JP2011121957A5 - - Google Patents

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Publication number
JP2011121957A5
JP2011121957A5 JP2011000273A JP2011000273A JP2011121957A5 JP 2011121957 A5 JP2011121957 A5 JP 2011121957A5 JP 2011000273 A JP2011000273 A JP 2011000273A JP 2011000273 A JP2011000273 A JP 2011000273A JP 2011121957 A5 JP2011121957 A5 JP 2011121957A5
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JP
Japan
Prior art keywords
flt4
antibody
fragment
pharmaceutical composition
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2011000273A
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English (en)
Japanese (ja)
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JP2011121957A (ja
JP5784310B2 (ja
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Publication date
Priority claimed from US09/169,079 external-priority patent/US6824777B1/en
Application filed filed Critical
Publication of JP2011121957A publication Critical patent/JP2011121957A/ja
Publication of JP2011121957A5 publication Critical patent/JP2011121957A5/ja
Application granted granted Critical
Publication of JP5784310B2 publication Critical patent/JP5784310B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2011000273A 1998-10-09 2011-01-04 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3) Expired - Lifetime JP5784310B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/169,079 1998-10-09
US09/169,079 US6824777B1 (en) 1992-10-09 1998-10-09 Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2000575533A Division JP4841724B2 (ja) 1998-10-09 1999-10-08 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2013097900A Division JP2013209382A (ja) 1998-10-09 2013-05-07 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)
JP2015077656A Division JP2015157829A (ja) 1998-10-09 2015-04-06 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)

Publications (3)

Publication Number Publication Date
JP2011121957A JP2011121957A (ja) 2011-06-23
JP2011121957A5 true JP2011121957A5 (cg-RX-API-DMAC10.html) 2012-09-27
JP5784310B2 JP5784310B2 (ja) 2015-09-24

Family

ID=22614189

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2000575533A Expired - Fee Related JP4841724B2 (ja) 1998-10-09 1999-10-08 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)
JP2011000273A Expired - Lifetime JP5784310B2 (ja) 1998-10-09 2011-01-04 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)
JP2011178553A Expired - Fee Related JP5642637B2 (ja) 1998-10-09 2011-08-17 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)
JP2013097900A Pending JP2013209382A (ja) 1998-10-09 2013-05-07 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)
JP2015077656A Pending JP2015157829A (ja) 1998-10-09 2015-04-06 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2000575533A Expired - Fee Related JP4841724B2 (ja) 1998-10-09 1999-10-08 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2011178553A Expired - Fee Related JP5642637B2 (ja) 1998-10-09 2011-08-17 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)
JP2013097900A Pending JP2013209382A (ja) 1998-10-09 2013-05-07 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)
JP2015077656A Pending JP2015157829A (ja) 1998-10-09 2015-04-06 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)

Country Status (13)

