JP2011133744A - Disinfectant for contact lens and disinfection unit for contact lens - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a disinfectant for contact lens capable of obtaining high disinfection effect in a short time, and to provide a disinfection unit for contact lens. <P>SOLUTION: The disinfectant for contact lens comprises: (A) a hydrogen peroxide or a peroxide that is dissolved into water and produces the hydrogen peroxide; and (B) a catalyst that includes a mixture and/or a reactant of a specified chelating agent or its derivative (b1) and at least one (b2) of copper compound and manganese compound. The disinfection unit for contact lens includes the disinfectant for contact lens and a neutralizer of the hydrogen peroxide. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a contact lens disinfectant and a contact lens disinfection unit.

The contact lens may be contaminated with tears such as proteins and lipids during wearing, and there is a risk that microorganisms such as bacteria may grow due to the dirt. Wearing contact lenses contaminated with microorganisms may cause damage to the cornea and the like. For this reason, when the contact lens is continuously used, it is necessary to perform cleaning for the purpose of removal and disinfection of dirt after wearing, and use the cleaned contact lens in a clean state.
Generally, there are two methods for disinfecting contact lenses: a method using boiling and a method using a disinfectant such as hydrogen peroxide. In recent years, disinfection methods using hydrogen peroxide have been widely used in place of boiling disinfection that requires a long time for disinfection.

  Conventionally, in order to improve the disinfection effect by hydrogen peroxide, for example, a contact lens cleaning composition using hydrogen peroxide, a boron compound and a sugar compound in combination has been proposed (for example, Patent Document 1). According to the present invention, the sterilizing power is improved. In addition, a contact lens disinfection method in which a contact lens is immersed in a disinfecting solution containing a metal phthalocyanine compound and hydrogen peroxide and then irradiated with light has been proposed (for example, Patent Document 2). According to this invention, a high bactericidal effect can be effectively obtained in the presence of a low concentration of hydrogen peroxide.

  By the way, there is a concern about unfavorable effects on the eyes, such as feeling strong irritation when hydrogen peroxide remains on the surface or inside of the contact lens after disinfection. For this reason, when hydrogen peroxide is used as a disinfectant, an operation such as decomposing hydrogen peroxide by neutralization is required.

  In order to solve these problems, a disinfection method in which a contact lens is immersed in a disinfecting solution containing 1000 ppm or less of hydrogen peroxide and a metal ion or a metal-EDTA complex and irradiated with visible light has been proposed (for example, Patent Documents). 3). According to this invention, the concentration of hydrogen peroxide is reduced, and the neutralization treatment is omitted.

JP 2004-24715 A JP 2004-97805 A JP 2004-141546 A

However, in the technique of Patent Document 1, although the disinfection effect is improved, it takes several hours to disinfect the disinfection time, that is, after the contact lens is immersed in the disinfectant solution. In addition, in the techniques of Patent Documents 2 and 3, an apparatus for irradiating light is necessary, and disinfection becomes complicated.
Therefore, the present invention is directed to a contact lens disinfectant and a contact lens disinfection unit that can easily obtain a high disinfection effect in a short time.

  The disinfectant for contact lenses of the present invention includes (A): hydrogen peroxide or a peroxide that dissolves in water to generate hydrogen peroxide, and (B): any one of the following formulas (I) to (III): And / or a derivative thereof (b1) and a catalyst body containing a mixture and / or a reaction product of at least one of a copper compound and a manganese compound (b2).

（式中、Ｘは水素原子、アルカリ金属、又はアルカリ土類金属を表す。ｐは１又は２の整数を表し、ｐが２の場合、Ｘは同一のものでも、異なるものでも良い。）

(In the formula, X represents a hydrogen atom, an alkali metal, or an alkaline earth metal. P represents an integer of 1 or 2, and when p is 2, X may be the same or different.)

