JP2011511762A5 - - Google Patents
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- Publication number
- JP2011511762A5 JP2011511762A5 JP2010540846A JP2010540846A JP2011511762A5 JP 2011511762 A5 JP2011511762 A5 JP 2011511762A5 JP 2010540846 A JP2010540846 A JP 2010540846A JP 2010540846 A JP2010540846 A JP 2010540846A JP 2011511762 A5 JP2011511762 A5 JP 2011511762A5
- Authority
- JP
- Japan
- Prior art keywords
- hedgehog
- tissue
- antibody
- binding
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000289669 Erinaceus europaeus Species 0.000 claims 34
- 238000000034 method Methods 0.000 claims 31
- 206010028980 Neoplasm Diseases 0.000 claims 21
- 201000011510 cancer Diseases 0.000 claims 11
- 125000000539 amino acid group Chemical group 0.000 claims 10
- 230000014509 gene expression Effects 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 238000001514 detection method Methods 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 238000005259 measurement Methods 0.000 claims 6
- 238000001262 western blot Methods 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 5
- 230000002159 abnormal effect Effects 0.000 claims 2
- 230000002018 overexpression Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000027355 Ferocactus setispinus Species 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000008467 tissue growth Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1723207P | 2007-12-28 | 2007-12-28 | |
| US61/017,232 | 2007-12-28 | ||
| US9986408P | 2008-09-24 | 2008-09-24 | |
| US61/099,864 | 2008-09-24 | ||
| PCT/US2008/088059 WO2009086324A1 (en) | 2007-12-28 | 2008-12-22 | Anti-hedgehog antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011511762A JP2011511762A (ja) | 2011-04-14 |
| JP2011511762A5 true JP2011511762A5 (enExample) | 2012-02-16 |
| JP5715420B2 JP5715420B2 (ja) | 2015-05-07 |
Family
ID=40433914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540846A Expired - Fee Related JP5715420B2 (ja) | 2007-12-28 | 2008-12-22 | 抗ヘッジホッグ抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8030454B2 (enExample) |
| EP (1) | EP2235063B1 (enExample) |
| JP (1) | JP5715420B2 (enExample) |
| AU (1) | AU2008345246B2 (enExample) |
| CA (1) | CA2709399C (enExample) |
| ES (1) | ES2551736T3 (enExample) |
| WO (1) | WO2009086324A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102573832B (zh) * | 2009-08-25 | 2015-07-22 | 阿布拉科斯生物科学有限公司 | 利用紫杉烷和刺猬抑制剂的纳米颗粒组合物的联合治疗 |
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| US8945627B2 (en) | 2011-05-05 | 2015-02-03 | Wisconsin Alumni Research Foundation | Micelles for the solubilization of gossypol |
| PH12022550313A1 (en) | 2011-06-23 | 2023-01-23 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| US9814703B2 (en) | 2013-11-14 | 2017-11-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of BMP signaling |
| US11867696B2 (en) * | 2015-02-06 | 2024-01-09 | Cell Idx, Inc. | Antigen-coupled immunoreagents |
| CN104645358A (zh) * | 2015-02-09 | 2015-05-27 | 中国人民解放军第二军医大学 | 一种胰腺癌靶向的纳米级超声造影剂及其制备方法和应用 |
| US10548908B2 (en) | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
| CN112805299B (zh) | 2018-10-05 | 2025-09-16 | 西雅图儿童医院以西雅图儿童研究机构名义经营 | 针对原发性免疫缺陷、胱氨酸病和威尔逊病的新生儿筛查 |
| US11940448B2 (en) | 2020-03-31 | 2024-03-26 | Seattle Children's Hospital | Proteomic screening for lysosomal storage diseases |
| US12523662B2 (en) | 2020-04-02 | 2026-01-13 | Seattle Children's Hospital | Antibodies that specifically bind peptides associated with the primary immunodeficiencies: Wiskott-Aldrich syndrome and x-linked agammaglobulinemia |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4946783A (en) | 1987-01-30 | 1990-08-07 | President And Fellows Of Harvard College | Periplasmic protease mutants of Escherichia coli |
| IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
| EP0604580A1 (en) | 1991-09-19 | 1994-07-06 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES |
| US7060450B1 (en) * | 1993-12-30 | 2006-06-13 | President And Fellows Of Harvard College | Screening assays for agonists and antagonists of the hedgehog signaling pathway |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| JPH114695A (ja) * | 1997-04-25 | 1999-01-12 | Hayashibara Biochem Lab Inc | ヘッジホッグ蛋白質 |
| AU767066B2 (en) * | 1999-03-03 | 2003-10-30 | Curis, Inc. | Methods of modulating lipid metabolism and storage |
| IL153115A0 (en) * | 2000-06-16 | 2003-06-24 | Curis Inc | Angiogenesis-modulating compositions and uses |
| US7498304B2 (en) * | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| CA2425356C (en) * | 2000-10-13 | 2015-10-06 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
| ES2707393T3 (es) * | 2004-03-26 | 2019-04-03 | Curis Inc | Moduladores de interferencia de ARN de señalización de hedgehog y usos de los mismos |
-
2008
- 2008-12-22 EP EP08867163.1A patent/EP2235063B1/en active Active
- 2008-12-22 AU AU2008345246A patent/AU2008345246B2/en not_active Ceased
- 2008-12-22 ES ES08867163.1T patent/ES2551736T3/es active Active
- 2008-12-22 US US12/341,910 patent/US8030454B2/en not_active Expired - Fee Related
- 2008-12-22 JP JP2010540846A patent/JP5715420B2/ja not_active Expired - Fee Related
- 2008-12-22 CA CA2709399A patent/CA2709399C/en not_active Expired - Fee Related
- 2008-12-22 WO PCT/US2008/088059 patent/WO2009086324A1/en not_active Ceased
-
2011
- 2011-08-24 US US13/217,191 patent/US20120028829A1/en not_active Abandoned
-
2012
- 2012-08-13 US US13/584,711 patent/US8338112B1/en not_active Expired - Fee Related
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