JP2011504108A5 - - Google Patents

Info

Publication number

JP2011504108A5

JP2011504108A5 JP2010534507A JP2010534507A JP2011504108A5 JP 2011504108 A5 JP2011504108 A5 JP 2011504108A5 JP 2010534507 A JP2010534507 A JP 2010534507A JP 2010534507 A JP2010534507 A JP 2010534507A JP 2011504108 A5 JP2011504108 A5 JP 2011504108A5

Authority

JP

Japan

Prior art keywords

peptide

phe

fusion protein

cancer

seq

Prior art date

2008-11-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 28
• 108020001507 fusion proteins Proteins 0.000 claims 11
• 102000037865 fusion proteins Human genes 0.000 claims 11
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 125000003275 alpha amino acid group Chemical group 0.000 claims 7
• 201000010099 disease Diseases 0.000 claims 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
• 102000039446 nucleic acids Human genes 0.000 claims 6
• 108020004707 nucleic acids Proteins 0.000 claims 6
• 150000007523 nucleic acids Chemical class 0.000 claims 6
• 208000015181 infectious disease Diseases 0.000 claims 5
• 230000001613 neoplastic effect Effects 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 4
• 230000002068 genetic effect Effects 0.000 claims 4
• 208000035473 Communicable disease Diseases 0.000 claims 3
• 150000001413 amino acids Chemical class 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 102100027581 Forkhead box protein P3 Human genes 0.000 claims 2
• 101710088098 Forkhead box protein P3 Proteins 0.000 claims 2
• 206010043276 Teratoma Diseases 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000003200 Adenoma Diseases 0.000 claims 1
• 206010001233 Adenoma benign Diseases 0.000 claims 1
• 208000035143 Bacterial infection Diseases 0.000 claims 1
• 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
• 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 201000009030 Carcinoma Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
• 206010017533 Fungal infection Diseases 0.000 claims 1
• 241000711549 Hepacivirus C Species 0.000 claims 1
• 241000700721 Hepatitis B virus Species 0.000 claims 1
• 208000017604 Hodgkin disease Diseases 0.000 claims 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 206010024612 Lipoma Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 208000031888 Mycoses Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000007256 Nevus Diseases 0.000 claims 1
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 208000030852 Parasitic disease Diseases 0.000 claims 1
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 206010038389 Renal cancer Diseases 0.000 claims 1
• 206010039491 Sarcoma Diseases 0.000 claims 1
• 101800001707 Spacer peptide Proteins 0.000 claims 1
• 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
• 208000036142 Viral infection Diseases 0.000 claims 1
• 208000022362 bacterial infectious disease Diseases 0.000 claims 1
• 230000004071 biological effect Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 239000002552 dosage form Substances 0.000 claims 1
• 201000004101 esophageal cancer Diseases 0.000 claims 1
• 201000010536 head and neck cancer Diseases 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 201000011066 hemangioma Diseases 0.000 claims 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
• 208000023525 immature teratoma Diseases 0.000 claims 1
• 230000001506 immunosuppresive effect Effects 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 230000003834 intracellular effect Effects 0.000 claims 1
• 238000002955 isolation Methods 0.000 claims 1
• 201000010982 kidney cancer Diseases 0.000 claims 1
• 201000010260 leiomyoma Diseases 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 210000004698 lymphocyte Anatomy 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 201000000289 malignant teratoma Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 201000000271 mature teratoma Diseases 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 201000000050 myeloid neoplasm Diseases 0.000 claims 1
• 208000008798 osteoma Diseases 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 208000003154 papilloma Diseases 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 208000017572 squamous cell neoplasm Diseases 0.000 claims 1
• 206010046766 uterine cancer Diseases 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1