（式中、Ｘ^１〜Ｘ^４は同一でも異なっていてもよく、それぞれ水素原子、アルカリ金属、アルカリ土類金属、カチオン性アンモニウム基からなる群より選ばれる１種を表し、Ｑは水素原子又はアルキル基を表し、Ｒは水素原子又は水酸基を表し、ｎ_１は０又は１である。）

(Wherein X ^{1 to} X ⁴ may be the same or different and each represents one selected from the group consisting of a hydrogen atom, an alkali metal, an alkaline earth metal, and a cationic ammonium group, and Q is a hydrogen atom or Represents an alkyl group, R represents a hydrogen atom or a hydroxyl group, and n ₁ is 0 or 1.)

（式中、Ｙはアルキル基、カルボキシル基、スルホ基、又はアミノ基、水酸基、又は水素原子を表し、Ｘ^５〜Ｘ^７は同一でも異なっていてもよく、それぞれ水素原子、アルカリ金属、アルカリ土類金属、カチオン性アンモニウム基からなる群より選ばれる１種を表し、ｎ_２は０から５の整数を表す。）

(In the formula, Y represents an alkyl group, a carboxyl group, a sulfo group, an amino group, a hydroxyl group, or a hydrogen atom, and X ^{5 to} X ⁷ may be the same or different, and each represents a hydrogen atom, an alkali metal, or an alkaline earth. metalloid, represents one selected from the group consisting of cationic ammonium group, n ₂ represents an integer of 0 to 5.)

The contact lens disinfection unit of the present invention comprises the contact lens disinfectant of the present invention and a hydrogen peroxide neutralizing agent.
The contact lens disinfection unit of the present invention comprises the contact lens disinfectant of the present invention and a platinum member.

  According to the present invention, a contact lens can be sterilized easily and in a short time, and a high sterilizing effect can be obtained.

(Contact lens disinfection unit)
The contact lens disinfecting unit of the present invention (hereinafter sometimes simply referred to as a disinfecting unit) includes a contact lens disinfectant (hereinafter sometimes simply referred to as a disinfectant), a hydrogen peroxide neutralizing agent, or a platinum member. Are provided.

[Disinfectant for contact lenses]
The disinfectant of this invention has (A) component and (B) component.

[(A) component]
The component (A) is hydrogen peroxide or a peroxide that dissolves in water to generate hydrogen peroxide, and it is preferable to use hydrogen peroxide.
Examples of peroxides that dissolve in water to generate hydrogen peroxide (hereinafter sometimes referred to simply as peroxides) include sodium percarbonate, sodium perborate, sodium perborate trihydrate, and the like. From the viewpoints of solubility during use and stability during storage, sodium percarbonate is preferred.

  The content of the component (A) in the disinfectant is not particularly limited. At the time of disinfecting the contact lens, the hydrogen peroxide concentration in the disinfecting solution in which the contact lens is immersed is, for example, 0.001 to 5 g / 100 mL. It is preferable to mix | blend, it is more preferable to mix | blend so that it may become 0.005-0.1g / 100mL, and it is further more preferable to mix | blend so that it may become 0.005-0.03g / 100mL. If the content of the component (A) is 0.001 g / 100 mL or more, the contact lens can be sufficiently disinfected, and if it is 5 g / 100 mL or less, the contact lens can be prevented from being deteriorated / damaged during disinfection. Decomposition of the component (A) during storage can be suppressed. In particular, if the content of the component (A) is in the range of 0.005 to 0.03 g / 100 mL, it can be sufficiently disinfected in a short time, shorten the neutralization time after disinfection, and reduce the amount of neutralizing agent. be able to.

[Component (B)]
The component (B) is a mixture or compound of the component (b1) and the component (b2). Here, the “mixture” means a state in which the component (b1) and the component (b2) are independently added to the disinfectant. The “compound” means a complex of the component (b1) and the copper and / or manganese derived from the component (b2). From the viewpoint of improving the disinfection effect, the component (B) is preferably a compound of the component (b1) and the component (b2).
The complex structure of the compound of the component (b1) and the component (b2) is not particularly limited, and the number of ligands per copper and / or manganese atom may be one or plural, and one complex There may be one or more copper and / or manganese atoms constituting. That is, the complex may be mononuclear, binuclear, or cluster. Moreover, when it is a polynuclear complex, the transition metal contained in this may be only one kind of copper and / or manganese, or may be plural kinds, for example, when copper and manganese are mixed. Good. Furthermore, in the case of a polynuclear complex, it may be cross-linked by a cross-linking species such as oxygen, sulfur or halogen atom.

