JP2011214987A - バイオマーカー - Google Patents
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- JP2011214987A JP2011214987A JP2010083198A JP2010083198A JP2011214987A JP 2011214987 A JP2011214987 A JP 2011214987A JP 2010083198 A JP2010083198 A JP 2010083198A JP 2010083198 A JP2010083198 A JP 2010083198A JP 2011214987 A JP2011214987 A JP 2011214987A
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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Abstract
【解決手段】 がんに罹患した脊椎動物から化学放射線療法による治療前に採取された血液中の、可溶性インターロイキン6受容体、MIP−1β、および、プラスミノーゲン活性化因子阻害因子活性型の濃度を測定することによって、その個体の有するがんに対する化学放射線療法治療効果を予測でき、可溶性インターロイキン6受容体の濃度を測定することにより、その脊椎動物の予後を判断することができる。
【選択図】 なし
Description
本明細書において、がんに対する化学放射線療法による治療効果を予測するためのバイオマーカー(治療効果予測マーカーとも称する)は、化学放射線療法の治療効果が高いがんを有する患者(著効群)を抽出するためのバイオマーカー(著効マーカー)、化学放射線療法の治療効果が低いがんを有する患者(非著効群)を抽出するためのバイオマーカー(非著効マーカー)を含む。また、化学放射線療法を受けた扁平上皮癌患者の予後を予測するためのバイオマーカー(予後予測マーカーとも称する)は、化学放射線療法後に外科的に癌除去手術を受けた患者において、予後が長い患者と短い患者を識別するためのバイオマーカーである。
バイオマーカーの測定の対象となる動物は、本発明に係るバイオマーカーが少なくとも1種類存在する脊椎動物であればヒトでもヒト以外でもよく、ヒト、マウス、ラット、イヌ、ネコ、ウマ、ヒツジ、ウサギ、ブタ、サル等の哺乳動物であることが好ましく、ヒトであることが最も好ましい。また、脊椎動物の年齢、性別は制限されない。以下、ヒトの患者を例にして説明する。
本発明に係るバイオマーカーの使用方法には、例えば以下のような態様が含まれる。
がんに罹患した脊椎動物から化学放射線療法による治療前に採血して得られた血液中のバイオマーカーの含有量を測定することにより、その個体の有するがんに対する化学放射線療法の治療効果を予測することができる。
がんに罹患し、化学放射線療法前に採血した後、外科手術で癌を除去した脊椎動物において、採血した血液中のバイオマーカーの含有量を測定することにより、その個体の有する予後を予測することができる。
sILR6の測定についてはBiosource 社のExtracelular Luminex Kit sILR6 (品番LHR0061)、MIP−1βの測定についてはBiosource 社のExtracelular Luminex Kit MIP-1β (品番LHC1051)、PAI-1の測定についてはR&D 社のPAI-1, Human, Fluorokine MAP kit (商品コードLOB1359)を用い、日立ソフトにおいて委託解析を行った。
Quantikine Human IL-6 sR Immunoassay(R&D systems 社)を用いたサンドイッチELISA法により、血中sIL6R濃度をSRLで委託測定した。
Claims (8)
- 扁平上皮癌に対する化学放射線療法の治療効果を予測するためのバイオマーカーであって、
可溶性インターロイキン6受容体、マクロファージ炎症性タンパク質1β、および、プラスミノーゲン活性化因子阻害因子活性型から成る群から選択されることを特徴とするバイオマーカー。 - 化学放射線療法を受けた扁平上皮癌患者の予後を予測するためのバイオマーカーであって、
可溶性インターロイキン6受容体であることを特徴とするバイオマーカー。 - 前記扁平上皮癌が、頭頚部扁平上皮癌あるいは食道扁平上皮癌であることを特徴とする、請求項1または2に記載のバイオマーカー。
- 前記化学放射線療法が術前化学放射線療法であることを特徴とする、請求項2に記載のバイオマーカー。
- バイオマーカーの濃度を測定する方法であって、
化学放射線療法による治療前に採取された血液において、請求項1に記載の1種類以上のバイオマーカーの濃度を測定することを特徴とする測定方法。 - 前記血液が、扁平上皮癌患者の血液であることを特徴とする、請求項5に記載の測定方法。
- 前記バイオマーカーに対する特異的抗体を用いて当該バイオマーカーの濃度を測定することを特徴とする、請求項5または6に記載の測定方法。
- 扁平上皮癌が、頭頚部扁平上皮癌あるいは食道扁平上皮癌であることを特徴とする、請求項6または7に記載の測定方法。
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
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JP2010083198A JP5702944B2 (ja) | 2010-03-31 | 2010-03-31 | バイオマーカー |
PCT/JP2011/058259 WO2011125858A1 (ja) | 2010-03-31 | 2011-03-31 | バイオマーカー |
EP11765758.5A EP2554994B1 (en) | 2010-03-31 | 2011-03-31 | Soluble interleukin-6 receptor as biomarker |
US13/637,994 US20130137592A1 (en) | 2010-03-31 | 2011-03-31 | Biomarkers |
CN201180027158.2A CN102985824B (zh) | 2010-03-31 | 2011-03-31 | 生物标志物 |
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JP2010083198A JP5702944B2 (ja) | 2010-03-31 | 2010-03-31 | バイオマーカー |
