JP2010536750A - １１β−ヒドロキシステロイドデヒドロゲナーゼＩ型を阻害するのに有用な６置換スルホニルアザビシクロ［３．２．１］オクタン - Google Patents
１１β−ヒドロキシステロイドデヒドロゲナーゼＩ型を阻害するのに有用な６置換スルホニルアザビシクロ［３．２．１］オクタン Download PDFInfo
- Publication number
- JP2010536750A JP2010536750A JP2010521002A JP2010521002A JP2010536750A JP 2010536750 A JP2010536750 A JP 2010536750A JP 2010521002 A JP2010521002 A JP 2010521002A JP 2010521002 A JP2010521002 A JP 2010521002A JP 2010536750 A JP2010536750 A JP 2010536750A
- Authority
- JP
- Japan
- Prior art keywords
- azabicyclo
- trimethyl
- sulfonyl
- octane
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC1(C2)CC(C)(C)CC2*(CCc(cc2)ccc2Cl)C1 Chemical compound CC1(C2)CC(C)(C)CC2*(CCc(cc2)ccc2Cl)C1 0.000 description 14
- IOBLKINZLRFWQY-UHFFFAOYSA-N CC(C)(CC(C)(C1)C2)C1N2S(C1C=CC(c2c[s]nn2)=CC1)(=O)=O Chemical compound CC(C)(CC(C)(C1)C2)C1N2S(C1C=CC(c2c[s]nn2)=CC1)(=O)=O IOBLKINZLRFWQY-UHFFFAOYSA-N 0.000 description 1
- NLLCWCJAYYGSOC-UHFFFAOYSA-N CC(C)(CC(C)(C1)C2)C1N2S(c1c(C)c(Cl)ccc1)(=O)=O Chemical compound CC(C)(CC(C)(C1)C2)C1N2S(c1c(C)c(Cl)ccc1)(=O)=O NLLCWCJAYYGSOC-UHFFFAOYSA-N 0.000 description 1
- BOTCGRKBKXHKGG-UHFFFAOYSA-N CC(C)(CC(C)(C1)C2)C1N2S(c1ccc(C2CCCCC2)cc1)(=O)=O Chemical compound CC(C)(CC(C)(C1)C2)C1N2S(c1ccc(C2CCCCC2)cc1)(=O)=O BOTCGRKBKXHKGG-UHFFFAOYSA-N 0.000 description 1
- ORORTAFGOXDKJA-UHFFFAOYSA-N CC(C)(CC(C)(C1)C2)C1N2[IH](c(cc1)ccc1-[n]1nccc1)(=O)=O Chemical compound CC(C)(CC(C)(C1)C2)C1N2[IH](c(cc1)ccc1-[n]1nccc1)(=O)=O ORORTAFGOXDKJA-UHFFFAOYSA-N 0.000 description 1
- LSXZITLMXVOHDX-UHFFFAOYSA-N CC(C)(c(cc1)ccc1S(N1CC(C)(C2)CC(C)(C)C2C1)(=O)=O)OC Chemical compound CC(C)(c(cc1)ccc1S(N1CC(C)(C2)CC(C)(C)C2C1)(=O)=O)OC LSXZITLMXVOHDX-UHFFFAOYSA-N 0.000 description 1
- XNAQVZLLVBQHRF-UHFFFAOYSA-N CC(C)(c(cc1)ccc1[N](N1C(C2)CC(C)(C)CC2(C)C1)(O)O)O Chemical compound CC(C)(c(cc1)ccc1[N](N1C(C2)CC(C)(C)CC2(C)C1)(O)O)O XNAQVZLLVBQHRF-UHFFFAOYSA-N 0.000 description 1
- KUYFZTKZACBUKR-UHFFFAOYSA-N CC(C)(c1ccc(C(N(O)O)N2C(C3)CC(C)(C)CC3(C)C2)cc1)O Chemical compound CC(C)(c1ccc(C(N(O)O)N2C(C3)CC(C)(C)CC3(C)C2)cc1)O KUYFZTKZACBUKR-UHFFFAOYSA-N 0.000 description 1
- PFLIVFURCRUADV-UHFFFAOYSA-N CC(C)Oc(cc1)ccc1S(N1C(C2)C(C)(C)CC2(C)C1)(=O)=O Chemical compound CC(C)Oc(cc1)ccc1S(N1C(C2)C(C)(C)CC2(C)C1)(=O)=O PFLIVFURCRUADV-UHFFFAOYSA-N 0.000 description 1
- DXWCDVOWCGRPGO-UHFFFAOYSA-N CC(C)c(cc1)ccc1S(N1C(C2)CC(C)(C)CC2(C)C1)(O)=O Chemical compound CC(C)c(cc1)ccc1S(N1C(C2)CC(C)(C)CC2(C)C1)(O)=O DXWCDVOWCGRPGO-UHFFFAOYSA-N 0.000 description 1
- VPBNDYXNSQJLCF-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c([s]1)ccc1Cl)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c([s]1)ccc1Cl)=O VPBNDYXNSQJLCF-UHFFFAOYSA-N 0.000 description 1
- NTZNUVCIPXFGMV-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c(c(F)ccc1)c1F)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c(c(F)ccc1)c1F)(=O)=O NTZNUVCIPXFGMV-UHFFFAOYSA-N 0.000 description 1
- BKOMDRLPTRFXBN-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c(c1n[o]nc11)ccc1Cl)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c(c1n[o]nc11)ccc1Cl)(=O)=O BKOMDRLPTRFXBN-UHFFFAOYSA-N 0.000 description 1
