JP2011507919A5 - - Google Patents
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- Publication number
- JP2011507919A5 JP2011507919A5 JP2010540056A JP2010540056A JP2011507919A5 JP 2011507919 A5 JP2011507919 A5 JP 2011507919A5 JP 2010540056 A JP2010540056 A JP 2010540056A JP 2010540056 A JP2010540056 A JP 2010540056A JP 2011507919 A5 JP2011507919 A5 JP 2011507919A5
- Authority
- JP
- Japan
- Prior art keywords
- fix
- water
- ser
- hydrophilic polymer
- soluble hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010076282 Factor IX Proteins 0.000 claims 40
- 102100022641 Coagulation factor IX Human genes 0.000 claims 39
- 229960004222 factor ix Drugs 0.000 claims 35
- 229920001477 hydrophilic polymer Polymers 0.000 claims 16
- 238000000034 method Methods 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 7
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 229940050526 hydroxyethylstarch Drugs 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000031169 hemorrhagic disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000009429 hemophilia B Diseases 0.000 claims 1
- 229960002885 histidine Drugs 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US926307P | 2007-12-27 | 2007-12-27 | |
| PCT/EP2008/010925 WO2009083187A1 (en) | 2007-12-27 | 2008-12-19 | Chemically modified factor ix |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011507919A JP2011507919A (ja) | 2011-03-10 |
| JP2011507919A5 true JP2011507919A5 (https=) | 2012-02-09 |
Family
ID=40344940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540056A Pending JP2011507919A (ja) | 2007-12-27 | 2008-12-19 | 修飾第ｉｘ因子 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20090176708A1 (https=) |
| EP (4) | EP2568041A1 (https=) |
| JP (1) | JP2011507919A (https=) |
| KR (1) | KR20100110799A (https=) |
| CN (1) | CN101952422A (https=) |
| AU (1) | AU2008342260B2 (https=) |
| CA (1) | CA2709960A1 (https=) |
| IL (1) | IL206095A0 (https=) |
| NZ (3) | NZ598193A (https=) |
| RU (1) | RU2010131189A (https=) |
| WO (1) | WO2009083187A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2353588B1 (en) | 2010-01-21 | 2015-04-15 | Agricultural Technology Research Institute | A sustained release preparation of factor IX |
| AR095527A1 (es) | 2013-03-15 | 2015-10-21 | Biogen Idec Inc | Formulaciones de polipéptido fc-factor ix |
| AR099340A1 (es) * | 2014-02-12 | 2016-07-13 | Novo Nordisk As | Conjugados del factor de coagulación ix |
| EA202092926A3 (ru) | 2014-03-24 | 2021-10-29 | Биовератив Терапьютикс Инк. | Лиофилизированные составы, содержащие фактор ix |
| CN114729317A (zh) | 2019-11-29 | 2022-07-08 | 新泽西鲁特格斯州立大学 | 脐带血血浆制品、组织和细胞外泌体的分离方法，其组合物及使用方法 |
| CN114786481A (zh) * | 2019-11-29 | 2022-07-22 | 新泽西鲁特格斯州立大学 | 用于储存血液制品的组合物、试剂盒和方法及其使用方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS538750B2 (https=) | 1971-08-18 | 1978-03-31 | ||
| AT348548B (de) | 1977-04-08 | 1979-02-26 | Laevosan Gmbh & Co Kg | Verfahren zur herstellung von alsblutplasma- expander geeignerter hydroxyaethylstaerke |
| US5614500A (en) * | 1983-03-04 | 1997-03-25 | The Scripps Research Institute | Compositions containing highly purified factor IX proteins prepared by immunoaffinity chromatography |
| DE3313600A1 (de) | 1983-04-14 | 1984-10-18 | Laevosan-Gesellschaft mbH & Co. KG, Linz | Plasmastreckmittel auf staerkebasis und verfahren zu ihrer herstellung |
| DE19975071I2 (de) | 1989-06-16 | 2000-02-03 | Fresenius Ag | Hydroxyethylstaerke als Plasmaexpander Verfahren zu ihrer Herstellung und Verwendung als kolloidales Plasmaersatzmittel |