Country Link
US (4) US8444957B2 (cg-RX-API-DMAC10.html)
EP (1) EP1119371B1 (cg-RX-API-DMAC10.html)
JP (5) JP4841724B2 (cg-RX-API-DMAC10.html)
CN (1) CN100340291C (cg-RX-API-DMAC10.html)
AT (1) ATE489108T1 (cg-RX-API-DMAC10.html)
AU (2) AU774266B2 (cg-RX-API-DMAC10.html)
CA (1) CA2345276C (cg-RX-API-DMAC10.html)
DE (1) DE69942981D1 (cg-RX-API-DMAC10.html)
DK (1) DK1119371T3 (cg-RX-API-DMAC10.html)
ES (1) ES2357406T3 (cg-RX-API-DMAC10.html)
NO (1) NO20011759L (cg-RX-API-DMAC10.html)
NZ (2) NZ529063A (cg-RX-API-DMAC10.html)
WO (1) WO2000021560A1 (cg-RX-API-DMAC10.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818220B1 (en) 1994-11-14 2004-11-16 Licentia Ltd. Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof
US7727761B2 (en) 1995-08-01 2010-06-01 Vegenics Limited Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
US6361946B1 (en) 1997-02-05 2002-03-26 Licentia Ltd Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
PT848755E (pt) 1995-09-08 2003-12-31 Genentech Inc Proteina relacionada com o vegf
US7125714B2 (en) 1997-02-05 2006-10-24 Licentia Ltd. Progenitor cell materials and methods
JP4841724B2 (ja) * 1998-10-09 2011-12-21 ベジェニクス ピーティーワイ リミテッド 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)
US7223724B1 (en) 1999-02-08 2007-05-29 Human Genome Sciences, Inc. Use of vascular endothelial growth factor to treat photoreceptor cells
EP1553414A1 (en) * 1999-04-13 2005-07-13 Medarex, Inc. Methods for the diagnosis and treatment of metastatic prostate tumors
AU3988401A (en) 2000-02-25 2001-09-03 Ludwig Inst Cancer Res Materials and methods involving hybrid vascular endothelial growth factor dnas and proteins
KR20020059609A (ko) 2000-08-04 2002-07-13 벤슨 로버트 에이치. 혈관 내피 성장 인자 2
US7611711B2 (en) 2001-01-17 2009-11-03 Vegenics Limited VEGFR-3 inhibitor materials and methods
JP4669984B2 (ja) * 2001-01-19 2011-04-13 ベジェニクス リミテッド 腫瘍画像化のターゲットとしてのF1t4(VEGFR−3)および抗腫瘍療法
JP2004536579A (ja) 2001-04-13 2004-12-09 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド 血管内皮増殖因子2
US7109165B2 (en) 2001-05-18 2006-09-19 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
WO2003002144A1 (en) * 2001-06-26 2003-01-09 Imclone Systems Incorporated Bispecific antibodies that bind to vegf receptors
US20030113324A1 (en) * 2001-10-01 2003-06-19 Kari Alitalo Neuropilin/VEGF-C/VEGFR-3 materials and methods
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
EP1432724A4 (en) * 2002-02-20 2006-02-01 Sirna Therapeutics Inc RNA inhibition mediated inhibition of MAP KINASE GENES
US8003613B2 (en) 2003-11-17 2011-08-23 University Of Florida Research Foundation, Inc. Methods and compositions for inducing apoptosis
ATE452188T1 (de) 2004-02-10 2010-01-15 Sirna Therapeutics Inc Rna-interferenz-vermittelte hemmung der genexpression unter verwendung multifunktioneller sina (short interfering nucleic acid)
US20060024302A1 (en) 2004-03-05 2006-02-02 Ludwig Institute For Cancer Research Chimeric anti-VEGF-D antibodies and humanized anti-VEGF-D antibodies and methods of using same
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
ES2363758T3 (es) 2005-08-15 2011-08-16 Vegenics Pty Ltd Vegf y pdgf modificados con propiedades angiogénicas mejoradas.
US8305579B2 (en) 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US9201063B2 (en) 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US9677125B2 (en) 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
US9011861B2 (en) 2010-02-25 2015-04-21 Schepens Eye Research Institute Therapeutic compositions for the treatment of dry eye disease
WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
US20150246118A1 (en) 2012-10-26 2015-09-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Lyve-1 antagonists for preventing or treating a pathological condition associated with lymphangiogenesis
MY170528A (en) 2013-02-18 2019-08-09 Vegenics Pty Ltd Vegfr-3 ligand binding molecules and uses thereof
WO2014182635A1 (en) 2013-05-08 2014-11-13 Baldwin Megan E Biomarkers for age-related macular degeneration (amd)
KR102131370B1 (ko) 2013-10-18 2020-07-08 삼성전자주식회사 Vegf-c에 특이적으로 결합하는 폴리펩타이드 및 그의 용도
CN114262683B (zh) * 2022-03-01 2022-06-17 中国科学院动物研究所 一种表达vegfr3 d2多肽的细菌制剂及其构建方法和应用