<(B1) component>
The component (b1) is a compound represented by the structure of any of the following formulas (I) to (III) (hereinafter referred to as compounds (I) to (III)) or a derivative thereof, and the coordination position is 5 The following chelating agents.

<< Compound (I) >>
Compound (I) is represented by the following formula (I).

In the above formula (I), X represents a hydrogen atom, an alkali metal, or an alkaline earth metal.
Examples of the alkali metal include Na and K. Examples of the alkaline earth metal include Ca (in this case, “—COOX” becomes “—COOCa _1/2 ”).
When X is an alkali metal or an alkaline earth metal, it is indicated as “—COOM” (M represents an alkali metal or an alkaline earth metal), and when compound (I) is introduced into a solvent such as water, Part or all of “—COOM” becomes “—COO ⁻ ” and an alkali metal or alkaline earth metal ion. And the part of “—COO ⁻ ” can be complexed with copper and / or manganese derived from the component (b2).
Therefore, even if X is an alkali metal or an alkaline earth metal, it can be used as the component (b1) constituting the present invention. Among these, X is preferably a hydrogen atom.

In compound (I), p representing the number of “—COOX” represents an integer of 1 or 2, and is more preferably 2. When p is 2, X may be the same or different from each other.
When p is 1, the bonding position of “—COOX” to the pyridine ring is preferably α-position with respect to the nitrogen atom. When p is 2, at least one “—COOX” is preferably bonded to the α-position. The remaining “—COOX” may be bonded to any one of the α to γ positions, but more preferably the other α position.
Specific examples of compound (I) include compounds represented by the following formulas (1) and (2). In the formulas (1) and (2), X is marked as hydrogen H as a representative example, but the compound (I) is not limited to this structure, and is appropriately selected depending on the purpose. can do.

In addition, as the component (b1) which is a derivative of the compound (I), in the above formula (I), all or part of “—COOX” is a sulfo group (SO ₃ H), an amino group (NH ₂ ), a hydroxyl group ( OH), a nitro group (NO ₂ ), or an optionally substituted alkyl group (C _n H _{2n + 1} ) or the like. When the alkyl group is substituted, the alkyl group may be linear or branched. Preferably carbon number of an alkyl group is 1-30, More preferably, it is 1-18. In the alkyl group, part of the hydrogen atoms may be substituted with a substituent. Examples of the substituent include a sulfo group, an amino group, a hydroxyl group, a nitro group, and a carboxyl group.

Specific examples of such component (b1) include compounds represented by the following formulas (3) to (8). The present invention is not limited to this structure, and can be appropriately selected according to the purpose. As a typical example, X is labeled as hydrogen H.
From the viewpoint of stabilizing the coordination and improving the disinfection effect, it is preferable that “—COOX” of the compound (I) is not substituted.

≪Compound (II) ≫
Compound (II) is represented by the following formula (II).

In the above formula (II), X ^{1 to} X ⁴ may be the same or different and each represents one selected from the group consisting of a hydrogen atom, an alkali metal, an alkaline earth metal, and a cationic ammonium group.
When X ^{1 to} X ⁴ are as described above, when this compound (II) is added to a solvent such as water, “—COOX ¹ ”, “—COOX ² ”, “—COOX ³ ”, “—COOX” ⁴ ”is ionized to become“ —COO ⁻ ”, and an anion represented by the following formula (11) is generated. Then, the “—COO ⁻ ” portion of the anion can be complexed with copper and / or manganese derived from the component (b2).
Preferably, all of X ^{1 to} X ⁴ are sodium or potassium. When one or more of X ^{1 to} X ⁴ are an alkaline earth metal M, the portion is indicated as “—COOM _1/2 ”.
Q represents a hydrogen atom or an alkyl group, preferably a hydrogen atom. R represents a hydrogen atom or a hydroxyl group, preferably a hydrogen atom. n ₁ represents an integer of 0 or 1, and is preferably 1.

