JP2010539895A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010539895A5 JP2010539895A5 JP2010525439A JP2010525439A JP2010539895A5 JP 2010539895 A5 JP2010539895 A5 JP 2010539895A5 JP 2010525439 A JP2010525439 A JP 2010525439A JP 2010525439 A JP2010525439 A JP 2010525439A JP 2010539895 A5 JP2010539895 A5 JP 2010539895A5
- Authority
- JP
- Japan
- Prior art keywords
- snorna
- nucleic acid
- sequence
- modified
- genbank accession
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020003224 Small Nucleolar RNA Proteins 0.000 claims 77
- 102000042773 Small Nucleolar RNA Human genes 0.000 claims 77
- 150000007523 nucleic acids Chemical class 0.000 claims 49
- 102000039446 nucleic acids Human genes 0.000 claims 40
- 108020004707 nucleic acids Proteins 0.000 claims 40
- 210000004027 cell Anatomy 0.000 claims 17
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 15
- 241000616464 Wallacemonas collosoma Species 0.000 claims 15
- 238000000034 method Methods 0.000 claims 15
- 230000000295 complement effect Effects 0.000 claims 9
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 241000223105 Trypanosoma brucei Species 0.000 claims 5
- 238000010367 cloning Methods 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 238000012545 processing Methods 0.000 claims 4
- 230000001105 regulatory effect Effects 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 101100444344 Caenorhabditis elegans eat-17 gene Proteins 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 2
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 2
- 241000222702 Leishmania tarentolae Species 0.000 claims 2
- 108091036066 Three prime untranslated region Proteins 0.000 claims 2
- 108020004566 Transfer RNA Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 108091070501 miRNA Proteins 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 240000005528 Arctium lappa Species 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 102000008300 Mutant Proteins Human genes 0.000 claims 1
- 108010021466 Mutant Proteins Proteins 0.000 claims 1
- 241000223104 Trypanosoma Species 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 230000001276 controlling effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000007877 drug screening Methods 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 238000011160 research Methods 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0718542.4A GB0718542D0 (en) | 2007-09-22 | 2007-09-22 | Targeted modulation of gene expression |
| GB0718542.4 | 2007-09-22 | ||
| PCT/GB2008/003211 WO2009037490A1 (en) | 2007-09-22 | 2008-09-22 | Targeted modulation of gene expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539895A JP2010539895A (ja) | 2010-12-24 |
| JP2010539895A5 true JP2010539895A5 (enExample) | 2011-11-10 |
| JP5756631B2 JP5756631B2 (ja) | 2015-07-29 |
Family
ID=38670367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525439A Expired - Fee Related JP5756631B2 (ja) | 2007-09-22 | 2008-09-22 | 遺伝子発現の標的調節 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110212058A1 (enExample) |
| EP (1) | EP2205739B1 (enExample) |
| JP (1) | JP5756631B2 (enExample) |
| CN (1) | CN101868543A (enExample) |
| GB (1) | GB0718542D0 (enExample) |
| WO (1) | WO2009037490A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013022092A1 (ja) * | 2011-08-11 | 2013-02-14 | 学校法人新潟科学技術学園新潟薬科大学 | ヒト血液がん細胞のアポトーシスを誘導するヘプタマー型スモールガイド核酸 |
| GB201117482D0 (en) * | 2011-10-11 | 2011-11-23 | Univ Dundee | Targetiing of miRNA precursors |
