JP2011503212A5 - - Google Patents
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- Publication number
- JP2011503212A5 JP2011503212A5 JP2010534267A JP2010534267A JP2011503212A5 JP 2011503212 A5 JP2011503212 A5 JP 2011503212A5 JP 2010534267 A JP2010534267 A JP 2010534267A JP 2010534267 A JP2010534267 A JP 2010534267A JP 2011503212 A5 JP2011503212 A5 JP 2011503212A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- tissue
- nitrite
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 28
- 210000001519 tissue Anatomy 0.000 claims 11
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims 7
- 230000000302 ischemic effect Effects 0.000 claims 7
- 208000028867 ischemia Diseases 0.000 claims 4
- 206010052428 Wound Diseases 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 210000004204 blood vessel Anatomy 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 206010022562 Intermittent claudication Diseases 0.000 claims 2
- 210000002808 connective tissue Anatomy 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical group [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 230000029663 wound healing Effects 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 206010017076 Fracture Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- AZFNGPAYDKGCRB-XCPIVNJJSA-M [(1s,2s)-2-amino-1,2-diphenylethyl]-(4-methylphenyl)sulfonylazanide;chlororuthenium(1+);1-methyl-4-propan-2-ylbenzene Chemical compound [Ru+]Cl.CC(C)C1=CC=C(C)C=C1.C1=CC(C)=CC=C1S(=O)(=O)[N-][C@@H](C=1C=CC=CC=1)[C@@H](N)C1=CC=CC=C1 AZFNGPAYDKGCRB-XCPIVNJJSA-M 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 229910001959 inorganic nitrate Inorganic materials 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 208000023589 ischemic disease Diseases 0.000 claims 1
- 208000030175 lameness Diseases 0.000 claims 1
- 201000002818 limb ischemia Diseases 0.000 claims 1
- 230000036244 malformation Effects 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 210000000944 nerve tissue Anatomy 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- RAFRTSDUWORDLA-UHFFFAOYSA-N phenyl 3-chloropropanoate Chemical compound ClCCC(=O)OC1=CC=CC=C1 RAFRTSDUWORDLA-UHFFFAOYSA-N 0.000 claims 1
- 235000010289 potassium nitrite Nutrition 0.000 claims 1
- 239000004304 potassium nitrite Substances 0.000 claims 1
- 230000000284 resting effect Effects 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 235000010288 sodium nitrite Nutrition 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000008736 traumatic injury Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US315007P | 2007-11-15 | 2007-11-15 | |
| US61/003,150 | 2007-11-15 | ||
| PCT/US2008/083830 WO2009065142A2 (en) | 2007-11-15 | 2008-11-17 | Use of nitrite salts in chronic ischemia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014097072A Division JP5908527B2 (ja) | 2007-11-15 | 2014-05-08 | 慢性虚血における亜硝酸塩の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011503212A JP2011503212A (ja) | 2011-01-27 |
| JP2011503212A5 true JP2011503212A5 (https=) | 2012-02-16 |
| JP5795165B2 JP5795165B2 (ja) | 2015-10-14 |
Family
ID=40639493
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534267A Active JP5795165B2 (ja) | 2007-11-15 | 2008-11-17 | 慢性虚血における亜硝酸塩の使用 |
| JP2014097072A Expired - Fee Related JP5908527B2 (ja) | 2007-11-15 | 2014-05-08 | 慢性虚血における亜硝酸塩の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014097072A Expired - Fee Related JP5908527B2 (ja) | 2007-11-15 | 2014-05-08 | 慢性虚血における亜硝酸塩の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9649334B2 (https=) |
| EP (1) | EP2219657A4 (https=) |
| JP (2) | JP5795165B2 (https=) |
| CN (1) | CN101939014B (https=) |
| AU (1) | AU2008322437B2 (https=) |
| IL (1) | IL205720A (https=) |