Specific examples of the compound (II) include compounds represented by the following formulas (12) to (15). In these formulas (12) to (15), as a typical example, X ^{1 to} X ⁴ are all hydrogen H, but the compound (II) is limited to these structures. It can be selected according to the purpose.

In addition, as a derivative of the compound (II), all or a part of “—COOX ¹ ”, “—COOX ² ”, “—COOX ³ ”, “—COOX ⁴ ” is an alkyl group, a sulfo group, or an amino group. And the like are substituted. When the alkyl group is substituted, the alkyl group may be linear or branched. Preferably carbon number of an alkyl group is 1-30, More preferably, it is 1-18. In the alkyl group, part of the hydrogen atoms may be substituted with a substituent. Examples of the substituent include a sulfo group, an amino group, a hydroxyl group, a nitro group, and a carboxyl group.
From the viewpoint of stabilizing the coordination and improving the disinfection effect, it is preferable that “—COOX ¹ ”, “—COOX ² ”, “—COOX ³ ”, and “—COOX ⁴ ” of the compound (II) are not substituted.

≪Compound (III) ≫
Compound (III) is represented by the following formula (III).

In the formula (III), Y represents an alkyl group, a carboxyl group, a sulfo group, an amino group, or a hydrogen atom, and X ^{5 to} X ⁷ may be the same or different, and each represents a hydrogen atom, an alkali metal, 1 type selected from the group consisting of alkaline earth metals and cationic ammonium groups.
When X ^{5 to} X ⁷ are as described above, when this compound (III) is added to a solvent such as water, “—COOX ⁵ ”, “—COOX ⁶ ”, “—COOX ⁷ ” are ionized. , “—COO ⁻ ”, and the “—COO ⁻ ” portion of this anion can be complexed with the copper and / or manganese derived from the component (b2).
Preferably, X ^{5 to} X ⁷ are all sodium or potassium. When at least one of X ^{5 to} X ⁷ is an alkaline earth metal M, the portion is indicated as “—COOM _1/2 ”.
N ₂ represents an integer of 0 to 5, and preferably n ₂ is 0 to 2.

Specific examples of compound (III) include compounds represented by the following formulas (18) to (30). Note that, in these formulas (18) to (30), as a representative example, the case where X ^{5 to} X ⁷ are all hydrogen H is shown, but the compound (III) is limited to these structures. It can be selected according to the purpose.

In addition, as a derivative of compound (III), a structure in which all or part of “—COOX ⁵ ”, “—COOX ⁶ ”, “—COOX ⁷ ” is substituted with an alkyl group, a sulfo group, an amino group or the like. Is mentioned. When the alkyl group is substituted, the alkyl group may be linear or branched. Preferably carbon number of an alkyl group is 1-30, More preferably, it is 1-18. In the alkyl group, part of the hydrogen atoms may be substituted with a substituent. Examples of the substituent include a sulfo group, an amino group, a hydroxyl group, a nitro group, and a carboxyl group.
From the viewpoint of stabilizing the coordination and improving the disinfection effect, it is preferable that “—COOX ⁵ ”, “—COOX ⁶ ”, and “—COOX ⁷ ” of the compound (III) are not substituted.

<(B2) component>
The component (b2) is a copper compound and / or a manganese compound. The component (b2) is not particularly limited as long as it is soluble in water and releases copper or manganese ions at that time. Examples of water-soluble copper or manganese compounds include inorganic salt compounds such as nitrate, sulfate, chloride, perchlorate, ammonium chloride, cyanide, acetate, acetylacetonate, gluconate, Organic compounds such as oxalate and tartrate are listed. Among these, copper sulfate or manganese sulfate is preferable from the viewpoint of improving the disinfection effect.
These can be used individually by 1 type or in combination of 2 or more types.

