JP2011120514A - Dispersion medium for powdery supplement - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a supplement mixed liquid-making kit by combining a dispersion medium suitable for powdery supplements and a fine particle dispersion medium with powdery supplements. <P>SOLUTION: The fine particle dispersion medium is a solution having a viscosity of 10-300 Pa s at a shear deformation speed of 0.01 1/sec. The solution is an aqueous solution of 0.017% gellan gum and 0.45 wt.% psyllium seed gum, an aqueous solution of 0.025 wt.% gellan gum, or an aqueous solution of 0.04% gellan gum and 0.0048 wt.% pectin. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a dispersion medium for powdered supplements.

Supplements, which are nutritional supplements, are attracting attention and are in widespread use. Common supplement dosage forms include tablets, soft capsules, and hard capsules. The dosage form differs depending on the nature of the supplement, such as water solubility and oil solubility, and the character such as odor. Conventionally, the dosage form is a composition formulated based on a set formulation.
Many people use multiple types of supplements. In addition, there is a need for a prescription tailored to each individual by changing the component ratio according to the user regardless of the existing prescription amount. When a dry powder is formulated and packaged, it may not disperse in water or may adhere to a cup or the like.
Many attempts have been made to devise solutions to dissolve insoluble drugs. For example, Patent Document 1 (JP 2004-65016), for minerals such as magnesium and calcium, or Mg salts such as MgCl ₂ (magnesium chloride) or MgSO ₄ (magnesium sulfate), CaCl ₂ (calcium chloride) and the like The Ca salt is easily soluble in water but has a strong bitter taste, while magnesium hydroxide and calcium carbonate, which are hardly soluble in water, are mixed with a dispersion medium composed of water, citric acid, and glycine. It is disclosed that it is possible to provide a mineral-containing solution that dissolves by use and is stable without bitterness for more than one month.

JP 2004-65016 A

  An object of the present invention is to provide a dispersion medium suitable for powdered supplements.

1. A dispersion medium for powder, which is a solution having a viscosity of 10 to 300 Pa · s at a shear deformation rate of 0.01 1 / sec.
2. 1. The powder is a powdery supplement. The dispersion medium for powder as described.
3. The solution is an aqueous solution containing 0.017% gellan gum and 0.45% by weight psyllium seed gum. Or 2. The dispersion medium for powder as described.
4). 1. The solution is a gellan gum 0.025% by weight aqueous solution. Or 2. The dispersion medium for powder as described.
5). The solution is an aqueous solution containing 0.04% gellan gum and 0.0048% by weight pectin. Or 2. The dispersion medium for powder as described.
6). 1. Powdered supplement containing multiple types of vitamins ~ 5. A dispersion medium for powder according to any one of the above.
7). 5. The average bulk specific gravity of the powdered supplement is 0.57. The dispersion medium for powder as described.
8.1. ~ 7. A supplement mixture preparation kit comprising a powder dispersion medium described in any of the above and a powdered supplement.

Powders such as powdered supplements can be homogeneously dispersed in the solution, and when the container is tilted and poured out, there is little residue in the container, so the powder can be taken. In the case of a solution, powders such as supplements with low storage stability and supplements prescribed for each person can be mixed with the dispersion medium of the present invention and taken immediately before drinking.
The powder and dispersion medium can be easily used as a set. As an example of such a set, a plastic bottle provided with a cap with a small container is suitable.

The figure which shows the mixed body of a powder supplement. The graph which shows the relationship between the shear rate of a dispersion medium, and a viscosity. An example of a container.

  The present applicant provides a dispersion medium for mixing and drinking supplements and drugs in the form of powder such as granules, just before taking. Insoluble compositions and solutions that are poorly preserved may be drunk after being mixed or dissolved in water or the like immediately before taking. In particular, the present invention provides a dispersion medium that is easy to use at the time of drinking, for supplements of the order that is a composition blended in a prescription tailored to individual users.

<Powder>
In the present invention, a powder form including a granular form is used, which is used by mixing or dissolving in a dispersion medium immediately before drinking. Just before drinking refers to drinking within about 30 minutes after mixing or dissolving. It's not like making barley tea and drinking it all day long. Examples of powders include powder supplements, pharmaceuticals, and dried foods. Composition forms in which a plurality of types are mixed are also included.

  The powdered supplement can be a dried or granulated product that can generally be ingested as a health food material.

  Examples include water-soluble and fat-soluble vitamins, polysaccharides such as dietary fiber, monosaccharides to oligosaccharides, proteins, peptides, amino acids, minerals, various vegetable powders, royal jelly, propolis, mushroom extract, plant extract, etc. It is done.

