AU2008345246B2 - Anti-hedgehog antibodies - Google Patents

Anti-hedgehog antibodies Download PDF

Info

Publication number
AU2008345246B2
AU2008345246B2 AU2008345246A AU2008345246A AU2008345246B2 AU 2008345246 B2 AU2008345246 B2 AU 2008345246B2 AU 2008345246 A AU2008345246 A AU 2008345246A AU 2008345246 A AU2008345246 A AU 2008345246A AU 2008345246 B2 AU2008345246 B2 AU 2008345246B2
Authority
AU
Australia
Prior art keywords
hedgehog
antibody
tissue
cells
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008345246A
Other languages
English (en)
Other versions
AU2008345246A1 (en
Inventor
Suzanna J. Scales
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AU2008345246A1 publication Critical patent/AU2008345246A1/en
Application granted granted Critical
Publication of AU2008345246B2 publication Critical patent/AU2008345246B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57545—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2008345246A 2007-12-28 2008-12-22 Anti-hedgehog antibodies Ceased AU2008345246B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1723207P 2007-12-28 2007-12-28
US61/017,232 2007-12-28
US9986408P 2008-09-24 2008-09-24
US61/099,864 2008-09-24
PCT/US2008/088059 WO2009086324A1 (en) 2007-12-28 2008-12-22 Anti-hedgehog antibodies

Publications (2)

Publication Number Publication Date
AU2008345246A1 AU2008345246A1 (en) 2009-07-09
AU2008345246B2 true AU2008345246B2 (en) 2014-08-07

Family

ID=40433914

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008345246A Ceased AU2008345246B2 (en) 2007-12-28 2008-12-22 Anti-hedgehog antibodies

Country Status (7)

Country Link
US (3) US8030454B2 (enExample)
EP (1) EP2235063B1 (enExample)
JP (1) JP5715420B2 (enExample)
AU (1) AU2008345246B2 (enExample)
CA (1) CA2709399C (enExample)
ES (1) ES2551736T3 (enExample)
WO (1) WO2009086324A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102573832B (zh) * 2009-08-25 2015-07-22 阿布拉科斯生物科学有限公司 利用紫杉烷和刺猬抑制剂的纳米颗粒组合物的联合治疗
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
US8945627B2 (en) 2011-05-05 2015-02-03 Wisconsin Alumni Research Foundation Micelles for the solubilization of gossypol
PH12022550313A1 (en) 2011-06-23 2023-01-23 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
US9814703B2 (en) 2013-11-14 2017-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of BMP signaling
US11867696B2 (en) * 2015-02-06 2024-01-09 Cell Idx, Inc. Antigen-coupled immunoreagents
CN104645358A (zh) * 2015-02-09 2015-05-27 中国人民解放军第二军医大学 一种胰腺癌靶向的纳米级超声造影剂及其制备方法和应用
US10548908B2 (en) 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
CN112805299B (zh) 2018-10-05 2025-09-16 西雅图儿童医院以西雅图儿童研究机构名义经营 针对原发性免疫缺陷、胱氨酸病和威尔逊病的新生儿筛查
US11940448B2 (en) 2020-03-31 2024-03-26 Seattle Children's Hospital Proteomic screening for lysosomal storage diseases
US12523662B2 (en) 2020-04-02 2026-01-13 Seattle Children's Hospital Antibodies that specifically bind peptides associated with the primary immunodeficiencies: Wiskott-Aldrich syndrome and x-linked agammaglobulinemia

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4946783A (en) 1987-01-30 1990-08-07 President And Fellows Of Harvard College Periplasmic protease mutants of Escherichia coli
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
EP0604580A1 (en) 1991-09-19 1994-07-06 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
US7060450B1 (en) * 1993-12-30 2006-06-13 President And Fellows Of Harvard College Screening assays for agonists and antagonists of the hedgehog signaling pathway
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
JPH114695A (ja) * 1997-04-25 1999-01-12 Hayashibara Biochem Lab Inc ヘッジホッグ蛋白質
AU767066B2 (en) * 1999-03-03 2003-10-30 Curis, Inc. Methods of modulating lipid metabolism and storage
IL153115A0 (en) * 2000-06-16 2003-06-24 Curis Inc Angiogenesis-modulating compositions and uses
US7498304B2 (en) * 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
CA2425356C (en) * 2000-10-13 2015-10-06 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
ES2707393T3 (es) * 2004-03-26 2019-04-03 Curis Inc Moduladores de interferencia de ARN de señalización de hedgehog y usos de los mismos

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Shh (H-160):sc-9024" SANTA CRUZ BIOTECHNOLOGY DATASHEETS. 2000. Retrieved from the Internet: URL:http://datasheets.scbt.com/sc-9024.pdf [retrieved on 2009-03-18]. *

Also Published As

Publication number Publication date
EP2235063A1 (en) 2010-10-06
AU2008345246A1 (en) 2009-07-09
EP2235063B1 (en) 2015-09-02
ES2551736T3 (es) 2015-11-23
CA2709399C (en) 2021-01-19
US8030454B2 (en) 2011-10-04
CA2709399A1 (en) 2009-07-09
US20130011853A1 (en) 2013-01-10
US20100003239A1 (en) 2010-01-07
JP2011511762A (ja) 2011-04-14
US20120028829A1 (en) 2012-02-02
JP5715420B2 (ja) 2015-05-07
HK1146595A1 (zh) 2011-06-24
WO2009086324A1 (en) 2009-07-09
US8338112B1 (en) 2012-12-25

Similar Documents

Publication Publication Date Title
AU2008345246B2 (en) Anti-hedgehog antibodies
US10273308B2 (en) Methods of producing antibodies specific for p95
CN107011439B (zh) 抗叶酸受体α抗体及其应用
EP1978973B1 (en) Use hedgehog kinase antagonists to inhibit hedgehog signaling and to treat cancer
JP2006517109A (ja) アンフィレグリン抗体ならびに癌および乾癬を処置するためのその使用
TW200823293A (en) Novel anti-Notch3 antibodies and their use in the detection and diagnosis of disease
JP2002526028A (ja) ヒトトール相同体
KR20200055770A (ko) Napi2b 표적 요법에 대한 반응을 예측하기 위한 조성물 및 방법
KR20020073181A (ko) Ｌｉｖ-1 관련 단백질, 이를 코딩하는 폴리뉴클레오티드및 암의 치료를 위한 그의 용도
JP2020532572A (ja) 癌の診断に有用な抗体
MXPA05003440A (es) Uso de antigenos a33 y jam-it.
KR101771714B1 (ko) 변이체 ｈｈｉｐ1 단백질 및 방법 및 그의 용도
JP2010511060A (ja) 神経膠腫の診断及び治療方法
EP3656794A1 (en) Composition and methods for detecting cancer
CA2422538C (en) Notch receptor agonists and uses
HK1146595B (en) Anti-hedgehog antibodies
JP4705469B2 (ja) 抗ｂａｍｂｉ抗体、及びそれを含有する大腸癌及び肝臓癌の診断剤又は治療剤
CA2647277A1 (en) Method for using boc/cdo to modulate hedgehog signaling
CN100422345C (zh) 用于检测ppn/mg61多聚核苷酸存在和水平的试剂盒
KR20120140097A (ko) 암 진단 및 치료용 조성물 및 방법
AU2013204025A1 (en) Methods of using hedgehog kinase antagonists to inhibit hedgehog signaling and to treat hedgehog mediated disorders

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired