JP2011102272A5 - - Google Patents

Info

Publication number

JP2011102272A5

JP2011102272A5 JP2009258356A JP2009258356A JP2011102272A5 JP 2011102272 A5 JP2011102272 A5 JP 2011102272A5 JP 2009258356 A JP2009258356 A JP 2009258356A JP 2009258356 A JP2009258356 A JP 2009258356A JP 2011102272 A5 JP2011102272 A5 JP 2011102272A5

Authority

JP

Japan

Prior art keywords

yangambin

pinoresinol

sesamin

group

silvathesmin

Prior art date

2009-11-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 claims 5
• PEUUVVGQIVMSAW-RZTYQLBFSA-N (+)-Eudesmin Chemical compound C1=C(OC)C(OC)=CC=C1[C@@H]1[C@@H](CO[C@@H]2C=3C=C(OC)C(OC)=CC=3)[C@@H]2CO1 PEUUVVGQIVMSAW-RZTYQLBFSA-N 0.000 claims 4
• HGXBRUKMWQGOIE-AFHBHXEDSA-N (+)-pinoresinol Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@@H]3[C@@H]([C@H](OC3)C=3C=C(OC)C(O)=CC=3)CO2)=C1 HGXBRUKMWQGOIE-AFHBHXEDSA-N 0.000 claims 3
• PEYUIKBAABKQKQ-AFHBHXEDSA-N (+)-sesamin Chemical compound C1=C2OCOC2=CC([C@H]2OC[C@H]3[C@@H]2CO[C@@H]3C2=CC=C3OCOC3=C2)=C1 PEYUIKBAABKQKQ-AFHBHXEDSA-N 0.000 claims 3
• PEUUVVGQIVMSAW-UHFFFAOYSA-N Diaeudesmin Natural products C1=C(OC)C(OC)=CC=C1C1C(COC2C=3C=C(OC)C(OC)=CC=3)C2CO1 PEUUVVGQIVMSAW-UHFFFAOYSA-N 0.000 claims 3
• HRLFUIXSXUASEX-RZTYQLBFSA-N Yangambin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2[C@@H]3[C@@H]([C@H](OC3)C=3C=C(OC)C(OC)=C(OC)C=3)CO2)=C1 HRLFUIXSXUASEX-RZTYQLBFSA-N 0.000 claims 3
• 150000001875 compounds Chemical class 0.000 claims 3
• PEYUIKBAABKQKQ-UHFFFAOYSA-N epiasarinin Natural products C1=C2OCOC2=CC(C2OCC3C2COC3C2=CC=C3OCOC3=C2)=C1 PEYUIKBAABKQKQ-UHFFFAOYSA-N 0.000 claims 3
• HRLFUIXSXUASEX-UHFFFAOYSA-N lirioresinol-beta-dimethyl ether Natural products COC1=C(OC)C(OC)=CC(C2C3C(C(OC3)C=3C=C(OC)C(OC)=C(OC)C=3)CO2)=C1 HRLFUIXSXUASEX-UHFFFAOYSA-N 0.000 claims 3
• OHOPKHNWLCMLSW-UHFFFAOYSA-N pinoresinol Natural products C1=C(O)C(OC)=CC(C2C3C(C(OC3)C=3C=C(CO)C(O)=CC=3)CO2)=C1 OHOPKHNWLCMLSW-UHFFFAOYSA-N 0.000 claims 3
• 235000007221 pinoresinol Nutrition 0.000 claims 3
• VRMHCMWQHAXTOR-CMOCDZPBSA-N sesamin Natural products C1=C2OCOC2=CC([C@@H]2OC[C@@]3(C)[C@H](C=4C=C5OCOC5=CC=4)OC[C@]32C)=C1 VRMHCMWQHAXTOR-CMOCDZPBSA-N 0.000 claims 3
• BURBOJZOZGMMQF-UHFFFAOYSA-N xanthoxylol Natural products C1=C(O)C(OC)=CC=C1C1C(COC2C=3C=C4OCOC4=CC=3)C2CO1 BURBOJZOZGMMQF-UHFFFAOYSA-N 0.000 claims 3
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 229960000956 coumarin Drugs 0.000 claims 2
