JP2011142907A - 免疫調節製剤としてのラクトバチルス・パラカゼイlt12株 - Google Patents
免疫調節製剤としてのラクトバチルス・パラカゼイlt12株 Download PDFInfo
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- JP2011142907A JP2011142907A JP2010288109A JP2010288109A JP2011142907A JP 2011142907 A JP2011142907 A JP 2011142907A JP 2010288109 A JP2010288109 A JP 2010288109A JP 2010288109 A JP2010288109 A JP 2010288109A JP 2011142907 A JP2011142907 A JP 2011142907A
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- lactobacillus paracasei
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- paracasei strain
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Abstract
【解決手段】単離されたラクトバチルス・パラカゼイLT12株、および免疫調節活性を有するその変異株。ならびに該ラクトバチルス・パラカゼイ株を含有する、免疫応答の調節およびアレルギー治療のための組成物。
【選択図】図1
Description
(1)形態的特性:
(a) 細胞の形状と大きさ:細菌はMRSブロス中において一晩37℃で培養し、顕微鏡で観察したとき、桿状で円形の端部を示す。
(b) 運動:運動性
(c) 鞭毛:なし
(d) 胞子形成:胞子形成なし
(e) グラム染色:陽性
(2)培養特性:
(a) 培地:ラクトバチルスMRSブロス(Difco、米国)、最終pH6.2〜6.5
(b) 培養条件:37℃、嫌気性または好気性培養
(3)生理特性:
(a) カタラーゼ:陽性
(b) オキシダーゼ:陰性
(c) API50CHL検査:結果を表1に示す。
(4)遺伝的特性:
Claims (21)
- アグリカルチュラル・リサーチ・カルチャー・コレクションに寄託番号NRRL−B50327として寄託されたLT12またはその遺伝子組み換え変異株である、単離されたラクトバチルス・パラカゼイ株。
- 前記ラクトバチルス・パラカゼイ株が、アグリカルチュラル・リサーチ・カルチャー・コレクションに寄託番号NRRL−B50327として寄託されたLT12である、請求項1に記載の単離されたラクトバチルス・パラカゼイ株。
- 請求項1に記載のラクトバチルス・パラカゼイLT12株を含む組成物。
- 前記ラクトバチルス・パラカゼイ株が、アグリカルチュラル・リサーチ・カルチャー・コレクションに寄託番号NRRL−B50327として寄託されたLT12である、請求項3に記載の組成物。
- 抗アレルギー活性を有する、請求項3に記載の組成物。
- 免疫調節活性および抗アレルギー活性を有する、請求項3に記載の組成物。
- 前記ラクトバチルス・パラカゼイ株が生菌である、請求項3に記載の組成物。
- 前記ラクトバチルス・パラカゼイLT12株が不活化されている、請求項3に記載の組成物。
- 食品、飲料または薬剤である、請求項3に記載の組成物。
- 第2のラクトバチルス・パラカゼイ株をさらに含む、請求項3に記載の組成物。
- 前記ラクトバチルス・パラカゼイ株の前記第2のラクトバチルス・パラカゼイ株に対する比率が、細菌数で2:1から100:1の間である、請求項10に記載の組成物。
- 免疫調節活性及び/または抗アレルギー活性を有する、請求項11に記載の組成物。
- 食品、飲料または薬剤である、請求項10に記載の組成物。
- 有効量の請求項1のラクトバチルス・パラカゼイLT12株およびその製薬上許容される担体を含む、免疫調節のための組成物。
- 前記ラクトバチルス・パラカゼイ株が、アグリカルチュラル・リサーチ・カルチャー・コレクションに寄託番号NRRL−B50327として寄託されたLT12である、請求項14に記載の組成物。
- 自然免疫または適応免疫を調節する、請求項14に記載の組成物。
- サイトカイン産生を刺激する、請求項14に記載の組成物。
- 前記サイトカインが、IL−1α、IL−6、IL−10、IFN−γ、MCP-2およびTNF-αからなる群から選択される、請求項17に記載の組成物。
- 有効量の請求項1に記載のラクトバチルス・パラカゼイ株およびその製薬上許容される担体を含む、アレルギー治療のための組成物。
- 前記ラクトバチルス・パラカゼイ株が、アグリカルチュラル・リサーチ・カルチャー・コレクションに寄託番号NRRL−B50327として寄託されたLT12である、請求項19に記載の組成物。
- 被験者がIgE媒介性即時型過敏症またはT細胞媒介性遅延型過敏症に罹患している、請求項19に記載の組成物。
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US12/646,275 US8372392B2 (en) | 2009-12-23 | 2009-12-23 | Lactobacillus paracasei strain LT12 as immunity regulatory agent |
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