JP2010540606A5 - - Google Patents
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- Publication number
- JP2010540606A5 JP2010540606A5 JP2010527519A JP2010527519A JP2010540606A5 JP 2010540606 A5 JP2010540606 A5 JP 2010540606A5 JP 2010527519 A JP2010527519 A JP 2010527519A JP 2010527519 A JP2010527519 A JP 2010527519A JP 2010540606 A5 JP2010540606 A5 JP 2010540606A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- daptz
- compound
- patient
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 238000009472 formulation Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 208000010877 cognitive disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- LZILOGCFZJDPTG-UHFFFAOYSA-N 10h-phenothiazine-3,7-diamine Chemical compound C1=C(N)C=C2SC3=CC(N)=CC=C3NC2=C1 LZILOGCFZJDPTG-UHFFFAOYSA-N 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 208000015114 central nervous system disease Diseases 0.000 claims 3
- 230000001149 cognitive effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 208000019838 Blood disease Diseases 0.000 claims 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 2
- 206010028289 Muscle atrophy Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 206010034010 Parkinsonism Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 208000007502 anemia Diseases 0.000 claims 2
- 230000007850 degeneration Effects 0.000 claims 2
- 230000003111 delayed effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000014951 hematologic disease Diseases 0.000 claims 2
- 208000018706 hematopoietic system disease Diseases 0.000 claims 2
- 238000002372 labelling Methods 0.000 claims 2
- 201000000585 muscular atrophy Diseases 0.000 claims 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 claims 1
- 206010053567 Coagulopathies Diseases 0.000 claims 1
- 208000011990 Corticobasal Degeneration Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 1
- 206010013142 Disinhibition Diseases 0.000 claims 1
- 206010018901 Haemoglobinaemia Diseases 0.000 claims 1
- 208000031220 Hemophilia Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000001089 Multiple system atrophy Diseases 0.000 claims 1
- 208000027089 Parkinsonian disease Diseases 0.000 claims 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 102000019355 Synuclein Human genes 0.000 claims 1
- 108050006783 Synuclein Proteins 0.000 claims 1
- 208000034799 Tauopathies Diseases 0.000 claims 1
- 208000002903 Thalassemia Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 208000015294 blood coagulation disease Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 230000009852 coagulant defect Effects 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 208000007475 hemolytic anemia Diseases 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000005135 methemoglobinemia Diseases 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 230000020763 muscle atrophy Effects 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000008447 perception Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000003523 substantia nigra Anatomy 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96054407P | 2007-10-03 | 2007-10-03 | |
| US60/960,544 | 2007-10-03 | ||
| PCT/GB2008/003315 WO2009044127A1 (en) | 2007-10-03 | 2008-10-01 | Therapeutic use of diaminophenothiazines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540606A JP2010540606A (ja) | 2010-12-24 |
| JP2010540606A5 true JP2010540606A5 (OSRAM) | 2011-11-17 |
| JP5592261B2 JP5592261B2 (ja) | 2014-09-17 |
Family