  An emulsifier and a chelating agent for improving dispersibility can also be added to the powdered supplement of the present invention. Specifically, sucrose fatty acid esters, glycerin fatty acid esters, lecithin, various saponins, phosphates, and the like that can be used as foods and food additives can be appropriately selected according to the properties of the powder supplement.

<Dispersion medium>
The dispersion medium used in the present invention is a solution having a viscosity of 10 to 300 Pa · s at a shear deformation rate of 0.01 1 / sec. (1) Gellan gum 0.017%, psyllium seed gum 0.45% by weight aqueous solution, (2) Gellan gum 0.025% by weight aqueous solution, (3) Gellan gum 0.04%, pectin 0.0048% by weight aqueous solution Can be provided by adjusting to
As a result of searching for a dispersion medium using a gelling agent, the present inventor was able to find a dispersion medium having a low dispersibility and a remaining cup after drinking. It was difficult to find a common term simply. As a result of paying attention to the shear rate and the viscosity, the zero shear viscosity, which is the region that behaves as a Newtonian fluid in the region where the shear rate is extremely low, is 45 to 1500 Pa · s, and the viscosity when the shear rate is 0.01 1 / sec is 10 It was found that a solution of ~ 300 Pa · s is suitable.

  Gelling gum, pectin, psyllium seed gum, xanthan gum, locust bean gum, carrageenan, gum arabic, gelatin, starch, dextrin, cellulose, sodium caseinate, glycerin, erythritol, etc. Sugar alcohols.

<Form>
It is possible to provide a combination of a dispersion medium and a powdery material stored in a container.
A dispersion medium packed in a container such as a PET bottle and a powdered supplement package can be used as a set, and the powder supplement can be mixed with the dispersion medium and used at the time of drinking. The parcel can also be stored in a cap with a small storage section. A dispersion medium such as a gelling agent is subjected to a treatment such as warming, stirring and dissolving, and filled in a container in a solution state.
For example, a bottle provided with a cap with a storage part can be used. Powder can be stored in the cap storage part, the dispersion medium of the present invention can be stored in the bottle container body, and the powder in the cap can be mixed with the dispersion medium just before taking and used for drinking.
FIG. 3 shows an example of a combination kit in which powders such as powdered supplements are housed in a cap part, a dispersion medium is housed in a container body, and the powder can be mixed with the dispersion medium at the time of taking. (A) shows a state in which the powder 2 is enclosed in a container 3 containing the dispersion medium 1 and a cap 4 having a small storage part. The state where the tip of the blade body 6 provided in the cap pierces the seal 5 by pushing the cap 4 and the powder 2 is mixed with the dispersion medium 1 is shown in FIG. (C) shows a cross section of the middle part of the cap 4. In this example, the blade body 6 has a cross shape, and a device for ensuring the powder storage space and enlarging the opening of the seal 5 is devised. ing.

[Test example]
[Dispersion medium adjustment]
1. Dispersion medium formulation
Nine types of dispersion media were prepared by blending ingredients consisting of gellan gum, pectin, psyllium seed gum, dextrin, ph adjuster, gelling aid and water, and adjusting the temperature and stirring. The formulation is as described in Table 1.

2. Preparation of dispersion medium (1) In the dispersion medium (b), 0.50 g of a gelling agent was weighed, and dissolved with stirring at 80 ° C. for 10 minutes with about 80 g of hot water. After adding 0.05% calcium lactate as a gelling aid, it was adjusted to 100 g and used.
(2) Dispersion media (c) to (f) weighed 0.010 g, (d) 0.025 g, (e) 0.050 g, and (f) 0.075 g, respectively, and 80 g After stirring and dissolving in a hot water of about 90 ° C. for 10 minutes, it was adjusted to 100 g and used.
(3) The dispersion media (g) to (i) were prepared by weighing 0.10 g of a gelling agent (g), (h) 0.025 g, and (i) 0.50 g, respectively, After stirring and dissolving for 10 minutes, it was adjusted to 100 g and used.

[Adjustment of powder supplement]
We used multivitamin granules containing the following vitamins.
1. Multivitamin composition
Mixing ratio (wt%)
・ VB mix (NOF Corporation 25.0
・ Carotene (granule) (Kyowa Hakko Kogyo Co., Ltd.) 10.0
・ Vitamin C (NOF Corporation) 55.0
・ Vitamin D3 powder (BASF Japan Ltd.) 1.0
・ D-α Tocopherol Powder (Eisai Co., Ltd.) 9.0

2. Preparation of granules (1) Equipment used <granulation>
Agitation granulator; high speed mixer
LFS-GS-2J (Fukae Powtech Co., Ltd.)
<Drying>
Fluidized bed granulator: Fluidized bed granulated coating device MP-01
(Powrec Co., Ltd.)

