JP2011502147A5 - - Google Patents
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- JP2011502147A5 JP2011502147A5 JP2010532037A JP2010532037A JP2011502147A5 JP 2011502147 A5 JP2011502147 A5 JP 2011502147A5 JP 2010532037 A JP2010532037 A JP 2010532037A JP 2010532037 A JP2010532037 A JP 2010532037A JP 2011502147 A5 JP2011502147 A5 JP 2011502147A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- pharmaceutical composition
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- contacting
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 17
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000002798 polar solvent Substances 0.000 claims 5
- 229940126062 Compound A Drugs 0.000 claims 4
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 4
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical group [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical group [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 2
- DNISYQIZVIFCRA-UHFFFAOYSA-N 4-(1-aminoethyl)-2,6-ditert-butylphenol Chemical compound CC(N)C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 DNISYQIZVIFCRA-UHFFFAOYSA-N 0.000 claims 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- DTMFCPVMRRFMQE-UHFFFAOYSA-N COc(c(OC)cc1ncc2)cc1c2Oc(cc1OCC2)ccc1N2C(Nc1n[o]c(CO)c1)=O Chemical compound COc(c(OC)cc1ncc2)cc1c2Oc(cc1OCC2)ccc1N2C(Nc1n[o]c(CO)c1)=O DTMFCPVMRRFMQE-UHFFFAOYSA-N 0.000 description 1
- 0 Cc1cc(NC(N(CCOc2c3)c2ccc3Oc2c(cc(*)c(OC)c3)c3ncc2)=*)n[o]1 Chemical compound Cc1cc(NC(N(CCOc2c3)c2ccc3Oc2c(cc(*)c(OC)c3)c3ncc2)=*)n[o]1 0.000 description 1
- DOKTUYMPPOUFNS-UHFFFAOYSA-N Cc1cc(NC(N(CCOc2c3)c2ccc3Oc2c(cc(c(O)c3)OC)c3ncc2)=O)n[o]1 Chemical compound Cc1cc(NC(N(CCOc2c3)c2ccc3Oc2c(cc(c(O)c3)OC)c3ncc2)=O)n[o]1 DOKTUYMPPOUFNS-UHFFFAOYSA-N 0.000 description 1
- QIIPQYDSKRYMFG-UHFFFAOYSA-N OC(Oc1ccccc1)=O Chemical compound OC(Oc1ccccc1)=O QIIPQYDSKRYMFG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94807P | 2007-10-29 | 2007-10-29 | |
| US61/000,948 | 2007-10-29 | ||
| PCT/US2008/012224 WO2009058267A2 (en) | 2007-10-29 | 2008-10-28 | Benzomorpholine derivatives and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011502147A JP2011502147A (ja) | 2011-01-20 |
| JP2011502147A5 true JP2011502147A5 (https=) | 2011-09-22 |
| JP5343082B2 JP5343082B2 (ja) | 2013-11-13 |
Family
ID=40394086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532037A Expired - Fee Related JP5343082B2 (ja) | 2007-10-29 | 2008-10-28 | ベンゾモルホリン誘導体および使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7795254B2 (https=) |
| EP (1) | EP2220078B1 (https=) |
| JP (1) | JP5343082B2 (https=) |
| AU (1) | AU2008319366B2 (https=) |
| CA (1) | CA2703257C (https=) |
| ES (1) | ES2417009T3 (https=) |
| MX (1) | MX2010004620A (https=) |
| WO (1) | WO2009058267A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH684182A5 (de) | 1991-10-15 | 1994-07-29 | Escher Wyss Ag | Rotationsdruckmaschine. |
| AU2011254657B2 (en) * | 2010-05-19 | 2016-02-04 | Sandoz Ag | Preparation of posaconazole intermediates |
| EP2571847B1 (en) | 2010-05-19 | 2016-09-21 | Sandoz AG | Process for the preparation of chiral hydrazides |
| JP5955837B2 (ja) | 2010-05-19 | 2016-07-20 | サンド・アクチエンゲゼルシヤフト | ポサコナゾール及びポサコナゾール中間体の精製 |
| CA2838051C (en) | 2011-06-16 | 2019-09-24 | Sandoz Ag | Process for the preparation of a chiral compound |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3755332A (en) | 1971-07-01 | 1973-08-28 | Ciba Geigy Corp | Substituted 4 indazolaminoquinolines |
| US4916135A (en) | 1989-05-08 | 1990-04-10 | Hoechst Roussel Pharmaceuticals Inc. | N-heteroaryl-4-quinolinamines |
| GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| AU4547396A (en) | 1995-01-31 | 1996-08-21 | Zenyaku Kogyo Kabushiki Kaisha | Thioquinoline derivatives |
