主炎症性因子のうち少なくとも1つの阻害剤、たとえばアスピリン、ケトロラク(ketorolac)、フルルビプロフェン(flurbiprofen)、イブプロフェン(ibuprofen)、ナプロキセン(naproxen)、インドメタシン(indomethacin)、アスピリン、ケトプロフェン(ketoprofen)、ピロキシカム(piroxicam)、メクロフェナム酸(meclofenamic acid)、ノルジヒドグアイアレチン酸(nordihydoguaiaretic acid)、およびその混合物から選択されるもの;
1.0.54.抗酸化剤、たとえば補酵素Q10、PQQ、ビタミンC、ビタミンE、ビタミンA、アネトール−ジチオチオン(anethole−dithiothione)、およびその混合物からなる群から選択されるものを含む、前記のいずれかの組成物;
1.0.55.抗微生物剤が貧溶性である、前記のいずれかの組成物;
1.0.56.トリクロサンを含む、前記のいずれかの組成物;
1.0.57.トリクロサンおよびキシリトールを含む、前記のいずれかの組成物;
1.0.58.トリクロサン、キシリトールおよび沈降炭酸カルシウムを含む、前記のいずれかの組成物;
1.0.59.全組成物重量の0.01〜5重量%の量の抗細菌剤を含む、前記のいずれかの組成物;
1.0.60.全組成物重量の0.01〜1重量%の量のトリクロサンを含む、前記のいずれかの組成物;
1.0.61.全組成物重量の約0.3%の量のトリクロサンを含む、前記のいずれかの組成物;
1.0.62.増白剤を含む、前記のいずれかの組成物;
1.0.63.ペルオキシド、亜塩素酸金属塩、ペルボレート、ペルカーボネート、ペルオキシ酸、次亜塩素酸塩、およびその組合わせからなる群から選択される増白活性物質から選択される増白剤を含む、前記のいずれかの組成物;
1.0.64.過酸化水素または下記の過酸化水素源を含む、前記のいずれかの組成物:たとえば過酸化尿素、またはペルオキシド塩もしくは複合体(たとえばペルオキシホスフェート、ペルオキシカーボネート、ペルボレート、ペルオキシシリケートまたはペルスルフェート塩;たとえばペルオキシリン酸カルシウム、過ホウ酸ナトリウム、ナトリウムカーボネートペルオキシド、ペルオキシリン酸ナトリウム、および過硫酸カリウム);
1.0.65.さらに、細菌の付着を妨害または阻止する薬剤、たとえばソルブロール(solbrol)またはキトサンを含む、前記のいずれかの組成物;
1.0.66.さらに、下記のものから選択されるカルシウムおよびホスフェートの供給源を含む、前記のいずれかの組成物:(i)カルシウム−ガラス複合体、たとえばカルシウムナトリウムホスホシリケート、および(ii)カルシウム−タンパク質複合体、たとえばカゼインホスホペプチド−非晶質リン酸カルシウム;
1.0.67.さらに、可溶性カルシウム塩、たとえば硫酸カルシウム、塩化カルシウム、硝酸カルシウム、酢酸カルシウム、乳酸カルシウム、およびその組合わせから選択されるものを含む、前記のいずれかの組成物;
1.0.68.さらに、生理的に許容できるカリウム塩、たとえば硝酸カリウムまたは塩化カリウムを、象牙質知覚過敏を軽減するのに有効な量で含む、前記のいずれかの組成物;
1.0.69.約0.1%から約7.5%までの生理的に許容できるカリウム塩、たとえば硝酸カリウムおよび/または塩化カリウムを含む、前記のいずれかの組成物;
1.0.70.アルギニン塩、たとえば塩酸アルギニン、リン酸アルギニンまたは重炭酸アルギニン;トリクロサン;陰イオン界面活性剤、たとえばラウリル硫酸ナトリウム;および可溶性フッ化物塩、たとえばモノフルオロリン酸ナトリウムまたはフッ化ナトリウムを含む練り歯磨きである、前記のいずれかの組成物;