  The blending amount of the component (b1) is defined according to the molar ratio with the component (b2), and is preferably equimolar or more, more preferably 2 molar equivalents or more, more preferably 5 molar equivalents or more with respect to the component (b2). Is more preferable. When the blending amount of the component (b1) is less than 1 times the molar ratio with respect to the component (b2), decomposition of the component (A) and damage / discoloration of the contact lens may not be suppressed. It is preferable that the component (b1) is excessive with respect to the component (b2) in terms of the stability of the component (B), but from the viewpoint of the disinfection effect, the component (b1) is 20 moles relative to the component (b2). Less than the amount is preferred.

  The blending amount of the component (b2) in the disinfectant is not particularly limited, but 0.0001 to 0.05 g / 100 mL is preferable in the disinfecting solution in which the contact lens is immersed when disinfecting the contact lens. 0.01 g / 100 mL is more preferable. When the blending amount of the component (b2) is less than 0.0001 g / 100 mL, it is difficult to improve the disinfection effect by the component (A), and when it exceeds 0.05 g / 100 mL, the component (A) is decomposed during storage. However, it may be difficult to obtain a sufficient disinfecting effect, or the contact lens may be deteriorated or discolored.

〔Neutralizer〕
The neutralizing agent is not particularly limited as long as it can neutralize hydrogen peroxide, and examples thereof include hydrogen peroxide-degrading enzymes such as catalase, sodium thiosulfate, etc. Among them, catalase or sodium thiosulfate is preferable.
When sodium thiosulfate is used as the neutralizing agent, it is preferable that the amount of sodium thiosulfate in the neutralizing agent is 0.0001 to 1.0 g / 100 mL when dissolved in the disinfectant. . This is because neutralization becomes insufficient when the amount of sodium thiosulfate used is less than 0.0001 g / 100 mL, and an improvement in neutralization rate or the like cannot be expected even when the amount exceeds 1.0 g / 100 mL.
When using catalase as a neutralizing agent, it is preferable to mix the neutralizing agent so that the concentration of catalase is 100 to 100,000 units / 100 mL in the disinfectant solution.

[Platinum parts]
The platinum member is a member for decomposing and neutralizing hydrogen peroxide in the disinfectant solution. Examples of the platinum member include a platinum disk provided at a position immersed in a disinfectant solution in a part of a lens case used when disinfecting a contact lens. The mass of the platinum disk can be determined in consideration of the amount of the disinfectant used for one disinfection and the hydrogen peroxide concentration in the disinfectant, and is, for example, about 0.1 to 2 mg.

[Optional ingredients]
In addition to the above-described components, other components can be added to the disinfectant and disinfecting unit of the present invention as long as the effects of the present invention are not impaired. For example, the hydrogen peroxide solution can contain a buffering agent such as boric acid, an isotonic agent such as sodium chloride, and a pH adjuster such as sodium hydroxide or hydrochloric acid. In addition, the component (B) or the neutralizing agent may contain a binder such as polyethylene glycol and a dissolution accelerator such as sodium sulfate.

(Dosage form and production method)
The dosage form of the disinfectant and neutralizing agent of the present invention is not particularly limited, and may be a liquid or a solid.
For example, the disinfection unit may be configured by a hydrogen peroxide solution in which hydrogen peroxide is dissolved, a catalyst solution in which the component (B) is dissolved, and a neutralizer solution in which the neutralizer is dissolved. In the case of such a dosage form, the disinfection unit (disinfection unit A) can be produced by dissolving hydrogen peroxide, the component (B), and the neutralizing agent in water at respective arbitrary concentrations. The pH of the hydrogen peroxide solution is about 3-7.
The disinfecting unit may be composed of the aqueous hydrogen peroxide solution, the solid (b1) component, the solid (b2) component, and the solid neutralizer. In the case of such a dosage form, a hydrogen peroxide solution is prepared, and a component (b1), a component (b2), and a neutralizing agent are prepared as solids (powder, etc.), respectively. B) can be produced.
Or the disinfection unit may be comprised by the said hydrogen peroxide aqueous solution and the solid formulation containing (B) component and a neutralizing agent. In the case of such a dosage form, the hydrogen peroxide solution is prepared by mixing the component (B), the neutralizing agent, the binder and the like and then compressing the tablet. And a disinfection unit (disinfection unit C) composed of a tablet containing a neutralizing agent.
Or it is good also as a solid formulation which contains the peroxide which melt | dissolves in water and generate | occur | produces hydrogen peroxide, (B) component, and the neutralizing agent individually or all, respectively. In the case of such a dosage form, the peroxide, the component (B), the neutralizing agent, the binder and the like are mixed and then tableted to produce a single tablet disinfection unit (disinfection unit D).
In addition, even if a lens member is provided with a platinum member and the lens case, the hydrogen peroxide solution, and the catalyst solution or the solid (B) component constitute a disinfection unit (disinfection unit E) Good.