| GB9505702D0 (en) | 1995-03-21 | 1995-05-10 | Agrevo Uk Ltd | Fungicidal compounds |
| GB9505651D0 (en) | 1995-03-21 | 1995-05-10 | Agrevo Uk Ltd | AgrEvo UK Limited |
| GB9514265D0 (en) | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
| US6143764A (en) | 1995-11-07 | 2000-11-07 | Kirin Beer Kabushiki Kaisha | Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same |
| ATE201873T1 (de) | 1995-11-14 | 2001-06-15 | Pharmacia & Upjohn Spa | Aryl- und heteroaryl- purin- und pyridopyrimidin- derivate |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| DE19614718A1 (de) | 1996-04-15 | 1997-10-16 | Hoechst Schering Agrevo Gmbh | Substituierte Pyridine/Pyrimidine, Verfahren zu ihrer Herstellung, und ihre Verwendung als Schädlingsbekämpfungsmittel |
| GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| WO1999054309A1 (en) | 1998-04-23 | 1999-10-28 | Takeda Chemical Industries, Ltd. | Naphthalene derivatives, their production and use |
| US6313129B1 (en) | 1998-08-21 | 2001-11-06 | Hughes Institute | Therapeutic compounds |
| SK288365B6 (sk) | 1999-02-10 | 2016-07-01 | Astrazeneca Ab | Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy |
| US6258820B1 (en) | 1999-03-19 | 2001-07-10 | Parker Hughes Institute | Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines |
| ES2231179T3 (es) | 1999-04-12 | 2005-05-16 | Aventis Pharma Limited | Compuestos de heteroarilo biciclicos sustituidos como antagonistas de la integrina. |
| US6849625B2 (en) | 2000-10-13 | 2005-02-01 | Astrazeneca Ab | Quinazoline derivatives with anti-tumour activity |
| DE60137273D1 (de) | 2000-10-20 | 2009-02-12 | Eisai R&D Man Co Ltd | Verfahren zur Herstellung von 4-Phenoxy chinolin Derivaten |
| EP2258366B1 (en) | 2001-06-22 | 2013-04-03 | Kirin Pharma Kabushiki Kaisha | Quinoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same |
| GB0126433D0 (en) | 2001-11-03 | 2002-01-02 | Astrazeneca Ab | Compounds |
| JP2005515176A (ja) | 2001-11-03 | 2005-05-26 | アストラゼネカ アクチボラグ | 抗腫瘍剤としてのキナゾリン誘導体 |
| JP4608215B2 (ja) | 2002-02-01 | 2011-01-12 | アストラゼネカ アクチボラグ | キナゾリン化合物 |
| US7645878B2 (en) | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
| NZ535985A (en) | 2002-03-29 | 2007-04-27 | Chiron Corp | Substituted benzazoles and use thereof as RAF kinase inhibitors |
| EP1548008A4 (en) | 2002-08-23 | 2008-08-06 | Kirin Pharma Kk | COMPOUND WITH TGF-BETA-HEMMENDER EFFECT AND THIS MEDICAL COMPOSITION CONTAINING |
| EP1603884A4 (en) | 2003-02-28 | 2008-05-28 | Encysive Pharmaceuticals Inc | PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE AND NAPHTHALENE UROTENSIN II RECEPTOR ANTAGONISTS |
| US7320989B2 (en) | 2003-02-28 | 2008-01-22 | Encysive Pharmaceuticals, Inc. | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists |
| US7531553B2 (en) | 2003-03-21 | 2009-05-12 | Amgen Inc. | Heterocyclic compounds and methods of use |
| GB0310401D0 (en) | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
| US7312330B2 (en) | 2003-12-24 | 2007-12-25 | Renovis, Inc. | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
| JP4932495B2 (ja) * | 2004-01-23 | 2012-05-16 | アムゲン インコーポレイテッド | 化合物及び使用方法 |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
-
2008
- 2008-10-28 WO PCT/US2008/012224 patent/WO2009058267A2/en not_active Ceased
- 2008-10-28 AU AU2008319366A patent/AU2008319366B2/en not_active Ceased
- 2008-10-28 JP JP2010532037A patent/JP5343082B2/ja not_active Expired - Fee Related
- 2008-10-28 MX MX2010004620A patent/MX2010004620A/es active IP Right Grant
- 2008-10-28 ES ES08845711T patent/ES2417009T3/es active Active
- 2008-10-28 US US12/290,223 patent/US7795254B2/en not_active Expired - Fee Related
- 2008-10-28 EP EP08845711.4A patent/EP2220078B1/en active Active
- 2008-10-28 CA CA2703257A patent/CA2703257C/en not_active Expired - Fee Related