1.0.71.たとえばブラッシングにより口腔に適用した際に、口内乾燥を軽減し、および/または水分補給効果の知覚を発生させ、かつ場合により下記のために有効な、前記のいずれかの組成物:(i)齲歯、たとえば唾液流出の減少および口内乾燥から生じる齲歯の形成を軽減または抑制する、(ii)たとえば定量光誘導蛍光(quantitative light−induced fluorescence)(QLF)または電気的齲食測定(electrical caries measurement)(ECM)により検出される初期のエナメル質病変を軽減、修復または抑制する、(iii)歯の脱灰を軽減または抑制し、再石灰化を促進する、(iv)歯の過敏性を軽減する、(v)歯肉炎を軽減または抑制する、(vi)口内の潰瘍または切り傷の治癒を促進する、(vii)酸産生細菌のレベルを低下させる、(viii)アルギニン分解細菌の相対レベルを高める、(ix)口腔における微生物バイオフィルムの形成を抑制する、(x)糖負荷後の歯垢pHを少なくともpH5.5のレベルに上昇および/または維持する、(xi)歯垢の蓄積を軽減する、(xiii)たとえば口腔組織を介した全身感染の潜在性を低下させることにより、心血管の健康状態を含めた全身の健康状態を増進する、ならびに/あるいは(xiv)歯の侵食を軽減する、(xv)歯を増白する、(xvi)歯を齲食原性細菌に対して免疫化する、(xvii)歯および口腔を清浄にする、ならびに(xvii)口内乾燥による睡眠障害(sleep disruption)を軽減する;
1.0.72.前記のいずれかの組成物において述べた成分を組み合わせることにより得られた、または得ることができる、組成物;
1.0.73.マウスリンス、練り歯磨き、歯磨きゲル、歯磨き粉、非研磨ゲル、ムース、フォーム、口内スプレー、トローチ、口内錠、インプラント義歯、およびペットケア製品から選択される形態の、前記のいずれかの組成物;
1.0.74.組成物が練り歯磨きである、前記のいずれかの組成物;
1.0.75.組成物が、場合によりさらに、水、研磨剤、界面活性剤、発泡剤、ビタミン、ポリマー、酵素、湿潤剤、増粘剤、抗微生物剤、保存剤、着香剤、着色剤、および/またはその組合わせのうち1以上を含む練り歯磨きである、前記のいずれかの組成物;
1.0.76.組成物がマウスウォッシュである、組成物1.0〜1.0.72のいずれかの組成物;
1.0.77.組成物がチューインガムである、組成物1.0〜1.0.72のいずれかの組成物;
1.0.78.さらに、ブレスフレッシュナー(breath freshner)、芳香剤または着香剤を含む、前記のいずれかの組成物。
2.1 方法2.0のうち、下記のためにも有効な方法:(i)齲歯の形成を軽減または抑制する、(ii)たとえば定量光誘導蛍光(QLF)または電気的齲食測定(ECM)により検出される初期のエナメル質病変を軽減、修復または抑制する、(iii)歯の脱灰を軽減または抑制し、再石灰化を促進する、(iv)歯の過敏性を軽減する、(v)歯肉炎を軽減または抑制する、(vi)口内の潰瘍または切り傷の治癒を促進する、(vii)酸産生細菌のレベルを低下させる、(viii)アルギニン分解細菌の相対レベルを高める、(ix)口腔における微生物バイオフィルムの形成を抑制する、(x)糖負荷後の歯垢pHを少なくともpH5.5のレベルに上昇および/または維持する、(xi)歯垢の蓄積を軽減する、(xiii)たとえば口腔組織を介した全身感染の潜在性を低下させることにより、心血管の健康状態を含めた全身の健康状態を増進する、ならびに/あるいは(xiv)歯の侵食を軽減する、ならびに(xv)歯および口腔を清浄にする;
2.2 方法2.0または2.2のうち、組成物が少なくとも7.5%のアルギニンを含むもの;
2.3 方法2.0〜2.2のうち、組成物が少なくとも10%の重炭酸アルギニンを含むもの;
2.4 方法2.0〜2.3のうち、組成物が少なくとも5%の湿潤剤を含むもの;
2.5 方法2.0〜2.4のうち、患者が口内乾燥の素因をもつもの;
2.6 方法2.0〜2.5のうち、患者が口内乾燥を患っているもの;
2.7 方法2.0〜2.6のうち、患者が口内乾燥の結果として食物咀嚼困難を有するもの;
2.8 方法2.0〜2.7のうち、患者が口内乾燥の結果として嚥下困難を有するもの;
2.9 方法2.0〜2.8のうち、患者が口内乾燥の結果として言語困難を有するもの;
2.10 方法2.0〜2.9のうち、患者が口内乾燥の結果として舌の日和見感染症にも罹患しているもの;
2.11 方法2.0〜2.10のうち、口内乾燥の原因が疾患であるもの;
2.12 方法2.0〜2.11のうち、患者が薬剤で処置されており、その薬剤が口内乾燥の原因であるもの;
2.13 方法2.0〜2.12のうち、口内乾燥が慢性的であるもの;
2.14 方法2.0〜2.13のうち、組成物が約7.5%から約25.0%までのアルギニンを含むもの;