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JP2011214987A true JP2011214987A (ja) | 2011-10-27 |
JP5702944B2 JP5702944B2 (ja) | 2015-04-15 |
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US (1) | US20130137592A1 (ja) |
EP (1) | EP2554994B1 (ja) |
JP (1) | JP5702944B2 (ja) |
CN (1) | CN102985824B (ja) |
WO (1) | WO2011125858A1 (ja) |
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CA2962551C (en) * | 2014-09-24 | 2023-10-24 | National Cancer Center | Method for evaluating efficacy of chemoradiotherapy against squamous cell carcinoma |
CN113906298A (zh) * | 2019-03-27 | 2022-01-07 | 新加坡保健服务集团有限公司 | 对腹膜癌扩散具有治疗意义的生物标志物 |
CN111269956B (zh) * | 2020-02-25 | 2023-04-18 | 福建医科大学 | 检测菌群的试剂在制备食管鳞癌患者预后预测标志物的试剂或试剂盒中的应用 |
WO2022148866A1 (en) | 2021-01-08 | 2022-07-14 | Alpspitz Bioscience Gmbh | Use of biomarkers for predicting the clinical and/or treatment outcome of a human subject |
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WO2002099114A2 (en) * | 2001-06-01 | 2002-12-12 | Baylor College Of Medicine | Methods to determine prognosis after therapy for bladder cancer |
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US6107090A (en) * | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
CA2318740A1 (en) * | 1998-01-26 | 1999-07-29 | Biotech Australia Pty. Limited | Pai-2 and t-pa as diagnostic markers of periodontal disease |
CN1518604A (zh) * | 2001-05-09 | 2004-08-04 | 克利夫兰大学医院 | 用新型基因标记、与之相关的方法和组合物来评测皮肤的紫外辐射损伤 |
US20030044862A1 (en) * | 2001-06-22 | 2003-03-06 | The Board Of Trustees Of The Leland Stanford Jr. University | Diagnostic marker for tumor hypoxia and prognosis |
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- 2011-03-31 WO PCT/JP2011/058259 patent/WO2011125858A1/ja active Application Filing
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- 2011-03-31 US US13/637,994 patent/US20130137592A1/en not_active Abandoned
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WO2002099114A2 (en) * | 2001-06-01 | 2002-12-12 | Baylor College Of Medicine | Methods to determine prognosis after therapy for bladder cancer |
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JPN6011020501; Bayer Christine et al.: 'PAI-1 levels predict response to fractionated irradiation in 10 human squamous cell carcinoma lines' Radiotherapy and oncology Vol.86, No.3, Page.361-368, 2008 * |
JPN6014023646; Cancer Epidemiol Biomarkers Prev Vol.16, No.1, Page.102-107, 2007 * |
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CN102985824B (zh) | 2015-02-25 |
CN102985824A (zh) | 2013-03-20 |
EP2554994A4 (en) | 2013-10-30 |
US20130137592A1 (en) | 2013-05-30 |
EP2554994A1 (en) | 2013-02-06 |
WO2011125858A1 (ja) | 2011-10-13 |
JP5702944B2 (ja) | 2015-04-15 |
EP2554994B1 (en) | 2016-10-19 |
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