CA1099885A - Method of cleaning contact lenses - Google Patents
Method of cleaning contact lensesInfo
- Publication number
- CA1099885A CA1099885A CA308,549A CA308549A CA1099885A CA 1099885 A CA1099885 A CA 1099885A CA 308549 A CA308549 A CA 308549A CA 1099885 A CA1099885 A CA 1099885A
- Authority
- CA
- Canada
- Prior art keywords
- accordance
- alkali metal
- contact lenses
- solution
- ascorbic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
- A61L12/124—Hydrogen peroxide; Peroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
Abstract
ABSTRACT
Method and composition for disinfecting and cleaning contact lenses using a reduction oxidizing system comprising an ene-diol and a water-soluble peroxide.
Method and composition for disinfecting and cleaning contact lenses using a reduction oxidizing system comprising an ene-diol and a water-soluble peroxide.
Description
~g~
The present invention relates to a method and composition for disinfecting and cleaning of contact lenses.
The object of the present invention is to obtain a method for disinfecting and cleaning of contact lenses, which method eliminates the use of electric boiling apparatus, and which eliminates the use of a chemical cleansing product which may cause allergic reactions~
Contact lenses are today mostly used in the form of soft contact lenses, i.e., contact lenses manufactured from a polymer which is soft and may thus easily adapt to the shape of the eye. One polymer used is a copolymer between hydroxyethyl methacrylate and ethylene glycol dimethacrylate, which polymer is essentially inert--pharmacologically, physiolgically, and toxicologically.
The polymer is used in hydrated state and cooperates thus with the eye liquid.
Soft contact lenses may also be manufactured from silica gum.
Soft contact lenses have become more and more used by those which have to correct their vision as such lenses are very convenient to wear once one has been used to them.
In practice the soft contact lenses will be contaminated with microorganisms from the surroundings as well as it will be stained with protein deposits from the eye. In order not to cause eye infections the lenses have to be disinfected once every 24 hrs and in order not to become dirty and give a blurred vision, they have to be cleaned even so often.
It has been found that the microorganism ~lora often is altered from normal eye-mi,croorganism flora to a microorganism flora containing aerobic intestine micro-organisms whén chemical disinfectants have been used for a time. Thus E. coli, Pseudomonas, Proteus, Staphylo-.
~ ~ .
.. . . . .
..
coccii, Coryne bacterias, B. subtilis and Candidafungus have been found.
However, in order not to cause bacterial infec-tions in the eye the lenses have to be disinfected once every 24 hrs as mentioned above. The most commonly used method is thereby the "hot method", which means that the lenses are placed in a closed chamber containing an aqueous saline solution which chamber is held above boiling water for about 20 min. The chamber and its contents are thereby hot sterilized and the lenses may be used as soon as they have reached ambient temperature.
The "hot method", ho~ever, has its drawbacks in that one needs a thermostatic guided boiler, preferably distilled water, and electricity. At home there are as a rule no major problems about that but being out travelling it may be a bit of a problem to carry the boiler with, to obtain an adapter between different electric appliances etc. The off-boiling water may also create a problem in that it may cause corrosion or other similar problems if the boiler should be placed on the same spot week after week.
Another method is to rinse the lenses with a solution containing`a bactericidal (and virucidal) compo-sition. Compounds used for this purpose are i.a.
chlorohexidine-digluconate, alkyltriethanol-ammonium-chloride, iodophors, thiomersal (a Hg-compound), sodiurn tetracemedine, sorbic acid.
It is also known to use a 3% solution of hydrogen peroxide for cleaning and disinfection.
Being out travelling the chemical method is to be preferred as one then only needs a package of tablets to be dissolved in distilled water. The amount o~ wa-ter needed - is small.
;, . ' ~ ' .
-It has, however, turned out that some people got allergic reactions in the eyes when they use the "chemical method". So far one is not sure about the reasons for the allergic reactions but the users are asked to be careful when using these chemical systems and to use the "hot method" in between.
