JP2011511634A5 - - Google Patents
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- JP2011511634A5 JP2011511634A5 JP2010545021A JP2010545021A JP2011511634A5 JP 2011511634 A5 JP2011511634 A5 JP 2011511634A5 JP 2010545021 A JP2010545021 A JP 2010545021A JP 2010545021 A JP2010545021 A JP 2010545021A JP 2011511634 A5 JP2011511634 A5 JP 2011511634A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- item
- cancer stem
- cell
- mirna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 31
- 239000002679 microRNA Substances 0.000 claims description 17
- 108091070501 miRNA Proteins 0.000 claims description 14
- 210000000130 stem cell Anatomy 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 11
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 10
- 239000002246 antineoplastic agent Substances 0.000 claims description 7
- 229940127089 cytotoxic agent Drugs 0.000 claims description 7
- 108091023796 miR-182 stem-loop Proteins 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 108091027559 Mir-96 microRNA Proteins 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 108091058688 miR-141 stem-loop Proteins 0.000 claims description 5
- 108091029500 miR-183 stem-loop Proteins 0.000 claims description 5
- 108091059199 miR-200a stem-loop Proteins 0.000 claims description 5
- 108091089775 miR-200b stem-loop Proteins 0.000 claims description 5
- 108091074450 miR-200c stem-loop Proteins 0.000 claims description 5
- 108091059135 miR-429 stem-loop Proteins 0.000 claims description 5
- 108091086713 miR-96 stem-loop Proteins 0.000 claims description 5
- 108091070961 miR-96-3 stem-loop Proteins 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 108700011259 MicroRNAs Proteins 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- 238000001727 in vivo Methods 0.000 claims description 3
- 230000037041 intracellular level Effects 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 3
- 102100032912 CD44 antigen Human genes 0.000 claims description 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 2
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims description 2
- 108091034117 Oligonucleotide Proteins 0.000 claims description 2
- 102100038081 Signal transducer CD24 Human genes 0.000 claims description 2
- 239000000074 antisense oligonucleotide Substances 0.000 claims description 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 108091028049 Mir-221 microRNA Proteins 0.000 claims 2
- 108091025686 miR-199a stem-loop Proteins 0.000 claims 2
- 108091028080 MiR-132 Proteins 0.000 claims 1
- 108091046841 MiR-150 Proteins 0.000 claims 1
- 108091033773 MiR-155 Proteins 0.000 claims 1
- 108091028108 MiR-212 Proteins 0.000 claims 1
- 108091026807 MiR-214 Proteins 0.000 claims 1
- 108091093085 MiR-338 Proteins 0.000 claims 1
- 108091028066 Mir-126 Proteins 0.000 claims 1
- 108091028076 Mir-127 Proteins 0.000 claims 1
- 108091062140 Mir-223 Proteins 0.000 claims 1
- 108091060585 Mir-31 Proteins 0.000 claims 1
- 230000002222 downregulating effect Effects 0.000 claims 1
- 108091091360 miR-125b stem-loop Proteins 0.000 claims 1
- 108091079658 miR-142-1 stem-loop Proteins 0.000 claims 1
- 108091071830 miR-142-2 stem-loop Proteins 0.000 claims 1
- 108091032320 miR-146 stem-loop Proteins 0.000 claims 1
- 108091024530 miR-146a stem-loop Proteins 0.000 claims 1
- 108091043612 miR-146b stem-loop Proteins 0.000 claims 1
- 108091039097 miR-193b stem-loop Proteins 0.000 claims 1
- 108091064378 miR-196b stem-loop Proteins 0.000 claims 1
- 108091092012 miR-199b stem-loop Proteins 0.000 claims 1
- 108091053935 miR-212 stem-loop Proteins 0.000 claims 1
