JP2010531871A - ３−アザ−ビシクロ［３．３．０］オクタン化合物 - Google Patents
３−アザ−ビシクロ［３．３．０］オクタン化合物 Download PDFInfo
- Publication number
- JP2010531871A JP2010531871A JP2010514232A JP2010514232A JP2010531871A JP 2010531871 A JP2010531871 A JP 2010531871A JP 2010514232 A JP2010514232 A JP 2010514232A JP 2010514232 A JP2010514232 A JP 2010514232A JP 2010531871 A JP2010531871 A JP 2010531871A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- thiazole
- aza
- bicyclo
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *C(*)(C1)C[C@](C2)C1C(CNC(*)=O)N2C(*)=O Chemical compound *C(*)(C1)C[C@](C2)C1C(CNC(*)=O)N2C(*)=O 0.000 description 3
- ZGJSEYKPSAMUIV-WCKHTFKRSA-N CC(C1)C[C@H]2[C@@H]1CN[C@@H]2CNC(c1c(C)[o]nc1C)=O Chemical compound CC(C1)C[C@H]2[C@@H]1CN[C@@H]2CNC(c1c(C)[o]nc1C)=O ZGJSEYKPSAMUIV-WCKHTFKRSA-N 0.000 description 1
- RXIUWBXOHNEXQK-FXYBZAJKSA-N CC(C1)C[C@H]2[C@@H]1CN[C@@H]2CNC(c1c2OCCOc2ccc1)=O Chemical compound CC(C1)C[C@H]2[C@@H]1CN[C@@H]2CNC(c1c2OCCOc2ccc1)=O RXIUWBXOHNEXQK-FXYBZAJKSA-N 0.000 description 1
- ADJXCKYUVPWTRR-HSTDOPHLSA-N CC(C1)C[C@H]2[C@@H]1CN[C@@H]2CNC(c1c[n](cc[s]2)c2n1)=O Chemical compound CC(C1)C[C@H]2[C@@H]1CN[C@@H]2CNC(c1c[n](cc[s]2)c2n1)=O ADJXCKYUVPWTRR-HSTDOPHLSA-N 0.000 description 1
- BWXYTYLQHCOHTD-AHKRTSGYSA-N CC(C1)C[C@H]2[C@@H]1CN[C@@H]2CNC(c1n[o]c2ccccc12)=O Chemical compound CC(C1)C[C@H]2[C@@H]1CN[C@@H]2CNC(c1n[o]c2ccccc12)=O BWXYTYLQHCOHTD-AHKRTSGYSA-N 0.000 description 1
- KEGFFRBAGNNBSH-DLYLHQSZSA-N CC1C[C@@H]2C(C3)([C@H]3NC(/C=N/N(C)C3=C(C)CCCC3)=O)NC[C@@H]2C1 Chemical compound CC1C[C@@H]2C(C3)([C@H]3NC(/C=N/N(C)C3=C(C)CCCC3)=O)NC[C@@H]2C1 KEGFFRBAGNNBSH-DLYLHQSZSA-N 0.000 description 1
- ARDLLNZTJDWGTA-UHFFFAOYSA-N COC(C(C(N)O)=O)=O Chemical compound COC(C(C(N)O)=O)=O ARDLLNZTJDWGTA-UHFFFAOYSA-N 0.000 description 1
- GELUMSFOWDPBFI-UHFFFAOYSA-N COC(C(N)N)=O Chemical compound COC(C(N)N)=O GELUMSFOWDPBFI-UHFFFAOYSA-N 0.000 description 1
- HMSBBDYIOJRENS-GARJFASQSA-N O=C(c1cnc2[s]cc[n]12)NC[C@H]1NC[C@H]2[C@@H]1CCC2 Chemical compound O=C(c1cnc2[s]cc[n]12)NC[C@H]1NC[C@H]2[C@@H]1CCC2 HMSBBDYIOJRENS-GARJFASQSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2007052598 | 2007-07-03 | ||
| PCT/IB2008/052656 WO2009004584A1 (en) | 2007-07-03 | 2008-07-02 | 3-aza-bicyclo[3.3.0]octane compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2010531871A true JP2010531871A (ja) | 2010-09-30 |
Family
ID=39863067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514232A Ceased JP2010531871A (ja) | 2007-07-03 | 2008-07-02 | ３−アザ−ビシクロ［３．３．０］オクタン化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8106215B2 (de) |
| EP (1) | EP2164847B1 (de) |
| JP (1) | JP2010531871A (de) |
| KR (1) | KR20100041805A (de) |
| CN (1) | CN101730696B (de) |
| AT (1) | ATE524466T1 (de) |
| AU (1) | AU2008272449A1 (de) |
| BR (1) | BRPI0813218A2 (de) |
