JP2011505336A5 - - Google Patents
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- Publication number
- JP2011505336A5 JP2011505336A5 JP2010532071A JP2010532071A JP2011505336A5 JP 2011505336 A5 JP2011505336 A5 JP 2011505336A5 JP 2010532071 A JP2010532071 A JP 2010532071A JP 2010532071 A JP2010532071 A JP 2010532071A JP 2011505336 A5 JP2011505336 A5 JP 2011505336A5
- Authority
- JP
- Japan
- Prior art keywords
- azacytidine
- pharmaceutical composition
- composition according
- aza
- deoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98463807P | 2007-11-01 | 2007-11-01 | |
| US99278107P | 2007-12-06 | 2007-12-06 | |
| US3409308P | 2008-03-05 | 2008-03-05 | |
| US8606908P | 2008-08-04 | 2008-08-04 | |
| US9085208P | 2008-08-21 | 2008-08-21 | |
| PCT/US2008/012430 WO2009058394A1 (en) | 2007-11-01 | 2008-11-03 | Cytidine analogs for treatment of myelodysplastic syndromes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011505336A JP2011505336A (ja) | 2011-02-24 |
| JP2011505336A5 true JP2011505336A5 (enExample) | 2011-12-22 |
Family
ID=40367738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532071A Pending JP2011505336A (ja) | 2007-11-01 | 2008-11-03 | 骨髄異形成症候群治療のためのシチジンアナログ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100311683A1 (enExample) |
| EP (1) | EP2211870A1 (enExample) |
| JP (1) | JP2011505336A (enExample) |
| CA (1) | CA2742252A1 (enExample) |
| WO (1) | WO2009058394A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8404716B2 (en) | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US11116782B2 (en) | 2002-10-15 | 2021-09-14 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US6943249B2 (en) * | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
| US6887855B2 (en) | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
| JP5095216B2 (ja) | 2003-11-14 | 2012-12-12 | ローラス セラピューティクス インコーポレーテッド | アリールイミダゾールおよびその抗癌剤としての使用 |
| US8846628B2 (en) | 2008-05-15 | 2014-09-30 | Celgene Corporation | Oral formulations of cytidine analogs and methods of use thereof |
| CA2789365A1 (en) | 2009-02-10 | 2010-08-19 | Celgene International Sarl | Methods for treating non-small cell lung cancer using 5-azacytidine |
| KR20140019820A (ko) | 2011-03-31 | 2014-02-17 | 셀진 인터내셔널 에스에이알엘 | 5-아자시티딘의 합성 |
| WO2013022872A1 (en) * | 2011-08-10 | 2013-02-14 | Celgene Corporation | Gene methylation biomarkers and methods of use thereof |
| BR112014010417A2 (pt) | 2011-11-01 | 2014-11-18 | Celgene Corp | Métodos para o tratamento de cânceres com o uso de formulações orais de análogos de citidina |
| JP6231988B2 (ja) | 2011-11-03 | 2017-11-15 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｎｅｄｄ８活性化酵素阻害剤および低メチル化剤の投与 |
| US9493500B2 (en) * | 2012-07-19 | 2016-11-15 | Richard Daifuku | Fluorinated pyrimidine analogs and methods of use thereof |
| AU2013381886B2 (en) * | 2013-03-15 | 2018-08-16 | Epigenetics Pharma Llc | Fluorinated pyrimidine analogs and methods of use thereof |
| WO2015051302A1 (en) * | 2013-10-04 | 2015-04-09 | Aptose Biosciences Inc. | Compositions and methods for treating cancers |
| LT3182996T (lt) | 2014-08-22 | 2023-03-10 | Celgene Corporation | Daugybinės mielomos gydymo būdai imunomoduliuojančiais junginiais derinyje su antikūnais |
| EP3419631A4 (en) * | 2016-02-26 | 2019-12-04 | Epigenetics Pharma, LLC | METHOD OF TREATING WILD TYPE TP53 TUMORS USING 2 ', 2'-DIFLUORO-5-AZA-2'-DEOXYCYTIDINE OR PRODRUGS THEREOF |
