JP2011509282A5 - - Google Patents

Download PDF

Info

Publication number
JP2011509282A5
JP2011509282A5 JP2010541840A JP2010541840A JP2011509282A5 JP 2011509282 A5 JP2011509282 A5 JP 2011509282A5 JP 2010541840 A JP2010541840 A JP 2010541840A JP 2010541840 A JP2010541840 A JP 2010541840A JP 2011509282 A5 JP2011509282 A5 JP 2011509282A5
Authority
JP
Japan
Prior art keywords
furo
benzamide
pyrrole
oxodihydro
oxopentan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010541840A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011509282A (ja
JP5587790B2 (ja
Filing date
Publication date
Priority claimed from GB0800338A external-priority patent/GB0800338D0/en
Priority claimed from GB0808669A external-priority patent/GB0808669D0/en
Application filed filed Critical
Priority claimed from PCT/GB2009/000039 external-priority patent/WO2009087379A2/en
Publication of JP2011509282A publication Critical patent/JP2011509282A/ja
Publication of JP2011509282A5 publication Critical patent/JP2011509282A5/ja
Application granted granted Critical
Publication of JP5587790B2 publication Critical patent/JP5587790B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010541840A 2008-01-09 2009-01-07 化合物 Expired - Fee Related JP5587790B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0800338.6 2008-01-09
GB0800338A GB0800338D0 (en) 2008-01-09 2008-01-09 Compounds
GB0808669A GB0808669D0 (en) 2008-05-13 2008-05-13 Compounds
GB0808669.6 2008-05-13
PCT/GB2009/000039 WO2009087379A2 (en) 2008-01-09 2009-01-07 Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases

Publications (3)

Publication Number Publication Date
JP2011509282A JP2011509282A (ja) 2011-03-24
JP2011509282A5 true JP2011509282A5 (enExample) 2012-02-23
JP5587790B2 JP5587790B2 (ja) 2014-09-10

Family

ID=40791443

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010541840A Expired - Fee Related JP5587790B2 (ja) 2008-01-09 2009-01-07 化合物

Country Status (4)