(2) Production Raw materials other than carotene beads were charged into a high speed mixer, 10% of water was added to the raw material weight, and kneading was carried out for 3 minutes at 300 rpm agitator and 3000 rpm chopper.
Thereafter, the kneaded product obtained was dried with a fluidized bed granulator at an air supply temperature of 70 ° C. to obtain granules. The obtained granules and carotene beads were mixed in a plastic bag to prepare multivitamin granules.

(3) Composition of powder particle size A granule preparation having a particle size distribution with the following ratio was produced by measurement with a sieve shaker (manufactured by Tsutsui Chemical Co., Ltd., device name: MICRO VIBRO SIFTER M-2).

Particles exceeding 1.00mm: 0.3%,
0.71-1.00mm particles: 16.4%,
0.50-0.71mm particles: 21.9%
0.30-1.50mm particles: 40.4%
0.25-0.30mm particles: 6.6%,
0.18-0.25mm particles: 9.5%
0.15-0 / 18mm particles: 2.3%
Particles less than 0.15mm: 2.6%
(4) Average bulk specific gravity The average bulk specific gravity of the obtained multivitamin granule was 0.57.

3. Evaluation of dispersibility (1) Dispersion treatment, outflow treatment After a glass vial with a diameter of 24 mm is filled with the dispersion medium (a) to (i) to a height of 30 mm and cooled, 0.5 g of the multivitamin granule is added. Shake vigorously up and down 10 times to mix.
The container was tilted to remove the gel.
(2) Evaluation Evaluation of the mixed body and evaluation of the state of the multivitamin granules remaining in the vial container after taking out the discharged multivitamin granule powder were performed according to the following criteria. The evaluation results are shown in Table 2.
The mixed body was evaluated for a state immediately after mixing, 5 minutes, 10 minutes, and 15 minutes. This is an evaluation assuming a usage pattern in which powder is dispersed and taken immediately before taking. An example of a mixture is shown in FIG.

<Mixed body evaluation>
0: Not dispersed or mixed in the solution 1: Mixed with the solution but precipitated 2: Mixed with the solution and no precipitation 3: Dispersed homogeneously in the solution

<Evaluation of state after removal>
0: Cannot be taken out even if tilted 1: Comes out when tilted, but there is a lot of residual 2: Comes out when tilted, there is not much residual

<Comprehensive evaluation>
×: 0 to 5 (not different from water or lower than water)
Δ: 6 to 9 (Better than water but leaves challenges)
○: 10-14 (very good at solving problems)

4). Evaluation of Physical Properties of Dispersion Medium The physical properties of the dispersion medium were tested for the relationship between shear rate and viscosity. A 3 mm thick gel was prepared on a plastic petri dish having a diameter of 5 cm and used for the test. The portion that protruded from the plate during measurement was removed. The measurement results are shown in FIG.
(1) Equipment used TA Instruments viscoelasticity measuring device Stress control rheometer AR-G2
(2) Measurement conditions Plate used: 4cm diameter aluminum parallel plate
Gap: 2000μm
Steady flow viscosity measurement mode: Measured in the range of shear rate 1.0E-04 to 1.0E-01

5). Results In Table 2, paying attention to (b), (d), and (g), which are overall evaluation “◯”, the physical properties of the dispersion medium were confirmed. The viscosity at a shear deformation rate of 0.01 1 / sec was 10%. It was found that a solution of ~ 300 Pa · s was included.
In particular, it can be seen that a gellan gum 0.025 wt% aqueous solution, gellan gum 0.04%, pectin 0.0048 wt% aqueous solution are suitable.

Claims (8)

  A dispersion medium for powder, which is a solution having a viscosity of 10 to 300 Pa · s at a shear deformation rate of 0.01 1 / sec.   The powder dispersion medium according to claim 1, wherein the powder is a powder supplement.   The powder dispersion medium according to claim 1 or 2, wherein the solution is an aqueous solution containing 0.017% gellan gum and 0.45% by weight psyllium seed gum.   The powder dispersion medium according to claim 1 or 2, wherein the solution is a gellan gum 0.025 wt% aqueous solution.   The dispersion medium for powder according to claim 1 or 2, wherein the solution is an aqueous solution of 0.04% gellan gum and 0.0048% by weight of pectin.   The powder dispersion medium according to any one of claims 2 to 5, wherein the powder supplement contains a plurality of types of vitamins.   The powder dispersion medium according to claim 6, wherein an average bulk specific gravity of the powder supplement is 0.57. A kit for preparing a supplement mixture comprising the powder dispersion medium according to any one of claims 1 to 7 and a powder supplement.