| WO2017189647A1 (en) * | 2016-04-26 | 2017-11-02 | Memorial Sloan Kettering Cancer Center | Methods and compositions for the treatment of myelodysplastic syndrome |
| JP2021501203A (ja) | 2017-10-30 | 2021-01-14 | アプトース バイオサイエンシズ インコーポレイテッド | がん治療用のアリールイミダゾール |
| GB201917899D0 (en) * | 2019-12-06 | 2020-01-22 | Nanexa Ab | New composition |
| KR20230097089A (ko) * | 2020-10-27 | 2023-06-30 | 보르 바이오파마 인크. | 조혈 악성종양을 치료하기 위한 조성물 및 방법 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641758A (en) * | 1993-11-10 | 1997-06-24 | Kluge; Michael | Cytarabine derivatives, the preparation and use thereof |
| US6096757A (en) * | 1998-12-21 | 2000-08-01 | Schering Corporation | Method for treating proliferative diseases |
| AU771015B2 (en) * | 1999-03-18 | 2004-03-11 | Celgene Corporation | Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels |
| DE60118571T2 (de) * | 2000-05-15 | 2007-02-01 | Celgene Corp. | Pharmazeutische zusammensetzungen zur behandlung von krebs welche thalidomid und topoisomerase inhibitoren enthalten |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US7393862B2 (en) * | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
| AU2003231950A1 (en) * | 2002-05-30 | 2003-12-19 | Celgene Corporation | Modulating cell differentiation and treating myeloproliferative disorders with JNK/MKK inhibitors |
| US7189740B2 (en) * | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| MXPA05003889A (es) * | 2002-10-15 | 2005-06-22 | Celgene Corp | Farmacos inhibidores de citosina selectiva para tratar sindrome mielodisplastico. |
| CA2503150A1 (en) * | 2002-10-31 | 2004-05-21 | Supergen, Inc. | Pharmaceutical formulations targeting specific regions of the gastrointestinal tract |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US20040152632A1 (en) * | 2002-11-06 | 2004-08-05 | Wyeth | Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome |
| US6887855B2 (en) * | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
| US6943249B2 (en) * | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
| KR101164696B1 (ko) * | 2004-04-14 | 2012-07-11 | 셀진 코포레이션 | 골수이형성 증후군의 치료 및 관리를 위한 면역조절화합물의 사용 방법 및 상기 화합물을 포함하는 조성물 |
| AU2004319759A1 (en) * | 2004-04-14 | 2005-11-24 | Celgene Corporation | Use of selective cytokine inhibitory drugs in myelodysplastic syndromes |
| US20060128654A1 (en) * | 2004-12-10 | 2006-06-15 | Chunlin Tang | Pharmaceutical formulation of cytidine analogs and derivatives |
| EP2043633B1 (en) * | 2006-07-18 | 2016-07-06 | University of Rochester | Thiadiazolidinone derivatives for treating cancer |
| WO2008027049A1 (en) * | 2006-08-30 | 2008-03-06 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
| WO2008028193A2 (en) * | 2006-09-01 | 2008-03-06 | Pharmion Corporation | Colon-targeted oral formulations of cytidine analogs |
| US8846628B2 (en) * | 2008-05-15 | 2014-09-30 | Celgene Corporation | Oral formulations of cytidine analogs and methods of use thereof |
-
2008
- 2008-11-03 US US12/740,636 patent/US20100311683A1/en not_active Abandoned
- 2008-11-03 CA CA2742252A patent/CA2742252A1/en not_active Abandoned
- 2008-11-03 JP JP2010532071A patent/JP2011505336A/ja active Pending
- 2008-11-03 EP EP08845256A patent/EP2211870A1/en not_active Withdrawn
- 2008-11-03 WO PCT/US2008/012430 patent/WO2009058394A1/en not_active Ceased