CN101868543A - 基因表达的靶向调节 - Google Patents

基因表达的靶向调节 Download PDF

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Publication number
CN101868543A
CN101868543A CN200880117264A CN200880117264A CN101868543A CN 101868543 A CN101868543 A CN 101868543A CN 200880117264 A CN200880117264 A CN 200880117264A CN 200880117264 A CN200880117264 A CN 200880117264A CN 101868543 A CN101868543 A CN 101868543A
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CN
China
Prior art keywords
snorna
sequence
nucleic acid
modified
cells
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Pending
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CN200880117264A
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English (en)
Chinese (zh)
Inventor
安格斯·莱恩·莱蒙德
小野基晴
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University of Dundee
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University of Dundee
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Application filed by University of Dundee filed Critical University of Dundee
Publication of CN101868543A publication Critical patent/CN101868543A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN200880117264A 2007-09-22 2008-09-22 基因表达的靶向调节 Pending CN101868543A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0718542.4A GB0718542D0 (en) 2007-09-22 2007-09-22 Targeted modulation of gene expression
GB0718542.4 2007-09-22
PCT/GB2008/003211 WO2009037490A1 (en) 2007-09-22 2008-09-22 Targeted modulation of gene expression

Publications (1)

Publication Number Publication Date
CN101868543A true CN101868543A (zh) 2010-10-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880117264A Pending CN101868543A (zh) 2007-09-22 2008-09-22 基因表达的靶向调节

Country Status (6)

Country Link
US (1) US20110212058A1 (enExample)
EP (1) EP2205739B1 (enExample)
JP (1) JP5756631B2 (enExample)
CN (1) CN101868543A (enExample)
GB (1) GB0718542D0 (enExample)
WO (1) WO2009037490A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108473527A (zh) * 2015-12-09 2018-08-31 切除生物治疗公司 用于消除免疫抑制疗法期间jc病毒激活和pml(进行性多灶性白质脑病)风险的基因编辑方法和组合物
CN112020557A (zh) * 2018-03-27 2020-12-01 罗切斯特大学 用于假尿苷化的核酸分子
CN116525001A (zh) * 2023-04-27 2023-08-01 西安交通大学 一种基于深度学习的rna修饰位点预测模型的构建方法
CN116694759A (zh) * 2023-02-17 2023-09-05 中国人民解放军军事科学院军事医学研究院 Scarna12基因调节细胞增殖与存活中的应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013022092A1 (ja) * 2011-08-11 2013-02-14 学校法人新潟科学技術学園新潟薬科大学 ヒト血液がん細胞のアポトーシスを誘導するヘプタマー型スモールガイド核酸
GB201117482D0 (en) * 2011-10-11 2011-11-23 Univ Dundee Targetiing of miRNA precursors
LT3198033T (lt) 2014-09-26 2022-05-10 Janssen Pharmaceutica Nv Fgfr mutantinių genų rinkinių panaudojimas identifikuojant vėžiu sergančius pacientus, kurie reaguos į gydymą fgfr inhibitoriumi
CA3084810A1 (en) * 2017-12-08 2019-06-13 University Of Connecticut Compositions and methods for treating disorders of genomic imprinting
WO2024102659A1 (en) * 2022-11-08 2024-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Directed acetylation of mrna through engineered snorna adapters

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108473527A (zh) * 2015-12-09 2018-08-31 切除生物治疗公司 用于消除免疫抑制疗法期间jc病毒激活和pml(进行性多灶性白质脑病)风险的基因编辑方法和组合物
US11491207B2 (en) 2015-12-09 2022-11-08 Excision Biotherapeutics, Inc. Gene editing methods and compositions for eliminating risk of JC virus activation and PML (progressive multifocal leukoencephalopathy) during immunosuppressive therapy
CN112020557A (zh) * 2018-03-27 2020-12-01 罗切斯特大学 用于假尿苷化的核酸分子
CN112020557B (zh) * 2018-03-27 2025-02-11 罗切斯特大学 用于假尿苷化的核酸分子
CN116694759A (zh) * 2023-02-17 2023-09-05 中国人民解放军军事科学院军事医学研究院 Scarna12基因调节细胞增殖与存活中的应用
CN116694759B (zh) * 2023-02-17 2023-12-15 中国人民解放军军事科学院军事医学研究院 Scarna12基因调节细胞增殖与存活中的应用
CN116525001A (zh) * 2023-04-27 2023-08-01 西安交通大学 一种基于深度学习的rna修饰位点预测模型的构建方法

Also Published As

Publication number Publication date
US20110212058A1 (en) 2011-09-01
JP5756631B2 (ja) 2015-07-29
EP2205739A1 (en) 2010-07-14
WO2009037490A1 (en) 2009-03-26
JP2010539895A (ja) 2010-12-24
EP2205739B1 (en) 2014-07-02
GB0718542D0 (en) 2007-10-31

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Application publication date: 20101020