JP2011510272A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011510272A5 JP2011510272A5 JP2010542434A JP2010542434A JP2011510272A5 JP 2011510272 A5 JP2011510272 A5 JP 2011510272A5 JP 2010542434 A JP2010542434 A JP 2010542434A JP 2010542434 A JP2010542434 A JP 2010542434A JP 2011510272 A5 JP2011510272 A5 JP 2011510272A5
- Authority
- JP
- Japan
- Prior art keywords
- mass spectrometry
- item
- substrate according
- acid
- ascorbic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 47
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 44
- 238000004949 mass spectrometry Methods 0.000 claims description 36
- 239000000758 substrate Substances 0.000 claims description 36
- 239000011159 matrix material Substances 0.000 claims description 25
- 229960005070 ascorbic acid Drugs 0.000 claims description 22
- 235000010323 ascorbic acid Nutrition 0.000 claims description 22
- 239000011668 ascorbic acid Substances 0.000 claims description 22
- 102000039446 nucleic acids Human genes 0.000 claims description 21
- 108020004707 nucleic acids Proteins 0.000 claims description 21
- 150000007523 nucleic acids Chemical class 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 17
- 239000000654 additive Substances 0.000 claims description 16
- 230000000996 additive effect Effects 0.000 claims description 16
- BRARRAHGNDUELT-UHFFFAOYSA-N 3-hydroxypicolinic acid Chemical compound OC(=O)C1=NC=CC=C1O BRARRAHGNDUELT-UHFFFAOYSA-N 0.000 claims description 14
- VBIXEXWLHSRNKB-UHFFFAOYSA-N ammonium oxalate Chemical compound [NH4+].[NH4+].[O-]C(=O)C([O-])=O VBIXEXWLHSRNKB-UHFFFAOYSA-N 0.000 claims description 11
- 238000004989 laser desorption mass spectroscopy Methods 0.000 claims description 8
- 238000003795 desorption Methods 0.000 claims description 7
- 102000053602 DNA Human genes 0.000 claims description 6
- 108020004414 DNA Proteins 0.000 claims description 6
- YXVFQADLFFNVDS-UHFFFAOYSA-N diammonium citrate Chemical compound [NH4+].[NH4+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O YXVFQADLFFNVDS-UHFFFAOYSA-N 0.000 claims description 6
- 229920002477 rna polymer Polymers 0.000 claims description 6
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 235000012431 wafers Nutrition 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 238000003491 array Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 210000001520 comb Anatomy 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000012491 analyte Substances 0.000 description 16
- 238000004458 analytical method Methods 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/014,671 | 2008-01-15 | ||
| US12/014,671 US7888127B2 (en) | 2008-01-15 | 2008-01-15 | Methods for reducing adduct formation for mass spectrometry analysis |
| PCT/US2009/031020 WO2009091841A2 (en) | 2008-01-15 | 2009-01-14 | Compositions and processes for improved mass spectrometry analysis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013095670A Division JP5651842B2 (ja) | 2008-01-15 | 2013-04-30 | 改善された質量分析法分析のための組成物およびプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011510272A JP2011510272A (ja) | 2011-03-31 |
| JP2011510272A5 true JP2011510272A5 (https=) | 2012-01-12 |
| JP5400799B2 JP5400799B2 (ja) | 2014-01-29 |
Family
ID=40850960
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010542434A Active JP5400799B2 (ja) | 2008-01-15 | 2009-01-14 | 改善された質量分析法分析のための組成物およびプロセス |
| JP2013095670A Expired - Fee Related JP5651842B2 (ja) | 2008-01-15 | 2013-04-30 | 改善された質量分析法分析のための組成物およびプロセス |
