JP2011508785A - デコイインフルエンザ処置 - Google Patents
デコイインフルエンザ処置 Download PDFInfo
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- JP2011508785A JP2011508785A JP2010541576A JP2010541576A JP2011508785A JP 2011508785 A JP2011508785 A JP 2011508785A JP 2010541576 A JP2010541576 A JP 2010541576A JP 2010541576 A JP2010541576 A JP 2010541576A JP 2011508785 A JP2011508785 A JP 2011508785A
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Classifications
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
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- Urology & Nephrology (AREA)
- Hematology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1878308P | 2008-01-03 | 2008-01-03 | |
| PCT/US2009/030056 WO2009089119A2 (en) | 2008-01-03 | 2009-01-02 | Decoy influenza therapies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011508785A true JP2011508785A (ja) | 2011-03-17 |
| JP2011508785A5 JP2011508785A5 (enExample) | 2012-02-23 |
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|---|---|---|---|
| JP2010541576A Pending JP2011508785A (ja) | 2008-01-03 | 2009-01-02 | デコイインフルエンザ処置 |
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| Country | Link |
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| US (1) | US8815522B2 (enExample) |
| EP (1) | EP2237787A4 (enExample) |
| JP (1) | JP2011508785A (enExample) |
| KR (1) | KR20100111275A (enExample) |
| CN (1) | CN101951927A (enExample) |
| AU (1) | AU2009204345A1 (enExample) |
| CA (1) | CA2711330A1 (enExample) |
| WO (1) | WO2009089119A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2766899C (en) | 2009-07-02 | 2021-05-04 | Massachusetts Institute Of Technology | Compositions and methods for diagnosing and/or treating influenza infection |
| EP2528615B1 (en) * | 2010-01-27 | 2020-05-13 | Massachusetts Institute of Technology | Engineered polypeptide agents for targeted broad spectrum influenza neutralization |
| WO2011130575A1 (en) * | 2010-04-16 | 2011-10-20 | Massachusetts Institute Of Technology | Modular glycan arrays |
| JP2013541528A (ja) * | 2010-09-21 | 2013-11-14 | マサチューセッツ インスティテュート オブ テクノロジー | ヒト適応ｈａポリペプチド、ワクチン、およびインフルエンザの処置 |
| AU2011312178B2 (en) | 2010-10-04 | 2016-05-12 | Massachusetts Institute Of Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| WO2014116723A1 (en) * | 2013-01-22 | 2014-07-31 | The Charles Stark Draper Laboratory, Inc. | Multivalent liposome formulations |
| US10526375B2 (en) | 2013-06-05 | 2020-01-07 | Massachusetts Institute Of Technology | Human Adaptation of H7 HA |
| KR101529654B1 (ko) | 2013-11-15 | 2015-06-19 | 한국지질자원연구원 | 시추부 경사를 감안한 시추시스템 및 이를 이용한 심도 보정 방법 |
| US20160256388A1 (en) * | 2015-03-05 | 2016-09-08 | Uri Galili | Compositions and methods for treatment of respiratory tract infections |
| HK1248248A1 (zh) | 2015-06-25 | 2018-10-12 | 南洋理工大学 | 广谱抗感染肽 |
| CA3080656A1 (en) | 2017-10-30 | 2019-05-09 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20070243629A1 (en) * | 2003-10-20 | 2007-10-18 | Glykos Finland Oy | High Affinity Ligands for Influenza Virus and Methods for Their Production |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| JP4651213B2 (ja) * | 2001-03-27 | 2011-03-16 | 株式会社グライコメディクス | インフルエンザウイルス・ヘマグルチニン結合性ペプチド |
| AU2007251256B2 (en) | 2006-01-26 | 2013-03-07 | Recopharma Ab | Compositions and methods for inhibiting viral adhesion |
| BE1017134A5 (nl) | 2006-05-11 | 2008-03-04 | Delaere Marc | Borstel voor een schrob-,veeg- en/of boenmachine en sproei-inrichting voor het reinigen van meerdere door middel van groeven en/of voegen van elkaar gescheiden oppervlakten. |
| JP2010501074A (ja) * | 2006-08-14 | 2010-01-14 | マサチューセッツ・インスティテュート・オブ・テクノロジー | グリカンのデータマイニングシステム |
| CN101501696A (zh) * | 2006-08-14 | 2009-08-05 | 麻省理工学院 | 聚糖数据挖掘系统 |
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2009
- 2009-01-02 EP EP09700461A patent/EP2237787A4/en not_active Withdrawn
- 2009-01-02 CA CA2711330A patent/CA2711330A1/en not_active Abandoned
- 2009-01-02 WO PCT/US2009/030056 patent/WO2009089119A2/en not_active Ceased
- 2009-01-02 AU AU2009204345A patent/AU2009204345A1/en not_active Abandoned
- 2009-01-02 JP JP2010541576A patent/JP2011508785A/ja active Pending
- 2009-01-02 KR KR1020107015592A patent/KR20100111275A/ko not_active Withdrawn
- 2009-01-02 US US12/348,265 patent/US8815522B2/en active Active
- 2009-01-02 CN CN2009801016606A patent/CN101951927A/zh active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070243629A1 (en) * | 2003-10-20 | 2007-10-18 | Glykos Finland Oy | High Affinity Ligands for Influenza Virus and Methods for Their Production |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009204345A1 (en) | 2009-07-16 |
| US20100004195A1 (en) | 2010-01-07 |
| US8815522B2 (en) | 2014-08-26 |
| CA2711330A1 (en) | 2009-07-16 |
| EP2237787A2 (en) | 2010-10-13 |
| KR20100111275A (ko) | 2010-10-14 |
| CN101951927A (zh) | 2011-01-19 |
| EP2237787A4 (en) | 2012-03-21 |
| WO2009089119A3 (en) | 2009-12-30 |
| WO2009089119A2 (en) | 2009-07-16 |
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