JP2011174933A5 - - Google Patents
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- Publication number
- JP2011174933A5 JP2011174933A5 JP2011050083A JP2011050083A JP2011174933A5 JP 2011174933 A5 JP2011174933 A5 JP 2011174933A5 JP 2011050083 A JP2011050083 A JP 2011050083A JP 2011050083 A JP2011050083 A JP 2011050083A JP 2011174933 A5 JP2011174933 A5 JP 2011174933A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- peptide
- kit
- urine
- kit according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 54
- 108090000765 processed proteins & peptides Proteins 0.000 claims 44
- 210000002700 urine Anatomy 0.000 claims 25
- 206010033128 Ovarian cancer Diseases 0.000 claims 24
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 23
- 125000003275 alpha amino acid group Chemical group 0.000 claims 19
- 239000003446 ligand Substances 0.000 claims 13
- 239000000439 tumor marker Substances 0.000 claims 10
- 102000004190 Enzymes Human genes 0.000 claims 9
- 108090000790 Enzymes Proteins 0.000 claims 9
- 102000003735 Mesothelin Human genes 0.000 claims 8
- 108090000015 Mesothelin Proteins 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 108090001008 Avidin Proteins 0.000 claims 4
- 102000001626 Kazal Pancreatic Trypsin Inhibitor Human genes 0.000 claims 4
- 108010093811 Kazal Pancreatic Trypsin Inhibitor Proteins 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 238000004458 analytical method Methods 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 238000001356 surgical procedure Methods 0.000 claims 3
- 108010050201 2-hydroxybutyrate dehydrogenase Proteins 0.000 claims 2
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 claims 2
- 102100032912 CD44 antigen Human genes 0.000 claims 2
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 claims 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 2
- 102000005927 Cysteine Proteases Human genes 0.000 claims 2
- 108010005843 Cysteine Proteases Proteins 0.000 claims 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims 2
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims 2
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims 2
- RMINQIRDFIBNLE-NNRWGFCXSA-N O-[N-acetyl-alpha-neuraminyl-(2->6)-N-acetyl-alpha-D-galactosaminyl]-L-serine Chemical compound O1[C@H](OC[C@H](N)C(O)=O)[C@H](NC(=O)C)[C@@H](O)[C@@H](O)[C@H]1CO[C@@]1(C(O)=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C1 RMINQIRDFIBNLE-NNRWGFCXSA-N 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010090804 Streptavidin Proteins 0.000 claims 2
- BMQYVXCPAOLZOK-UHFFFAOYSA-N Trihydroxypropylpterisin Natural products OCC(O)C(O)C1=CN=C2NC(N)=NC(=O)C2=N1 BMQYVXCPAOLZOK-UHFFFAOYSA-N 0.000 claims 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 230000004807 localization Effects 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- BMQYVXCPAOLZOK-XINAWCOVSA-N neopterin Chemical compound OC[C@@H](O)[C@@H](O)C1=CN=C2NC(N)=NC(=O)C2=N1 BMQYVXCPAOLZOK-XINAWCOVSA-N 0.000 claims 2
- 108010064245 urinary gonadotropin fragment Proteins 0.000 claims 2
- 235000011330 Armoracia rusticana Nutrition 0.000 claims 1
- 240000003291 Armoracia rusticana Species 0.000 claims 1
- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 claims 1
- 102000003992 Peroxidases Human genes 0.000 claims 1
- 108010079337 Tissue Polypeptide Antigen Proteins 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
- 239000002753 trypsin inhibitor Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/388,930 US20040180387A1 (en) | 2003-03-13 | 2003-03-13 | Detection of urinary mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of ovarian cancer |
| US10/388,930 | 2003-03-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507164A Division JP4722834B2 (ja) | 2003-03-13 | 2004-03-15 | 卵巣癌査定のための尿のメソセリン／巨核球可能化因子関連ペプチド（ｍｅｓｏｔｈｅｌｉｎ／ｍｅｇａｋａｒｙｏｃｙｔｅｐｏｔｅｎｔｉａｔｉｎｇｆａｃｔｏｒｆａｍｉｌｙｐｅｐｔｉｄｅ）の検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011174933A JP2011174933A (ja) | 2011-09-08 |
| JP2011174933A5 true JP2011174933A5 (cg-RX-API-DMAC7.html) | 2012-06-07 |
| JP5570029B2 JP5570029B2 (ja) | 2014-08-13 |
Family
ID=32962160
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507164A Expired - Lifetime JP4722834B2 (ja) | 2003-03-13 | 2004-03-15 | 卵巣癌査定のための尿のメソセリン／巨核球可能化因子関連ペプチド（ｍｅｓｏｔｈｅｌｉｎ／ｍｅｇａｋａｒｙｏｃｙｔｅｐｏｔｅｎｔｉａｔｉｎｇｆａｃｔｏｒｆａｍｉｌｙｐｅｐｔｉｄｅ）の検出 |