| JP2014056293A Pending JP2014122922A (ja) | 2008-01-15 | 2014-03-19 | 改善された質量分析法分析のための組成物およびプロセス |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013095670A Expired - Fee Related JP5651842B2 (ja) | 2008-01-15 | 2013-04-30 | 改善された質量分析法分析のための組成物およびプロセス |
| JP2014056293A Pending JP2014122922A (ja) | 2008-01-15 | 2014-03-19 | 改善された質量分析法分析のための組成物およびプロセス |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US7888127B2 (https=) |
| EP (2) | EP2242561B1 (https=) |
| JP (3) | JP5400799B2 (https=) |
| KR (1) | KR101733248B1 (https=) |
| CN (2) | CN106404879B (https=) |
| AU (2) | AU2009205404B2 (https=) |
| CA (1) | CA2711943C (https=) |
| EA (1) | EA017342B1 (https=) |
| ES (2) | ES2601359T3 (https=) |
| WO (1) | WO2009091841A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7888127B2 (en) | 2008-01-15 | 2011-02-15 | Sequenom, Inc. | Methods for reducing adduct formation for mass spectrometry analysis |
| US8110797B2 (en) * | 2009-02-06 | 2012-02-07 | Florida State University Research Foundation, Inc. | Electrospray ionization mass spectrometry methodology |
| JP5895694B2 (ja) * | 2012-05-11 | 2016-03-30 | 株式会社島津製作所 | マトリックス支援レーザ脱離イオン化質量分析用マトリックス |
| EP3300015B1 (en) * | 2013-03-12 | 2019-08-14 | Panacea Biomatx Inc. | System for making customized formulations for individuals |
| US9305756B2 (en) | 2013-03-13 | 2016-04-05 | Agena Bioscience, Inc. | Preparation enhancements and methods of use for MALDI mass spectrometry |
| US10451544B2 (en) | 2016-10-11 | 2019-10-22 | Genotox Laboratories | Methods of characterizing a urine sample |
| CN106483191B (zh) * | 2016-10-27 | 2019-03-08 | 吉林大学 | 一种通过消除甜点效应提高质谱检测重复性的方法 |
| CN108051503A (zh) * | 2017-10-31 | 2018-05-18 | 北京毅新博创生物科技有限公司 | 改善质谱检测微生物结晶的方法及产品 |
| CN107884466A (zh) * | 2017-10-31 | 2018-04-06 | 北京毅新博创生物科技有限公司 | 校正质谱检测微生物样品的准确率的方法及产品 |
| CN108008003A (zh) * | 2017-10-31 | 2018-05-08 | 北京毅新博创生物科技有限公司 | 改善质谱检测核酸结晶的方法及产品 |
| CN108008002A (zh) * | 2017-10-31 | 2018-05-08 | 北京毅新博创生物科技有限公司 | 校正质谱检测核酸样品的准确率的方法及产品 |
| CN107907585A (zh) * | 2017-11-09 | 2018-04-13 | 广州禾信康源医疗科技有限公司 | 靶板及其制作方法 |
| CN108845023A (zh) * | 2018-03-30 | 2018-11-20 | 清华大学 | 一种激光解吸附离子化质谱检测方法 |
| CN109541012A (zh) * | 2018-11-23 | 2019-03-29 | 杭州汇健科技有限公司 | 一种用于质谱分析的通用型纳米芯片及其制备方法与应用 |
| CN110129893A (zh) * | 2019-03-25 | 2019-08-16 | 为康（苏州）基因科技有限公司 | 一种芯片的制备方法及其应用 |
| KR102410207B1 (ko) * | 2020-03-06 | 2022-06-20 | 주식회사 우성제약 | 고성능 액체 크래마토그래피-질량분석기를 이용한 타우린아미드의 정량 분석 방법 |
| CN112316847A (zh) * | 2020-11-11 | 2021-02-05 | 吉林大学 | 一种磷氮化合物的高温高压合成方法 |
| CN113447560B (zh) * | 2021-05-24 | 2022-12-09 | 上海交通大学 | 一种基于金属离子加成的小分子代谢物碎裂控制方法及应用 |
| CN116297805A (zh) * | 2023-02-28 | 2023-06-23 | 厦门金诺花生物技术有限公司 | 用于maldi-ms的核酸基质溶液及其制备 |
| CN116660359A (zh) * | 2023-05-19 | 2023-08-29 | 中元汇吉生物技术股份有限公司 | 一种质谱分析用组合物、芯片及其应用 |
| CN117074509B (zh) * | 2023-07-31 | 2024-04-23 | 广东省农业科学院农业生物基因研究中心 | 一种基于核壳纳米材料检测类胡萝卜素的质谱方法 |
| CN117368300B (zh) * | 2023-11-14 | 2024-08-09 | 浙江迪谱诊断技术有限公司 | 核酸质谱基质的试剂组合及其制备方法和应用 |
| WO2025144071A1 (ru) * | 2023-12-28 | 2025-07-03 | Общество с ограниченной ответственностью "Ионоскоп" | Времяпролетный масс-анализатор |
| CN120168526A (zh) * | 2024-07-05 | 2025-06-20 | 齐鲁工业大学(山东省科学院) | 一种降尿酸益生菌及产品 |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0612994A3 (de) * | 1993-02-26 | 1996-03-06 | Ciba Geigy Ag | Matrix für die matrix-unterstützte Laserdesorptions-Massenspektroskopie. |
| CN1202260C (zh) | 1996-01-23 | 2005-05-18 | 佳根基因组学公司 | 利用大小分离技术分析核酸分子的方法和组合物 |