- YWQDBCGAODDCTR-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c(cc1)cc(C=C2)c1OC2=O)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c(cc1)cc(C=C2)c1OC2=O)(=O)=O YWQDBCGAODDCTR-UHFFFAOYSA-N 0.000 description 1
- KAFKJWKZTUZLKI-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c(cc1)ccc1C(C)=O)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c(cc1)ccc1C(C)=O)(=O)=O KAFKJWKZTUZLKI-UHFFFAOYSA-N 0.000 description 1
- DGOBKUGWFJQMGH-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c(cc1)ccc1I)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c(cc1)ccc1I)(=O)=O DGOBKUGWFJQMGH-UHFFFAOYSA-N 0.000 description 1
- RSCNWESDVSUEDX-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c(cn1)ccc1Oc1ccccc1)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c(cn1)ccc1Oc1ccccc1)(=O)=O RSCNWESDVSUEDX-UHFFFAOYSA-N 0.000 description 1
- MKCBZYIGDIXNJO-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c1c(C(OC)=O)[s]cc1)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c1c(C(OC)=O)[s]cc1)(=O)=O MKCBZYIGDIXNJO-UHFFFAOYSA-N 0.000 description 1
- QHNHESJCGKXXBD-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c1c(C)[o]nc1C)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c1c(C)[o]nc1C)(=O)=O QHNHESJCGKXXBD-UHFFFAOYSA-N 0.000 description 1
- NBWVYUMQHGTPNR-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c1c(C)c(cc(cc2)Cl)c2[s]1)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c1c(C)c(cc(cc2)Cl)c2[s]1)(=O)=O NBWVYUMQHGTPNR-UHFFFAOYSA-N 0.000 description 1
- ZRDDXSDYDVYFKW-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c1ccc(N2CCOCC2)nc1)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c1ccc(N2CCOCC2)nc1)(=O)=O ZRDDXSDYDVYFKW-UHFFFAOYSA-N 0.000 description 1
- PGWWVWIUIJDDGS-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2S(c1ccccc1C#N)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2S(c1ccccc1C#N)(=O)=O PGWWVWIUIJDDGS-UHFFFAOYSA-N 0.000 description 1
- KQXYHVPFXHVSET-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2[S](C)(c(cc1)ccc1S=O)(=O)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2[S](C)(c(cc1)ccc1S=O)(=O)=O KQXYHVPFXHVSET-UHFFFAOYSA-N 0.000 description 1
- NQDOMBRQXKSSNQ-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2[S](Cc1ccccc1)(=O)#[O] Chemical compound CC(C1)(C2)CC(C)(C)CC1N2[S](Cc1ccccc1)(=O)#[O] NQDOMBRQXKSSNQ-UHFFFAOYSA-N 0.000 description 1
- DJIGQOVKTTZOAX-UHFFFAOYSA-N CC(C1)(C2)CC(C)(C)CC1N2[S](c(cc1)ccc1C(C)=O)(O)(=C)=O Chemical compound CC(C1)(C2)CC(C)(C)CC1N2[S](c(cc1)ccc1C(C)=O)(O)(=C)=O DJIGQOVKTTZOAX-UHFFFAOYSA-N 0.000 description 1
- GODFUJWJAQKGRN-UHFFFAOYSA-N CC(CC1C2)CC(C)(C)C1N2S(c(cc1)ccc1Oc1ccccc1)(=O)=O Chemical compound CC(CC1C2)CC(C)(C)C1N2S(c(cc1)ccc1Oc1ccccc1)(=O)=O GODFUJWJAQKGRN-UHFFFAOYSA-N 0.000 description 1
- UPVQVDVSHPSNRH-UHFFFAOYSA-N CC(c(cc1)ccc1S(N1C(C2)CC(C)(C)CC2(C)C1)(=O)=O)OC Chemical compound CC(c(cc1)ccc1S(N1C(C2)CC(C)(C)CC2(C)C1)(=O)=O)OC UPVQVDVSHPSNRH-UHFFFAOYSA-N 0.000 description 1
- UUNXYANHBSYOHR-UHFFFAOYSA-N CC1(CC(C)(C)CC2C1)[IH]N2S(C1C=C(CCC=C2)C2=CC1)(=O)=O Chemical compound CC1(CC(C)(C)CC2C1)[IH]N2S(C1C=C(CCC=C2)C2=CC1)(=O)=O UUNXYANHBSYOHR-UHFFFAOYSA-N 0.000 description 1
