JP2010533649A - B7−dc改変体 - Google Patents

B7−dc改変体 Download PDF

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Publication number
JP2010533649A
JP2010533649A JP2010516276A JP2010516276A JP2010533649A JP 2010533649 A JP2010533649 A JP 2010533649A JP 2010516276 A JP2010516276 A JP 2010516276A JP 2010516276 A JP2010516276 A JP 2010516276A JP 2010533649 A JP2010533649 A JP 2010533649A
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polypeptide
variant
cells
cell
amino acid
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JP2010533649A5 (https=
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リーピン チェン,
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Johns Hopkins University
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Johns Hopkins University
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70532B7 molecules, e.g. CD80, CD86
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2010516276A 2007-07-13 2008-07-11 B7−dc改変体 Pending JP2010533649A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94978507P 2007-07-13 2007-07-13
PCT/US2008/069819 WO2009029342A2 (en) 2007-07-13 2008-07-11 B7-dc variants

Publications (2)

Publication Number Publication Date
JP2010533649A true JP2010533649A (ja) 2010-10-28
JP2010533649A5 JP2010533649A5 (https=) 2011-08-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010516276A Pending JP2010533649A (ja) 2007-07-13 2008-07-11 B7−dc改変体

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US (2) US8153595B2 (https=)
EP (2) EP2170946A2 (https=)
JP (1) JP2010533649A (https=)
CN (1) CN101784564B (https=)
AU (1) AU2008293885A1 (https=)
CA (1) CA2693707A1 (https=)
WO (1) WO2009029342A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
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JP2020500010A (ja) * 2016-10-20 2020-01-09 アルパイン イミューン サイエンシズ インコーポレイテッド 分泌性バリアント免疫調節タンパク質および改変細胞療法
JP2020511144A (ja) * 2017-03-16 2020-04-16 アルパイン イミューン サイエンシズ インコーポレイテッド Pd−l2バリアント免疫調節タンパク質及びその使用
JP2023058027A (ja) * 2017-03-16 2023-04-24 アルパイン イミューン サイエンシズ インコーポレイテッド Cd80バリアント免疫調節タンパク質及びその使用

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CN103965363B (zh) * 2013-02-06 2021-01-15 上海白泽生物科技有限公司 与pd-1和vegf高效结合的融合蛋白、其编码序列及用途
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JP2020514321A (ja) 2017-02-01 2020-05-21 モデルナティーエックス, インコーポレイテッド 活性化がん遺伝子変異ペプチドをコードする免疫調節治療mRNA組成物
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CN106924718A (zh) * 2017-04-27 2017-07-07 中山大学 B7‑dc突变体在治疗哮喘中的应用
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Cited By (5)

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JP2020500010A (ja) * 2016-10-20 2020-01-09 アルパイン イミューン サイエンシズ インコーポレイテッド 分泌性バリアント免疫調節タンパク質および改変細胞療法
JP2020511144A (ja) * 2017-03-16 2020-04-16 アルパイン イミューン サイエンシズ インコーポレイテッド Pd−l2バリアント免疫調節タンパク質及びその使用
JP2023058027A (ja) * 2017-03-16 2023-04-24 アルパイン イミューン サイエンシズ インコーポレイテッド Cd80バリアント免疫調節タンパク質及びその使用
JP2025076434A (ja) * 2017-03-16 2025-05-15 アルパイン イミューン サイエンシズ インコーポレイテッド Cd80バリアント免疫調節タンパク質及びその使用
JP7702928B2 (ja) 2017-03-16 2025-07-18 アルパイン イミューン サイエンシズ インコーポレイテッド Cd80バリアント免疫調節タンパク質及びその使用

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EP2514762A2 (en) 2012-10-24
CN101784564B (zh) 2014-07-02
EP2514762A3 (en) 2013-01-16
US8445447B2 (en) 2013-05-21
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WO2009029342A3 (en) 2009-08-20
CN101784564A (zh) 2010-07-21
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US8153595B2 (en) 2012-04-10
US20120164168A1 (en) 2012-06-28

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