JP2011505349A5 - - Google Patents

Info

Publication number

JP2011505349A5

JP2011505349A5 JP2010535473A JP2010535473A JP2011505349A5 JP 2011505349 A5 JP2011505349 A5 JP 2011505349A5 JP 2010535473 A JP2010535473 A JP 2010535473A JP 2010535473 A JP2010535473 A JP 2010535473A JP 2011505349 A5 JP2011505349 A5 JP 2011505349A5

Authority

JP

Japan

Prior art keywords

composition according

strain

composition

bacteria

mast cells

Prior art date

2008-12-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000000203 mixture Substances 0.000 claims 23
• 210000003630 histaminocyte Anatomy 0.000 claims 16
• 241000894006 Bacteria Species 0.000 claims 9
• 230000001580 bacterial effect Effects 0.000 claims 8
• 230000020411 cell activation Effects 0.000 claims 5
• 230000002265 prevention Effects 0.000 claims 5
• 238000000034 method Methods 0.000 claims 4
• 238000012216 screening Methods 0.000 claims 4
• 230000004913 activation Effects 0.000 claims 3
• 230000002401 inhibitory effect Effects 0.000 claims 3
• 241000186012 Bifidobacterium breve Species 0.000 claims 2
• 206010020751 Hypersensitivity Diseases 0.000 claims 2
• 241000194036 Lactococcus Species 0.000 claims 2
• 208000026935 allergic disease Diseases 0.000 claims 2
• 230000007815 allergy Effects 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 239000006166 lysate Substances 0.000 claims 2
• LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• PHEDXBVPIONUQT-UHFFFAOYSA-N Cocarcinogen A1 Natural products CCCCCCCCCCCCCC(=O)OC1C(C)C2(O)C3C=C(C)C(=O)C3(O)CC(CO)=CC2C2C1(OC(C)=O)C2(C)C PHEDXBVPIONUQT-UHFFFAOYSA-N 0.000 claims 1
• 235000013960 Lactobacillus bulgaricus Nutrition 0.000 claims 1
• 244000199866 Lactobacillus casei Species 0.000 claims 1
• 235000013958 Lactobacillus casei Nutrition 0.000 claims 1
• 241000186672 Lactobacillus delbrueckii subsp. bulgaricus Species 0.000 claims 1
• 241000194017 Streptococcus Species 0.000 claims 1
• HATRDXDCPOXQJX-UHFFFAOYSA-N Thapsigargin Natural products CCCCCCCC(=O)OC1C(OC(O)C(=C/C)C)C(=C2C3OC(=O)C(C)(O)C3(O)C(CC(C)(OC(=O)C)C12)OC(=O)CCC)C HATRDXDCPOXQJX-UHFFFAOYSA-N 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 239000012190 activator Substances 0.000 claims 1
• 102000007478 beta-N-Acetylhexosaminidases Human genes 0.000 claims 1
• 108010085377 beta-N-Acetylhexosaminidases Proteins 0.000 claims 1
• 239000003710 calcium ionophore Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 235000015872 dietary supplement Nutrition 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• CJAONIOAQZUHPN-KKLWWLSJSA-N ethyl 12-[[2-[(2r,3r)-3-[2-[(12-ethoxy-12-oxododecyl)-methylamino]-2-oxoethoxy]butan-2-yl]oxyacetyl]-methylamino]dodecanoate Chemical compound CCOC(=O)CCCCCCCCCCCN(C)C(=O)CO[C@H](C)[C@@H](C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC CJAONIOAQZUHPN-KKLWWLSJSA-N 0.000 claims 1
• 230000037406 food intake Effects 0.000 claims 1
• 235000013376 functional food Nutrition 0.000 claims 1
• PGHMRUGBZOYCAA-UHFFFAOYSA-N ionomycin Natural products O1C(CC(O)C(C)C(O)C(C)C=CCC(C)CC(C)C(O)=CC(=O)C(C)CC(C)CC(CCC(O)=O)C)CCC1(C)C1OC(C)(C(C)O)CC1 PGHMRUGBZOYCAA-UHFFFAOYSA-N 0.000 claims 1
• PGHMRUGBZOYCAA-ADZNBVRBSA-N ionomycin Chemical compound O1[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)C(/O)=C/C(=O)[C@@H](C)C[C@@H](C)C[C@@H](CCC(O)=O)C)CC[C@@]1(C)[C@@H]1O[C@](C)([C@@H](C)O)CC1 PGHMRUGBZOYCAA-ADZNBVRBSA-N 0.000 claims 1
• 229940004208 lactobacillus bulgaricus Drugs 0.000 claims 1
• 229940017800 lactobacillus casei Drugs 0.000 claims 1
• PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 claims 1
• 239000000047 product Substances 0.000 claims 1
• 229960005322 streptomycin Drugs 0.000 claims 1
• IXFPJGBNCFXKPI-FSIHEZPISA-N thapsigargin Chemical compound CCCC(=O)O[C@H]1C[C@](C)(OC(C)=O)[C@H]2[C@H](OC(=O)CCCCCCC)[C@@H](OC(=O)C(\C)=C/C)C(C)=C2[C@@H]2OC(=O)[C@@](C)(O)[C@]21O IXFPJGBNCFXKPI-FSIHEZPISA-N 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1