JP2010538618A5 - - Google Patents
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- JP2010538618A5 JP2010538618A5 JP2010524259A JP2010524259A JP2010538618A5 JP 2010538618 A5 JP2010538618 A5 JP 2010538618A5 JP 2010524259 A JP2010524259 A JP 2010524259A JP 2010524259 A JP2010524259 A JP 2010524259A JP 2010538618 A5 JP2010538618 A5 JP 2010538618A5
- Authority
- JP
- Japan
- Prior art keywords
- donor
- antibody
- library
- specific antibody
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000013598 vector Substances 0.000 claims description 58
- 108020004707 nucleic acids Proteins 0.000 claims description 44
- 102000039446 nucleic acids Human genes 0.000 claims description 44
- 150000007523 nucleic acids Chemical class 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 34
- 201000010099 disease Diseases 0.000 claims description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 31
- 239000000427 antigen Substances 0.000 claims description 28
- 108091007433 antigens Proteins 0.000 claims description 28
- 102000036639 antigens Human genes 0.000 claims description 28
- 239000012634 fragment Substances 0.000 claims description 26
- 239000002773 nucleotide Substances 0.000 claims description 26
- 125000003729 nucleotide group Chemical group 0.000 claims description 26
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 22
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 22
- 108020004999 messenger RNA Proteins 0.000 claims description 10
- 241001515965 unidentified phage Species 0.000 claims description 9
- 241000712431 Influenza A virus Species 0.000 claims description 8
- 108091092724 Noncoding DNA Proteins 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 8
- 230000003472 neutralizing effect Effects 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 108020004705 Codon Proteins 0.000 claims description 6
- 108060003951 Immunoglobulin Proteins 0.000 claims description 6
- 102000018358 immunoglobulin Human genes 0.000 claims description 6
- 230000016784 immunoglobulin production Effects 0.000 claims description 6
- 210000004698 lymphocyte Anatomy 0.000 claims description 6
- 101150098499 III gene Proteins 0.000 claims description 5
- 108091026890 Coding region Proteins 0.000 claims description 4
- 241001500351 Influenzavirus A Species 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 230000000405 serological effect Effects 0.000 claims description 4
- 230000037432 silent mutation Effects 0.000 claims description 4
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 241001473385 H5N1 subtype Species 0.000 claims description 2
- 108091023045 Untranslated Region Proteins 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 210000001165 lymph node Anatomy 0.000 claims description 2
- 238000002824 mRNA display Methods 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims description 2
- 238000002818 protein evolution Methods 0.000 claims description 2
- 238000010839 reverse transcription Methods 0.000 claims description 2
- 238000002702 ribosome display Methods 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 210000000952 spleen Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 6
- 238000002372 labelling Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/853,795 US8148085B2 (en) | 2006-05-15 | 2007-09-11 | Donor specific antibody libraries |
| PCT/US2008/075998 WO2009036157A1 (en) | 2007-09-11 | 2008-09-11 | Donor specific antibody libraries |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010538618A JP2010538618A (ja) | 2010-12-16 |
| JP2010538618A5 true JP2010538618A5 (https=) | 2012-11-15 |
Family
ID=40220152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524259A Withdrawn JP2010538618A (ja) | 2007-09-11 | 2008-09-11 | ドナー特異的抗体ライブラリー |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8148085B2 (https=) |
| EP (1) | EP2190477A1 (https=) |