| FR2702160B1 (fr) | 1993-03-02 | 1995-06-02 | Biovecteurs As | Vecteurs particulaires synthétiques et procédé de préparation. |
| DE4310974C2 (de) | 1993-04-03 | 1996-08-01 | Fresenius Ag | Verwendung von Hydroxyethylstärke zur Verbesserung der Mikrozirkulation |
| FR2704145B1 (fr) | 1993-04-21 | 1995-07-21 | Pasteur Institut | Vecteur particulaire et composition pharmaceutique le contenant. |
| US5621039A (en) * | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| FR2723849B1 (fr) | 1994-08-31 | 1997-04-11 | Biovector Therapeutics Sa | Procede pour augmenter l'immunogenicite, produit obtenu et composition pharmaceutique |
| BR9807936A (pt) * | 1997-04-08 | 2000-02-22 | Baxter Ag | Preparação farmacêutica imuno-tolerante de complexo de pró-trombina, processo para a produção de uma preparação, e, utilização de uma preparação |
| US7179617B2 (en) * | 2001-10-10 | 2007-02-20 | Neose Technologies, Inc. | Factor IX: remolding and glycoconjugation of Factor IX |
| CA2521784C (en) | 2003-04-08 | 2012-03-27 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
| WO2005014655A2 (en) * | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
| AU2004296860B2 (en) * | 2003-12-03 | 2010-04-22 | Novo Nordisk A/S | Glycopegylated factor IX |
| US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| DE502005001896D1 (en) | 2004-03-01 | 2007-12-20 | Braun Melsungen Ag | Hydroxyethylstärke |
| TWI417303B (zh) * | 2004-03-11 | 2013-12-01 | Fresenius Kabi De Gmbh | 經由還原胺化作用製得之羥烷基澱粉及蛋白質的接合物 |
| ATE469216T1 (de) * | 2004-08-17 | 2010-06-15 | Csl Behring Gmbh | Modifizierte vitamin-k-abhängige polypeptide |
| AU2006222187A1 (en) * | 2005-03-11 | 2006-09-14 | Fresenius Kabi Deutschland Gmbh | Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch |
| US7375084B2 (en) * | 2006-03-07 | 2008-05-20 | Baxter International Inc. | Highly phosphorylated and sulfated recombinant factor IX |
| EP1999097B1 (en) | 2006-03-29 | 2011-12-21 | DSM IP Assets B.V. | Curcumin synthesis |
| EP2423305A1 (en) * | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modified coagulation factor IX polypeptides and use thereof for treatment |
| CA2689557C (en) * | 2007-06-15 | 2018-08-14 | National Research Council Of Canada | Engineered versions of polysialyltransferases with enhanced enzymatic properties |
-
2008
- 2008-12-19 NZ NZ598193A patent/NZ598193A/xx not_active IP Right Cessation
- 2008-12-19 EP EP12008214A patent/EP2568041A1/en not_active Withdrawn
- 2008-12-19 RU RU2010131189/10A patent/RU2010131189A/ru not_active Application Discontinuation
- 2008-12-19 CA CA2709960A patent/CA2709960A1/en not_active Abandoned
- 2008-12-19 CN CN2008801232530A patent/CN101952422A/zh active Pending
- 2008-12-19 WO PCT/EP2008/010925 patent/WO2009083187A1/en not_active Ceased
- 2008-12-19 NZ NZ585835A patent/NZ585835A/en not_active IP Right Cessation
- 2008-12-19 NZ NZ603997A patent/NZ603997A/xx not_active IP Right Cessation
- 2008-12-19 EP EP08868384A patent/EP2247723A1/en not_active Withdrawn
- 2008-12-19 AU AU2008342260A patent/AU2008342260B2/en not_active Expired - Fee Related
- 2008-12-19 EP EP12008215A patent/EP2568042A1/en not_active Withdrawn
- 2008-12-19 US US12/339,619 patent/US20090176708A1/en not_active Abandoned
- 2008-12-19 JP JP2010540056A patent/JP2011507919A/ja active Pending
- 2008-12-19 KR KR1020107014071A patent/KR20100110799A/ko not_active Ceased
- 2008-12-19 EP EP12008216A patent/EP2568043A1/en not_active Withdrawn
-
2010
- 2010-05-31 IL IL206095A patent/IL206095A0/en unknown
-
2011
- 2011-12-29 US US13/339,823 patent/US20120177625A1/en not_active Abandoned
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