ID=40220337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527519A Active JP5592261B2 (ja) | 2007-10-03 | 2008-10-01 | ジアミノフェノチアジンの治療的使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9149481B2 (OSRAM) |
| EP (2) | EP2954932B1 (OSRAM) |
| JP (1) | JP5592261B2 (OSRAM) |
| CN (1) | CN101883567B (OSRAM) |
| AU (1) | AU2008306688B2 (OSRAM) |
| BR (1) | BRPI0818182B1 (OSRAM) |
| CA (2) | CA3027974C (OSRAM) |
| DK (2) | DK2954932T3 (OSRAM) |
| ES (2) | ES2546819T3 (OSRAM) |
| HR (1) | HRP20151006T1 (OSRAM) |
| HU (1) | HUE025199T2 (OSRAM) |
| MY (1) | MY161656A (OSRAM) |
| PL (2) | PL2954932T3 (OSRAM) |
| PT (2) | PT2205245E (OSRAM) |
| SI (2) | SI2954932T1 (OSRAM) |
| WO (1) | WO2009044127A1 (OSRAM) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY143757A (en) | 2006-03-29 | 2011-07-15 | Wista Lab Ltd | 3,7-diamond-10h-phenothiazine salts and their use |
| SI2954932T1 (sl) * | 2007-10-03 | 2019-01-31 | Wista Laboratories Ltd. | Terapevtska uporaba diaminofenotiazinov |
| US8785434B2 (en) | 2010-04-30 | 2014-07-22 | Prosetta Antiviral Inc. | Antiviral compounds |
| US9192611B2 (en) | 2010-11-30 | 2015-11-24 | Wista Laboratories Ltd. | Formulations comprising methylthioninium chloride |
| CA2826286C (en) | 2011-01-31 | 2021-09-21 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| SG192666A1 (en) | 2011-02-11 | 2013-09-30 | Wista Lab Ltd | Phenothiazine diaminium salts and their use |
| CN102690244A (zh) * | 2011-03-22 | 2012-09-26 | 中国科学院上海生命科学研究院 | 调节α-突触核蛋白积聚的物质及其制药用途 |
| EP2699241B1 (en) | 2011-04-20 | 2016-07-27 | Prosetta Antiviral Inc. | Antiviral compounds |
| US20130315825A1 (en) * | 2012-05-03 | 2013-11-28 | Washington University | Tricyclic heteroaromatic compounds as alpha-synuclein ligands |
| CN103864717B (zh) * | 2014-04-04 | 2015-11-11 | 山东理工大学 | 一种针状亚甲基白晶体的制备方法 |
| CN103923036B (zh) * | 2014-04-24 | 2015-09-16 | 山东理工大学 | 一种棒状亚甲基蓝晶体的制备方法 |
| CN105541756B (zh) * | 2015-12-17 | 2018-02-09 | 陕西方舟制药有限公司 | 一种制备1‑(3，7‑双二甲氨基‑吩噻嗪‑10‑基)乙酮的方法 |
| EP3487505B1 (en) | 2016-07-25 | 2023-05-03 | WisTa Laboratories Ltd. | Administration and dosage of diaminophenothiazines |
| GB201614834D0 (en) | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| EP4364801B1 (en) | 2018-07-26 | 2025-11-12 | TauRx Therapeutics Management Ltd. | Optimised dosage of diaminophenothiazines in populations |
| WO2020201828A1 (en) | 2019-04-05 | 2020-10-08 | Tauc3 Biologics Limited | Anti-tauc3 antibodies and uses thereof |
| GB201909493D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Therapeutic interactions |
| GB201909454D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Enhancers |
| GB201909506D0 (en) | 2019-07-02 | 2019-08-14 | Wista Lab Ltd | Synaptopathies |
| CN111956245A (zh) * | 2020-08-27 | 2020-11-20 | 复旦大学附属肿瘤医院 | 术后认知功能障碍预防评估方法，系统和装置 |
| WO2023232764A1 (en) | 2022-05-31 | 2023-12-07 | Wista Laboratories Ltd. | Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds |
| AU2023346900A1 (en) | 2022-09-21 | 2025-04-10 | TauRx Therapeutics Management Ltd | Novel formulations and vehicles |
| WO2024163665A1 (en) * | 2023-01-31 | 2024-08-08 | Unlearn.AI, Inc. | Systems and methods for prognostic covariate adjustment in logistic regression for randomized controlled trial design |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022788D0 (en) * | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
| DE4140192C2 (de) * | 1991-12-05 | 1996-02-29 | Alfatec Pharma Gmbh | Sol-gesteuerte Thermokolloidmatrix auf Gelatinebasis für perorale Retardformen |