| JP (1) | JP2010538618A (https=) |
| CN (1) | CN101854950A (https=) |
| AU (1) | AU2008298939A1 (https=) |
| WO (1) | WO2009036157A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7584439B2 (en) * | 2006-12-07 | 2009-09-01 | Agere Systems Inc. | Cell modeling for integrated circuit design with characterization of upstream driver strength |
| EP3009145A1 (en) | 2009-03-30 | 2016-04-20 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
| AU2010247530B2 (en) * | 2009-05-11 | 2016-10-13 | Janssen Vaccines & Prevention B.V. | Human binding molecules capable of neutralizing influenza virus H3N2 and uses thereof |
| CN102482345A (zh) * | 2009-05-13 | 2012-05-30 | 航道生物技术有限责任公司 | 针对流感病毒的中和分子 |
| AU2010254136B2 (en) * | 2009-05-26 | 2016-09-29 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| US20110077966A1 (en) * | 2009-09-28 | 2011-03-31 | Augusta E.N.T., P.C. | Allergy electronic medical record system and method |
| CA2790380A1 (en) | 2010-02-18 | 2011-08-25 | Mount Sinai School Of Medicine | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| EP3248615A1 (en) | 2010-03-30 | 2017-11-29 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
| EP2633049B1 (en) * | 2010-10-27 | 2018-10-10 | Harrisvaccines Inc | Methods and compositions to protect aquatic invertebrates from disease |
| PT3415619T (pt) * | 2011-04-28 | 2021-03-22 | Univ Leland Stanford Junior | Identificação de polinucleótidos associados a uma amostra |
| US20230287392A1 (en) * | 2011-04-28 | 2023-09-14 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of Polynucleotides Associated with a Sample |
| IN2014CN02114A (https=) | 2011-09-20 | 2015-05-29 | Sinai School Medicine | |
| MX350282B (es) * | 2011-09-30 | 2017-09-01 | Celltrion Inc | Molecula de union que tiene actividad neutralizadora del virus de la influenza a, producida a partir de celulas b humanas. |
| US9977861B2 (en) * | 2012-07-18 | 2018-05-22 | Illumina Cambridge Limited | Methods and systems for determining haplotypes and phasing of haplotypes |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| EA201591164A1 (ru) | 2012-12-18 | 2015-11-30 | Икан Скул Оф Медсин Эт Маунт Синай | Вакцины против вируса гриппа и их применение |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| US9562101B2 (en) | 2013-06-21 | 2017-02-07 | Novartis Ag | Lectin-like oxidized LDL receptor 1 antibodies and methods of use |
| AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
| US9850302B2 (en) | 2013-07-12 | 2017-12-26 | Prothena Biosciences Limited | Antibodies that recognize IAPP |
| US9951131B2 (en) | 2013-07-12 | 2018-04-24 | Prothena Biosciences Limited | Antibodies that recognize IAPP |
| US20150225770A1 (en) * | 2014-02-12 | 2015-08-13 | U.S. Army Research Laboratory Attn: Rdrl-Loc-I | Phenotype-neutral barcodes for digital analysis |
| KR101740030B1 (ko) | 2014-03-07 | 2017-05-29 | 사회복지법인 삼성생명공익재단 | ScFv 항체 라이브러리, 이의 제조방법 및 이를 이용한 ScFv 항체 스크리닝 방법 |
| EP3126384B1 (en) * | 2014-04-01 | 2020-12-02 | Adimab, LLC | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
| JP6744856B2 (ja) | 2014-04-08 | 2020-08-19 | プロセナ・バイオサイエンシズ・リミテッド | α−シヌクレインを認識する抗体を含む血液脳関門シャトル |
| US20180008702A1 (en) | 2014-12-05 | 2018-01-11 | Celltrion Inc. | Adjuvant composition containing at least one influenza virus neutralizing and binding molecule and vaccine composition containing same |
| EP3247389A4 (en) | 2015-01-23 | 2019-10-30 | Icahn School of Medicine at Mount Sinai | INFLUENZAVIRUSSCHUTZIMPFPLÄNE |
| US10336816B2 (en) * | 2015-02-24 | 2019-07-02 | Academia Sinica | Phage-displayed single-chain variable fragment library |
| IL293963A (en) | 2015-09-01 | 2022-08-01 | Univ California | Modular polypeptide libraries and methods for their preparation and use |
