MX2010001825A - Sulfonil azabiciclo[3.2.1]octanos 6-sustituidos utiles para inhibir 11beta-hidroxiesteroide deshidrogenasa tipo-1. - Google Patents

Sulfonil azabiciclo[3.2.1]octanos 6-sustituidos utiles para inhibir 11beta-hidroxiesteroide deshidrogenasa tipo-1.

Info

Publication number
MX2010001825A
MX2010001825A MX2010001825A MX2010001825A MX2010001825A MX 2010001825 A MX2010001825 A MX 2010001825A MX 2010001825 A MX2010001825 A MX 2010001825A MX 2010001825 A MX2010001825 A MX 2010001825A MX 2010001825 A MX2010001825 A MX 2010001825A
Authority
MX
Mexico
Prior art keywords
hydroxysteroid dehydrogenase
azabicyclo
inhibit
dehydrogenase type
useful
Prior art date
Application number
MX2010001825A
Other languages
English (en)
Inventor
Samuel Chackalamannil
Craig D Boyle
Unmesh G Shah
Claire M Lankin
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2010001825A publication Critical patent/MX2010001825A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

En sus muchas modalidades, la presente invención se refiere a una nueva clase de compuestos sulfonil 1,3,3-trialquil-6-azabiciclo[3. 2.1]octano 6-sustituidos útiles para inhibir 1ß-hidroxiesteroide deshidrogenasa tipo 1, composiciones farmacéuticas que contienen los compuestos, y métodos de tratamiento, prevención, inhibición o mejoramiento de una o más condiciones asociadas con la expresión de 1ß-hidroxiesteroide deshidrogenasa tipo 1 que usan dichos compuestos o composiciones farmacéuticas.
MX2010001825A 2007-08-15 2008-08-12 Sulfonil azabiciclo[3.2.1]octanos 6-sustituidos utiles para inhibir 11beta-hidroxiesteroide deshidrogenasa tipo-1. MX2010001825A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95598507P 2007-08-15 2007-08-15
PCT/US2008/009609 WO2009023181A1 (en) 2007-08-15 2008-08-12 6-SUBSTITUTED SULFONYL AZABICYCLO[3.2.1]OCTANES USEFUL TO INHIBIT 11β-HYDROXYSTEROID DEHYDROGENASE TYPE-1

Publications (1)

Publication Number Publication Date
MX2010001825A true MX2010001825A (es) 2010-03-10

Family

ID=39944385

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001825A MX2010001825A (es) 2007-08-15 2008-08-12 Sulfonil azabiciclo[3.2.1]octanos 6-sustituidos utiles para inhibir 11beta-hidroxiesteroide deshidrogenasa tipo-1.

Country Status (7)

Country Link
US (1) US8466149B2 (es)
EP (1) EP2188293B1 (es)
JP (1) JP2010536750A (es)
CN (1) CN101821271A (es)
CA (1) CA2696288A1 (es)
MX (1) MX2010001825A (es)
WO (1) WO2009023181A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2019026575A1 (ja) * 2017-08-04 2019-02-07 国立大学法人名古屋大学 花成時期調節剤、農薬組成物及び植物の花成時期の調節方法
CN111743898A (zh) * 2020-06-11 2020-10-09 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 11β-HSD1抑制剂在应激环境下保护神经干细胞的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL154306A0 (en) * 2003-02-05 2003-09-17 Rimonyx Pharmaceuticals Ltd Pharmaceutical compositions comprising thieno [2,3-c] pyridine derivatives and use thereof
CA2628179A1 (en) 2005-11-15 2007-05-24 Vertex Pharmaceuticals Incorporated Azaindazoles useful as inhibitors of kinases
WO2008140792A1 (en) * 2007-05-10 2008-11-20 Avalon Pharmaceuticals Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof

Also Published As

Publication number Publication date
WO2009023181A1 (en) 2009-02-19
JP2010536750A (ja) 2010-12-02
US20110237559A1 (en) 2011-09-29
EP2188293A1 (en) 2010-05-26
CA2696288A1 (en) 2009-02-19
EP2188293B1 (en) 2019-05-01
CN101821271A (zh) 2010-09-01
US8466149B2 (en) 2013-06-18

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