Country Link
US (3) US8501744B2 (enExample)
EP (2) EP2719700A1 (enExample)
JP (1) JP5587790B2 (enExample)
WO (1) WO2009087379A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU581929B2 (en) * 1985-09-16 1989-03-09 Schering Corporation Antihypertensive agents, pharmaceutical compositions containing them and processes for the preparation of the agents and compositions
GB0817424D0 (en) 2008-09-24 2008-10-29 Medivir Ab Protease inhibitors
US9724351B2 (en) 2012-08-23 2017-08-08 Alios Biopharma, Inc. Compounds for the treatment of paramoxyvirus viral infections
WO2014111465A1 (en) 2013-01-17 2014-07-24 Sanofi Isomannide derivatives as inhibitors of soluble epoxide hydrolase
PH12021550330A1 (en) * 2013-08-21 2022-09-28 Janssen Biopharma Inc Antiviral compounds
KR102323515B1 (ko) 2013-09-12 2021-11-05 얀센 바이오파마, 인코퍼레이트. 아자-피리돈 화합물 및 이의 용도
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3444216A (en) 1966-11-16 1969-05-13 Upjohn Co Process for the oxidation of primary and secondary alcohols
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US5128448A (en) 1990-01-10 1992-07-07 Hoffman-La Roche Inc. CCK analogs with appetite regulating activity
US5374623A (en) 1992-08-20 1994-12-20 Prototek, Inc. Cysteine protease inhibitors effective for in vivo use
CA2111930A1 (en) 1992-12-25 1994-06-26 Ryoichi Ando Aminoketone derivatives
DZ2285A1 (fr) 1996-08-08 2002-12-25 Smithkline Beecham Corp Inhibiteurs de protéase de la cystéine.
US6043218A (en) 1996-10-22 2000-03-28 Medical University Of South Carolina Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides
AR013079A1 (es) 1997-05-06 2000-12-13 Smithkline Beecham Corp Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios
HUP0004400A3 (en) 1997-11-05 2002-10-28 Novartis Ag Dipeptide nitriles, process for their preparation, pharmaceutical compositions comprising thereof and their use
GB9806287D0 (en) 1998-03-24 1998-05-20 Synphar Lab Inc Monobactam enzyme inhibitors
MA26618A1 (fr) 1998-04-09 2004-12-20 Smithkline Beecham Corp Composes et compositions pharmaceutiques pour le traitement du paludisme
DZ2815A1 (fr) 1998-06-12 2003-12-01 Smithkline Beecham Corp Inhibiteurs de protéase.
WO2000009653A2 (en) 1998-08-14 2000-02-24 Smithkline Beecham Corporation Method of inhibiting cathepsin k
ES2142773B1 (es) 1998-10-07 2001-01-01 Lacer Sa Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
CO5150165A1 (es) 1998-11-13 2002-04-29 Smithkline Beecham Plc Inhibidores de proteasa: tipo catepsina k
JP2002537294A (ja) 1999-02-20 2002-11-05 アストラゼネカ アクチボラグ カテプシンｌ及びカテプシンｓの阻害剤としてのジ−及びトリペプチドニトリル誘導体
GB9903861D0 (en) 1999-02-20 1999-04-14 Zeneca Ltd Chemical compounds
JP2002537293A (ja) 1999-02-20 2002-11-05 アストラゼネカ アクチボラグ カテプシンｌおよび／またはカテプシンｓの阻害剤としてのアセタミドアセトニトリル誘導体
WO2000051998A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
EA200100972A1 (ru) 1999-03-15 2002-02-28 Аксис Фармасьютикалз, Инк. Новые соединения и композиции как ингибиторы протеаз
US6506733B1 (en) 1999-03-15 2003-01-14 Axys Pharmaceuticals, Inc. Compounds and compositions as protease inhibitors
TW200404789A (en) 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
GB9907683D0 (en) 1999-04-06 1999-05-26 Synphar Lab Inc Substituted azetidin-2-ones as cysteine protease inhibitors
GB9911417D0 (en) 1999-05-18 1999-07-14 Peptide Therapeutics Ltd Furanone derivatives as inhibitors of cathepsin s
GB9917909D0 (en) 1999-07-31 1999-09-29 Synphar Lab Inc Cysteine protease inhibitors
WO2001009910A1 (de) 1999-08-03 2001-02-08 Siemens Aktiengesellschaft Ausschaltverzögerungsschaltung für ein elektromechanisches schaltgerät
NZ518255A (en) 1999-09-13 2004-11-26 Boehringer Ingelheim Pharma Novel spiroheterocyclic compounds useful as reversible inhibitors of cysteine proteases
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
AU7490900A (en) 1999-09-16 2001-04-17 Axys Pharmaceuticals, Inc. Chemical compounds and compositions and their use as cathepsin s inhibitors
GB9925264D0 (en) 1999-10-26 1999-12-29 Zeneca Ltd Chemical compounds
EP1229911A4 (en) 1999-11-10 2003-05-07 Smithkline Beecham Corp PROTEASE INHIBITORS
WO2001034160A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
KR100468254B1 (ko) 1999-12-24 2005-01-27 에프. 호프만-라 로슈 아게 카텝신 ｋ 억제제로서의 니트릴 유도체
JP2003525874A (ja) 2000-01-06 2003-09-02 メルク フロスト カナダ アンド カンパニー プロテアーゼ阻害剤としての新規化合物および組成物
GB0003111D0 (en) 2000-02-10 2000-03-29 Novartis Ag Organic compounds
AU2001245764A1 (en) 2000-03-15 2001-09-24 Axys Pharmaceuticals, Inc. Novel compounds and compositions as protease inhibitors
AU4344101A (en) 2000-03-21 2001-10-03 Smithkline Beecham Corp Protease inhibitors
WO2001077073A1 (en) 2000-04-06 2001-10-18 Merck Frosst Canada & Co. Cathepsin cysteine protease inhibitors
CO5280093A1 (es) 2000-04-18 2003-05-30 Smithkline Beecham Corp Metodos de tratamiento
HUP0301231A2 (hu) 2000-06-14 2003-08-28 Smithkline Beecham Corp. Proteáz inhibitorok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US6462076B2 (en) 2000-06-14 2002-10-08 Hoffmann-La Roche Inc. Beta-amino acid nitrile derivatives as cathepsin K inhibitors
WO2002017924A1 (en) 2000-09-01 2002-03-07 Smithkline Beecham Corporation Method of treatment
WO2002032879A1 (en) 2000-10-19 2002-04-25 Naeja Pharmaceutical Inc. Dihydropyrimidine derivatives as cysteine protease inhibitors
JP2004523506A (ja) 2000-12-22 2004-08-05 アクシス・ファーマシューティカルズ・インコーポレイテッド カテプシン阻害剤としての新規な化合物と組成物
IL156776A0 (en) 2001-01-17 2004-02-08 Amura Therapeutics Ltd Inhibitors of cruzipain and other cysteine proteases
ATE356130T1 (de) 2001-01-17 2007-03-15 Amura Therapeutics Ltd Inhibitoren von cruzipain und anderen cysteinproteasen
US20020156063A1 (en) 2001-04-06 2002-10-24 Setti Eduardo L. Arylacetamido-ketobenzoxazole as cysteine protease inhibitors
AU2002342682A1 (en) 2001-05-17 2002-11-25 Smithkline Beecham Corporation Protease inhibitors
FR2826572B1 (fr) 2001-06-29 2005-10-07 Oreal Compositions contenant un derive d'hydroxydiphenyl ether inhibant le developpement des odeurs corporelles
EP1411933A1 (en) 2001-08-03 2004-04-28 SmithKline Beecham Corporation Alpha-ketoamide derivatives as cathepsin k inhibitors
AR036375A1 (es) 2001-08-30 2004-09-01 Novartis Ag Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos
RS19504A (sr) 2001-09-14 2007-02-05 Aventis Pharmaceuticals Inc., Nova jedinjenja i kompozicije kao inhibitori katepsina
EP1434769A2 (en) 2001-10-02 2004-07-07 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cysteine proteases
JP2005508979A (ja) 2001-10-29 2005-04-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド システインプロテアーゼの可逆性インヒビターとして有用な化合物
DE60225316T2 (de) 2001-11-13 2009-02-26 AXYS Pharmaceuticals, Inc., South San Francisco Cyanoalkylamino-derivate als protease-hemmer
HUP0401906A3 (en) 2001-11-14 2008-07-28 Aventis Pharma Inc Novel cathepsin s inhibitors, process for their preparation and pharmaceutical compositions containing them
US20060100431A1 (en) 2002-07-16 2006-05-11 Amura Therapeutics Limited Biologically active compounds
BRPI0506719A (pt) * 2004-01-08 2007-05-02 Medivir Ab composto, composição farmacêutica, e, uso de um composto
WO2006064286A1 (en) 2004-12-13 2006-06-22 Medivir Uk Ltd Cathepsin s inhibitors
GB0614044D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614042D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds

Similar Documents

Publication Publication Date Title
US7638627B2 (en) Process of preparing imatinib and imatinib prepared thereby
TW200745111A (en) New compounds
EP2693876B1 (en) Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds
JP2010526129A5 (enExample)
US20230338376A1 (en) Aminopyrimidine amide autophagy inhibitors and methods of use thereof
UA81635C2 (en) 2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12.
MY130803A (en) New quinuclidine amide derivatives
CN111225896A (zh) 免疫调节剂化合物
BR112020014160A2 (pt) Compostos de benzamida
NO20051695L (no) Nye spirokondenserte kinazolinoner og deres anvendelse som fosfodiestereaseinbibitorer
DE602004024375D1 (de) Carboxamidderivate
JP2010532387A5 (enExample)
JP2006509000A5 (enExample)
IS8132A (is) Pýrósóló-kínasólín afleiður, aðferð við framleiðslu þeirra og notkun sem kínasa hindrar
ATE447571T1 (de) Pyrroloä2,3-büpyridinderivate, die als kinaseinhibitoren wirken; verfahren zu deren herstellung und pharmazeutische zusammensetzung, die diese enthält
MY145613A (en) Novel compounds
BRPI0413393A (pt) fexofenadina, composição farmaceuticamente aceitável, método de tratamento antihistamìnico, composição, processo para preparar fexofenadina e uso de fexofenadina
CN110312531A (zh) 治疗性树枝状体
JP2012513390A5 (enExample)
SE0302192D0 (sv) Novel compounds
MX2009010165A (es) Nuevas imidazo[4,5-b]piridina-7-carboxamidas 704.
GB0109122D0 (en) Novel compounds
WO2009087379A3 (en) Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases
DE60008399D1 (de) Carbonsäuren und acylsulfonamide, solche verbindungen enthaltende zubereitungen und behandlungsmethoden
SE0102440D0 (sv) New compound