It has thus been a common requirement that it should be possible to obtain a chemical method which eliminates the above mentioned drawbacks.
The present invention relates thus to a method and composition for disinfecting and cleaning contact lenses whereby a reduction-oxidizing system is used which system comprises an ene-diol compound selected from the group consisting of ascorbic acid, isoascorbic acid, dihydroxymaleic acid, dihydroxyfumaric acid, and reductic acid, or salts, or derivatives thereof, and a oxidizing agent in the form of a water soluble peroxide selected rom the group consisting of alkali metal percarbonates, carbamide peroxide, and hydrogen peroxide, which system in a solution, preferably an aqueous solutionl is brought into contact with the contact lens(-es) to be disinfected for a time long enough to disinfect.
According to a preferred embodiment ascorbic acid or isoascorbic acid is used together with sodium percarbonate, more preferred is thereby ascorbic acid.
Under certain circumstances the system can be furthe~ activated by means of a catalyst in the form of a heavy metal salt, preferably copper sulphate.
The concentrations of the ene-diol compound and the oxidizing agent should be equivalent. The concentra-tions may however differ from each other.
A concentration of ascorbic acid of 0.0001 molar is known to give an antimicrobial effect. Strong antimi~
crobial effect is found when the concentration reaches 0.002 molar and thereabove.
`: :
.
.
The concentration of copper sulphate may be 0.000004 to 0.0004 percent by weight, preferably in the range of about 0.00001. Such low concentrations are below the toxic levels for the most sensitive tissues found.
Besides Cu, Fe, Mn, Ni, and Co may be used as catalysts.
The salts of the ene-diol compounds used are sodium, potassium or calcium salts. Derivatives used are such as the esters of fatty acids having 2-18 carbon atoms, such as the acetate, palmitate or stearate.
The present redox system is preferably available as a pulverulent, granular or tablet formulation which is to be dissolved in a predetermined amount of distilled water.
Example 1 A dry mixture of 35.2 mg of ascorbic acid and 31.4 mg sodium percarbonate was prepared and packed in a moisture proof package further containing a drying agent, separate from the mixture per se. The mixture as in pulverulent form is added to and dissolved in 100 ml of distilled water into which the soft contact lenses are placed. The soft contact lenses are allowed to stay in the solution for 5 min. whereupon they are removed and, if desired, rinsed with saline solution.
The time set for disinfection, 5 min., is enough to get antimicrobial activity, and in any case the solution will have no effect after one hour due to end of reaction. The soft lenses may be kept in the solution durin~ the night if so desired, as the redox system is "self-destroyable".
Example 2 Isoascorbic acid, ~0.001 mole), was added to 100 ml of a solution of hydrogen peroxide (0.002 moles) in distilled water. Soft lenses were placed therein and treated for 5 min. After removal o -the lenses from the .
:
.
.
.
.
solution they were rinsed with saline solution.
Example 3 Granules containing ascorbic acid and sodium percarbonate in equivalent amounts were manufactured and packed in moisture proof packages. ~ach package contained granules in an amount to give a 0.0005 molar concentration of each of the components in 100 ml of distilled water.
Example 4 17.6 mg of ascorbic acid, 15.7 mg of sodium percarbonate and 40 ~g copper sulphate were dissolved in 100 ml of distilled water. Soft contact lenses were soaked into the solution for 5 min. and were then rinsed with saline solution.
As the redox-system is activated in the presence of water a solution has to be prepared immediately before use, and consequently a dry mixture be stored moisture-free in a moisture tight bag or the like.
The present redox-system has shown to be more effective against E.coli than hydrogen peroxide.
Solution containing (I) 8 mM sodium ascorbate, 8 mN H202 and 0.03% CuSO4 was used and compared with a solution (II) of 8 mM H2O2 and 0.03~ CuSO4. Control:
Saline solution.
A suspension of E.coli was exposed to the solutions above and 0.1 ml volumes were removed and spread on Endoagar plates after 5, 15, 30, and 60 minutes exp~sure to the test solutions. The results are given in Table 1 below. Double tests were carried out. The colony numbers are given for each test.
