JP2011508785A5 - - Google Patents
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- Publication number
- JP2011508785A5 JP2011508785A5 JP2010541576A JP2010541576A JP2011508785A5 JP 2011508785 A5 JP2011508785 A5 JP 2011508785A5 JP 2010541576 A JP2010541576 A JP 2010541576A JP 2010541576 A JP2010541576 A JP 2010541576A JP 2011508785 A5 JP2011508785 A5 JP 2011508785A5
- Authority
- JP
- Japan
- Prior art keywords
- umbrella
- glycan
- topology
- composition
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101710154606 Hemagglutinin Proteins 0.000 claims description 86
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 86
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 86
- 101710176177 Protein A56 Proteins 0.000 claims description 86
- 150000004676 glycans Chemical class 0.000 claims description 86
- 239000000185 hemagglutinin Substances 0.000 claims description 86
- 150000001413 amino acids Chemical class 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 18
- 206010022000 influenza Diseases 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 101150038582 PSMC5 gene Proteins 0.000 claims description 12
- 235000000346 sugar Nutrition 0.000 claims description 12
- 230000003993 interaction Effects 0.000 claims description 9
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- 150000008163 sugars Chemical class 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 241000712461 unidentified influenza virus Species 0.000 claims description 6
- MSWZFWKMSRAUBD-UHFFFAOYSA-N 2-Amino-2-Deoxy-Hexose Chemical compound NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 4
- SQVRNKJHWKZAKO-LUWBGTNYSA-N N-acetylneuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)CC(O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-LUWBGTNYSA-N 0.000 claims description 4
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 4
- 150000002402 hexoses Chemical class 0.000 claims description 4
- 229920001542 oligosaccharide Polymers 0.000 claims description 4
- 150000002482 oligosaccharides Chemical class 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical class CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 description 43
- 102000005962 receptors Human genes 0.000 description 7
- 108020003175 receptors Proteins 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 5
- 241000700605 Viruses Species 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical group 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1878308P | 2008-01-03 | 2008-01-03 | |
| PCT/US2009/030056 WO2009089119A2 (en) | 2008-01-03 | 2009-01-02 | Decoy influenza therapies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011508785A JP2011508785A (ja) | 2011-03-17 |
| JP2011508785A5 true JP2011508785A5 (enExample) | 2012-02-23 |
Family
ID=40853715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010541576A Pending JP2011508785A (ja) | 2008-01-03 | 2009-01-02 | デコイインフルエンザ処置 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8815522B2 (enExample) |
| EP (1) | EP2237787A4 (enExample) |
| JP (1) | JP2011508785A (enExample) |
| KR (1) | KR20100111275A (enExample) |
| CN (1) | CN101951927A (enExample) |
| AU (1) | AU2009204345A1 (enExample) |
| CA (1) | CA2711330A1 (enExample) |
| WO (1) | WO2009089119A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2766899C (en) | 2009-07-02 | 2021-05-04 | Massachusetts Institute Of Technology | Compositions and methods for diagnosing and/or treating influenza infection |
| EP2528615B1 (en) * | 2010-01-27 | 2020-05-13 | Massachusetts Institute of Technology | Engineered polypeptide agents for targeted broad spectrum influenza neutralization |
| WO2011130575A1 (en) * | 2010-04-16 | 2011-10-20 | Massachusetts Institute Of Technology | Modular glycan arrays |
| JP2013541528A (ja) * | 2010-09-21 | 2013-11-14 | マサチューセッツ インスティテュート オブ テクノロジー | ヒト適応ｈａポリペプチド、ワクチン、およびインフルエンザの処置 |
| AU2011312178B2 (en) | 2010-10-04 | 2016-05-12 | Massachusetts Institute Of Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| WO2014116723A1 (en) * | 2013-01-22 | 2014-07-31 | The Charles Stark Draper Laboratory, Inc. | Multivalent liposome formulations |
| US10526375B2 (en) | 2013-06-05 | 2020-01-07 | Massachusetts Institute Of Technology | Human Adaptation of H7 HA |
| KR101529654B1 (ko) | 2013-11-15 | 2015-06-19 | 한국지질자원연구원 | 시추부 경사를 감안한 시추시스템 및 이를 이용한 심도 보정 방법 |
| US20160256388A1 (en) * | 2015-03-05 | 2016-09-08 | Uri Galili | Compositions and methods for treatment of respiratory tract infections |
| HK1248248A1 (zh) | 2015-06-25 | 2018-10-12 | 南洋理工大学 | 广谱抗感染肽 |
| CA3080656A1 (en) | 2017-10-30 | 2019-05-09 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| JP4651213B2 (ja) * | 2001-03-27 | 2011-03-16 | 株式会社グライコメディクス | インフルエンザウイルス・ヘマグルチニン結合性ペプチド |
| FI20031536A0 (fi) * | 2003-10-20 | 2003-10-20 | Biotie Therapies Oyj | Korkean affiniteetin ligandit influenssavirukselle ja menetelmät niiden valmistamiseen |
| AU2007251256B2 (en) | 2006-01-26 | 2013-03-07 | Recopharma Ab | Compositions and methods for inhibiting viral adhesion |
| BE1017134A5 (nl) | 2006-05-11 | 2008-03-04 | Delaere Marc | Borstel voor een schrob-,veeg- en/of boenmachine en sproei-inrichting voor het reinigen van meerdere door middel van groeven en/of voegen van elkaar gescheiden oppervlakten. |
| JP2010501074A (ja) * | 2006-08-14 | 2010-01-14 | マサチューセッツ・インスティテュート・オブ・テクノロジー | グリカンのデータマイニングシステム |
| CN101501696A (zh) * | 2006-08-14 | 2009-08-05 | 麻省理工学院 | 聚糖数据挖掘系统 |
-
2009
- 2009-01-02 EP EP09700461A patent/EP2237787A4/en not_active Withdrawn
- 2009-01-02 CA CA2711330A patent/CA2711330A1/en not_active Abandoned
- 2009-01-02 WO PCT/US2009/030056 patent/WO2009089119A2/en not_active Ceased
- 2009-01-02 AU AU2009204345A patent/AU2009204345A1/en not_active Abandoned
- 2009-01-02 JP JP2010541576A patent/JP2011508785A/ja active Pending
- 2009-01-02 KR KR1020107015592A patent/KR20100111275A/ko not_active Withdrawn
- 2009-01-02 US US12/348,265 patent/US8815522B2/en active Active
- 2009-01-02 CN CN2009801016606A patent/CN101951927A/zh active Pending
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