CN101820924A - 造影剂 - Google Patents

造影剂 Download PDF

Info

Publication number
CN101820924A
CN101820924A CN200880111358A CN200880111358A CN101820924A CN 101820924 A CN101820924 A CN 101820924A CN 200880111358 A CN200880111358 A CN 200880111358A CN 200880111358 A CN200880111358 A CN 200880111358A CN 101820924 A CN101820924 A CN 101820924A
Authority
CN
China
Prior art keywords
chemical compound
amino
aforementioned
iodo
defined formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880111358A
Other languages
English (en)
Chinese (zh)
Inventor
D·G·温
I·M·纽恩顿
H·普里布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CN101820924A publication Critical patent/CN101820924A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200880111358A 2007-10-12 2008-10-10 造影剂 Pending CN101820924A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20075241 2007-10-12
NO20075241 2007-10-12
PCT/EP2008/063584 WO2009047315A1 (en) 2007-10-12 2008-10-10 Contrast agents

Publications (1)

Publication Number Publication Date
CN101820924A true CN101820924A (zh) 2010-09-01

Family

ID=39985925

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880111358A Pending CN101820924A (zh) 2007-10-12 2008-10-10 造影剂

Country Status (6)

Country Link
US (1) US20100221191A1 (https=)
EP (1) EP2203189B1 (https=)
JP (1) JP2011500530A (https=)
CN (1) CN101820924A (https=)
ES (1) ES2389974T3 (https=)
WO (1) WO2009047315A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013026773A1 (en) 2011-08-19 2013-02-28 Dsm Ip Assets B.V. Synthesis of r-biphenylalaninol

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101209633B1 (ko) * 2009-09-09 2012-12-06 주식회사 휴메딕스 페길레이션된 삼요오드화 아릴 화합물 및 그를 포함하는 ｘ-선 조영제

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE344166B (https=) 1966-12-13 1972-04-04 Pharmacia Ab
US3804892A (en) 1967-12-28 1974-04-16 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
SE315974B (https=) 1967-12-28 1969-10-13 Pharmacia Ab
US3763227A (en) 1967-12-28 1973-10-02 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
DE2628517C2 (de) 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
IT1207226B (it) 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3038853A1 (de) 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
DK160868C (da) 1982-11-08 1991-10-14 Nyegaard & Co As Trijodfenylderivater, fremgangsmaader til fremstilling deraf og radiologisk praeparat indeholdende dem
FR2634571B1 (fr) 1988-07-19 1990-10-19 Kodak Pathe Procede d'organisation et de lecture d'un support magnetique et support en faisant application
GB9020091D0 (en) 1990-09-14 1990-10-24 Nycomed As Contrast media
IT1245853B (it) 1990-11-16 1994-10-25 Bracco Spa 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
GB9303992D0 (en) 1993-02-26 1993-04-14 Nycomed Imaging As Contrast agents
AU6114396A (en) 1995-06-16 1997-01-15 Biophysica Foundation Formyl derivatives as nonionic contrast media
US6072069A (en) 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
EP1186305A1 (en) 2000-09-07 2002-03-13 Schering Aktiengesellschaft New brominated compounds as contrast media for X-ray mammography
EP1492776B1 (en) 2002-03-27 2008-10-29 FUJIFILM Corporation Iodinated triglyceride analogs
WO2007094683A1 (en) * 2006-02-15 2007-08-23 Ge Healthcare As Contrast agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013026773A1 (en) 2011-08-19 2013-02-28 Dsm Ip Assets B.V. Synthesis of r-biphenylalaninol

Also Published As

Publication number Publication date
EP2203189B1 (en) 2012-07-18
WO2009047315A1 (en) 2009-04-16
JP2011500530A (ja) 2011-01-06
EP2203189A1 (en) 2010-07-07
ES2389974T3 (es) 2012-11-05
US20100221191A1 (en) 2010-09-02

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20100901