Table 1 Relation of Bacterial Effect to Time of Exposure Solution Colony Numbers Control 331;342 334;318 II 354;343353;310 298;324245;271 I 80 90 0;0 0;0 0;0 The present system is active against B. proteus, Pseudomonas pyocyanea, Candida albicans, and poliomyelitis virus. Strong bactericidal effect has also been found with streptococcii, pneumococcii, Salmonella typhimurium, Corynebacterium diphtheriae, Hemophilus pertussis and others.
; The present redox-system has a decomposing effect on mucus, which means that the antimicrobial effect will be better as viscosity is lowered and the redox system morei easily will reach the microbes.
Hard contact lenses may as well be cleaned and disinfected according to the present method and with the use of the present composition.
The concentration of the redox system may well reach 0.01-0.04 molar, whereby the concentrations of enediol compound and peroxide donor are preferably equimolar.
Sodium chloride may be introduced into the composition in such an amount as to create a saline 3~ solutlon when the reaction is completed.
, .
- ' - : , , ' ,,
The present invention relates to a method and composition for disinfecting and cleaning of contact lenses.
The object of the present invention is to obtain a method for disinfecting and cleaning of contact lenses, which method eliminates the use of electric boiling apparatus, and which eliminates the use of a chemical cleansing product which may cause allergic reactions~
Contact lenses are today mostly used in the form of soft contact lenses, i.e., contact lenses manufactured from a polymer which is soft and may thus easily adapt to the shape of the eye. One polymer used is a copolymer between hydroxyethyl methacrylate and ethylene glycol dimethacrylate, which polymer is essentially inert--pharmacologically, physiolgically, and toxicologically.
The polymer is used in hydrated state and cooperates thus with the eye liquid.
Soft contact lenses may also be manufactured from silica gum.
Soft contact lenses have become more and more used by those which have to correct their vision as such lenses are very convenient to wear once one has been used to them.
In practice the soft contact lenses will be contaminated with microorganisms from the surroundings as well as it will be stained with protein deposits from the eye. In order not to cause eye infections the lenses have to be disinfected once every 24 hrs and in order not to become dirty and give a blurred vision, they have to be cleaned even so often.
It has been found that the microorganism ~lora often is altered from normal eye-mi,croorganism flora to a microorganism flora containing aerobic intestine micro-organisms whén chemical disinfectants have been used for a time. Thus E. coli, Pseudomonas, Proteus, Staphylo-.
~ ~ .
.. . . . .
..
coccii, Coryne bacterias, B. subtilis and Candidafungus have been found.
However, in order not to cause bacterial infec-tions in the eye the lenses have to be disinfected once every 24 hrs as mentioned above. The most commonly used method is thereby the "hot method", which means that the lenses are placed in a closed chamber containing an aqueous saline solution which chamber is held above boiling water for about 20 min. The chamber and its contents are thereby hot sterilized and the lenses may be used as soon as they have reached ambient temperature.
The "hot method", ho~ever, has its drawbacks in that one needs a thermostatic guided boiler, preferably distilled water, and electricity. At home there are as a rule no major problems about that but being out travelling it may be a bit of a problem to carry the boiler with, to obtain an adapter between different electric appliances etc. The off-boiling water may also create a problem in that it may cause corrosion or other similar problems if the boiler should be placed on the same spot week after week.
Another method is to rinse the lenses with a solution containing`a bactericidal (and virucidal) compo-sition. Compounds used for this purpose are i.a.
chlorohexidine-digluconate, alkyltriethanol-ammonium-chloride, iodophors, thiomersal (a Hg-compound), sodiurn tetracemedine, sorbic acid.
It is also known to use a 3% solution of hydrogen peroxide for cleaning and disinfection.
Being out travelling the chemical method is to be preferred as one then only needs a package of tablets to be dissolved in distilled water. The amount o~ wa-ter needed - is small.
;, . ' ~ ' .