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652639A (en) 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4543439A (en) 1982-12-13 1985-09-24 Massachusetts Institute Of Technology Production and use of monoclonal antibodies to phosphotyrosine-containing proteins
WO1985003357A1 (en) 1984-01-30 1985-08-01 Icrf Patents Ltd. Improvements relating to growth factors
KR0130906B1 (ko) 1987-03-11 1998-04-23 팜이탈리아 카를로 에르바 에스. 알. 엘. 면역글로불린 결합체, 이의 제조방법 및 이를 포함하는 약제학적 조성물
ES2092468T3 (es) 1988-01-22 1996-12-01 Zymogenetics Inc Metodos para producir analogos de receptores secretados.
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2011450C (en) 1989-03-07 2002-06-04 Tadatsugu Taniguchi Recombinant b-chain of the il-2 receptor
EP0474744B1 (en) 1989-05-22 1994-08-03 Zymogenetics, Inc. Pdgf -alpha- receptor
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
EP0584082B1 (en) 1991-01-31 2000-05-31 Cor Therapeutics, Inc. Domains of extracellular region of human platelet derived growth factor receptor polypeptides
US5256766A (en) 1991-02-19 1993-10-26 The Regents Of The University Of California Recombinant thrombin receptor and related pharmaceuticals
ATE221915T1 (de) 1991-02-22 2002-08-15 American Cyanamid Co Identifizierung eines menschlichen rezeptor- tyrosinkinasegens
US5231001A (en) 1991-03-14 1993-07-27 The United States Of America As Represented By The Department Of Health And Human Services Trk tyrosine kinase receptor is the physiological receptor for nerve growth factor
US5367057A (en) 1991-04-02 1994-11-22 The Trustees Of Princeton University Tyrosine kinase receptor flk-2 and fragments thereof
US5185438A (en) 1991-04-02 1993-02-09 The Trustees Of Princeton University Nucleic acids encoding hencatoporetic stem cell receptor flk-2
US5270458A (en) 1991-04-02 1993-12-14 The Trustees Of Princeton University Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2
CA2078539C (en) 1991-09-18 2005-08-02 Kenya Shitara Process for producing humanized chimera antibody
CA2127540A1 (en) 1992-01-09 1993-07-22 Juha Partanen Tie, a novel endothelial cell receptor tyrosine kinase
US6331302B1 (en) 1992-01-22 2001-12-18 Genentech, Inc. Protein tyrosine kinase agonist antibodies
US5635177A (en) 1992-01-22 1997-06-03 Genentech, Inc. Protein tyrosine kinase agonist antibodies
JPH07504813A (ja) 1992-01-22 1995-06-01 ニユー・イングランド・デイーコネス・ホスピタル 新規蛋白質チロシンキナーゼ類
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
US5776755A (en) 1992-10-09 1998-07-07 Helsinki University Licensing, Ltd. FLT4, a receptor tyrosine kinase
US6824777B1 (en) 1992-10-09 2004-11-30 Licentia Ltd. Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
KR100335584B1 (ko) 1992-10-28 2002-11-29 제넨테크, 인코포레이티드 혈관내피세포성장인자에대한길항제
US5763441A (en) 1992-11-13 1998-06-09 Sugen, Inc. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US5712395A (en) 1992-11-13 1998-01-27 Yissum Research Development Corp. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
DE4337197C1 (de) 1993-10-30 1994-08-25 Biotest Pharma Gmbh Verfahren zur selektiven Herstellung von Hybridomazellinien, die monoklonale Antikörper mit hoher Zytotoxizität gegen humanes CD16-Antigen produzieren, sowie Herstellung bispezifischer monoklonaler Antikörper unter Verwendung derartiger monoklonaler Antikörper und des CD30-HRS-3-Antikörpers zur Therapie menschlicher Tumore
US5700823A (en) 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
DK0751992T3 (da) 1994-03-08 2006-03-06 Human Genome Sciences Inc Karendotelvækstfaktor 2
US6608182B1 (en) 1994-03-08 2003-08-19 Human Genome Sciences, Inc. Human vascular endothelial growth factor 2
GB9410534D0 (en) 1994-05-26 1994-07-13 Lynxvale Ltd Improvements in or relating to growth factor inhibitors
AU694524B2 (en) * 1994-06-09 1998-07-23 Helsinki University Licensing Ltd Oy Flt4 receptor tyrosine kinase and its use in diagnosis and therapy
US5763733A (en) 1994-10-13 1998-06-09 Enzon, Inc. Antigen-binding fusion proteins
WO1998033917A1 (en) 1994-11-14 1998-08-06 The Ludwig Institute For Cancer Research Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof
US6645933B1 (en) 1995-08-01 2003-11-11 Helsinki University Licensing Ltd. Oy Receptor ligand VEGF-C
PT848755E (pt) 1995-09-08 2003-12-31 Genentech Inc Proteina relacionada com o vegf
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
WO1998005293A2 (en) * 1996-08-02 1998-02-12 The Children's Medical Center Corporation Method of regulating the female reproductive system through angiogenesis inhibitors
EP0956339B1 (en) 1996-08-23 2005-10-12 Ludwig Institute For Cancer Research Recombinant vascular endothelial cell growth factor d (vegf-d)
CA2315977A1 (en) 1997-12-24 1999-07-08 Ludwig Institute For Cancer Research Expression vectors and cell lines expressing vascular endothelial growth factor d, and method of treating melanomas
JP4841724B2 (ja) * 1998-10-09 2011-12-21 ベジェニクス ピーティーワイ リミテッド 腫瘍イメージングおよび抗腫瘍治療の標的としてのFlt4(VERG−3)
KR101681886B1 (ko) 2015-04-06 2016-12-12 서울대학교산학협력단 지르코니아 결합능을 가지는 펩타이드

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