• 235000001671 coumarin Nutrition 0.000 claims 2
• 229930186916 eudesmin Natural products 0.000 claims 2
• 210000001365 lymphatic vessel Anatomy 0.000 claims 2
• -1 silvathesmin Chemical compound 0.000 claims 2
• 239000003381 stabilizer Substances 0.000 claims 2
• WEKCEGQSIIQPAQ-IRBNZIFYSA-N (+)-syringaresinol beta-D-glucoside Chemical compound COC1=C(O)C(OC)=CC([C@@H]2[C@@H]3[C@@H]([C@H](OC3)C=3C=C(OC)C(O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=C(OC)C=3)CO2)=C1 WEKCEGQSIIQPAQ-IRBNZIFYSA-N 0.000 claims 1
• PEUUVVGQIVMSAW-DJDZNOHASA-N (3r,3as,6r,6as)-3,6-bis(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@H](CO[C@H]2C=3C=C(OC)C(OC)=CC=3)[C@H]2CO1 PEUUVVGQIVMSAW-DJDZNOHASA-N 0.000 claims 1
• TWORTZAXDSRCIT-UHFFFAOYSA-N 1-(2-hydroxyethyl)cyclohexane-1,4-diol Chemical compound OCCC1(O)CCC(O)CC1 TWORTZAXDSRCIT-UHFFFAOYSA-N 0.000 claims 1
• CPJKKWDCUOOTEW-YJPXFSGGSA-N 4-[(3s,3ar,6r,6ar)-6-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@@H](CO[C@@H]2C=3C=C(OC)C(O)=CC=3)[C@@H]2CO1 CPJKKWDCUOOTEW-YJPXFSGGSA-N 0.000 claims 1
• 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 1
• FFDULTAFAQRACT-JSGUJALWSA-N Eleutheroside E Chemical compound COC1=CC([C@@H]2[C@@H]3[C@H]([C@@H](OC3)C=3C=C(OC)C(O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=C(OC)C=3)CO2)=CC(OC)=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O FFDULTAFAQRACT-JSGUJALWSA-N 0.000 claims 1
• FFDULTAFAQRACT-MWBGVTEFSA-N Eleutheroside E Natural products COc1cc(cc(OC)c1O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@@H]3OC[C@H]4[C@H]3CO[C@@H]4c5cc(OC)c(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c(OC)c5 FFDULTAFAQRACT-MWBGVTEFSA-N 0.000 claims 1
• 101100481410 Mus musculus Tek gene Proteins 0.000 claims 1
• 239000012190 activator Substances 0.000 claims 1
• MKRWWSNBWNFVDX-UHFFFAOYSA-N eleutheroside E1 Natural products COC1=CC(C(C)=O)=CC=C1OC1C(O)C(O)C(O)C(COC2C(C(O)(CO)CO2)O)O1 MKRWWSNBWNFVDX-UHFFFAOYSA-N 0.000 claims 1
• 230000035800 maturation Effects 0.000 claims 1
• 238000010606 normalization Methods 0.000 claims 1
• 230000006641 stabilisation Effects 0.000 claims 1
• 238000011105 stabilization Methods 0.000 claims 1
• 230000008961 swelling Effects 0.000 claims 1
• CPJKKWDCUOOTEW-UHFFFAOYSA-N sylvatesmin Natural products C1=C(OC)C(OC)=CC=C1C1C(COC2C=3C=C(OC)C(O)=CC=3)C2CO1 CPJKKWDCUOOTEW-UHFFFAOYSA-N 0.000 claims 1
• 230000002792 vascular Effects 0.000 claims 1