| CA2248084A1 (en) | 1996-03-04 | 1997-09-12 | Genetrace Systems, Inc. | Methods of screening nucleic acids using mass spectrometry |
| DE19618032C2 (de) | 1996-05-04 | 2000-04-13 | Bruker Daltonik Gmbh | Lagerfähig vorpräparierte Maldi-Probenträger |
| US5786146A (en) * | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| ATE464123T1 (de) * | 1997-06-20 | 2010-04-15 | Univ New York | Elektrosprühen von lösungen zur massenherstellung von chips und molekülbibliotheken |
| AU738237B2 (en) | 1997-07-22 | 2001-09-13 | Qiagen Genomics, Inc. | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques |
| DE19754978C2 (de) | 1997-12-11 | 2000-07-13 | Bruker Daltonik Gmbh | Probenträger für die MALDI-Massenspektrometrie nebst Verfahren zur Herstellung der Platten und zum Aufbringen der Proben |
| US6723564B2 (en) * | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
| US6037118A (en) * | 1998-05-14 | 2000-03-14 | University Of Maryland Baltimore County | Viral characterization by direct detection of capsid proteins |
| EP1144127A1 (de) | 1998-12-24 | 2001-10-17 | Bayer Aktiengesellschaft | Verfahren zur herstellung einer ultraphoben oberfläche durch sandstrahlen |
| KR100689730B1 (ko) | 1998-12-24 | 2007-03-09 | 키아겐 게엠베하 | 초소성 표면 |
| AU5716300A (en) * | 1999-06-25 | 2001-01-31 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Method for scavenging radicals with urocanic acid, derivatives and analogues |
| US6454924B2 (en) | 2000-02-23 | 2002-09-24 | Zyomyx, Inc. | Microfluidic devices and methods |
| CA2301451A1 (en) * | 2000-03-20 | 2001-09-21 | Thang T. Pham | Method for analysis of analytes by mass spectrometry |
| DE10043042C2 (de) | 2000-09-01 | 2003-04-17 | Bruker Daltonik Gmbh | Verfahren zum Belegen eines Probenträgers mit Biomolekülen für die massenspektrometrische Analyse |
| AU2002227305A1 (en) * | 2000-10-27 | 2002-05-06 | Microbiosciences, Inc. | Micro storage, reaction and detection cells and methods and apparatus for use thereof |
| US20020142483A1 (en) * | 2000-10-30 | 2002-10-03 | Sequenom, Inc. | Method and apparatus for delivery of submicroliter volumes onto a substrate |
| US20060051741A1 (en) | 2002-10-04 | 2006-03-09 | Protosera Inc. | Plate for mass spectrometry, process for preparing the same and use thereof |
| DE10112515B4 (de) * | 2001-03-09 | 2004-02-12 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität |
| WO2004072616A2 (en) | 2003-02-10 | 2004-08-26 | Waters Investments Limited | A sample preparation plate for mass spectrometry |
| GB0120131D0 (en) | 2001-08-17 | 2001-10-10 | Micromass Ltd | Maldi target plate |
| US20030100082A1 (en) * | 2001-10-31 | 2003-05-29 | Mary Ann Lila | Methods for isolation of proanthocyanidins from flavonoid-producing cell culture |
| US20030141253A1 (en) * | 2001-12-07 | 2003-07-31 | Bihan Thierry Le | Apparatus for efficient liquid chromatography/mass spectrometry processing |
| SE0202415D0 (sv) | 2001-12-11 | 2002-08-13 | Thomas Laurell | Dockable processing module |
| WO2003071274A1 (de) | 2002-02-22 | 2003-08-28 | Sunyx Surface Nanotechnologies Gmbh | Verwendung von ultraphoben oberflächen mit einer vielzahl hydrophiler bereiche zur analyse von proben |
| AU2003220291A1 (en) * | 2002-03-15 | 2003-09-29 | Epigenomics Ag | Discovery and diagnostic methods using 5-methylcytosine dna glycosylase |
| WO2003091692A2 (en) * | 2002-04-23 | 2003-11-06 | California Institute Of Technology | Methods for evaluation of in vitro aminoacyl trna production using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry |
| JP2005526972A (ja) * | 2002-05-02 | 2005-09-08 | シファーゲン バイオシステムズ， インコーポレイテッド | 多糖系ヒドロゲルをコーティングした表面を有するバイオチップ |
| US7105809B2 (en) * | 2002-11-18 | 2006-09-12 | 3M Innovative Properties Company | Microstructured polymeric substrate |
| CA2507189C (en) * | 2002-11-27 | 2018-06-12 | Sequenom, Inc. | Fragmentation-based methods and systems for sequence variation detection and discovery |
| US20040122598A1 (en) * | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in food products and cosmetics thereby |
| US6822230B2 (en) | 2002-12-23 | 2004-11-23 | Agilent Technologies, Inc. | Matrix-assisted laser desorption/ionization sample holders and methods of using the same |
| JP4074921B2 (ja) | 2003-03-14 | 2008-04-16 | 日本電気株式会社 | 質量分析システムおよび分析方法 |
| US7442542B2 (en) | 2003-03-24 | 2008-10-28 | Agency For Science, Technology And Research | Shallow multi-well plastic chip for thermal multiplexing |
| US6891156B2 (en) | 2003-04-30 | 2005-05-10 | Perkin Elmer Instruments Llc | Sample plate for matrix-assisted laser desorption and ionization mass spectrometry |
| US20060183128A1 (en) * | 2003-08-12 | 2006-08-17 | Epigenomics Ag | Methods and compositions for differentiating tissues for cell types using epigenetic markers |
| US7019288B2 (en) | 2003-09-30 | 2006-03-28 | Sequenom, Inc. | Methods of making substrates for mass spectrometry analysis and related devices |
| JP4532874B2 (ja) * | 2003-10-07 | 2010-08-25 | キヤノン株式会社 | 質量分析可能な原子群を構成単位とする鎖状構造を有する分子に対して付加情報を付与して、情報記録コードとして利用する方法 |
| US20050133715A1 (en) * | 2003-12-23 | 2005-06-23 | Applied Biosystems | Matrix with noise reduction additive and disposable target containing the same |
| EP1700327A4 (en) | 2003-12-31 | 2010-05-05 | Ionwerks Inc | MALDI-IM-ORTHO-TOF MASS SPECTROMETRY WITH SIMULTANEOUS POSITIVE AND NEGATIVE MODE DETECTION |
| JP2005221250A (ja) | 2004-02-03 | 2005-08-18 | Jeol Ltd | 質量スペクトルの解析方法および装置 |
| US20050178959A1 (en) | 2004-02-18 | 2005-08-18 | Viorica Lopez-Avila | Methods and compositions for assessing a sample by maldi mass spectrometry |
| US7985424B2 (en) * | 2004-04-20 | 2011-07-26 | Dendritic Nanotechnologies Inc. | Dendritic polymers with enhanced amplification and interior functionality |
| US20060023808A1 (en) * | 2004-05-17 | 2006-02-02 | Hajivandi Mahbod R | Compositions, kits, and methods for calibration in mass spectrometry |
| US20060243899A1 (en) * | 2004-05-24 | 2006-11-02 | Shimadzu Corporation | Method for selective measurement of specific substances from a mixture by maldi mass spectrometry |
| US20060110833A1 (en) | 2004-09-09 | 2006-05-25 | Agnes George R | Method and apparatus for coupling an analyte supply to an electrodynamic droplet processor |
| WO2006047614A2 (en) * | 2004-10-26 | 2006-05-04 | Invitrogen Corporation | Compositions and methods for analyzing biomolecules using mass spectroscopy |
| EP1830184B1 (en) | 2004-10-29 | 2010-12-15 | Japan Science and Technology Agency | Substrate for maldi-tof ms and mass spectrometry method using the same |
| US20060094065A1 (en) * | 2004-10-30 | 2006-05-04 | Viorica Lopez-Avila | Methods of analyzing a sample by MALDI-mass spectrometry |
| EP1817430B1 (en) | 2004-11-29 | 2009-09-16 | Klinikum der Universität Regensburg | Means and methods for detecting methylated dna |
| KR100544860B1 (ko) | 2005-02-07 | 2006-01-24 | (주)프로테오니크 | 시료 플레이트 및 이의 제조방법 |
