JP2010535799A5 - - Google Patents

Info

Publication number

JP2010535799A5

JP2010535799A5 JP2010520272A JP2010520272A JP2010535799A5 JP 2010535799 A5 JP2010535799 A5 JP 2010535799A5 JP 2010520272 A JP2010520272 A JP 2010520272A JP 2010520272 A JP2010520272 A JP 2010520272A JP 2010535799 A5 JP2010535799 A5 JP 2010535799A5

Authority

JP

Japan

Prior art keywords

methoxy

cyclohexyl

indolo

benzazepine

sulfonyl

Prior art date

2008-08-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• -1 pyrrolopyridinyl Chemical group 0.000 claims 47
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 43
• FRUWAONHRDGSAL-UHFFFAOYSA-N 7h-indolo[2,1-a][2]benzazepine-10-carboxylic acid Chemical compound C1=CCN2C3=CC(C(=O)O)=CC=C3C=C2C2=CC=CC=C21 FRUWAONHRDGSAL-UHFFFAOYSA-N 0.000 claims 41
• 125000000217 alkyl group Chemical group 0.000 claims 36
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 34
• HJHICYAWGPPIND-UHFFFAOYSA-N 7h-indolo[2,1-a][2]benzazepine-10-carboxamide Chemical compound C1=CCN2C3=CC(C(=O)N)=CC=C3C=C2C2=CC=CC=C21 HJHICYAWGPPIND-UHFFFAOYSA-N 0.000 claims 33
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 24
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 19
• 229910052739 hydrogen Inorganic materials 0.000 claims 16
• 239000001257 hydrogen Substances 0.000 claims 16
• 150000001875 compounds Chemical class 0.000 claims 13
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 12
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 12
• 125000003545 alkoxy group Chemical group 0.000 claims 11
• 125000001424 substituent group Chemical group 0.000 claims 11
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
• 125000000753 cycloalkyl group Chemical group 0.000 claims 10
• 125000002393 azetidinyl group Chemical group 0.000 claims 8
• 125000002757 morpholinyl group Chemical group 0.000 claims 8
• 125000004193 piperazinyl group Chemical group 0.000 claims 8
• 125000003386 piperidinyl group Chemical group 0.000 claims 8
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 8
• 125000004568 thiomorpholinyl group Chemical group 0.000 claims 8
• 125000003282 alkyl amino group Chemical group 0.000 claims 7
• 125000004663 dialkyl amino group Chemical group 0.000 claims 7
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
• 125000001475 halogen functional group Chemical group 0.000 claims 6
• 150000002431 hydrogen Chemical class 0.000 claims 6
• QRKIDYBDEVJLFN-UHFFFAOYSA-N 5h-indolo[2,1-a][2]benzazepine-10-carboxamide Chemical compound C1C=CN2C3=CC(C(=O)N)=CC=C3C=C2C2=CC=CC=C21 QRKIDYBDEVJLFN-UHFFFAOYSA-N 0.000 claims 5
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 5
• 125000001188 haloalkyl group Chemical group 0.000 claims 5
• 125000004076 pyridyl group Chemical group 0.000 claims 5
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 3
• 125000003373 pyrazinyl group Chemical group 0.000 claims 3
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
• 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 2
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
• 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 2
• 125000006255 cyclopropyl carbonyl group Chemical group [H]C1([H])C([H])([H])C1([H])C(*)=O 0.000 claims 2
• 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• 125000004438 haloalkoxy group Chemical group 0.000 claims 2
• 125000004692 haloalkylcarbonyl group Chemical group 0.000 claims 2
• 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 2
• UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 2
• 125000002098 pyridazinyl group Chemical group 0.000 claims 2
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
• OTDWHDOTZWWCFA-UHFFFAOYSA-N 12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2,4,6,8,10,13,15,17-nonaene-9-carboxamide Chemical compound C=1N2C3=CC=CC=C3C=C2C2=CC=CC=C2C2=C(C(=O)N)C2=1 OTDWHDOTZWWCFA-UHFFFAOYSA-N 0.000 claims 1
• MOXSHYPJVULGBJ-UHFFFAOYSA-N 13-cyclohexyl-3-methoxy-6-[2-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)phenyl]-n-propan-2-ylsulfonyl-7h-indolo[2,1-a][2]benzazepine-10-carboxamide Chemical compound C12=CC=C(C(=O)NS(=O)(=O)C(C)C)C=C2N2CC(C=3C(=CC=CC=3)C(=O)N3C4CCC3CN(C)C4)=CC3=CC(OC)=CC=C3C2=C1C1CCCCC1 MOXSHYPJVULGBJ-UHFFFAOYSA-N 0.000 claims 1
• 208000005176 Hepatitis C Diseases 0.000 claims 1
• 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
• 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 1
• 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
• 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 1
• 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
• 125000005433 dihydrobenzodioxinyl group Chemical group O1C(COC2=C1C=CC=C2)* 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 208000010710 hepatitis C virus infection Diseases 0.000 claims 1
• 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
• 125000001041 indolyl group Chemical group 0.000 claims 1
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
• 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1