- 108091028397 miR-212-1 stem-loop Proteins 0.000 claims 1
- 108091028945 miR-212-2 stem-loop Proteins 0.000 claims 1
- 108091061917 miR-221 stem-loop Proteins 0.000 claims 1
- 108091063489 miR-221-1 stem-loop Proteins 0.000 claims 1
- 108091055391 miR-221-2 stem-loop Proteins 0.000 claims 1
- 108091031076 miR-221-3 stem-loop Proteins 0.000 claims 1
- 108091080321 miR-222 stem-loop Proteins 0.000 claims 1
- 108091079013 miR-34b Proteins 0.000 claims 1
- 108091084018 miR-34b stem-loop Proteins 0.000 claims 1
- 108091063470 miR-34b-1 stem-loop Proteins 0.000 claims 1
- 108091049916 miR-34b-2 stem-loop Proteins 0.000 claims 1
- 108091057222 miR-34b-3 stem-loop Proteins 0.000 claims 1
- 108091092639 miR-34b-4 stem-loop Proteins 0.000 claims 1
- 108091028761 miR-409 stem-loop Proteins 0.000 claims 1
- 108091029445 miR-432 stem-loop Proteins 0.000 claims 1
- 108091031190 miR-495 stem-loop Proteins 0.000 claims 1
- 108091046338 miR-521 stem-loop Proteins 0.000 claims 1
- 108091043430 miR-521-1 stem-loop Proteins 0.000 claims 1
- 108091044256 miR-521-2 stem-loop Proteins 0.000 claims 1
- 108091048420 miR-521-3 stem-loop Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 231100001221 nontumorigenic Toxicity 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 230000003915 cell function Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 230000004066 metabolic change Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2557408P | 2008-02-01 | 2008-02-01 | |
| PCT/US2009/000593 WO2009097136A1 (en) | 2008-02-01 | 2009-01-30 | Methods and compositions relating to carcinoma stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511634A JP2011511634A (ja) | 2011-04-14 |
| JP2011511634A5 true JP2011511634A5 (enExample) | 2012-03-22 |
Family
ID=40913151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545021A Pending JP2011511634A (ja) | 2008-02-01 | 2009-01-30 | ガン幹細胞に関連する方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110021607A1 (enExample) |
| EP (1) | EP2247750A4 (enExample) |
| JP (1) | JP2011511634A (enExample) |
| CN (1) | CN101981206A (enExample) |
| AU (1) | AU2009209415A1 (enExample) |
| CA (1) | CA2713469A1 (enExample) |
| WO (1) | WO2009097136A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110172293A1 (en) * | 2008-07-08 | 2011-07-14 | Fish Jason E | Methods and Compositions for Modulating Angiogenesis |
| US7888035B2 (en) | 2008-10-30 | 2011-02-15 | Caris Mpi, Inc. | Methods for assessing RNA patterns |
| EP3181705A1 (en) | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| EP2316972A1 (en) * | 2009-10-29 | 2011-05-04 | Deutsches Krebsforschungszentrum | Circulating miRNAs as non-invasive markers for diagnosis and staging in prostate cancer |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| US20120156246A1 (en) * | 2010-06-16 | 2012-06-21 | Bamdad Cynthia C | Reprogramming cancer cells |
| EP2638159B1 (en) * | 2010-11-11 | 2019-04-24 | University of Miami | Compositions, kits and methods for treatment of cardiovascular, immunological, and inflammatory diseases |
| US8895509B2 (en) | 2010-11-23 | 2014-11-25 | Georgia Tech Research Corporation | MIR-200 family induces mesenchymal-to-epithelial transition (MET) in ovarian cancer cells |
| TW201239097A (en) * | 2010-12-17 | 2012-10-01 | Sanofi Sa | MiRNAs in joint disease |
| CN102168085A (zh) * | 2011-01-31 | 2011-08-31 | 中山大学肿瘤防治中心 | 抑制miR-130b基因表达的siRNA和表达载体及其在制备提高肝癌治疗效果的药物中的应用 |
| EP4086338A1 (en) | 2011-03-17 | 2022-11-09 | Minerva Biotechnologies Corporation | Method for making pluripotent stem cells |