| EP1869222A4 (en) * | 2005-04-15 | 2010-01-20 | Oncomethylome Sciences S A | METHYLATION MARKERS FOR THE DIAGNOSIS AND TREATMENT OF CANCER |
| US7351959B2 (en) | 2005-05-13 | 2008-04-01 | Applera Corporation | Mass analyzer systems and methods for their operation |
| US20080023630A1 (en) | 2005-11-22 | 2008-01-31 | Ciphergen Biosystems Inc. | Polymer probe doped with conductive material for mass spectrometry |
| GB0524782D0 (en) * | 2005-12-05 | 2006-01-11 | Chiron Srl | Analysis of samples |
| EP1814137A3 (en) | 2006-01-27 | 2008-04-23 | Sony DADC Austria AG | Mass spectrometry target assembly |
| JP4732951B2 (ja) * | 2006-05-22 | 2011-07-27 | 株式会社島津製作所 | Ｍａｌｄｉ用サンプル調製方法及び質量分析方法 |
| EP3260556B1 (en) | 2006-05-31 | 2019-07-31 | Sequenom, Inc. | Methods for the extraction of nucleic acid from a sample |
| AU2007260750A1 (en) | 2006-06-16 | 2007-12-21 | Sequenom, Inc. | Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample |
| US8262900B2 (en) * | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| LT2557517T (lt) * | 2007-07-23 | 2023-01-10 | The Chinese University Of Hong Kong | Nukleino rūgščių sekos disbalanso nustatymas |
| WO2009032779A2 (en) | 2007-08-29 | 2009-03-12 | Sequenom, Inc. | Methods and compositions for the size-specific seperation of nucleic acid from a sample |
| WO2009032781A2 (en) | 2007-08-29 | 2009-03-12 | Sequenom, Inc. | Methods and compositions for universal size-specific polymerase chain reaction |
| AU2008308457A1 (en) | 2007-10-04 | 2009-04-09 | Halcyon Molecular | Sequencing nucleic acid polymers with electron microscopy |
| EP2217930B1 (en) | 2007-10-24 | 2013-03-06 | Tallinn University Of Technology | Maldi ms-based high-throughput screening method for substances inhibiting aggregation of alzheimer's amyloid beta peptides |
| US7888127B2 (en) | 2008-01-15 | 2011-02-15 | Sequenom, Inc. | Methods for reducing adduct formation for mass spectrometry analysis |
| WO2009120808A2 (en) * | 2008-03-26 | 2009-10-01 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| EP2106858B1 (en) | 2008-03-31 | 2011-11-02 | Sony DADC Austria AG | Substrate and target plate |
| WO2010004265A1 (en) | 2008-07-07 | 2010-01-14 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
| US8476013B2 (en) * | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| EP3770255A1 (en) | 2008-09-16 | 2021-01-27 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| JP2010078482A (ja) | 2008-09-26 | 2010-04-08 | Fujifilm Corp | 質量分析用基板および質量分析方法 |
| WO2010062914A1 (en) * | 2008-11-26 | 2010-06-03 | The Johns Hopkins University | Methods for identifying cancer risk |
| JP5317054B2 (ja) | 2008-12-26 | 2013-10-16 | 大日本塗料株式会社 | 質量分析用基板及びその製造方法並びに質量分析法 |
| EP3514244B1 (en) | 2009-04-03 | 2021-07-07 | Sequenom, Inc. | Nucleic acid preparation methods |
| US20110028333A1 (en) * | 2009-05-01 | 2011-02-03 | Brown University | Diagnosing, prognosing, and early detection of cancers by dna methylation profiling |
| US10388403B2 (en) * | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
| WO2011143659A2 (en) | 2010-05-14 | 2011-11-17 | Fluidigm Corporation | Nucleic acid isolation methods |
| EP2598560A2 (en) | 2010-07-30 | 2013-06-05 | Sony Corporation | A polymeric substrate having a glass-like surface and a chip made of said polymeric substrate |
| EP2416345A1 (en) | 2010-08-06 | 2012-02-08 | Philips Intellectual Property & Standards GmbH | Particle-based matrix carriers for mass spectrometry |