2.15 方法2.0〜2.14のうち、組成物が歯磨剤であるもの;
2.16 方法2.0〜2.15のうち、組成物が練り歯磨きであるもの;
2.17 方法2.0〜2.16のうち、組成物がゲルであるもの;
2.18 方法2.0〜2.17のうち、組成物を口腔に歯ブラシで適用するもの;
2.19 方法2.0〜2.15のうち、組成物がマウスウォッシュであるもの;
2.20 方法2.0〜2.19のうち、患者がその方法を1日1回より多く行なうもの;
2.21 方法2.0〜2.20のうち、患者がその方法を毎日行なうもの。
[0014] 本発明はさらに、口内乾燥を治療、改善、抑制または予防する際に使用するための、遊離または塩の型の塩基性アミノ酸を提供する。
[0055] 下記の成分から練り歯磨き組成物を調製して、7.50重量%のアルギニンを含む練り歯磨きを製造する。
[0056] 口内乾燥を患っている8人の患者に、実施例1の組成物を与える。実施例1の組成物で1日2回ブラッシングし、使用前、4日目および8日目に彼らの口内乾燥状態についての所見を記録するように、患者に指示する。
実施例3−アルギニンを含む人工唾液配合物
[0060] 下記の成分から人工唾液配合物を調製する。
Claims (32)
- 口内乾燥を治療、改善、抑制または予防する方法であって、その必要がある患者の口腔に、遊離または塩の型の塩基性アミノ酸を含む組成物を投与することを含む方法。
- 塩基性アミノ酸がアルギニンである、請求項1に記載の方法。
- アルギニンが重炭酸アルギニンの形である、請求項2に記載の方法。
- 組成物がさらに、下記のうち1以上を含む、請求項1、2または3に記載の方法:
a.カルシウムイオン源、
b.ホスフェートイオン源、
c.カリウムイオン源、
d.マグネシウムイオン源、
e.フッ化物源、
f.唾液の流出を促進する着香剤、
g.ポリオール系湿潤剤、
h.およびその組合わせ。 - 患者が口内乾燥の素因をもつ、前記請求項のいずれか1項に記載の方法。
- 患者が口内乾燥を患っている、前記請求項のいずれか1項に記載の方法。
- 患者が口内乾燥の結果として食物咀嚼困難を有する、前記請求項のいずれか1項に記載の方法。
- 患者が口内乾燥の結果として嚥下困難を有する、前記請求項のいずれか1項に記載の方法。
- 患者が口内乾燥の結果として言語困難を有する、前記請求項のいずれか1項に記載の方法。
- 患者が口内乾燥の結果として舌の日和見感染症にも罹患している、前記請求項のいずれか1項に記載の方法。
- 口内乾燥の原因が疾患である、前記請求項のいずれか1項に記載の方法。
- 患者が薬剤により処置されており、その薬剤が口内乾燥の原因である、前記請求項のいずれか1項に記載の方法。
- 口内乾燥が慢性的である、前記請求項のいずれか1項に記載の方法。
- 組成物が歯磨剤である、前記請求項のいずれか1項に記載の方法。
- 組成物がマウスリンスである、前記請求項のいずれか1項に記載の方法。
- マウスリンスが、カルシウム、ホスフェート、カリウム、マグネシウム、およびその組合わせから選択されるイオンを含む人工唾液である、請求項15に記載の方法。
- 齲食の発生を軽減または抑制する、前記請求項のいずれか1項に記載の方法。
- 遊離または塩の型のアルギニンを下記のうち1以上と共に含む人工唾液:
a.カルシウムイオン源、
b.ホスフェートイオン源、
c.カリウムイオン源、
d.マグネシウムイオン源、
e.フッ化物源、
f.唾液の流出を促進する着香剤、および/または
g.ポリオール系湿潤剤。 - 口内乾燥を治療、改善、抑制または予防する薬剤の製造のための、遊離または塩の型の塩基性アミノ酸の使用。
- 塩基性アミノ酸がアルギニンである、請求項19に記載の使用。
- アルギニンが重炭酸アルギニンの形である、請求項20に記載の使用。
- さらに下記のうち1以上を含む薬剤における、請求項19〜21のいずれか1項に記載の使用:
a.カルシウムイオン源、
b.ホスフェートイオン源、
c.カリウムイオン源、
d.マグネシウムイオン源、
e.フッ化物源、
f.唾液の流出を促進する着香剤、
g.ポリオール系湿潤剤、
h.およびその組合わせ。 - 薬剤が歯磨剤である、請求項22に記載の使用。
- 薬剤がマウスリンスである、請求項22に記載の使用。
