JP2011130770A5 - - Google Patents

Download PDF

Info

Publication number
JP2011130770A5
JP2011130770A5 JP2011012411A JP2011012411A JP2011130770A5 JP 2011130770 A5 JP2011130770 A5 JP 2011130770A5 JP 2011012411 A JP2011012411 A JP 2011012411A JP 2011012411 A JP2011012411 A JP 2011012411A JP 2011130770 A5 JP2011130770 A5 JP 2011130770A5
Authority
JP
Japan
Prior art keywords
cancer
tumor
sarcoma
cell
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011012411A
Other languages
English (en)
Japanese (ja)
Other versions
JP5372973B2 (ja
JP2011130770A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2011130770A publication Critical patent/JP2011130770A/ja
Publication of JP2011130770A5 publication Critical patent/JP2011130770A5/ja
Application granted granted Critical
Publication of JP5372973B2 publication Critical patent/JP5372973B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2011012411A 2002-06-19 2011-01-24 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー Expired - Lifetime JP5372973B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39020302P 2002-06-19 2002-06-19
US60/390,203 2002-06-19

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2010000787A Division JP2010110329A (ja) 2002-06-19 2010-01-05 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー

Publications (3)

Publication Number Publication Date
JP2011130770A JP2011130770A (ja) 2011-07-07
JP2011130770A5 true JP2011130770A5 (https=) 2012-05-10
JP5372973B2 JP5372973B2 (ja) 2013-12-18

Family

ID=30000526

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2004516175A Expired - Lifetime JP4488512B2 (ja) 2002-06-19 2003-06-19 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー
JP2010000787A Pending JP2010110329A (ja) 2002-06-19 2010-01-05 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー
JP2011012411A Expired - Lifetime JP5372973B2 (ja) 2002-06-19 2011-01-24 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2004516175A Expired - Lifetime JP4488512B2 (ja) 2002-06-19 2003-06-19 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー
JP2010000787A Pending JP2010110329A (ja) 2002-06-19 2010-01-05 新規のｒａａｇ１０細胞表面標的および当該標的を認識する抗体ファミリー

Country Status (12)

Country Link
US (3) US7527969B2 (https=)
EP (2) EP1565489B1 (https=)
JP (3) JP4488512B2 (https=)
AT (1) ATE488530T1 (https=)
AU (1) AU2003243749B2 (https=)
CA (1) CA2490399C (https=)
DE (1) DE60335022D1 (https=)
DK (1) DK1565489T3 (https=)
ES (1) ES2356444T3 (https=)
MX (1) MXPA04012664A (https=)
PT (1) PT1565489E (https=)
WO (1) WO2004001381A2 (https=)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04012664A (es) 2002-06-19 2005-08-15 Raven Biotechnologies Inc Objetivo de superficie celular raag10 novedoso y una familia de anticuerpos que reconocen ese objetivo.
ATE548389T1 (de) 2004-08-03 2012-03-15 Innate Pharma Therapeutische und diagnostische verfahren und zusammensetzungen zum targeting von 4ig-b7-h3 und dem entsprechenden nk-zellen-rezeptor
JP2009221164A (ja) 2008-03-17 2009-10-01 Nitto Denko Corp 肺線維症処置剤
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
EP1846032A4 (en) * 2005-01-31 2009-01-28 Raven Biotechnologies Inc LUCA2 AND THEREO BINDING ANTIBODIES
AU2006210589B2 (en) 2005-02-02 2011-12-08 Macrogenics West, Inc. ADAM-9 modulators
US9963510B2 (en) 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
US7718774B2 (en) * 2006-11-08 2010-05-18 Macrogenics, Inc. TES7 and antibodies that bind thereto
WO2008057632A1 (en) * 2006-11-09 2008-05-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Differential gene expression in physiological and pathological angiogenesis
KR101523698B1 (ko) 2007-01-22 2015-05-29 마크로제닉스 웨스트 인코퍼레이티드 사람 암 줄기세포
TWI407971B (zh) 2007-03-30 2013-09-11 日東電工股份有限公司 Cancer cells and tumor-related fibroblasts
AU2009258063B2 (en) 2007-06-21 2014-09-25 Macrogenics, Inc. BCR-complex-specific antibodies and methods of using same
EP2376109B1 (en) 2008-12-19 2019-01-23 MacroGenics, Inc. Covalent diabodies and uses thereof
ES2666152T3 (es) 2009-08-13 2018-05-03 The Johns Hopkins University Métodos de modulación de la función inmunitaria con anticuerpos anti-B7-H7CR
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
JP5998060B2 (ja) 2010-03-04 2016-09-28 マクロジェニクス，インコーポレーテッド Ｂ７−ｈ３と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用
EP2601216B1 (en) 2010-08-02 2018-01-03 MacroGenics, Inc. Covalent diabodies and uses thereof
JP5950428B2 (ja) 2010-08-05 2016-07-13 日東電工株式会社 線維化組織から正常組織を再生するための組成物
US8642951B2 (en) 2011-05-04 2014-02-04 Agilent Technologies, Inc. Device, system, and method for reflecting ions
CA2836873C (en) 2011-05-21 2019-10-22 Macrogenics, Inc. Deimmunized serum-binding domains and their use for extending serum half-life
RU2639459C2 (ru) 2011-06-21 2017-12-21 Нитто Денко Корпорейшн Апоптоз-индуцирующее средство
JP6340162B2 (ja) 2012-12-20 2018-06-06 日東電工株式会社 アポトーシス誘導剤
JP6076076B2 (ja) 2012-12-21 2017-02-08 日東電工株式会社 組織再生促進剤
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
KR20160135190A (ko) 2014-02-14 2016-11-25 앤드류 에스. 카이 혈관형성 암의 치료를 위한 개선된 방법
CA2944417A1 (en) 2014-04-02 2015-10-08 Nitto Denko Corporation A targeting molecule and a use thereof
EP3129425B1 (en) 2014-04-07 2019-04-10 Nitto Denko Corporation Polymer-based hydrotropes for hydrophobic drug delivery
JP6727765B2 (ja) 2014-06-17 2020-07-22 日東電工株式会社 アポトーシス誘導剤
CN108136010A (zh) 2015-10-08 2018-06-08 宏观基因有限公司 用于治疗癌症的联合疗法
US10954301B2 (en) 2015-12-14 2021-03-23 Macrogenics, Inc. Bispecific molecules having immunoreactivity with PD-1 and CTLA-4, and methods of use thereof
TWI781098B (zh) 2016-04-15 2022-10-21 美商宏觀基因股份有限公司 新穎的ｂ７-ｈ３-結合分子、其抗體藥物綴合物及其使用方法
MX2018014950A (es) 2016-06-07 2019-04-25 Macrogenics Inc Terapia de combinacion.
EP3458479B1 (en) * 2016-06-08 2020-11-04 AbbVie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
IL268836B2 (en) 2017-02-24 2024-04-01 Macrogenics Inc Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof
JP7264831B2 (ja) * 2017-06-15 2023-04-25 ディベロップメント センター フォー バイオテクノロジー 抗ｇｌｏｂｏ ｈ抗体を含有する抗体－薬物コンジュゲートおよびその使用
SG11202005557TA (en) 2017-12-12 2020-07-29 Macrogenics Inc Bispecific cd 16-binding molecules and their use in the treatment of disease
SG11202007572VA (en) 2018-02-15 2020-09-29 Macrogenics Inc Variant cd3-binding domains and their use in combination therapies for the treatment of disease
EP4106813A4 (en) 2020-02-21 2024-03-27 MacroGenics, Inc. CD137 BINDING MOLECULES AND THEIR USES
JP2024511277A (ja) 2021-02-19 2024-03-13 メビオン・メディカル・システムズ・インコーポレーテッド 粒子線治療システムのためのガントリー
MX2024000406A (es) 2021-07-19 2024-04-18 Regeneron Pharma Combinacion de inhibidores de puntos de control y un virus oncolitico para el tratamiento del cancer.
US20250152643A1 (en) 2022-02-17 2025-05-15 Regeneron Pharmaceuticals, Inc. Combinations of checkpoint inhibitors and oncolytic virus for treating cancer

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6054561A (en) 1984-02-08 2000-04-25 Chiron Corporation Antigen-binding sites of antibody molecules specific for cancer antigens
US5807715A (en) * 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5552391A (en) * 1990-01-16 1996-09-03 La Jolla Pharmaceutical Company Chemically-defined non-polymeric valency platform molecules and conjugates thereof
US5427908A (en) * 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
GB9115364D0 (en) * 1991-07-16 1991-08-28 Wellcome Found Antibody
AU669124B2 (en) * 1991-09-18 1996-05-30 Kyowa Hakko Kirin Co., Ltd. Process for producing humanized chimera antibody
ES2136092T3 (es) * 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US6180377B1 (en) * 1993-06-16 2001-01-30 Celltech Therapeutics Limited Humanized antibodies
US6001359A (en) * 1993-06-29 1999-12-14 Eli Lilly And Company Diagnosis of colon carcinoma using monoclonal antibodies to human influx peptide transporter
US5532159A (en) 1994-04-01 1996-07-02 The Ohio State University Monoclonal antibody to canine placental oncofetal protein for detecting cancer
US6265150B1 (en) * 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
JP3868740B2 (ja) 1998-03-10 2007-01-17 ジェネンテック・インコーポレーテッド 新規なポリペプチド及びそれをコードする核酸
AU4640600A (en) 1999-05-11 2000-11-21 Eli Lilly And Company Amyloid precursor protein protease and related nucleic acid compounds
EP1514933A1 (en) 1999-07-08 2005-03-16 Research Association for Biotechnology Secretory protein or membrane protein
EP1210428B1 (en) 1999-08-23 2015-03-18 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
WO2001014577A1 (en) 1999-08-24 2001-03-01 Smithkline Beecham Corporation Molecular cloning of a galanin like 7tm receptor (axor40)
US6429303B1 (en) 1999-09-03 2002-08-06 Curagen Corporation Nucleic acids encoding members of the human B lymphocyte activation antigen B7 family and methods of using the same
CA2389916A1 (en) * 1999-09-03 2001-03-15 Human Genome Sciences, Inc. B7-like polynucleotides, polypeptides, and antibodies
US6406840B1 (en) 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
US6416999B1 (en) * 2000-04-07 2002-07-09 Raven Biotechnologies, Inc. Human Müllerian duct-derived epithelial cells and methods of isolation and uses thereof
US6436704B1 (en) * 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US6987024B1 (en) 2000-04-10 2006-01-17 Raven Biotechnologies, Inc. Human ovarian mesothelial cells and methods of isolation and uses thereof
US20060154313A1 (en) * 2000-04-13 2006-07-13 Immunex Corporation Human B7 polypeptide B7-H3A
AU2001264747A1 (en) 2000-05-22 2001-12-03 Idec Pharmaceuticals Corporation Identification of unique binding interactions between certain antibodies and thehuman b7.1 and b7.2 co-stimulatory antigens
CA2412377A1 (en) * 2000-06-06 2001-12-13 Bristol-Myers Squibb Company B7-related nucleic acids and polypeptides and their uses for immunomodulation
EP1892251A3 (en) 2000-06-06 2008-12-31 Brystol-Myers Squibb Company B7-related nucleic acids and polypeptides and their uses for immunomodulation
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
US6635750B1 (en) 2000-07-20 2003-10-21 Millennium Pharmaceuticals, Inc. B7-H2 nucleic acids, members of the B7 family
US6891030B2 (en) * 2000-07-27 2005-05-10 Mayo Foundation For Medical Education And Research T-cell immunoregulatory molecule
AU2001286205A1 (en) * 2000-09-12 2002-03-26 Kirin Beer Kabushiki Kaisha Novel dendritic cell wall membrane and use thereof
US20030134283A1 (en) * 2000-10-03 2003-07-17 Peterson David P. Genes regulated in dendritic cell differentiation
EP1399187A4 (en) 2000-10-18 2005-09-21 Sloan Kettering Inst Cancer APPLICATIONS OF MONOCLONAL ANTIBODY 8H9
EP1401999A4 (en) * 2001-05-25 2005-09-14 Amgen Inc PROTEIN-2 MOLECULES ASSOCIATED WITH B7 AND USE THEREOF
US20070015144A9 (en) * 2001-05-25 2007-01-18 Genset, S.A. Human cDNAs and proteins and uses thereof
EP1390497A2 (en) * 2001-05-25 2004-02-25 Genset Human cdnas and proteins and uses thereof
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
WO2003014293A2 (en) * 2001-08-02 2003-02-20 Eli Lilly And Company Novel polypeptide analogs and fusions and their methods of use
CA2475356A1 (en) 2002-02-12 2003-08-21 Raven Biotechnologies, Inc. Human fetal bladder-derived epithelial cells
US20040162236A1 (en) * 2002-04-01 2004-08-19 John Alsobrook Therapeutic polypeptides, nucleic acids encoding same, and methods of use
MXPA04012664A (es) * 2002-06-19 2005-08-15 Raven Biotechnologies Inc Objetivo de superficie celular raag10 novedoso y una familia de anticuerpos que reconocen ese objetivo.
WO2004001004A2 (en) * 2002-06-21 2003-12-31 Johns Hopkins University School Of Medicine Membrane associated tumor endothelium markers

Similar Documents

Publication Publication Date Title
JP2011130770A5 (https=)
JP2010110329A5 (https=)
JP7259104B2 (ja) 抗ｔｒｏｐ２抗体－薬物コンジュゲート
CN110913908B (zh) 靶向msln的三特异性蛋白质及使用方法
KR101901558B1 (ko) 항체-약물 콘주게이트
JP2010508847A5 (https=)
CN118955716A (zh) 结合cd137的单结构域抗体
JP2010533498A5 (https=)
WO2015184941A1 (zh) 一种cd7纳米抗体、其编码序列及应用
JP2012502938A5 (https=)
JP2005532050A5 (https=)
CN113853388B (zh) 抗-egfrviii抗体及其抗原结合片段
TWI865753B (zh) 雙特異性抗體及其製造方法
CA2925915A1 (en) Anti-epcam antibodies and methods of use
JP2008526256A5 (https=)
AU2020200574B2 (en) Methods and products for preventing and/or treating metastatic cancer
WO2023066389A1 (zh) 靶向pd-1的双特异性抗体、及其制备和应用
TW202104259A (zh) 癌治療用醫藥
CN118638225B (zh) 抗mic a/b的抗体及用途