JP2010533478A - ガンマセクレターゼの阻害剤の基質特異性を同定するための組成物および方法 - Google Patents
ガンマセクレターゼの阻害剤の基質特異性を同定するための組成物および方法 Download PDFInfo
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- JP2010533478A JP2010533478A JP2010516305A JP2010516305A JP2010533478A JP 2010533478 A JP2010533478 A JP 2010533478A JP 2010516305 A JP2010516305 A JP 2010516305A JP 2010516305 A JP2010516305 A JP 2010516305A JP 2010533478 A JP2010533478 A JP 2010533478A
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| JPWO2009011426A1 (ja) * | 2007-07-19 | 2010-09-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ｃ−Ｍｅｔを利用したスクリーニング方法 |
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| EP2219028B1 (en) * | 2007-11-15 | 2012-09-12 | Eisai R&D Management Co., Ltd. | Screening method utilizing novel substrate epha7 for gamma-secretase |
| DK2223999T3 (en) * | 2007-11-30 | 2017-12-18 | Eisai R&D Man Co Ltd | EPHA4 POLYPEPTIDE WITH UNKNOWN ACTIVITY AND USE THEREOF |
| EP2653552B1 (en) | 2010-12-17 | 2016-10-19 | Eisai R&D Management Co., Ltd. | SCREENING METHOD USING GELATINASE-MEDIATED EphA4 CLEAVAGE REACTION AS AN INDICATOR |
| EP2703814B1 (en) | 2011-04-25 | 2017-11-01 | Eisai R&D Management Co., Ltd. | Method for detecting neurological disease associated with cognitive dysfunction by measuring epha4 extracellular domain |
| RU2627177C2 (ru) | 2012-06-22 | 2017-08-03 | Джентиум С.Р.Л. | Способ определения биологической активности дефибротида, основанный на применении эуглобулина |
| EP3759127A4 (en) * | 2018-03-02 | 2022-03-30 | Ionis Pharmaceuticals, Inc. | COMPOUNDS AND METHODS FOR MODULATING AMYLOID BETA PRECURSOR PROTEIN |
| CA3139398A1 (en) | 2019-07-01 | 2021-01-07 | Eisai R&D Management Co., Ltd. | Anti-epha4 antibody |
| WO2021174075A1 (en) * | 2020-02-27 | 2021-09-02 | Adeptrix Corp. | Multiplexed bead-based analytical assays |
| WO2021206910A1 (en) * | 2020-04-09 | 2021-10-14 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| KR20230043914A (ko) | 2020-07-28 | 2023-03-31 | 아이오니스 파마수티컬즈, 인코포레이티드 | App 발현을 감소시키기 위한 화합물 및 방법 |
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| US5441870A (en) | 1992-04-15 | 1995-08-15 | Athena Neurosciences, Inc. | Methods for monitoring cellular processing of β-amyloid precursor protein |
| US5604102A (en) * | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| US5605811A (en) * | 1992-10-26 | 1997-02-25 | Athena Neurosciences, Inc. | Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein |
| AU702293B2 (en) | 1993-10-27 | 1999-02-18 | Athena Neurosciences, Inc. | Transgenic animals harboring APP allele having Swedish mutation |
| DE10131899A1 (de) * | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| WO2007058987A1 (en) * | 2005-11-10 | 2007-05-24 | Bristol-Myers Squibb Company | Methods of identifying compounds that inhibit notch cleavage |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
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- 2008-07-14 WO PCT/US2008/070012 patent/WO2009012237A1/en not_active Ceased
- 2008-07-14 EP EP08826401A patent/EP2183598A1/en not_active Withdrawn
- 2008-07-14 CA CA 2692604 patent/CA2692604A1/en not_active Abandoned
- 2008-07-14 JP JP2010516305A patent/JP2010533478A/ja not_active Withdrawn
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2011
- 2011-03-08 US US13/043,278 patent/US20110306071A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020058360A (ja) * | 2014-11-27 | 2020-04-16 | ゲンチウム エス．アール．エル． | デフィブロチドの能力を決定する為の細胞に基づく方法 |
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|---|---|
| US20110306071A1 (en) | 2011-12-15 |
| WO2009012237A1 (en) | 2009-01-22 |
| CA2692604A1 (en) | 2009-01-22 |
| US20090023158A1 (en) | 2009-01-22 |
| EP2183598A1 (en) | 2010-05-12 |
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