JP2010538618A5 - - Google Patents
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- JP2010538618A5 JP2010538618A5 JP2010524259A JP2010524259A JP2010538618A5 JP 2010538618 A5 JP2010538618 A5 JP 2010538618A5 JP 2010524259 A JP2010524259 A JP 2010524259A JP 2010524259 A JP2010524259 A JP 2010524259A JP 2010538618 A5 JP2010538618 A5 JP 2010538618A5
- Authority
- JP
- Japan
- Prior art keywords
- donor
- antibody
- library
- specific antibody
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000013598 vector Substances 0.000 claims description 58
- 108020004707 nucleic acids Proteins 0.000 claims description 44
- 102000039446 nucleic acids Human genes 0.000 claims description 44
- 150000007523 nucleic acids Chemical class 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 34
- 201000010099 disease Diseases 0.000 claims description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 31
- 239000000427 antigen Substances 0.000 claims description 28
- 108091007433 antigens Proteins 0.000 claims description 28
- 102000036639 antigens Human genes 0.000 claims description 28
- 239000012634 fragment Substances 0.000 claims description 26
- 239000002773 nucleotide Substances 0.000 claims description 26
- 125000003729 nucleotide group Chemical group 0.000 claims description 26
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 22
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 22
- 108020004999 messenger RNA Proteins 0.000 claims description 10
- 241001515965 unidentified phage Species 0.000 claims description 9
- 241000712431 Influenza A virus Species 0.000 claims description 8
- 108091092724 Noncoding DNA Proteins 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 8
- 230000003472 neutralizing effect Effects 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 108020004705 Codon Proteins 0.000 claims description 6
- 108060003951 Immunoglobulin Proteins 0.000 claims description 6
- 102000018358 immunoglobulin Human genes 0.000 claims description 6
- 230000016784 immunoglobulin production Effects 0.000 claims description 6
- 210000004698 lymphocyte Anatomy 0.000 claims description 6
- 101150098499 III gene Proteins 0.000 claims description 5
- 108091026890 Coding region Proteins 0.000 claims description 4
- 241001500351 Influenzavirus A Species 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 230000000405 serological effect Effects 0.000 claims description 4
- 230000037432 silent mutation Effects 0.000 claims description 4
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 241001473385 H5N1 subtype Species 0.000 claims description 2
- 108091023045 Untranslated Region Proteins 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 210000001165 lymph node Anatomy 0.000 claims description 2
- 238000002824 mRNA display Methods 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims description 2
- 238000002818 protein evolution Methods 0.000 claims description 2
- 238000010839 reverse transcription Methods 0.000 claims description 2
- 238000002702 ribosome display Methods 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 210000000952 spleen Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 6
- 238000002372 labelling Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/853,795 US8148085B2 (en) | 2006-05-15 | 2007-09-11 | Donor specific antibody libraries |
| PCT/US2008/075998 WO2009036157A1 (en) | 2007-09-11 | 2008-09-11 | Donor specific antibody libraries |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010538618A JP2010538618A (ja) | 2010-12-16 |
| JP2010538618A5 true JP2010538618A5 (https=) | 2012-11-15 |
Family
ID=40220152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524259A Withdrawn JP2010538618A (ja) | 2007-09-11 | 2008-09-11 | ドナー特異的抗体ライブラリー |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8148085B2 (https=) |
| EP (1) | EP2190477A1 (https=) |
| JP (1) | JP2010538618A (https=) |
| CN (1) | CN101854950A (https=) |
| AU (1) | AU2008298939A1 (https=) |
| WO (1) | WO2009036157A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7584439B2 (en) * | 2006-12-07 | 2009-09-01 | Agere Systems Inc. | Cell modeling for integrated circuit design with characterization of upstream driver strength |
| WO2010117786A1 (en) | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
| CA2761648C (en) * | 2009-05-11 | 2019-03-12 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus h3n2 and uses thereof |
| CA2761681A1 (en) * | 2009-05-13 | 2010-11-18 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to influenza viruses |
| US8673314B2 (en) | 2009-05-26 | 2014-03-18 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| US20110077966A1 (en) * | 2009-09-28 | 2011-03-31 | Augusta E.N.T., P.C. | Allergy electronic medical record system and method |
| EP2536425B1 (en) | 2010-02-18 | 2019-06-19 | Icahn School of Medicine at Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| CN102939103A (zh) | 2010-03-30 | 2013-02-20 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| EP2633049B1 (en) * | 2010-10-27 | 2018-10-10 | Harrisvaccines Inc | Methods and compositions to protect aquatic invertebrates from disease |
| US20230287392A1 (en) * | 2011-04-28 | 2023-09-14 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of Polynucleotides Associated with a Sample |
| CN103732738A (zh) * | 2011-04-28 | 2014-04-16 | 小利兰斯坦福大学托管委员会 | 与样品相关的多核苷酸的鉴定 |
| EP4241785B1 (en) | 2011-09-20 | 2026-01-28 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| JP5998222B2 (ja) | 2011-09-30 | 2016-09-28 | セルトリオン・インコーポレイテッド | ヒトｂ細胞で生産されたインフルエンザａウイルス中和活性を持つ結合分子 |
| US9977861B2 (en) * | 2012-07-18 | 2018-05-22 | Illumina Cambridge Limited | Methods and systems for determining haplotypes and phasing of haplotypes |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| SG11201504728RA (en) | 2012-12-18 | 2015-07-30 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| UY35620A (es) | 2013-06-21 | 2015-01-30 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
| AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
| WO2015004633A1 (en) | 2013-07-12 | 2015-01-15 | Neotope Biosciences Limited | Antibodies that recognize islet-amyloid polypeptide (iapp) |
| US9850302B2 (en) | 2013-07-12 | 2017-12-26 | Prothena Biosciences Limited | Antibodies that recognize IAPP |
| US20150225770A1 (en) * | 2014-02-12 | 2015-08-13 | U.S. Army Research Laboratory Attn: Rdrl-Loc-I | Phenotype-neutral barcodes for digital analysis |
| WO2015133882A1 (ko) * | 2014-03-07 | 2015-09-11 | 사회복지법인 삼성생명공익재단 | ScFv 항체 라이브러리, 이의 제조방법 및 이를 이용한 ScFv 항체 스크리닝 방법 |
| EP4050026A1 (en) | 2014-04-01 | 2022-08-31 | Adimab, LLC | Method of obtaining or identifying one or more common light chains for use in preparing a multispecific antibody |
| CA2944402A1 (en) | 2014-04-08 | 2015-10-15 | Prothena Biosciences Limited | Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein |
| US20180008702A1 (en) * | 2014-12-05 | 2018-01-11 | Celltrion Inc. | Adjuvant composition containing at least one influenza virus neutralizing and binding molecule and vaccine composition containing same |
| US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| CN107614762B (zh) * | 2015-02-24 | 2022-08-05 | 台湾地区“中央研究院” | 一种由噬菌体表达的单链变异片段抗体库 |
| EP4282979A3 (en) * | 2015-09-01 | 2024-02-28 | The Regents of the University of California | Modular polypeptide libraries and methods of making and using same |
| MX2018015755A (es) | 2016-06-15 | 2019-08-29 | Icahn School Med Mount Sinai | Proteinas de hemaglutinina de virus de influenza y usos de las mismas. |
| PL3532612T3 (pl) * | 2016-10-31 | 2022-10-31 | Universität Zürich | Kolekcja znaczników i sposoby detekcji białek, korzystnie za pomocą spektrometrii masowej |
| US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
| CA3104297A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| US12545718B2 (en) | 2019-04-24 | 2026-02-10 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
| WO2021016529A1 (en) * | 2019-07-25 | 2021-01-28 | The Johns Hopkins University | Methods and compositions for hepatitis c virus (hcv) |
| WO2025019631A1 (en) | 2023-07-19 | 2025-01-23 | Icahn School Of Medicine At Mount Sinai | Immunogenic compositions containing inactivated influenza a virus and cpg oligonucleotide adjuvant and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA836080B (en) | 1982-08-23 | 1984-04-25 | Scripps Clinic Res | Broad spectrum influenza antisera |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US6337070B1 (en) * | 1993-04-29 | 2002-01-08 | Takara Shuzo Co., Ltd. | Polypeptides for use in generating anti-human influenza virus antibodies |
| EP0699750A1 (en) * | 1994-06-07 | 1996-03-06 | Gesellschaft für biotechnologische Forschung mbH (GBF) | A collection of phagemids, a collection of Escherichia coli cells carrying the phagemids, a collection of phagemid particles produced from said collection and phagemid particles obtained according to the process |
| US6169175B1 (en) * | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| US6607878B2 (en) * | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
| WO2000057183A1 (en) | 1999-03-23 | 2000-09-28 | Biovation Limited | Protein isolation and analysis |
| FR2817869B1 (fr) | 2000-12-07 | 2005-01-14 | Technopharm | Anticorps monoclonal humain dirige contre le virus influenza ou un fragment de celui-ci |
| WO2002061071A2 (en) | 2000-12-18 | 2002-08-08 | Dyax Corp. | Focused libraries of genetic packages |
| WO2003052101A1 (en) | 2001-12-14 | 2003-06-26 | Rosetta Inpharmatics, Inc. | Sample tracking using molecular barcodes |
| CA2478973A1 (en) | 2002-03-13 | 2003-09-25 | Kirin Beer Kabushiki Kaisha | Human monoclonal antibodies to influenza m2 protein and methods of making and using same |
| AU2004286201B2 (en) | 2003-09-10 | 2010-09-09 | Altheadx, Inc. | Expression profiling using microarrays |
| US20060073506A1 (en) | 2004-09-17 | 2006-04-06 | Affymetrix, Inc. | Methods for identifying biological samples |
| CA2622603C (en) | 2005-09-15 | 2014-06-17 | Crucell Holland B.V. | Method for preparing immunoglobulin libraries |
| GB0522460D0 (en) | 2005-11-03 | 2005-12-14 | Prendergast Patrick T | Composition and method for the treatment of avian influenza |
| WO2007089753A2 (en) | 2006-01-26 | 2007-08-09 | Hx Diagnostics, Inc. | Monoclonal antibodies binding to avian influenza virus subtype h5 haemagglutinin and uses thereof |
| WO2007134327A2 (en) | 2006-05-15 | 2007-11-22 | Sea Lane Biotechnologies, Llc. | Neutralizing antibodies to influenza viruses |
| EP2450377A1 (en) | 2006-09-07 | 2012-05-09 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof |
| CN101679974B (zh) | 2007-03-27 | 2015-09-30 | 航道生物技术有限责任公司 | 包含抗体替代轻链序列的构建体和文库 |
-
2007
- 2007-09-11 US US11/853,795 patent/US8148085B2/en active Active
-
2008
- 2008-09-11 WO PCT/US2008/075998 patent/WO2009036157A1/en not_active Ceased
- 2008-09-11 JP JP2010524259A patent/JP2010538618A/ja not_active Withdrawn
- 2008-09-11 EP EP08830817A patent/EP2190477A1/en not_active Withdrawn
- 2008-09-11 CN CN200880115462A patent/CN101854950A/zh active Pending
- 2008-09-11 AU AU2008298939A patent/AU2008298939A1/en not_active Abandoned
- 2008-09-11 US US12/676,737 patent/US20100291066A1/en not_active Abandoned
-
2012
- 2012-03-16 US US13/422,313 patent/US20120264647A1/en not_active Abandoned
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