  The method for producing the compound of the component (b1) and the component (b2) is not particularly limited as long as a complex of the component (b1) and the copper and / or manganese derived from the component (b2) can be formed. For example, the components (b1) and (b2) are added and dissolved in a solvent, and an alkali agent is added as necessary. The temperature is preferably room temperature to 100 ° C, more preferably about 25 ° C. These are stirred to react (reaction process). The stirring time is preferably 1 minute or more, more preferably 1 minute to 5 hours, and more preferably about 10 minutes. Immediately after completion of the reaction step, the solvent is distilled off from the reaction solution under reduced pressure, and the solid complex and by-product salt generated in the reaction step are recovered in the form of a mixture (recovery step).

Furthermore, you may employ | adopt the collection | recovery method which leaves the reaction liquid obtained at the reaction process for 1 hour-1 week in a cool dark place, and produces | generates the produced | generated precipitation, ie, a solid complex, by filtration. By providing such a step, the component (B) can be obtained as a higher purity complex.
In addition, when an unreacted ligand remains after reacting copper and / or manganese with a ligand composed of the component (b1), it is not always necessary to remove it, and it may be used as it is.

The solvent used in producing the complex is preferably a polar solvent, and examples thereof include water, ethanol, methanol, isopropanol, acetonitrile, acetone, dimethylacetamide, N, N-dimethylformamide, dimethylsulfoxide, dimethylacetamide, and the like. Among these, from the viewpoint of price, safety, ease of distillation, etc., one or more of water, ethanol, and methanol are preferable, and water is particularly preferable.
As the alkali agent, triethylamine, sodium hydroxide, sodium carbonate and the like can be used.

(Disinfection method)
The contact lens disinfection method using the disinfecting unit of the present invention is obtained by immersing a contact lens in a disinfecting solution in which the component (A) and the component (B) are dissolved, and then residual hydrogen peroxide in the disinfecting solution. Is to neutralize.
For example, when the disinfection unit A is used, an arbitrary amount of catalyst solution is added to a hydrogen peroxide solution having an arbitrary concentration to form a disinfecting solution, and the contact lens is immersed in the disinfecting solution to disinfect the contact lens. . Then, after the contact lens is immersed in the disinfecting solution for an arbitrary time, a neutralizer solution is added to the disinfecting solution to neutralize residual hydrogen peroxide. The immersion time of the contact lens in the disinfectant is not particularly limited, but is about 1 to 30 minutes, more preferably about 5 to 15 minutes.

When using the disinfection unit B, disinfect the solution by dissolving any amount of the components (b1) and (b2) in a hydrogen peroxide solution of any concentration to make the disinfection solution, and immersing the contact lens in this disinfection solution. I do. Then, after the contact lens is immersed in the disinfecting solution for an arbitrary time, the neutralizing agent can be dissolved in the disinfecting solution to neutralize the residual hydrogen peroxide.
In the case of using the disinfection unit C, a solid preparation containing the component (B) and the neutralizing agent is dissolved in a hydrogen peroxide solution having an arbitrary concentration to prepare a disinfection solution, and the contact lens is immersed in the disinfection solution. Can be disinfected and neutralized.
When the sterilization unit D is used, the sterilization unit D is dissolved in water to form a sterilization solution, and the contact lens is immersed in the sterilization solution for an arbitrary period of time so that sterilization and neutralization can be performed.
When using the disinfection unit (E), put a hydrogen peroxide solution and the component (B) into a lens case equipped with a platinum member to make a disinfection solution, and immerse the contact lens in this disinfection solution for an arbitrary period of time. Thus, disinfection and neutralization can be performed.