| CA (1) | CA2691373A1 (de) |
| ES (1) | ES2371514T3 (de) |
| PL (1) | PL2164847T3 (de) |
| WO (1) | WO2009004584A1 (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015506382A (ja) * | 2012-02-07 | 2015-03-02 | エオラス セラピューティクス， インコーポレイテッド | オレキシンレセプターアンタゴニストとしての置換プロリン／ピペリジン |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2662612A1 (en) * | 2006-09-29 | 2008-04-03 | Actelion Pharmaceuticals Ltd | 3-aza-bicyclo[3.1.0]hexane derivatives |
| ES2357992T3 (es) | 2006-12-01 | 2011-05-04 | Actelion Pharmaceuticals Ltd. | Derivados de 3-heteroaril(amino o amido)-1-(bifenil o feniltiazolil)carbonilpiperidina como inhibidores del receptor de orexina. |
| TW200833328A (en) | 2006-12-28 | 2008-08-16 | Actelion Pharmaceuticals Ltd | 2-aza-bicyclo[3.1.0]hexane derivatives |
| CL2008000836A1 (es) * | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
| JP2010528007A (ja) | 2007-05-23 | 2010-08-19 | メルク・シャープ・エンド・ドーム・コーポレイション | シクロプロピルピロリジンオレキシン受容体アンタゴニスト |
| WO2009040730A2 (en) * | 2007-09-24 | 2009-04-02 | Actelion Pharmaceuticals Ltd | Pyrrolidines and piperidines as orexin receptor antagonists |
| NZ588080A (en) * | 2008-02-21 | 2012-04-27 | Actelion Pharmaceuticals Ltd | 2-Aza-bicyclo[2.2.1]heptane derivatives |
| CN102015645B (zh) * | 2008-04-30 | 2012-11-14 | 埃科特莱茵药品有限公司 | 哌啶和吡咯烷化合物 |
| JP2012505263A (ja) * | 2008-10-14 | 2012-03-01 | アクテリオン ファーマシューティカルズ リミテッド | フェネチルアミド誘導体及びそれらのヘテロシクリル類似体 |
| AU2010310595B2 (en) | 2009-10-23 | 2015-07-16 | Janssen Pharmaceutica Nv | Disubstituted octahy - dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| LT2855453T (lt) | 2012-06-04 | 2017-02-27 | Actelion Pharmaceuticals Ltd. | Benzimidazolo prolino dariniai |
| KR102151288B1 (ko) | 2012-10-10 | 2020-09-03 | 이도르시아 파마슈티컬스 리미티드 | [오르토 바이 (헤테로 )아릴]-[2-(메타 바이 (헤테로 )아릴)-피롤리딘-1-일]-메타논 유도체인 오렉신 수용체 안타고니스트 |
| CN105051040A (zh) | 2013-03-12 | 2015-11-11 | 埃科特莱茵药品有限公司 | 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物 |
| ITMI20130706A1 (it) * | 2013-04-30 | 2014-10-31 | Dipharma Francis Srl | Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi |
| NO3077389T3 (de) | 2013-12-03 | 2018-02-10 | ||
| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
| PL3077391T3 (pl) | 2013-12-04 | 2019-01-31 | Idorsia Pharmaceuticals Ltd | Zastosowanie pochodnych benzimidazoloproliny |
| TW201613902A (en) | 2014-08-13 | 2016-04-16 | Eolas Therapeutics Inc | Difluoropyrrolidines as orexin receptor modulators |
| US10894789B2 (en) | 2016-02-12 | 2021-01-19 | Astrazeneca Ab | Halo-substituted piperidines as orexin receptor modulators |
| HUE058759T2 (hu) | 2016-03-10 | 2022-09-28 | Janssen Pharmaceutica Nv | Módszerek depresszió kezelésére orexin-2 receptor antagonisták alkalmazásával |
| KR102611212B1 (ko) | 2016-04-19 | 2023-12-07 | 삼성디스플레이 주식회사 | 액정 조성물 및 이를 포함하는 액정 표시 장치 |