| WO (1) | WO2009065142A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008322437B2 (en) | 2007-11-15 | 2013-11-07 | Louisiana State University | Use of nitrite salts in chronic ischemia |
| US8568793B2 (en) * | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| US20120237617A1 (en) | 2009-06-18 | 2012-09-20 | Theravasc Inc. | Use of nitrite salts in treating tissue damage |
| US20130209584A1 (en) * | 2009-10-14 | 2013-08-15 | Theravasc Inc. | Pharmaceutical formulations of nitrite and uses thereof |
| ES2633618T3 (es) | 2009-10-14 | 2017-09-22 | Theravasc Inc. | Formulaciones farmacéuticas de nitrito y sus usos |
| WO2014130691A2 (en) * | 2013-02-20 | 2014-08-28 | Theravasc Inc. | Pharmaceutical formulations of nitrite and uses thereof |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| ES2968200T3 (es) | 2016-01-27 | 2024-05-08 | Syk Tech Llc | Aparato y métodos de aplicación tópica de óxido nítrico |
| JP7333919B2 (ja) | 2017-09-05 | 2023-08-28 | エクセル メッド、エルエルシー | 虚血を治療するためのヘパリン組成物 |
| PH12021551384A1 (en) | 2019-01-02 | 2022-03-28 | Celagenex Res India Pvt Ltd | Synergistic nutritional compositions for pain management |
| US12459820B2 (en) | 2020-06-11 | 2025-11-04 | J. W. Randolph Miller | Stabilized and NO2-inhibited nitric oxide generating gels for inhaled nitric oxide therapy |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2914446A (en) | 1958-06-26 | 1959-11-24 | Upjohn Co | Nitrite stabilized ascorbic acid-cyanocobalamin compositions |
| US4650484A (en) | 1983-02-03 | 1987-03-17 | Alza Corporation | Method for treating ischemic conditions |
| IE64726B1 (en) | 1987-11-20 | 1995-08-23 | Elan Corp Plc | Pharmaceutical formulations for preventing drug tolerance |
| US5122384A (en) | 1989-05-05 | 1992-06-16 | Kv Pharmaceutical Company | Oral once-per-day organic nitrate formulation which does not induce tolerance |
| US5278192A (en) | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
| US6709681B2 (en) | 1995-02-17 | 2004-03-23 | Aberdeen University | Acidified nitrite as an antimicrobial agent |
| US20110196039A9 (en) | 1994-10-05 | 2011-08-11 | Kaesemeyer Wayne H | Controlled release arginine formulations |
| US5648101A (en) * | 1994-11-14 | 1997-07-15 | Tawashi; Rashad | Drug delivery of nitric oxide |
| US5770645A (en) | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US5994444A (en) | 1997-10-16 | 1999-11-30 | Medtronic, Inc. | Polymeric material that releases nitric oxide |
| US7371415B1 (en) | 1998-04-03 | 2008-05-13 | The Daily Wellness Company | Method and composition for improving sexual fitness |
| US7015876B1 (en) | 1998-06-03 | 2006-03-21 | Lear Corporation | Heads-up display with improved contrast |
| US6103275A (en) * | 1998-06-10 | 2000-08-15 | Nitric Oxide Solutions | Systems and methods for topical treatment with nitric oxide |
| WO2000003725A1 (en) | 1998-07-14 | 2000-01-27 | Paracelsian, Inc. | Method for identifying and confirming consistent bio-functionality of natural compositions |
| DE59905248D1 (de) | 1999-01-29 | 2003-05-28 | Disphar Int Bv | Pharmazeutische zusammensetzungen |
| GB9905425D0 (en) | 1999-03-09 | 1999-05-05 | Queen Mary & Westfield College | Pharmaceutical composition |
| US6314956B1 (en) | 1999-09-08 | 2001-11-13 | Duke University | Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders |
| WO2002009727A1 (en) * | 2000-07-28 | 2002-02-07 | Bioenergy, Inc. | Compositions and methods for improving cardiovascular function |
| GB0119011D0 (en) | 2001-08-03 | 2001-09-26 | Univ Aberdeen | Treatment of nail infections |
| EP1492509A1 (en) | 2001-12-18 | 2005-01-05 | ALZA Corporation | Dosage form providing time-varying patterns of drug delivery |
| EP1336602A1 (en) | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| CA2379211A1 (fr) | 2002-03-28 | 2003-09-28 | Institut De Cardiologie De Montreal | Utilisation du bleu de methylene pour renverser la reaction hemodynamique exageree induite par la combinaison d'un derive nitre et du sildenafil ou d'une molecule de meme classe (inhibiteur de la phosphodiesterase) |
| JP5564158B2 (ja) | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
| JP2007502831A (ja) | 2003-08-20 | 2007-02-15 | ニトロメッド インコーポレーティッド | ニトロソ化およびニトロシル化心血管化合物、組成物、ならびに使用方法 |
| US20050113409A1 (en) * | 2003-09-03 | 2005-05-26 | Pharmacia Corporation | Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith |
| US7362274B1 (en) * | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
| US20060083824A1 (en) | 2004-10-20 | 2006-04-20 | Pbm Products Llc | Nutritional supplements for glucose intolerant individuals |
| CN101227916A (zh) | 2005-05-24 | 2008-07-23 | 维尔金有限公司 | 预防和治疗发炎相关状况的组合物和方法 |
| BRPI0621321A2 (pt) | 2006-02-10 | 2011-12-06 | Mannatech Inc | formulações de suplemento dietético de multivitamìnico e multimineral natural para melhor absorção e utilização biológica |
| GB0607402D0 (en) * | 2006-04-12 | 2006-05-24 | Barts & London Nhs Trust | Therapeutic composition and use |
| US8333997B2 (en) * | 2006-06-21 | 2012-12-18 | Albert Einstein College Of Medicine Of Yeshiva University | Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof |
| KR20100014853A (ko) * | 2007-02-26 | 2010-02-11 | 존 런드버그 | 아질산염 및 질산염의 신규 용도 및 이를 함유하는 조성물 |
| DK2124638T3 (en) | 2007-02-26 | 2017-03-20 | Heartbeet Ltd | COMPOSITION INCREASING PERFORMANCE AND USING IT |
| WO2008153762A2 (en) | 2007-05-25 | 2008-12-18 | N30 Pharmaceuticals, Llc | S-nitrosothiol formulations and storage systems |
| AU2008322437B2 (en) | 2007-11-15 | 2013-11-07 | Louisiana State University | Use of nitrite salts in chronic ischemia |
| EP2237788A4 (en) | 2007-12-27 | 2013-06-05 | Aires Pharmaceuticals Inc | COMPOUNDS FOR OBTAINING AEROSOLIZED NITRITE AND NITRIC OXIDE AND USES THEREOF |
| WO2010036236A1 (en) | 2008-09-23 | 2010-04-01 | Baker Hughes Incorporated | Anchor assembly |
| US8568793B2 (en) | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| US20120237617A1 (en) | 2009-06-18 | 2012-09-20 | Theravasc Inc. | Use of nitrite salts in treating tissue damage |
| ES2633618T3 (es) | 2009-10-14 | 2017-09-22 | Theravasc Inc. | Formulaciones farmacéuticas de nitrito y sus usos |
| US20130209584A1 (en) | 2009-10-14 | 2013-08-15 | Theravasc Inc. | Pharmaceutical formulations of nitrite and uses thereof |
| US20140127329A1 (en) | 2011-03-31 | 2014-05-08 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Use of nitrites for the treatment of cerebral amyloid angiopathy, age associated dementia, and cognitive decline |
| US20140112983A1 (en) | 2011-04-14 | 2014-04-24 | Theravasc Inc. | Nitrite compositions and uses thereof |
| US9294956B2 (en) | 2011-12-29 | 2016-03-22 | Qualcomm Incorporated | Application-server-assisted preemptive multicast bearer establishment for real-time low-latency applications |
| WO2014130691A2 (en) * | 2013-02-20 | 2014-08-28 | Theravasc Inc. | Pharmaceutical formulations of nitrite and uses thereof |
-
2008
- 2008-11-17 AU AU2008322437A patent/AU2008322437B2/en not_active Ceased
- 2008-11-17 CN CN200880116483.4A patent/CN101939014B/zh not_active Expired - Fee Related
- 2008-11-17 EP EP08849380.4A patent/EP2219657A4/en not_active Withdrawn
- 2008-11-17 JP JP2010534267A patent/JP5795165B2/ja active Active
- 2008-11-17 WO PCT/US2008/083830 patent/WO2009065142A2/en not_active Ceased
- 2008-11-17 US US12/741,436 patent/US9649334B2/en active Active
-
2010
- 2010-05-12 IL IL205720A patent/IL205720A/en active IP Right Grant
-
2014
- 2014-05-08 JP JP2014097072A patent/JP5908527B2/ja not_active Expired - Fee Related
-
2017
- 2017-04-10 US US15/483,187 patent/US10864229B2/en active Active
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