  According to the present invention, the component (B) can improve the disinfection effect of hydrogen peroxide in the disinfecting solution, shorten the disinfection time, and reduce the concentration of hydrogen peroxide in the disinfecting solution. In addition, since no special device is required, the contact lens can be sterilized by a simple operation. Furthermore, since the disinfectant of the present invention exhibits a high disinfecting effect even under relatively low temperature conditions, it is possible to disinfect contact lenses simply and in a short time when selecting use conditions.

  The reason why the above-described effect can be obtained in the present invention is considered to be that the compound (complex) of the component (b1) and the component (b2) functions as a catalyst for promoting oxidative decomposition of microorganisms by hydrogen peroxide. Further, even when the component (b1) and the component (b2) are added to the disinfecting solution, anions generated from the component (b1) and copper and / or manganese derived from the component (b2) can be easily obtained. It is thought that it can form a complex and promote oxidative degradation of microorganisms by hydrogen peroxide.

EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated concretely, this invention is not limited to an Example.
(Raw material)
The raw materials used in each example are shown below.
[Component (A)]
A-1: Hydrogen peroxide, manufactured by Mitsubishi Gas Chemical Co., Ltd. [component (b1)]
b1-1: D, L-aspartic acid-N- [1,2-dicarboxyethyl] tetrasodium salt (IDS), manufactured by LANXESS Corporation b1-2: Methylglycine diacetic acid trisodium salt (MGDA), BASF Japan B1-3: 2,6-pyridinedicarboxylic acid, manufactured by Kanto Chemical Co., Ltd. [(b1) Component comparison product]
b1-4: Ethylenediaminetetraacetic acid (EDTA), manufactured by Nagase ChemteX Corporation [component (b2)]
b2-1: MnSO ₄ · 5H ₂ O, manufactured by Kanto Chemical Co., Ltd. b2-2: CuSO ₄ · 5H ₂ O, manufactured by Kanto Chemical Co., Ltd. [neutralizing agent]
C-1: Catalase, CALBIOCHEM-NOVABIOCHEM CORPORATION [Others]
Buffer: Boric acid, manufactured by Kominato Pharmaceutical Co., Ltd. Isotonic agent: Sodium chloride, manufactured by Tomita Pharmaceutical Co., Ltd. pH adjuster: Sodium hydroxide, Kominato Pharmaceutical Co., Ltd. Binder: PEG4000 (polyethylene glycol), manufactured by ADEKA Co., Ltd. Agent: Na ₂ SO ₄ · 10H ₂ O, Tomita Pharmaceutical Co., Ltd.

(Evaluation of disinfection effect)
The disinfection effect was evaluated by conducting the following bactericidal tests in accordance with ISO 14729 (stand-alone test Primary criteria) and classifying the results into the following evaluation criteria.

[Sterilization test]
A mixed preparation containing the catalyst and neutralizing agent of each example (hereinafter simply referred to as a mixed preparation) and a microbial solution of a known number of microorganisms were simultaneously added to 10 mL of the hydrogen peroxide solution of each example to obtain a disinfectant solution. . Ten minutes after adding the mixed preparation and the microorganism solution to the hydrogen peroxide solution, the disinfectant solution was collected and the number of microorganisms in the disinfectant solution was measured. That is, in the sterilization test, the disinfection effect of each example disinfection unit was measured with a disinfection / neutralization time of 10 minutes.
As a result of the measurement, in the case of bacteria, the average value was reduced by 99.9% (logarithm of 3 digits) or more with respect to the initial number of bacteria in the disinfectant solution. The case was determined as “nonconforming”. In the case of molds and yeasts, the average value of the initial number of bacteria in the disinfectant can be reduced by 90% (logarithm of 1 digit) or more as “conforming”, and the case of less than 90% as “nonconforming”. did. This operation was performed for each of the five types of microorganisms.
The microorganism used was P.P. aeruginosa ATCC 9027, S.A. aureus ATCC 6538, S. aureus. marcescens ATCC 13880 (bacteria), C.I. albicans ATCC 10231, F.I. Solani ATCC36031 (above, mold / yeast) was used. In addition, the microorganism solution was prepared so that the number of microorganisms in the disinfectant solution was 1 × 10 ⁵ to 1 × 10 ⁶ cfu / mL.