| US8610058B2 (en) | 2010-11-03 | 2013-12-17 | University Of North Texas | Silver and silver nanoparticle MALDI matrix utilizing online soft landing ion mobility |
| WO2012149339A2 (en) | 2011-04-29 | 2012-11-01 | Sequenom, Inc. | Quantification of a minority nucleic acid species |
| GB2493179B (en) | 2011-07-26 | 2018-09-05 | Kratos Analytical Ltd | MALDI sample preparation methods and targets |
| US9136099B2 (en) | 2012-07-04 | 2015-09-15 | Sony Dadc Austria Ag | Method and substrates for forming crystals |
| US9305756B2 (en) * | 2013-03-13 | 2016-04-05 | Agena Bioscience, Inc. | Preparation enhancements and methods of use for MALDI mass spectrometry |
| WO2015022172A1 (en) | 2013-08-14 | 2015-02-19 | Sony Dadc Austria Ag | Microfluidic device |
-
2008
- 2008-01-15 US US12/014,671 patent/US7888127B2/en active Active
-
2009
- 2009-01-14 EP EP09702741.1A patent/EP2242561B1/en not_active Not-in-force
- 2009-01-14 ES ES09702741.1T patent/ES2601359T3/es active Active
- 2009-01-14 AU AU2009205404A patent/AU2009205404B2/en not_active Ceased
- 2009-01-14 JP JP2010542434A patent/JP5400799B2/ja active Active
- 2009-01-14 EA EA201070855A patent/EA017342B1/ru not_active IP Right Cessation
- 2009-01-14 EP EP16181300.1A patent/EP3138623B1/en active Active
- 2009-01-14 CN CN201610753002.7A patent/CN106404879B/zh active Active
- 2009-01-14 KR KR1020107017996A patent/KR101733248B1/ko not_active Expired - Fee Related
- 2009-01-14 CN CN2009801088642A patent/CN101965221A/zh active Pending
- 2009-01-14 WO PCT/US2009/031020 patent/WO2009091841A2/en not_active Ceased
- 2009-01-14 CA CA2711943A patent/CA2711943C/en not_active Expired - Fee Related
- 2009-01-14 ES ES16181300T patent/ES2697408T3/es active Active
-
2011
- 2011-01-07 US US12/986,975 patent/US9310378B2/en active Active
-
2013
- 2013-04-30 JP JP2013095670A patent/JP5651842B2/ja not_active Expired - Fee Related
-
2014
- 2014-03-19 JP JP2014056293A patent/JP2014122922A/ja active Pending
- 2014-06-19 AU AU2014203336A patent/AU2014203336B2/en not_active Ceased
-
2016
- 2016-03-09 US US15/065,739 patent/US9873912B2/en active Active
-
2017
- 2017-12-13 US US15/840,432 patent/US10329612B2/en active Active
-
2019
- 2019-05-06 US US16/404,582 patent/US12077819B2/en active Active
-
2024
- 2024-08-29 US US18/819,941 patent/US20250115955A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011510272A5 (https=) | ||
| US20250115955A1 (en) | Compositions and processes for improved mass spectrometry analysis | |
| JP4630330B2 (ja) | ナノワイヤ支援レーザー脱離／イオン化質量分析 | |
| CN1675554A (zh) | 用于基质辅助激光解吸/离子化的基质及其应用 | |
| Oberacher et al. | Characterization of synthetic nucleic acids by electrospray ionization quadrupole time‐of‐flight mass spectrometry | |
| JP2007516448A (ja) | ノイズを減少する添加剤を含む改善されたマトリクスおよびそれを含む使い捨てターゲット | |
| Honda et al. | Improved method of the MALDI-TOF analysis of DNA with nanodot sample target plate | |
| JP2007309673A (ja) | 微量タンパク質の同定を可能にするｍａｌｄｉ型質量分析装置用サンプルプレート | |
| HK1233995A1 (en) | Compositions and processes for improved mass spectrometry analysis | |
| Banoub et al. | 1 Overview of Recent Developments in the Mass Spectrometry of Nucleic Acid | |
| HK1146536B (en) | Compositions and processes for improved mass spectrometry analysis | |
| St Pyrek | Mass spectrometry at low and high mass | |
| Zhu | Fundamental studies of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) and its applications to the analysis of biological materials | |
| McGown et al. | DNA-modified ITO surfaces for affinity MALDI-MS |