- マウスリンスが、カルシウム、ホスフェート、カリウム、マグネシウム、およびその組合わせから選択されるイオンを含む人工唾液である、請求項24に記載の使用。
- 口内乾燥の治療、改善、抑制または予防に使用するための、遊離または塩の型の塩基性アミノ酸。
- 塩基性アミノ酸がアルギニンである、請求項26に記載の塩基性アミノ酸。
- アルギニンが重炭酸アルギニンの形である、請求項27に記載の塩基性アミノ酸。
- さらに下記のうち1以上を含む組成物中における、請求項26〜28のいずれか1項に記載の塩基性アミノ酸:
a.カルシウムイオン源、
b.ホスフェートイオン源、
c.カリウムイオン源、
d.マグネシウムイオン源、
e.フッ化物源、
f.唾液の流出を促進する着香剤、
g.ポリオール系湿潤剤、
h.およびその組合わせ。 - 組成物が歯磨剤である、請求項29に記載の塩基性アミノ酸。
- 組成物がマウスリンスである、請求項29に記載の塩基性アミノ酸。
- マウスリンスが、カルシウム、ホスフェート、カリウム、マグネシウム、およびその組合わせから選択されるイオンを含む人工唾液である、請求項31に記載の塩基性アミノ酸。
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- 2009-02-06 CN CN201410756129.5A patent/CN104398396A/zh active Pending
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- 2009-02-06 TW TW098103771A patent/TWI409084B/zh not_active IP Right Cessation
- 2009-02-06 AR ARP090100427A patent/AR070355A1/es unknown
- 2009-02-06 CN CN2009801048912A patent/CN101951877A/zh active Pending
- 2009-02-06 WO PCT/US2009/033291 patent/WO2009100265A2/en active Application Filing
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Also Published As
Publication number | Publication date |
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CN104398396A (zh) | 2015-03-11 |
TWI409084B (zh) | 2013-09-21 |
RU2455001C2 (ru) | 2012-07-10 |
WO2009100265A2 (en) | 2009-08-13 |
RU2491928C1 (ru) | 2013-09-10 |
BRPI0906462A2 (pt) | 2015-07-14 |
TW200946135A (en) | 2009-11-16 |
MY157782A (en) | 2016-07-29 |
AU2009212321A1 (en) | 2009-08-13 |
EP2249789A4 (en) | 2014-01-15 |
RU2010137342A (ru) | 2012-03-20 |
CA2711263C (en) | 2014-01-21 |
MX2010005007A (es) | 2010-05-27 |
EP2249789A2 (en) | 2010-11-17 |
CA2711263A1 (en) | 2009-08-13 |
WO2009100265A3 (en) | 2009-11-05 |
US20110189110A1 (en) | 2011-08-04 |
CN101951877A (zh) | 2011-01-19 |
US10471283B2 (en) | 2019-11-12 |
AR070355A1 (es) | 2010-03-31 |
AU2009212321B2 (en) | 2012-04-19 |
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