JP2011503213A5 - - Google Patents
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- Publication number
- JP2011503213A5 JP2011503213A5 JP2010534273A JP2010534273A JP2011503213A5 JP 2011503213 A5 JP2011503213 A5 JP 2011503213A5 JP 2010534273 A JP2010534273 A JP 2010534273A JP 2010534273 A JP2010534273 A JP 2010534273A JP 2011503213 A5 JP2011503213 A5 JP 2011503213A5
- Authority
- JP
- Japan
- Prior art keywords
- microparticles
- group
- composition
- anesthetic
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011859 microparticle Substances 0.000 claims description 141
- 239000000203 mixture Substances 0.000 claims description 84
- 230000003444 anaesthetic effect Effects 0.000 claims description 61
- 229920000642 polymer Polymers 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 41
- 238000011068 loading method Methods 0.000 claims description 32
- 239000002245 particle Substances 0.000 claims description 27
- 229940079593 drug Drugs 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 21
- 239000003623 enhancer Substances 0.000 claims description 19
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 17
- 229960004194 lidocaine Drugs 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 16
- 239000003589 local anesthetic agent Substances 0.000 claims description 16
- 208000002193 Pain Diseases 0.000 claims description 12
- 239000003193 general anesthetic agent Substances 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims description 6
- 229940035674 anesthetics Drugs 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 4
- 241001494479 Pecora Species 0.000 claims description 2
- 239000012736 aqueous medium Substances 0.000 claims description 2
- 230000001804 emulsifying effect Effects 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 229960005015 local anesthetics Drugs 0.000 claims description 2
- 239000002609 medium Substances 0.000 claims description 2
- 239000007764 o/w emulsion Substances 0.000 claims description 2
- 230000001953 sensory effect Effects 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98909807P | 2007-11-19 | 2007-11-19 | |
| PCT/US2008/083940 WO2009067462A1 (en) | 2007-11-19 | 2008-11-18 | Prolonged release of local anesthetics using microparticles and surgery applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011503213A JP2011503213A (ja) | 2011-01-27 |
| JP2011503213A5 true JP2011503213A5 (cg-RX-API-DMAC7.html) | 2012-01-12 |
Family
ID=40667837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534273A Pending JP2011503213A (ja) | 2007-11-19 | 2008-11-18 | マイクロ粒子を使用する局所麻酔薬の持続放出および手術適用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20110081422A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2222284B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2011503213A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2705201C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009067462A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103619886B (zh) | 2011-06-29 | 2016-09-14 | 柯惠Lp公司 | 氧化纤维素的溶解 |
| US9271937B2 (en) | 2012-05-31 | 2016-03-01 | Covidien Lp | Oxidized cellulose microspheres |
| US10413566B2 (en) | 2013-03-15 | 2019-09-17 | Covidien Lp | Thixotropic oxidized cellulose solutions and medical applications thereof |
| US20150024031A1 (en) * | 2013-07-17 | 2015-01-22 | Baxter International Inc. | Methods And Compositions For Reducing Pain, Inflammation, And/Or Immunological Reactions Associated With Parenterally Administering A Primary Therapeutic Agent |
| EP2990033A1 (fr) * | 2014-08-26 | 2016-03-02 | Carlina Technologies | Procédé de préparation de nanoprécipites de peptide ou protéine de faible poids moléculaire |
| US10449152B2 (en) * | 2014-09-26 | 2019-10-22 | Covidien Lp | Drug loaded microspheres for post-operative chronic pain |
| GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| GB2551944B (en) | 2015-12-18 | 2021-09-01 | Midatech Pharma Wales Ltd | Microparticle production process and apparatus |
| GB2594652B (en) * | 2015-12-18 | 2022-05-04 | Midatech Pharma Wales Ltd | Microparticle liquid stream |
| JP2020536955A (ja) | 2017-10-06 | 2020-12-17 | ファウンドリー セラピューティクス， インコーポレイテッド | 治療剤の制御放出のための埋込み可能なデポー |
| EP3737433A1 (en) | 2018-01-08 | 2020-11-18 | Foundry Therapeutics, Inc. | Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents |
| EP3793536A1 (en) | 2018-05-12 | 2021-03-24 | Foundry Therapeutics, Inc. | Implantable polymer depots for the controlled release of therapeutic agents |
| WO2020047013A1 (en) | 2018-08-28 | 2020-03-05 | Foundry Therapeutics, Inc. | Polymer implants |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4728512A (en) * | 1985-05-06 | 1988-03-01 | American Home Products Corporation | Formulations providing three distinct releases |
| US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| US5922340A (en) * | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| EP1132080A3 (en) * | 1992-09-10 | 2001-10-17 | Children's Medical Center Corporation | Biodegradable polymer matrices for sustained delivery of local anesthetic agents |
| ATE212830T1 (de) * | 1993-11-19 | 2002-02-15 | Alkermes Inc | Herstellung biologisch abbaubarer, einen biologisch aktiven stoff enthaltender, mikropartikel |
| AUPN605795A0 (en) * | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
| EP0954301A4 (en) * | 1996-06-24 | 2006-03-08 | Euro Celtique Sa | SAFE METHODS OF LOCAL ANESTHESIA |
| BR9815499A (pt) * | 1997-07-02 | 2001-01-02 | Euro Celtique Sa | Anestesia prolongada nas juntas e nos espacos corporais. |
| US6451335B1 (en) * | 1998-07-02 | 2002-09-17 | Euro-Celtique S.A. | Formulations and methods for providing prolonged local anesthesia |
| KR100392501B1 (ko) * | 2000-06-28 | 2003-07-22 | 동국제약 주식회사 | 다중 에멀젼법에 의한 서방출성 미립구의 제조방법 |
| EP1363602A4 (en) * | 2001-01-25 | 2006-01-11 | Euro Celtique Sa | LOCAL ANESTHESIA, AND METHOD OF USE |
| US8846068B2 (en) * | 2008-04-18 | 2014-09-30 | Warsaw Orthopedic, Inc. | Methods and compositions for treating post-operative pain comprising a local anesthetic |
-
2008
- 2008-11-18 US US12/676,819 patent/US20110081422A1/en not_active Abandoned
- 2008-11-18 WO PCT/US2008/083940 patent/WO2009067462A1/en not_active Ceased
- 2008-11-18 JP JP2010534273A patent/JP2011503213A/ja active Pending
- 2008-11-18 CA CA2705201A patent/CA2705201C/en active Active
- 2008-11-18 EP EP08852557.1A patent/EP2222284B1/en active Active
-
2019
- 2019-08-23 US US16/549,701 patent/US20200085732A1/en active Pending
-
2021
- 2021-01-19 US US17/152,659 patent/US20210212934A1/en active Pending
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