- SBOPCBCLLOWLEB-UHFFFAOYSA-N CCOC(C)c(cc1)ccc1S(N1C(C2)CC(C)(C)CC2(C)C1)(=O)=O Chemical compound CCOC(C)c(cc1)ccc1S(N1C(C2)CC(C)(C)CC2(C)C1)(=O)=O SBOPCBCLLOWLEB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95598507P | 2007-08-15 | 2007-08-15 | |
| PCT/US2008/009609 WO2009023181A1 (en) | 2007-08-15 | 2008-08-12 | 6-SUBSTITUTED SULFONYL AZABICYCLO[3.2.1]OCTANES USEFUL TO INHIBIT 11β-HYDROXYSTEROID DEHYDROGENASE TYPE-1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010536750A true JP2010536750A (ja) | 2010-12-02 |
| JP2010536750A5 JP2010536750A5 (enExample) | 2011-06-23 |
Family
ID=39944385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521002A Withdrawn JP2010536750A (ja) | 2007-08-15 | 2008-08-12 | １１β−ヒドロキシステロイドデヒドロゲナーゼＩ型を阻害するのに有用な６置換スルホニルアザビシクロ［３．２．１］オクタン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8466149B2 (enExample) |
| EP (1) | EP2188293B1 (enExample) |
| JP (1) | JP2010536750A (enExample) |
| CN (1) | CN101821271A (enExample) |
| CA (1) | CA2696288A1 (enExample) |
| MX (1) | MX2010001825A (enExample) |
| WO (1) | WO2009023181A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019026575A1 (ja) * | 2017-08-04 | 2019-02-07 | 国立大学法人名古屋大学 | 花成時期調節剤、農薬組成物及び植物の花成時期の調節方法 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2021242753A1 (en) * | 2020-05-26 | 2021-12-02 | The Regents Of The University Of Michigan | Mitochondrial targeting compounds for the treatment of associated diseases |
| CN111743898A (zh) * | 2020-06-11 | 2020-10-09 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 11β-HSD1抑制剂在应激环境下保护神经干细胞的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL154306A0 (en) | 2003-02-05 | 2003-09-17 | Rimonyx Pharmaceuticals Ltd | Pharmaceutical compositions comprising thieno [2,3-c] pyridine derivatives and use thereof |
| EP1948657A1 (en) | 2005-11-15 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Azaindazoles useful as inhibitors of kinases |
| JP5782586B2 (ja) * | 2007-05-10 | 2015-09-24 | ドッグウッド ファーマシューティカルズ，インコーポレイテッド | フルオレン、アントラセン、キサンテン、ジベンゾスベロン、及びアクリジンの誘導体、並びに、それらの使用 |
-
2008
- 2008-08-12 CN CN200880112336A patent/CN101821271A/zh active Pending
- 2008-08-12 CA CA2696288A patent/CA2696288A1/en not_active Abandoned
- 2008-08-12 JP JP2010521002A patent/JP2010536750A/ja not_active Withdrawn
- 2008-08-12 US US12/672,817 patent/US8466149B2/en active Active
- 2008-08-12 EP EP08795217.2A patent/EP2188293B1/en active Active
- 2008-08-12 MX MX2010001825A patent/MX2010001825A/es not_active Application Discontinuation
- 2008-08-12 WO PCT/US2008/009609 patent/WO2009023181A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019026575A1 (ja) * | 2017-08-04 | 2019-02-07 | 国立大学法人名古屋大学 | 花成時期調節剤、農薬組成物及び植物の花成時期の調節方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110237559A1 (en) | 2011-09-29 |
| CN101821271A (zh) | 2010-09-01 |
| EP2188293A1 (en) | 2010-05-26 |
| EP2188293B1 (en) | 2019-05-01 |
| MX2010001825A (es) | 2010-03-10 |
| US8466149B2 (en) | 2013-06-18 |
| WO2009023181A1 (en) | 2009-02-19 |
| CA2696288A1 (en) | 2009-02-19 |
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| A300 | Application deemed to be withdrawn because no request for examination was validly filed |
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