〔Evaluation criteria〕
◎: “Compatible” for all five types of microorganisms
○: “Compatible” for 3 to 4 types of microorganisms
Δ: “Compatible” for 1 to 2 types of microorganisms
×: “Non-conformity” for all five types of microorganisms

(Examples 1-5, Comparative Examples 1-4)
According to the composition shown in Table 1, a hydrogen peroxide solution and a mixed preparation were prepared. The prepared hydrogen peroxide solution and the mixing agent were evaluated for disinfection effect, and the results are shown in Table 1. In addition, the composition of the hydrogen peroxide solution in the table indicates the ratio of each component in hydrogen peroxide, and the composition of the mixed preparation indicates the amount of each component used at one time.

(Reference Examples 1 and 2)
A commercially available contact lens disinfection unit was used to evaluate the disinfection effect. In addition, the reference example 1 evaluated the disinfection effect in the disinfection and neutralization time for 10 minutes, and the reference example 2 evaluated the disinfection effect in the minimum recommended immersion time (4 hours) of this commercial item.

As shown in the results of Examples 1 to 5 in Table 1, the disinfection unit to which the present invention was applied was able to perform disinfection and neutralization in a short time of 10 minutes, and a sufficient disinfection effect was obtained. On the other hand, Comparative Example 1 in which (b1) component is replaced with EDTA of coordination position 6 and Comparative Examples 2 to 4 which do not have either (b1) component or (b2) component have sufficient disinfection effect in 10 minutes. It was not obtained.
In addition, in Reference Example 2, although a sufficient disinfection effect was obtained, the concentration of the hydrogen peroxide solution was 3.0 g / 100 mL, and the disinfection / neutralization time was 4 hours.
In contrast, in Examples 1 to 5 to which the present invention is applied, even if the concentration of the hydrogen peroxide solution is as low as 0.03 to 0.005 g / 100 mL, a sufficient disinfection effect can be obtained in 10 minutes. It was.
From these results, it was found that by using the disinfection unit of the present invention, the disinfection / neutralization time can be significantly shortened and the hydrogen peroxide concentration can be reduced as compared with the conventional disinfection unit.

Claims (3)

(A): hydrogen peroxide or a peroxide that dissolves in water to generate hydrogen peroxide, and (B): a compound represented by any one of the following formulas (I) to (III) or a derivative thereof ( a disinfectant for contact lenses, comprising: a catalyst body comprising a mixture and / or a reaction product of b1) and at least one of a copper compound and a manganese compound (b2).

(In the formula, X represents a hydrogen atom, an alkali metal, or an alkaline earth metal. P represents an integer of 1 or 2, and when p is 2, X may be the same or different.)

(Wherein X ^{1 to} X ⁴ may be the same or different and each represents one selected from the group consisting of a hydrogen atom, an alkali metal, an alkaline earth metal, and a cationic ammonium group, and Q is a hydrogen atom or Represents an alkyl group, R represents a hydrogen atom or a hydroxyl group, and n ₁ is 0 or 1.)

(In the formula, Y represents an alkyl group, a carboxyl group, a sulfo group, an amino group, a hydroxyl group, or a hydrogen atom, and X ^{5 to} X ⁷ may be the same or different, and each represents a hydrogen atom, an alkali metal, or an alkaline earth. metalloid, represents one selected from the group consisting of cationic ammonium group, n ₂ represents an integer of 0 to 5.)   A contact lens disinfection unit comprising the contact lens disinfectant according to claim 1 and a hydrogen peroxide neutralizing agent.   A contact lens disinfection unit comprising the contact lens disinfectant according to claim 1 and a platinum member.