JP2011500530A5 - - Google Patents

Info

Publication number

JP2011500530A5

JP2011500530A5 JP2010528405A JP2010528405A JP2011500530A5 JP 2011500530 A5 JP2011500530 A5 JP 2011500530A5 JP 2010528405 A JP2010528405 A JP 2010528405A JP 2010528405 A JP2010528405 A JP 2010528405A JP 2011500530 A5 JP2011500530 A5 JP 2011500530A5

Authority

JP

Japan

Prior art keywords

compound

formula

same

bis

diagnostic

Prior art date

2008-10-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims 17
• 125000000217 alkyl group Chemical group 0.000 claims 4
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
• -1 2,3-dihydroxypropyl moiety Chemical group 0.000 claims 3
• 238000003384 imaging method Methods 0.000 claims 3
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 2
• 239000000032 diagnostic agent Substances 0.000 claims 2
• 229940039227 diagnostic agent Drugs 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• BKQLXOWTSJWKLF-UHFFFAOYSA-N 3-[(2,3-dihydroxypropanoylamino)-[3-[(2,3-dihydroxypropanoylamino)-[3-[2,3-dihydroxypropyl(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoyl]amino]-2-hydroxypropyl]carbamoyl]-n-(2,3-dihydroxypropyl)-n-(2-hydroxyethyl)-2,4,6-triiodobenzamide Chemical compound OCC(O)CN(CCO)C(=O)C1=C(I)C=C(I)C(C(=O)N(CC(O)CN(NC(=O)C(O)CO)C(=O)C=2C(=C(C(=O)N(CCO)CC(O)CO)C(I)=CC=2I)I)NC(=O)C(O)CO)=C1I BKQLXOWTSJWKLF-UHFFFAOYSA-N 0.000 claims 1
• QSMUCCTTXNYEPS-UHFFFAOYSA-N 3-[[3-[[3-[bis(2,3-dihydroxypropyl)carbamoyl]-2,4,6-triiodobenzoyl]-[(2-hydroxyacetyl)amino]amino]-2-hydroxypropyl]-[(2-hydroxyacetyl)amino]carbamoyl]-n,n-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzamide Chemical compound OCC(O)CN(CC(O)CO)C(=O)C1=C(I)C=C(I)C(C(=O)N(CC(O)CN(NC(=O)CO)C(=O)C=2C(=C(C(=O)N(CC(O)CO)CC(O)CO)C(I)=CC=2I)I)NC(=O)CO)=C1I QSMUCCTTXNYEPS-UHFFFAOYSA-N 0.000 claims 1
• YXAXYMDPRDFWDU-UHFFFAOYSA-N 3-[[3-[[3-[bis(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoyl]-[(2-hydroxyacetyl)amino]amino]-2-hydroxypropyl]-[(2-hydroxyacetyl)amino]carbamoyl]-n,n-bis(2-hydroxyethyl)-2,4,6-triiodobenzamide Chemical compound OCCN(CCO)C(=O)C1=C(I)C=C(I)C(C(=O)N(CC(O)CN(NC(=O)CO)C(=O)C=2C(=C(C(=O)N(CCO)CCO)C(I)=CC=2I)I)NC(=O)CO)=C1I YXAXYMDPRDFWDU-UHFFFAOYSA-N 0.000 claims 1
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
• 239000002872 contrast media Substances 0.000 claims 1
• 238000002405 diagnostic procedure Methods 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1