| JP2011050083A Expired - Lifetime JP5570029B2 (ja) | 2003-03-13 | 2011-03-08 | 卵巣癌査定のための尿のメソセリン／巨核球可能化因子関連ペプチド（ｍｅｓｏｔｈｅｌｉｎ／ｍｅｇａｋａｒｙｏｃｙｔｅｐｏｔｅｎｔｉａｔｉｎｇｆａｃｔｏｒｆａｍｉｌｙｐｅｐｔｉｄｅ）の検出 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507164A Expired - Lifetime JP4722834B2 (ja) | 2003-03-13 | 2004-03-15 | 卵巣癌査定のための尿のメソセリン／巨核球可能化因子関連ペプチド（ｍｅｓｏｔｈｅｌｉｎ／ｍｅｇａｋａｒｙｏｃｙｔｅｐｏｔｅｎｔｉａｔｉｎｇｆａｃｔｏｒｆａｍｉｌｙｐｅｐｔｉｄｅ）の検出 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20040180387A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2316969B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4722834B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004083449A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005072341A2 (en) * | 2004-01-21 | 2005-08-11 | Fujirebio America, Inc. | Detection of mesothelin-/megakaryocyte potentiating factor-related peptides in peritoneal fluid for assessment of the peritoneum and the peritoneal cavity |
| EP1716168A4 (en) * | 2004-01-21 | 2009-06-24 | Fujirebio America Inc | DETECTION OF PEPTIDES RELATING TO THE FACTOR FOR THE POTENTIATION OF URINARY MESOTHELIN- / MEGACARYOCYTES FOR THE EVALUATION OF MESOTHELIOMA |
| WO2009108932A2 (en) * | 2008-02-28 | 2009-09-03 | The Johns Hopkins University | Selectin ligands useful in the diagnosis and treatment of cancer |
| JP2010014691A (ja) * | 2008-06-20 | 2010-01-21 | Igaku Seibutsugaku Kenkyusho:Kk | 腹水中のメソテリン及び／又は巨核球増強因子を検出するための方法、キット、試薬及び装置 |
| US20120115244A1 (en) | 2010-11-09 | 2012-05-10 | Abbott Laboratories | Materials and methods for immunoassay of pterins |
| KR20140014116A (ko) | 2010-12-20 | 2014-02-05 | 제넨테크, 인크. | 항-메소텔린 항체 및 면역접합체 |
| CN103344761A (zh) * | 2013-04-23 | 2013-10-09 | 深圳市柏明胜医疗器械有限公司 | 一种he4量子点标记的双夹心免疫分析检测试剂盒及其应用 |
| US10534001B2 (en) * | 2014-10-02 | 2020-01-14 | Zora Biosciences Oy | Methods for detecting ovarian cancer |
| CN106841190B (zh) * | 2017-03-22 | 2020-07-24 | 西北师范大学 | 以TMB为显色剂的Ag+可视化检测方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| WO1987002671A1 (en) | 1985-11-01 | 1987-05-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5139744A (en) * | 1986-03-26 | 1992-08-18 | Beckman Instruments, Inc. | Automated laboratory work station having module identification means |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| AU665190B2 (en) | 1990-07-10 | 1995-12-21 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2093928C (en) * | 1990-10-12 | 2000-02-29 | Mark C. Willingham | Monoclonal antibodies for detection and treatment of cancer |
| DK0564531T3 (da) | 1990-12-03 | 1998-09-28 | Genentech Inc | Berigelsesfremgangsmåde for variantproteiner med ændrede bindingsegenskaber |
| DK1279731T3 (da) | 1991-03-01 | 2007-09-24 | Dyax Corp | Fremgangsmåde til udvikling af bindende miniproteiner |
| DK1471142T3 (da) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| JP3328341B2 (ja) * | 1991-12-27 | 2002-09-24 | 中外製薬株式会社 | 新規な巨核球増幅因子 |
| US5622835A (en) * | 1994-04-28 | 1997-04-22 | The Wistar Institute Of Anatomy & Biology | WT1 monoclonal antibodies |
| AU703769B2 (en) * | 1996-01-05 | 1999-04-01 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Mesothelium antigen and methods and kits for targeting it |
| US6770445B1 (en) * | 1999-02-26 | 2004-08-03 | Pacific Northwest Research Institute | Methods and compositions for diagnosing carcinomas |
| CA2369433A1 (en) * | 1999-02-26 | 2000-08-31 | Pacific Northwest Research Institute | Methods and compositions for diagnosing carcinomas |
| US20030087250A1 (en) * | 2001-03-14 | 2003-05-08 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer |
-
2003
- 2003-03-13 US US10/388,930 patent/US20040180387A1/en not_active Abandoned
-
2004
- 2004-03-15 WO PCT/US2004/007765 patent/WO2004083449A2/en not_active Ceased
- 2004-03-15 JP JP2006507164A patent/JP4722834B2/ja not_active Expired - Lifetime
- 2004-03-15 EP EP10012291.0A patent/EP2316969B1/en not_active Expired - Lifetime
- 2004-03-15 EP EP04720803A patent/EP1611250B1/en not_active Expired - Lifetime
-
2011
- 2011-03-08 JP JP2011050083A patent/JP5570029B2/ja not_active Expired - Lifetime
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