| LT3198033T (lt) | 2014-09-26 | 2022-05-10 | Janssen Pharmaceutica Nv | Fgfr mutantinių genų rinkinių panaudojimas identifikuojant vėžiu sergančius pacientus, kurie reaguos į gydymą fgfr inhibitoriumi |
| RU2018124657A (ru) | 2015-12-09 | 2020-01-09 | Эксижн Биотерапевтикс, Инк. | Способы редактирования генов и композиции для устранения риска активации вируса jc и пмл (прогрессирующая мультифокальная лейкоэнцефалопатия) во время иммуносупрессивной терапии |
| CA3084810A1 (en) * | 2017-12-08 | 2019-06-13 | University Of Connecticut | Compositions and methods for treating disorders of genomic imprinting |
| AU2019243946B2 (en) * | 2018-03-27 | 2025-03-06 | Proqr Therapeutics Ii B.V. | Nucleic acid molecules for pseudouridylation |
| WO2024102659A1 (en) * | 2022-11-08 | 2024-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Directed acetylation of mrna through engineered snorna adapters |
| CN116694759B (zh) * | 2023-02-17 | 2023-12-15 | 中国人民解放军军事科学院军事医学研究院 | Scarna12基因调节细胞增殖与存活中的应用 |
| CN116525001A (zh) * | 2023-04-27 | 2023-08-01 | 西安交通大学 | 一种基于深度学习的rna修饰位点预测模型的构建方法 |
-
2007
- 2007-09-22 GB GBGB0718542.4A patent/GB0718542D0/en not_active Ceased
-
2008
- 2008-09-22 US US12/679,208 patent/US20110212058A1/en not_active Abandoned
- 2008-09-22 CN CN200880117264A patent/CN101868543A/zh active Pending
- 2008-09-22 EP EP08806365.6A patent/EP2205739B1/en not_active Not-in-force
- 2008-09-22 WO PCT/GB2008/003211 patent/WO2009037490A1/en not_active Ceased
- 2008-09-22 JP JP2010525439A patent/JP5756631B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010539895A5 (enExample) | ||
| KR101785847B1 (ko) | 선형 이중가닥 ＤＮＡ를 활용한 ＣＲＩＳＰＲ／Ｃａｓ９ 시스템을 이용한 표적 유전체 교정 | |
| Luff et al. | An inverted repeat triggers cytosine methylation of identical sequences in Arabidopsis | |
| Niksic et al. | Functional analysis of cis-acting elements regulating the alternative splicing of human CFTR exon 9 | |
| JP2022526455A (ja) | Ｒｎａを編集する方法および組成物 | |
| AU2017242794A1 (en) | Novel minimal UTR sequences | |
| Parekh-Olmedo et al. | Targeted nucleotide exchange in Saccharomyces cerevisiae directed by short oligonucleotides containing locked nucleic acids | |
| JP2022548062A (ja) | 亢進したｄｎａ産生を有する修飾型細菌レトロエレメント | |
| TW202509233A (zh) | 用於治療α-1抗胰蛋白酶缺乏症之組合物及方法 | |
| CN118109512A (zh) | tpi1a基因缺失斑马鱼突变体的制备方法及磷酸丙糖异构酶缺乏症斑马鱼疾病模型的构建方法 | |
| US20250376701A1 (en) | Crispr-transposon systems and components | |
| CN112458080A (zh) | 一种获得针对lncRNA LOC157273的siRNA钓取方法 | |
| WO2013144663A2 (en) | Method of determination of neutral dna sequences in the genome, system for targeting sequences obtained thereby and methods for use thereof | |
| CN112980848B (zh) | 一种水稻糖诱导启动子srn1及其应用 | |
| Jiang et al. | Evolutionarily conserved 12-oxophytodienoate reductase trans-lncRNA pair affects disease resistance in tea (Camellia sinensis) via the jasmonic acid signaling pathway | |
| CN109628447B (zh) | 特异靶向羊友好位点H11的sgRNA及其编码DNA和应用 | |
| CN118581064A (zh) | 核酸修饰酶、包含其的碱基编辑器及其应用 | |
| CN116355068A (zh) | 调控玉米穗行数的dna序列、分子标记及其应用 | |
| CN114350836B (zh) | 促进水稻抽穗的QTL qHD1b及其应用 | |
| JP2009189318A (ja) | 組換え酵素を用いた遺伝子増幅方法 | |
| WO2023147558A2 (en) | Crispr methods for correcting bag3 gene mutations in vivo | |
| CN110551763B (zh) | CRISPR/SlutCas9基因编辑系统及其应用 | |
| WO2023050158A1 (zh) | 一种实现多碱基编辑的方法 | |
| Khanahmad et al. | A novel single step double positive double negative selection strategy for β-globin gene replacement | |
| de Semir et al. | Suitability of oligonucleotide‐mediated cystic fibrosis gene repair in airway epithelial cells |