JP2010538093A - シソ科ファミリーのセイタカナミキソウのエストロゲン性抽出物およびその使用 - Google Patents
シソ科ファミリーのセイタカナミキソウのエストロゲン性抽出物およびその使用 Download PDFInfo
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| US20100303936A1 (en) * | 2009-04-28 | 2010-12-02 | Bionovo, Inc. A Delaware Corporation | Method of reducing fat accumulation and inducing weight loss |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000069452A1 (en) * | 1999-05-17 | 2000-11-23 | Yoshio Takeda | Remedies for cancer and infection with helicobacter pylori and process for producing the same |
| WO2006107745A2 (en) * | 2005-04-01 | 2006-10-12 | Bionovo, Inc. | Composition for treatment of menopause |
| WO2007059149A2 (en) * | 2005-11-14 | 2007-05-24 | Bionovo, Inc. | Scutellaria barbata extract for the treatment of cancer |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2616328B1 (fr) | 1987-06-12 | 1990-03-02 | Moet Hennessy Rech | Composition a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un extrait de murier, ou au moins une flavone, en particulier une kuwanone et composition pharmaceutique, notamment dermatologique, a activite depigmentante, ou anti-inflammatoire, ou cosmetique, l'incorporant |
| JPH01175942A (ja) * | 1987-12-28 | 1989-07-12 | Sanyo Kokusaku Pulp Co Ltd | 抗ウイルス性医薬用組成物 |
| GB9103075D0 (en) | 1991-02-13 | 1991-03-27 | Washington Odur Ayuko | Trinitrobenzene derivatives and their therapeutic use |
| JPH0725761A (ja) * | 1993-07-09 | 1995-01-27 | Kureha Chem Ind Co Ltd | 軟骨保護剤 |
| US5837257A (en) * | 1996-07-09 | 1998-11-17 | Sage R&D | Use of plant extracts for treatment of HIV, HCV and HBV infections |
| US5874084A (en) * | 1996-07-19 | 1999-02-23 | Yng-Wong; Quing Non | Using complex herbal formulations to treat hot flashes |
| KR100221762B1 (ko) | 1996-10-29 | 1999-09-15 | 이승기 | 에모딘의 항암제로서의 용도 |
| AU746946B2 (en) * | 1997-03-21 | 2002-05-09 | Shiseido Company Ltd. | Immunopotentiators |
| MC2441A1 (fr) | 1997-07-31 | 1998-03-11 | Exsymol Sa | Composition cosmétique utile notamment pour le blanchiment de la peau et agent inhibiteur de la mélanogénèse comprenant une telle composition cosmétique |
| CN1059117C (zh) | 1997-11-25 | 2000-12-06 | 董有本 | 蝎毒肿瘤丸及其制备方法 |
| FR2784294B1 (fr) | 1998-10-12 | 2000-11-17 | Oreal | Composition cosmetique et/ou dermatologique renfermant au moins un extrait de murier, au moins un extrait de scutellaire et au moins un derive d'acide salicylique |
| US6304825B1 (en) * | 1999-01-19 | 2001-10-16 | Xerox Corporation | Rotary encoder error compensation system and method for photoreceptor surface motion sensing and control |
| FR2791573B1 (fr) * | 1999-03-30 | 2003-04-11 | Pf Medicament | Utilisation d'un extrait de serenoa repens pour la fabrication d'un medicament destine au traitement du cancer de la prostate |
| JP2001122871A (ja) | 1999-10-26 | 2001-05-08 | Nippon Kayaku Co Ltd | エストロゲン様作用薬剤 |
| CN1294009A (zh) | 1999-10-28 | 2001-05-09 | 马金发 | 抗癌中药制剂及其置备方法 |
| DE10031650A1 (de) * | 2000-06-29 | 2002-01-17 | Schwabe Willmar Gmbh & Co | Verwendung von Extrakten aus Sophora flavescens oder Sophora subprostrata zur Prophylaxe und Therapie von Krankheitszuständen, die durch einen Mangel an Östrogenen oder durch andere hormonelle Dysregulationen verursacht werden |
| JP4693963B2 (ja) | 2000-07-12 | 2011-06-01 | 丸善製薬株式会社 | エストロゲン様作用剤、コラーゲン産生促進剤、及び線維芽細胞増殖剤 |
| US6238707B1 (en) * | 2000-10-11 | 2001-05-29 | Zhang Chun | Herbal hormone balance composition |
| JP2005501816A (ja) * | 2000-12-12 | 2005-01-20 | ワックヴォム リミテッド | Scutellariaebarbataeから単離された活性な画分を含む組成物および使用方法 |
| JP2002284696A (ja) | 2001-03-28 | 2002-10-03 | Doi Keiko | ウイルス、真菌その他の菌性疾患の治療方法 |
| US6551627B1 (en) | 2001-05-03 | 2003-04-22 | Holomed Pharmaceuticals, Ltd. | Medicinal herbal compounds for the prevention and treatment of diabetes |
| KR100456981B1 (ko) | 2001-07-14 | 2004-11-10 | (주) 메드빌 | 식물추출물을 포함하는 골다공증 예방 또는 치료용 조성물및 그 제조 방법 |
| US6855344B2 (en) * | 2001-07-17 | 2005-02-15 | Integrated Chinese Medicine Holdings, Ltd. | Compositions and methods for prostate and kidney health and disorders, an herbal preparation |
| KR20030027208A (ko) | 2001-09-14 | 2003-04-07 | 주식회사 바이오딕스 | 생약을 함유하는 관절염 치료용 조성물 및 그 제조방법 |
| US6750248B2 (en) * | 2001-11-09 | 2004-06-15 | National University Of Singapore | Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof |
| US20050032882A1 (en) * | 2002-03-06 | 2005-02-10 | Sophie Chen | Botanical extract compositions and methods of use |
| JP2004155779A (ja) | 2002-10-16 | 2004-06-03 | Taisho Pharmaceut Co Ltd | 更年期症の予防・治療用経口組成物 |
| AU2002952453A0 (en) * | 2002-11-01 | 2002-11-21 | Novogen Research Pty Ltd | Aminated isoflavonoid derivatives and uses thereof |
| JP4474518B2 (ja) * | 2003-03-28 | 2010-06-09 | 学校法人日本大学 | 2−ヒドロキシイソフラバノンデヒドラターゼをコードするポリヌクレオチドおよびその応用 |
| WO2005044179A2 (en) * | 2003-06-27 | 2005-05-19 | Hong Kong University Of Science And Technology | Formulations containing astragalus extracts and uses thereof |
| ES2373663T3 (es) | 2003-09-08 | 2012-02-07 | Genyous Biomed International Inc. | Composiciones de extractos botánicos para terapia de cáncer. |
| US20050196409A1 (en) * | 2003-09-24 | 2005-09-08 | James Dao | Compositions of botanical extracts for treating malignancy-associated changes |
| US20050118290A1 (en) * | 2003-12-02 | 2005-06-02 | University Of Singapore | Compositions and method for treatment of steroid/nuclear receptor-mediated diseases |
| US20050208159A1 (en) * | 2004-03-16 | 2005-09-22 | Kang Kyung S | Phytoestrogenic composition comprising an extract of chinese licorice root, liquiritin or isoliquiritin |
| BRPI0510717B8 (pt) * | 2004-05-06 | 2021-05-25 | Bioresponse Llc | uso de 3,3' diindolilmetano (dim) ou 2-(indol-3-ilmetil)-3,3´-diindolilmetano (ltr) |
| US20050260285A1 (en) * | 2004-05-21 | 2005-11-24 | Dimateeo-Leggio Giovina | Healthy prostate formula |
| US7887851B2 (en) * | 2004-06-07 | 2011-02-15 | Kao Corporation | Aromatase activator |
| JP4939425B2 (ja) * | 2004-11-05 | 2012-05-23 | ジェノミック ヘルス, インコーポレイテッド | 乳癌の治療反応の予後および予測の分子指標 |
| JP2008520588A (ja) * | 2004-11-18 | 2008-06-19 | ビオファーマコペ デジン アンテルナショナル インク. | 植物抽出物およびその皮膚科使用法 |
| KR100589050B1 (ko) | 2004-11-23 | 2006-06-14 | 인하대학교 산학협력단 | 황기 추출물 및 그로부터 분리한 이소플라보노이드계화합물을 유효성분으로 하는 관절염 예방 및 치료용 조성물 |
| WO2006062876A2 (en) * | 2004-12-09 | 2006-06-15 | Merck & Co., Inc. | Estrogen receptor modulators |
| US7815949B2 (en) * | 2004-12-17 | 2010-10-19 | Bionovo, Inc. | Estrogenic extracts of Morus alba and uses thereof |
| JP2008524221A (ja) | 2004-12-17 | 2008-07-10 | バイオノボ・インコーポレーテッド | Epimedium属植物の抽出液を用いた方法 |
| AU2006259583A1 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| CN100349577C (zh) * | 2005-08-25 | 2007-11-21 | 深圳海王药业有限公司 | 黄芩总黄酮提取物及黄芩苷在抗骨质疏松药物制备中的用途 |
| HRP20170103T1 (hr) * | 2005-12-21 | 2017-03-24 | Janssen Pharmaceutica N.V. | Triazolopiridazini kao modulatori tirozin kinaze |
| CN101073600A (zh) | 2006-05-17 | 2007-11-21 | 赵赐安 | 一种治疗各种毒蛇咬伤的洗用解毒药 |
| BRPI0713198A2 (pt) | 2006-07-19 | 2012-10-16 | Osurf Ohio State University Res Foundation | modulares seletivos de receptores de androgênio, seus análogos e derivados, e seus usos |
| US7381432B2 (en) * | 2006-09-19 | 2008-06-03 | Jose Angel Olalde | Menopause disorder synergistic phyto-nutraceutical composition |
| US20080319051A1 (en) * | 2007-06-22 | 2008-12-25 | Bionovo, Inc. | Liquiritigenin and derivatives as selective estrogen receptor beta agonists |
| US20090042818A1 (en) * | 2007-06-22 | 2009-02-12 | Bionovo, Inc. | Liquiritigenin and Derivatives as Selective Estrogen Receptor Beta Agonists |
| WO2009021196A1 (en) * | 2007-08-08 | 2009-02-12 | Bionovo, Inc. | Extracts of ligustrum lucidum and uses thereof |
| JP2010539086A (ja) * | 2007-09-07 | 2010-12-16 | バイオノボ・インコーポレーテッド | マメ科ファミリーのクズのエストロゲン性抽出物およびその使用 |
| WO2009033025A1 (en) * | 2007-09-07 | 2009-03-12 | Bionovo, Inc. | Estrogenic extracts of asparagus conchinchinensis (lour.) merr of the liliaceae family and uses thereof |
| JP2010539085A (ja) * | 2007-09-07 | 2010-12-16 | バイオノボ・インコーポレーテッド | マメ科ファミリーのキバナオウギのエストロゲン性抽出物およびその使用 |
| US20090258942A1 (en) * | 2008-04-14 | 2009-10-15 | Bionovo, Inc. | Calycosin and analogs thereof for the treatment of estrogen receptor beta-mediated diseases |
| EP2310024A4 (en) * | 2008-05-06 | 2012-07-25 | Bionovo Inc | ESTROGENIC EXTRACTS FOR THE TREATMENT OF VAGINA AND VULVAATROPHY |
| EP2294402A2 (en) * | 2008-06-05 | 2011-03-16 | Bionovo Inc. | Method of quantification of multiple bioactives from botanical compositons |
| US20090312437A1 (en) * | 2008-06-06 | 2009-12-17 | Bionovo, Inc., A Delaware Corporation | Anthraquinones and Analogs from Rhuem palmatum for Treatment of Estrogen Receptor Beta-Mediated Conditions |
| WO2010053600A2 (en) * | 2008-06-13 | 2010-05-14 | Bionovo, Inc. | Nyasol and analogs thereof for the treatment of estrogen receptor beta-mediated diseases |
-
2008
- 2008-09-05 US US12/205,710 patent/US9155770B2/en active Active
- 2008-09-05 JP JP2010524197A patent/JP2010538093A/ja active Pending
- 2008-09-05 EP EP08799252A patent/EP2190292A4/en not_active Withdrawn
- 2008-09-05 CA CA 2698747 patent/CA2698747A1/en not_active Abandoned
- 2008-09-05 WO PCT/US2008/075468 patent/WO2009033075A1/en not_active Ceased
- 2008-09-05 AU AU2008296136A patent/AU2008296136A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000069452A1 (en) * | 1999-05-17 | 2000-11-23 | Yoshio Takeda | Remedies for cancer and infection with helicobacter pylori and process for producing the same |
| WO2006107745A2 (en) * | 2005-04-01 | 2006-10-12 | Bionovo, Inc. | Composition for treatment of menopause |
| WO2007059149A2 (en) * | 2005-11-14 | 2007-05-24 | Bionovo, Inc. | Scutellaria barbata extract for the treatment of cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| US9155770B2 (en) | 2015-10-13 |
| WO2009033075A1 (en) | 2009-03-12 |
| US20090068297A1 (en) | 2009-03-12 |
| AU2008296136A1 (en) | 2009-03-12 |
| EP2190292A4 (en) | 2012-12-26 |
| EP2190292A1 (en) | 2010-06-02 |
| CA2698747A1 (en) | 2009-03-12 |
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