| WO2013009705A2 (en) * | 2011-07-09 | 2013-01-17 | The Trustees Of Columbia University In The City Of New York | Biomarkers, methods, and compositions for inhibiting a multi-cancer mesenchymal transition mechanism |
| WO2013048345A1 (en) * | 2011-09-28 | 2013-04-04 | Agency For Science, Technology And Research | Methods and pharmaceutical compositions for treating cancer |
| US9352039B2 (en) * | 2012-02-09 | 2016-05-31 | The Regents Of The University Of Michigan | Method of reducing the number of EMT and MET type breast cancer stem cells |
| WO2013190091A1 (en) * | 2012-06-21 | 2013-12-27 | Ruprecht-Karls-Universität Heidelberg | CIRCULATING miRNAs AS MARKERS FOR BREAST CANCER |
| US20150344961A1 (en) * | 2012-09-11 | 2015-12-03 | New York University | Sera Based miRNAs as Non-Invasive Biomarkers in Melanoma |
| CN104415351A (zh) * | 2013-09-11 | 2015-03-18 | 中国人民解放军第二军医大学东方肝胆外科医院 | MicroRNA-429在制备抗肝癌药物中的应用 |
| CN103834692B (zh) * | 2014-02-27 | 2016-03-30 | 南京医科大学 | 一种用于表达lncRNA的慢病毒载体及其应用 |
| US9631194B2 (en) * | 2014-04-04 | 2017-04-25 | Beth Israel Deaconess Medical Center | Methods and compositions for use in treatment of FOXP2-related cancers |
| CN104513852B (zh) * | 2014-06-13 | 2016-08-24 | 南通大学附属医院 | miRNAs在胃癌干细胞中表达谱的分析方法 |
| US10533173B2 (en) | 2015-05-05 | 2020-01-14 | Jiangsu Micromedmark Biotech Co., Ltd. | Precursor miRNA and applications in tumor therapy thereof |
| US10568901B2 (en) | 2015-07-15 | 2020-02-25 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Micro-RNA for the treatment of malignant solid tumors and metastasis |
| WO2017207623A1 (en) * | 2016-05-31 | 2017-12-07 | Université de Lausanne | Mirna as biomarkers and regulators of cancer stem cells |
| US20190242900A1 (en) * | 2016-10-10 | 2019-08-08 | Kun-Chih Tsai | A novel invadopodia-specific marker of invasive cancer stem cells and the use thereof |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| CN107236749A (zh) * | 2017-06-07 | 2017-10-10 | 汕头大学医学院附属肿瘤医院 | 一种光学分子成像报告基因及其用途 |
| CN107858427B (zh) * | 2017-10-24 | 2021-03-02 | 昆明理工大学 | miR-429在制备乳腺癌诊断和检测试剂盒中的应用 |
| US20220275455A1 (en) * | 2019-07-08 | 2022-09-01 | Preferred Networks, Inc. | Data processing and classification for determining a likelihood score for breast disease |
| KR102414106B1 (ko) * | 2020-03-12 | 2022-06-29 | (주) 바이오인프라생명과학 | 유방암 진단용 다중 바이오마커 및 이의 용도 |
| US20230140044A1 (en) * | 2020-03-20 | 2023-05-04 | University Of Massachusetts | Micrornas for the prevention of clinical venous thromboembolic disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707829A (en) * | 1995-08-11 | 1998-01-13 | Genetics Institute, Inc. | DNA sequences and secreted proteins encoded thereby |
| WO2007081720A2 (en) * | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| WO2008095096A2 (en) * | 2007-01-31 | 2008-08-07 | Immune Disease Institute | Let-7 microrna and mimetics thereof as therapeutics for cancer |
| WO2010056737A2 (en) * | 2008-11-11 | 2010-05-20 | Mirna Therapeutics, Inc. | Methods and compositions involving mirnas in cancer stem cells |
-
2009
- 2009-01-30 WO PCT/US2009/000593 patent/WO2009097136A1/en not_active Ceased
- 2009-01-30 CA CA2713469A patent/CA2713469A1/en not_active Abandoned
- 2009-01-30 US US12/865,090 patent/US20110021607A1/en not_active Abandoned
- 2009-01-30 AU AU2009209415A patent/AU2009209415A1/en not_active Abandoned
- 2009-01-30 EP EP09706282A patent/EP2247750A4/en not_active Withdrawn
- 2009-01-30 JP JP2010545021A patent/JP2011511634A/ja active Pending
- 2009-01-30 CN CN2009801124738A patent/CN101981206A/zh active Pending
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