-It has, however, turned out that some people got allergic reactions in the eyes when they use the "chemical method". So far one is not sure about the reasons for the allergic reactions but the users are asked to be careful when using these chemical systems and to use the "hot method" in between.
It has thus been a common requirement that it should be possible to obtain a chemical method which eliminates the above mentioned drawbacks.
The present invention relates thus to a method and composition for disinfecting and cleaning contact lenses whereby a reduction-oxidizing system is used which system comprises an ene-diol compound selected from the group consisting of ascorbic acid, isoascorbic acid, dihydroxymaleic acid, dihydroxyfumaric acid, and reductic acid, or salts, or derivatives thereof, and a oxidizing agent in the form of a water soluble peroxide selected rom the group consisting of alkali metal percarbonates, carbamide peroxide, and hydrogen peroxide, which system in a solution, preferably an aqueous solutionl is brought into contact with the contact lens(-es) to be disinfected for a time long enough to disinfect.
According to a preferred embodiment ascorbic acid or isoascorbic acid is used together with sodium percarbonate, more preferred is thereby ascorbic acid.
Under certain circumstances the system can be furthe~ activated by means of a catalyst in the form of a heavy metal salt, preferably copper sulphate.
The concentrations of the ene-diol compound and the oxidizing agent should be equivalent. The concentra-tions may however differ from each other.
A concentration of ascorbic acid of 0.0001 molar is known to give an antimicrobial effect. Strong antimi~
crobial effect is found when the concentration reaches 0.002 molar and thereabove.
`: :
.
.
The concentration of copper sulphate may be 0.000004 to 0.0004 percent by weight, preferably in the range of about 0.00001. Such low concentrations are below the toxic levels for the most sensitive tissues found.
Besides Cu, Fe, Mn, Ni, and Co may be used as catalysts.
The salts of the ene-diol compounds used are sodium, potassium or calcium salts. Derivatives used are such as the esters of fatty acids having 2-18 carbon atoms, such as the acetate, palmitate or stearate.
The present redox system is preferably available as a pulverulent, granular or tablet formulation which is to be dissolved in a predetermined amount of distilled water.
Example 1 A dry mixture of 35.2 mg of ascorbic acid and 31.4 mg sodium percarbonate was prepared and packed in a moisture proof package further containing a drying agent, separate from the mixture per se. The mixture as in pulverulent form is added to and dissolved in 100 ml of distilled water into which the soft contact lenses are placed. The soft contact lenses are allowed to stay in the solution for 5 min. whereupon they are removed and, if desired, rinsed with saline solution.
The time set for disinfection, 5 min., is enough to get antimicrobial activity, and in any case the solution will have no effect after one hour due to end of reaction. The soft lenses may be kept in the solution durin~ the night if so desired, as the redox system is "self-destroyable".
Example 2 Isoascorbic acid, ~0.001 mole), was added to 100 ml of a solution of hydrogen peroxide (0.002 moles) in distilled water. Soft lenses were placed therein and treated for 5 min. After removal o -the lenses from the .
:
.
.
.
.
solution they were rinsed with saline solution.
Example 3 Granules containing ascorbic acid and sodium percarbonate in equivalent amounts were manufactured and packed in moisture proof packages. ~ach package contained granules in an amount to give a 0.0005 molar concentration of each of the components in 100 ml of distilled water.
Example 4 17.6 mg of ascorbic acid, 15.7 mg of sodium percarbonate and 40 ~g copper sulphate were dissolved in 100 ml of distilled water. Soft contact lenses were soaked into the solution for 5 min. and were then rinsed with saline solution.
As the redox-system is activated in the presence of water a solution has to be prepared immediately before use, and consequently a dry mixture be stored moisture-free in a moisture tight bag or the like.
The present redox-system has shown to be more effective against E.coli than hydrogen peroxide.
Solution containing (I) 8 mM sodium ascorbate, 8 mN H202 and 0.03% CuSO4 was used and compared with a solution (II) of 8 mM H2O2 and 0.03~ CuSO4. Control:
Saline solution.
A suspension of E.coli was exposed to the solutions above and 0.1 ml volumes were removed and spread on Endoagar plates after 5, 15, 30, and 60 minutes exp~sure to the test solutions. The results are given in Table 1 below. Double tests were carried out. The colony numbers are given for each test.
Table 1 Relation of Bacterial Effect to Time of Exposure Solution Colony Numbers Control 331;342 334;318 II 354;343353;310 298;324245;271 I 80 90 0;0 0;0 0;0 The present system is active against B. proteus, Pseudomonas pyocyanea, Candida albicans, and poliomyelitis virus. Strong bactericidal effect has also been found with streptococcii, pneumococcii, Salmonella typhimurium, Corynebacterium diphtheriae, Hemophilus pertussis and others.
; The present redox-system has a decomposing effect on mucus, which means that the antimicrobial effect will be better as viscosity is lowered and the redox system morei easily will reach the microbes.
Hard contact lenses may as well be cleaned and disinfected according to the present method and with the use of the present composition.
The concentration of the redox system may well reach 0.01-0.04 molar, whereby the concentrations of enediol compound and peroxide donor are preferably equimolar.
Sodium chloride may be introduced into the composition in such an amount as to create a saline 3~ solutlon when the reaction is completed.
, .
- ' - : , , ' ,,
Claims (8)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A method for disinfecting contact lenses comprising immersing a contact lens in an antimicrobially active aqueous solution of ascorbic acid, an alkali metal per carbonate, and an effective amount of copper salt catalyst, the concentration of ascorbic acid being at least about 0.0001 molar and the concentration of alkali metal percarbonate being at least about 0.0001 molar.
2. A method on accordance with claim 1 wherein the alkali metal percarbonate is sodium percarbonate.
3. A method in accordance with claim 1 wherein the catalyst is copper sulfate.
4. A method in accordance with claim 1, 2 or 3 wherein the concentration of copper sulfate is at least about 0.000004 percent by weight.
5. A method for disinfecting contact lenses, comprising providing a dry, essentially moisture-free mixture of ascorbic acid, an alkali metal percarbonate, and a copper salt catalyst, dissolving said mixture in an amount of water sufficient to provide 0.0001 molar ascorbic acid solution and a 0.0001 molar alkali metal per-carbonate solution, and immersing the contact lens in said solution for a sufficient time to cause disinfection.
6. A method in accordance with claim 5 wherein the alkali metal percarbonate is sodium percarbonate.
7. A method in accordance with claim 5 wherein the catalyst is copper sulfate.
8. A method in accordance with claim 5, 6 or 7 wherein the concentration of copper sulfate is at least about 0.000004 percent by weight.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7709348A SE425287B (en) | 1977-08-19 | 1977-08-19 | USING AN ANTI-MICROBIAL ACTIVE SOLUTION INCLUDING A REDUCTION OXIDATION SYSTEM FOR CLEANING AND DISINFECTING CONTACT LENSES |
| SE7709348-2 | 1977-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1099885A true CA1099885A (en) | 1981-04-28 |
Family
ID=20332046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA308,549A Expired CA1099885A (en) | 1977-08-19 | 1978-08-01 | Method of cleaning contact lenses |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS5452892A (en) |
| AU (1) | AU521269B2 (en) |
| CA (1) | CA1099885A (en) |
| DE (1) | DE2835652A1 (en) |
| GB (1) | GB2003033B (en) |
| SE (1) | SE425287B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775424A (en) * | 1986-07-31 | 1988-10-04 | Henkel Kommanditgesellshaft Auf Aktien | Disinfecting and cleaning system for contact lenses |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4529535A (en) * | 1982-06-01 | 1985-07-16 | Sherman Laboratories, Inc. | Soft contact lens wetting solution containing preservative system and method |
| US4510065A (en) * | 1982-06-01 | 1985-04-09 | Sherman Laboratories, Inc. | Soft contact lens preservative system, prophylactic cleaner and method |
| US4521375A (en) * | 1982-11-23 | 1985-06-04 | Coopervision, Inc. | Sterilizing treatment with hydrogen peroxide and neutralization of residual amounts thereof |
| AU573247B2 (en) * | 1983-08-25 | 1988-06-02 | Advanced Medical Optics, Inc. | Contact lens disinfection |
| JPS6359960A (en) * | 1985-08-30 | 1988-03-15 | ホ−ヤ株式会社 | Solution for soft contact lens |
| JPH0621905B2 (en) * | 1986-08-15 | 1994-03-23 | ホ−ヤ株式会社 | Contact lens cleaning composition |
| JPS6453684U (en) * | 1987-09-30 | 1989-04-03 | ||
| US5298182A (en) * | 1989-01-31 | 1994-03-29 | Ciba-Geigy Corporation | Rapid ophthalmic glycol/lower alkanol cleaning and disinfecting solution and method |
| NO913116L (en) * | 1990-08-15 | 1992-02-17 | Senju Pharma Co | PROCEDURE FOR CLEANING LARGE CONTACT LENSES. |
| WO1992004921A1 (en) * | 1990-09-25 | 1992-04-02 | Allergan, Inc. | Apparatus and method for disinfecting a contact lens and detecting the presence of an oxidative disinfectant |
| IT1243946B (en) * | 1990-11-29 | 1994-06-28 | Zeiss Carl Spa | METHOD FOR DISINFECTION AND CLEANING OF CONTACT LENSES. |
| AU9158491A (en) * | 1990-12-19 | 1992-07-22 | Allergan, Inc. | Compositions and methods for contact lens disinfecting |
| JP2838368B2 (en) * | 1994-07-22 | 1998-12-16 | 株式会社サンコンタクトレンズ | Enzyme cleaning solution for contact lenses |
| US6428580B2 (en) * | 1997-08-20 | 2002-08-06 | L'oreal | Use of ascorbic acid in permanent waving and hair coloring compositions |
| DE102006062616A1 (en) * | 2006-12-29 | 2008-07-03 | Anovis Biotech Gmbh | Contact lens cleaner contains a percarboxylic acid |
| CN106675798A (en) * | 2016-12-16 | 2017-05-17 | 安徽长庚光学科技有限公司 | Cleaning fluid for optical lens and preparation method thereof |
| GB2572364B (en) * | 2018-03-27 | 2023-04-12 | Selden Res Ltd | Improved Bleaching Compositions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3912451A (en) * | 1973-06-04 | 1975-10-14 | Warner Lambert Co | Method for removing hydrogen peroxide from soft contact lenses |
| US3908680A (en) * | 1973-10-12 | 1975-09-30 | Flow Pharma Inc | Methods for cleaning and bleaching plastic articles |
-
1977
- 1977-08-19 SE SE7709348A patent/SE425287B/en not_active IP Right Cessation
-
1978
- 1978-08-01 CA CA308,549A patent/CA1099885A/en not_active Expired
- 1978-08-07 AU AU38708/78A patent/AU521269B2/en not_active Expired
- 1978-08-14 DE DE19782835652 patent/DE2835652A1/en active Granted
- 1978-08-17 JP JP10042878A patent/JPS5452892A/en active Granted
- 1978-08-21 GB GB7834048A patent/GB2003033B/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775424A (en) * | 1986-07-31 | 1988-10-04 | Henkel Kommanditgesellshaft Auf Aktien | Disinfecting and cleaning system for contact lenses |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2835652A1 (en) | 1979-03-01 |
| AU521269B2 (en) | 1982-03-25 |
| GB2003033A (en) | 1979-03-07 |
| DE2835652C2 (en) | 1987-06-25 |
| JPS6134343B2 (en) | 1986-08-07 |
| SE425287B (en) | 1982-09-20 |
| AU3870878A (en) | 1980-02-14 |
| JPS5452892A (en) | 1979-04-25 |
| SE7709348L (en) | 1979-02-20 |
| GB2003033B (en) | 1982-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |