JP2010537988A5 - - Google Patents
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- Publication number
- JP2010537988A5 JP2010537988A5 JP2010522973A JP2010522973A JP2010537988A5 JP 2010537988 A5 JP2010537988 A5 JP 2010537988A5 JP 2010522973 A JP2010522973 A JP 2010522973A JP 2010522973 A JP2010522973 A JP 2010522973A JP 2010537988 A5 JP2010537988 A5 JP 2010537988A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- agent
- gel
- erythema
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 claims description 41
- 239000000499 gel Substances 0.000 claims description 21
- IWEGDQUCWQFKHS-UHFFFAOYSA-N 1-(1,3-dioxolan-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole Chemical compound O1C(C)(C)C(C)(C)OB1C1=CN(CC2OCCO2)N=C1 IWEGDQUCWQFKHS-UHFFFAOYSA-N 0.000 claims description 13
- 206010015150 Erythema Diseases 0.000 claims description 13
- 229960001724 brimonidine tartrate Drugs 0.000 claims description 13
- 231100000321 erythema Toxicity 0.000 claims description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical group COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 8
- 239000006071 cream Substances 0.000 claims description 7
- 241001303601 Rosacea Species 0.000 claims description 6
- 239000002537 cosmetic Substances 0.000 claims description 6
- 230000000149 penetrating effect Effects 0.000 claims description 6
- 201000004700 rosacea Diseases 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 5
- 230000002335 preservative effect Effects 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 239000003349 gelling agent Substances 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 239000003906 humectant Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 4
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 4
- 229960002216 methylparaben Drugs 0.000 claims description 4
- 239000003223 protective agent Substances 0.000 claims description 4
- 239000004408 titanium dioxide Substances 0.000 claims description 4
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 229960005323 phenoxyethanol Drugs 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 238000011200 topical administration Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 2
- 229960005150 glycerol Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 229960004063 propylene glycol Drugs 0.000 description 2
- 235000013772 propylene glycol Nutrition 0.000 description 2
- 229960005196 titanium dioxide Drugs 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96719107P | 2007-08-31 | 2007-08-31 | |
| PCT/US2008/010290 WO2009032223A1 (en) | 2007-08-31 | 2008-08-29 | Improved brimonidine compositions for treating erythema |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010537988A JP2010537988A (ja) | 2010-12-09 |
| JP2010537988A5 true JP2010537988A5 (cg-RX-API-DMAC7.html) | 2011-10-13 |
Family
ID=40407909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010522973A Abandoned JP2010537988A (ja) | 2007-08-31 | 2008-08-29 | 紅斑を治療するための改良ブリモニジン組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20090061020A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2200617A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010537988A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100055453A (cg-RX-API-DMAC7.html) |
| CN (2) | CN101808645A (cg-RX-API-DMAC7.html) |
| AR (1) | AR068816A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008296948A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0816097A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2698680A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010002392A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20100301L (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009032223A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8410102B2 (en) | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| US7812049B2 (en) * | 2004-01-22 | 2010-10-12 | Vicept Therapeutics, Inc. | Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists |
| KR101453601B1 (ko) * | 2009-05-29 | 2014-10-22 | 갈데르마 리써어치 앤드 디벨로프먼트 | 주입으로 인한 피부 반응 감소를 위한 필러와 아드레날린 수용체 작용제의 주사가능한 조합 |
| US20110224216A1 (en) * | 2009-10-26 | 2011-09-15 | Galderma Laboratories Inc. | Methods of Treating or Preventing Acute Erythema |
| EP2329849B1 (en) * | 2009-11-18 | 2015-04-29 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
| US8394800B2 (en) * | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| AU2011231543B2 (en) * | 2010-03-26 | 2015-01-15 | Galderma Research & Development | Improved methods and compositions for safe and effective treatment of erythema |
| CA2792649A1 (en) | 2010-03-26 | 2011-09-29 | Michael Graeber | Improved methods and compositions for safe and effective treatment of telangiectasia |
| FR2966366B1 (fr) * | 2010-10-21 | 2012-11-09 | Galderma Sa | Composition de gel de brimonidine |
| JP2013540142A (ja) * | 2010-10-21 | 2013-10-31 | ガルデルマ・ソシエテ・アノニム | 局所ゲル組成物 |
| EP2444068B2 (en) | 2010-10-21 | 2017-12-06 | Galderma S.A. | Brimonidine gel composition |
| FR2966365B1 (fr) * | 2010-10-21 | 2012-11-09 | Galderma Sa | Composition de gel topique |
| US8053427B1 (en) | 2010-10-21 | 2011-11-08 | Galderma R&D SNC | Brimonidine gel composition |
| CN107007546A (zh) | 2011-02-15 | 2017-08-04 | 阿勒根公司 | 用于治疗红斑痤疮的症状的羟甲唑啉药物乳膏组合物 |
| RU2014119879A (ru) | 2011-10-19 | 2015-11-27 | Галдерма С.А. | Способ снижения прилива крови к лицу при систематическом использовании ингибиторов фосфодиэстеразы типа 5 |
| US9283217B2 (en) | 2011-11-10 | 2016-03-15 | Allergan, Inc. | Pharmaceutical compositions comprising 7-(1 H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions |
| UA109359C2 (xx) * | 2011-11-10 | 2015-08-10 | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
| FR3000397A1 (fr) | 2012-12-31 | 2014-07-04 | Galderma Res & Dev | Combinaison de laropiprant et d'ivermectine pour le traitement de la rosacee |
| FR3000398A1 (fr) * | 2012-12-31 | 2014-07-04 | Galderma Res & Dev | Combinaison de laropiprant et de brimonidine pour le traitement de la rosacee |
| FR3015288B1 (fr) | 2013-12-19 | 2016-02-12 | Galderma Res & Dev | Utilsation du naratriptan dans le traitement de la rosacee |
| WO2015191917A1 (en) | 2014-06-11 | 2015-12-17 | Allergan, Inc. | Stabilized oxymetazoline formulations and their uses |
| WO2019014518A1 (en) * | 2017-07-14 | 2019-01-17 | Galderma Research And Development | METHODS AND COMPOSITIONS FOR REDUCING ADVERSE EFFECTS OF CHEMOTHERAPEUTIC TREATMENTS |
| CN113784712A (zh) | 2019-05-01 | 2021-12-10 | 克雷西奥生物科技有限公司 | 治疗瘙痒的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4285967A (en) * | 1978-06-30 | 1981-08-25 | Estee Lauder Inc. | Cosmetic preparation for reducing redness of blemishes |
| US4256763A (en) * | 1978-09-19 | 1981-03-17 | Mchugh John E | Treatment of herpes simplex infections and acne |
| GB8827968D0 (en) * | 1988-11-30 | 1989-01-05 | Boots Co Plc | Sunscreen compositions |
| US5916574A (en) * | 1996-10-09 | 1999-06-29 | Ideal Ideas, Inc. | Method of treating natural poison skin conditions |
| US6410045B1 (en) * | 1999-02-22 | 2002-06-25 | Clyde Lewis Schultz | Drug delivery system for antiglaucomatous medication |
| US6294553B1 (en) * | 2000-02-15 | 2001-09-25 | Allergan Sales, Inc. | Method for treating ocular pain |
| US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| US20050020600A1 (en) * | 2003-07-23 | 2005-01-27 | Scherer Warren J. | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
| US20050276765A1 (en) * | 2004-06-10 | 2005-12-15 | Paul Nghiem | Preventing skin damage |
| US20110224215A1 (en) * | 2007-12-21 | 2011-09-15 | Galderma Laboratories, Inc. | Pre-surgical treatment |
-
2008
- 2008-08-18 US US12/193,098 patent/US20090061020A1/en not_active Abandoned
- 2008-08-29 JP JP2010522973A patent/JP2010537988A/ja not_active Abandoned
- 2008-08-29 CA CA2698680A patent/CA2698680A1/en not_active Abandoned
- 2008-08-29 EP EP08795728A patent/EP2200617A4/en not_active Withdrawn
- 2008-08-29 CN CN200880105032A patent/CN101808645A/zh active Pending
- 2008-08-29 AU AU2008296948A patent/AU2008296948A1/en not_active Abandoned
- 2008-08-29 CN CN201110321688XA patent/CN102552112A/zh active Pending
- 2008-08-29 MX MX2010002392A patent/MX2010002392A/es not_active Application Discontinuation
- 2008-08-29 WO PCT/US2008/010290 patent/WO2009032223A1/en not_active Ceased
- 2008-08-29 BR BRPI0816097A patent/BRPI0816097A2/pt not_active IP Right Cessation
- 2008-08-29 KR KR1020107005023A patent/KR20100055453A/ko not_active Ceased
- 2008-09-01 AR ARP080103804A patent/AR068816A1/es not_active Application Discontinuation
-
2010
- 2010-03-04 NO NO20100301A patent/NO20100301L/no not_active Application Discontinuation
-
2011
- 2011-10-21 US US13/278,955 patent/US20120040016A1/en not_active Abandoned
-
2012
- 2012-07-12 US US13/547,531 patent/US20120282346A1/en not_active Abandoned
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