| CA3023143A1 (en) | 2016-06-15 | 2017-12-21 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| DK3532612T3 (da) | 2016-10-31 | 2022-09-19 | Univ Zuerich | Samling af markører og fremgangsmåder til proteindetektion, fortrinsvis ved massespektrometri |
| WO2018187706A2 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| EP3959216A4 (en) | 2019-04-24 | 2023-01-11 | Icahn School of Medicine at Mount Sinai | ANTI-INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF |
| WO2021016529A1 (en) * | 2019-07-25 | 2021-01-28 | The Johns Hopkins University | Methods and compositions for hepatitis c virus (hcv) |
| WO2025019631A1 (en) | 2023-07-19 | 2025-01-23 | Icahn School Of Medicine At Mount Sinai | Immunogenic compositions containing inactivated influenza a virus and cpg oligonucleotide adjuvant and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA836080B (en) | 1982-08-23 | 1984-04-25 | Scripps Clinic Res | Broad spectrum influenza antisera |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US6337070B1 (en) | 1993-04-29 | 2002-01-08 | Takara Shuzo Co., Ltd. | Polypeptides for use in generating anti-human influenza virus antibodies |
| EP0699750A1 (en) * | 1994-06-07 | 1996-03-06 | Gesellschaft für biotechnologische Forschung mbH (GBF) | A collection of phagemids, a collection of Escherichia coli cells carrying the phagemids, a collection of phagemid particles produced from said collection and phagemid particles obtained according to the process |
| US6169175B1 (en) * | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| US6607878B2 (en) * | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
| DE60029572T2 (de) | 1999-03-23 | 2007-07-26 | Biovation Ltd. | Isolierung und analyse von proteinen |
| FR2817869B1 (fr) | 2000-12-07 | 2005-01-14 | Technopharm | Anticorps monoclonal humain dirige contre le virus influenza ou un fragment de celui-ci |
| ES2430857T3 (es) | 2000-12-18 | 2013-11-22 | Dyax Corp. | Bibliotecas focalizadas de paquetes genéticos |
| WO2003052101A1 (en) | 2001-12-14 | 2003-06-26 | Rosetta Inpharmatics, Inc. | Sample tracking using molecular barcodes |
| KR20040111402A (ko) | 2002-03-13 | 2004-12-31 | 기린 비루 가부시키가이샤 | 인플루엔자 м2 단백질에 대한 인간 모노클로날 항체 및그의 제조 및 사용 방법 |
| DE602004026077D1 (de) | 2003-09-10 | 2010-04-29 | Althea Technologies Inc | Erstellung von expressionsprofilen unter verwendung von mikroarrays |
| US20060073506A1 (en) | 2004-09-17 | 2006-04-06 | Affymetrix, Inc. | Methods for identifying biological samples |
| US8642513B2 (en) | 2005-09-15 | 2014-02-04 | Crucell Holland B.V. | Method for preparing immunoglobulin libraries |
| GB0522460D0 (en) | 2005-11-03 | 2005-12-14 | Prendergast Patrick T | Composition and method for the treatment of avian influenza |
| CA2637837A1 (en) | 2006-01-26 | 2007-08-09 | Hx Diagnostics, Inc. | Monoclonal antibodies binding to avian influenza virus subtype h5 haemagglutinin and uses thereof |
| EP2024393A2 (en) | 2006-05-15 | 2009-02-18 | Sea Lane Biotechnologies,llc. | Neutralizing antibodies to influenza viruses |
| JP5161882B2 (ja) | 2006-09-07 | 2013-03-13 | クルセル ホランド ベー ヴェー | インフルエンザウイルスｈ５ｎ１を中和しうるヒト結合性分子およびその使用 |
| BRPI0809435A2 (pt) | 2007-03-27 | 2014-09-09 | Sea Lane Biotechnologies, Llc | Constructos e bibliotecas que compreendem sequências de cadeia leve substituida de anticorpos |
-
2007
- 2007-09-11 US US11/853,795 patent/US8148085B2/en active Active
-
2008
- 2008-09-11 US US12/676,737 patent/US20100291066A1/en not_active Abandoned
- 2008-09-11 AU AU2008298939A patent/AU2008298939A1/en not_active Abandoned
- 2008-09-11 EP EP08830817A patent/EP2190477A1/en not_active Withdrawn
- 2008-09-11 JP JP2010524259A patent/JP2010538618A/ja not_active Withdrawn
- 2008-09-11 WO PCT/US2008/075998 patent/WO2009036157A1/en not_active Ceased
- 2008-09-11 CN CN200880115462A patent/CN101854950A/zh active Pending
-
2012
- 2012-03-16 US US13/422,313 patent/US20120264647A1/en not_active Abandoned
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