| GB9506197D0 (en) * | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| US5972389A (en) | 1996-09-19 | 1999-10-26 | Depomed, Inc. | Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter |
| GB9710699D0 (en) | 1997-05-24 | 1997-07-16 | Danbiosyst Uk | Gastro-retentive controlled release system |
| GB0017060D0 (en) * | 2000-07-11 | 2000-08-30 | Hunter Fleming Ltd | Production, stabilisation and use of reduced forms of pharmaceutical compounds |
| GB0100119D0 (en) * | 2001-01-03 | 2001-02-14 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0101049D0 (en) * | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0106953D0 (en) | 2001-03-20 | 2001-05-09 | Univ Aberdeen | Neufofibrillary labels |
| US7410965B2 (en) * | 2002-05-29 | 2008-08-12 | Gruenenthal Gmbh | Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol |
| GB0322756D0 (en) | 2003-09-29 | 2003-10-29 | Univ Aberdeen | Methods of chemical synthesis |
| JP5186212B2 (ja) * | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物（ｍｔｃ）などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
| WO2006091728A2 (en) * | 2005-02-24 | 2006-08-31 | The Trustees Of The University Of Pennsylvania | Microtubule stabilizing compounds and methods of their use |
| US20070116757A1 (en) | 2005-11-08 | 2007-05-24 | Collegium Pharmaceutical, Inc. | Methylene Blue Derivatives |
| MY143757A (en) | 2006-03-29 | 2011-07-15 | Wista Lab Ltd | 3,7-diamond-10h-phenothiazine salts and their use |
| CN101460157B (zh) * | 2006-03-29 | 2015-09-02 | 维斯塔实验室有限公司 | 蛋白聚集抑制剂 |
| AU2007274057B2 (en) | 2006-07-11 | 2012-12-13 | TauRx Therapeutics Management Ltd | Methods of synthesis and/or purification of diaminophenothiazinium compounds |
| CA2690746C (en) * | 2007-06-19 | 2018-01-02 | Wista Laboratories Ltd | Phenothizine compounds for treating mild cognitive impairment |
| SI2954932T1 (sl) * | 2007-10-03 | 2019-01-31 | Wista Laboratories Ltd. | Terapevtska uporaba diaminofenotiazinov |
-
2008
- 2008-10-01 SI SI200832022T patent/SI2954932T1/sl unknown
- 2008-10-01 CN CN2008801190788A patent/CN101883567B/zh active Active
- 2008-10-01 PT PT88064654T patent/PT2205245E/pt unknown
- 2008-10-01 DK DK15161198.5T patent/DK2954932T3/en active
- 2008-10-01 AU AU2008306688A patent/AU2008306688B2/en active Active
- 2008-10-01 EP EP15161198.5A patent/EP2954932B1/en active Active
- 2008-10-01 BR BRPI0818182-9A patent/BRPI0818182B1/pt active IP Right Grant
- 2008-10-01 PL PL15161198T patent/PL2954932T3/pl unknown
- 2008-10-01 HU HUE08806465A patent/HUE025199T2/en unknown
- 2008-10-01 MY MYPI2010001396A patent/MY161656A/en unknown
- 2008-10-01 WO PCT/GB2008/003315 patent/WO2009044127A1/en not_active Ceased
- 2008-10-01 PL PL08806465T patent/PL2205245T3/pl unknown
- 2008-10-01 EP EP08806465.4A patent/EP2205245B1/en active Active
- 2008-10-01 CA CA3027974A patent/CA3027974C/en active Active
- 2008-10-01 HR HRP20151006TT patent/HRP20151006T1/hr unknown
- 2008-10-01 DK DK08806465.4T patent/DK2205245T3/en active
- 2008-10-01 US US12/681,511 patent/US9149481B2/en active Active
- 2008-10-01 ES ES08806465.4T patent/ES2546819T3/es active Active
- 2008-10-01 ES ES15161198T patent/ES2701089T3/es active Active
- 2008-10-01 CA CA2701075A patent/CA2701075C/en active Active
- 2008-10-01 SI SI200831497T patent/SI2205245T1/sl unknown
- 2008-10-01 PT PT15161198T patent/PT2954932T/pt unknown
- 2008-10-01 JP JP2010527519A patent/JP5592261B2/ja active Active
-
2015
- 2015-09-25 US US14/866,035 patent/US10188658B2/en active Active
-
2019
- 2019-01-15 US US16/248,746 patent/US20190151329A1/en not_active Abandoned
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