| WO2020007964A1 (en) | 2018-07-05 | 2020-01-09 | Idorsia Pharmaceuticals Ltd | 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives |
| WO2020099511A1 (en) | 2018-11-14 | 2020-05-22 | Idorsia Pharmaceuticals Ltd | Benzimidazole-2-methyl-morpholine derivatives |
| WO2023218023A1 (en) | 2022-05-13 | 2023-11-16 | Idorsia Pharmaceuticals Ltd | Thiazoloaryl-methyl substituted cyclic hydrazine-n-carboxamide derivatives |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001096302A1 (en) * | 2000-06-16 | 2001-12-20 | Smithkline Beecham P.L.C. | Piperidines for use as orexin receptor antagonists |
| WO2002044172A1 (en) * | 2000-11-28 | 2002-06-06 | Smithkline Beecham P.L.C. | Morpholine derivatives as antagonists of orexin receptors |
| WO2003041711A1 (en) * | 2001-11-10 | 2003-05-22 | Smithkline Beecham P.L.C. | Piperazine bis-amide derivatives and their use as antagonists of the orexin receptor |
| WO2004026866A1 (en) * | 2002-09-18 | 2004-04-01 | Glaxo Group Limited | N-aroyl cyclic amines as orexin receptor antagonists |
| WO2004047171A1 (en) * | 2002-11-20 | 2004-06-03 | Intel Corporation | Forming a cap above a metal layer |
| WO2008020405A2 (en) * | 2006-08-15 | 2008-02-21 | Actelion Pharmaceuticals Ltd | Azetidine compounds as orexin receptor antagonists |
| WO2008038251A2 (en) * | 2006-09-29 | 2008-04-03 | Actelion Pharmaceuticals Ltd | 3-aza-bicyclo[3.1.0]hexane derivatives |
| WO2008065626A2 (en) * | 2006-12-01 | 2008-06-05 | Actelion Pharmaceuticals Ltd | 3-heteroaryl (amino or amido)-1- (biphenyl or phenylthiazolyl) carbonylpiperidine derivativesas orexin receptor inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57139032A (en) | 1981-02-20 | 1982-08-27 | Takasago Corp | 2-(butan-2-on-3-yl)-5-methylphenol and perfumery composition containing the same |
| GB9319732D0 (en) * | 1993-09-24 | 1993-11-10 | Ucb Sa | Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety |
| US6191124B1 (en) | 1994-04-29 | 2001-02-20 | Pharmacia & Upjohn Company | Methanol derivatives for treatment of retroviral infections especially HIV infections |
| US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| US7432270B2 (en) | 2001-05-05 | 2008-10-07 | Smithkline Beecham P.L.C. | N-aroyl cyclic amines |
| ES2405594T3 (es) | 2002-09-25 | 2013-05-31 | Memory Pharmaceuticals Corporation | Idazoles, benzotiazoles y benzisotiazoles, y preparación y usos de los mismos |
| GB0225944D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| BRPI0508771A (pt) | 2004-03-25 | 2007-08-14 | Memory Pharm Corp | indazóis, benzotiazóis, benzoisotiazóis, benzisoxazóis, e a preparação e usos dos mesmos |
| JP2010534647A (ja) * | 2007-07-27 | 2010-11-11 | アクテリオン ファーマシューティカルズ リミテッド | ２−アザ−ビシクロ［３．３．０］オクタン誘導体 |
-
2008
- 2008-07-02 CA CA002691373A patent/CA2691373A1/en not_active Abandoned
- 2008-07-02 EP EP08763445A patent/EP2164847B1/de not_active Not-in-force
- 2008-07-02 BR BRPI0813218-6A2A patent/BRPI0813218A2/pt not_active IP Right Cessation
- 2008-07-02 CN CN2008800232482A patent/CN101730696B/zh not_active Expired - Fee Related
- 2008-07-02 JP JP2010514232A patent/JP2010531871A/ja not_active Ceased
- 2008-07-02 AU AU2008272449A patent/AU2008272449A1/en not_active Abandoned
- 2008-07-02 WO PCT/IB2008/052656 patent/WO2009004584A1/en active Application Filing
- 2008-07-02 AT AT08763445T patent/ATE524466T1/de active
- 2008-07-02 PL PL08763445T patent/PL2164847T3/pl unknown
- 2008-07-02 US US12/667,193 patent/US8106215B2/en not_active Expired - Fee Related
- 2008-07-02 ES ES08763445T patent/ES2371514T3/es active Active
- 2008-07-02 KR KR1020107002315A patent/KR20100041805A/ko not_active Application Discontinuation
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001096302A1 (en) * | 2000-06-16 | 2001-12-20 | Smithkline Beecham P.L.C. | Piperidines for use as orexin receptor antagonists |
| WO2002044172A1 (en) * | 2000-11-28 | 2002-06-06 | Smithkline Beecham P.L.C. | Morpholine derivatives as antagonists of orexin receptors |
| WO2003041711A1 (en) * | 2001-11-10 | 2003-05-22 | Smithkline Beecham P.L.C. | Piperazine bis-amide derivatives and their use as antagonists of the orexin receptor |
| WO2004026866A1 (en) * | 2002-09-18 | 2004-04-01 | Glaxo Group Limited | N-aroyl cyclic amines as orexin receptor antagonists |
| WO2004047171A1 (en) * | 2002-11-20 | 2004-06-03 | Intel Corporation | Forming a cap above a metal layer |
| WO2008020405A2 (en) * | 2006-08-15 | 2008-02-21 | Actelion Pharmaceuticals Ltd | Azetidine compounds as orexin receptor antagonists |
| WO2008038251A2 (en) * | 2006-09-29 | 2008-04-03 | Actelion Pharmaceuticals Ltd | 3-aza-bicyclo[3.1.0]hexane derivatives |
| WO2008065626A2 (en) * | 2006-12-01 | 2008-06-05 | Actelion Pharmaceuticals Ltd | 3-heteroaryl (amino or amido)-1- (biphenyl or phenylthiazolyl) carbonylpiperidine derivativesas orexin receptor inhibitors |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015506382A (ja) * | 2012-02-07 | 2015-03-02 | エオラス セラピューティクス， インコーポレイテッド | オレキシンレセプターアンタゴニストとしての置換プロリン／ピペリジン |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2164847A1 (de) | 2010-03-24 |
| ES2371514T3 (es) | 2012-01-04 |
| AU2008272449A1 (en) | 2009-01-08 |
| EP2164847B1 (de) | 2011-09-14 |
| RU2010103322A (ru) | 2011-08-10 |
| CN101730696A (zh) | 2010-06-09 |
| KR20100041805A (ko) | 2010-04-22 |
| WO2009004584A1 (en) | 2009-01-08 |
| US8106215B2 (en) | 2012-01-31 |
| BRPI0813218A2 (pt) | 2014-12-23 |
| ATE524466T1 (de) | 2011-09-15 |
| PL2164847T3 (pl) | 2012-02-29 |
| CN101730696B (zh) | 2013-01-09 |
| CA2691373A1 (en) | 2009-01-08 |
| US20100184808A1 (en) | 2010-07-22 |
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